ATE525354T1 - Benzofuranderivate als selektive androgenrezeptormodulatoren (sarms) - Google Patents

Benzofuranderivate als selektive androgenrezeptormodulatoren (sarms)

Info

Publication number
ATE525354T1
ATE525354T1 AT05732623T AT05732623T ATE525354T1 AT E525354 T1 ATE525354 T1 AT E525354T1 AT 05732623 T AT05732623 T AT 05732623T AT 05732623 T AT05732623 T AT 05732623T AT E525354 T1 ATE525354 T1 AT E525354T1
Authority
AT
Austria
Prior art keywords
sarms
androgen receptor
receptor modulators
selective androgen
benzofuran derivatives
Prior art date
Application number
AT05732623T
Other languages
English (en)
Inventor
James C Lanter
Zhihua Sui
James J Fiordeliso
Weiqin Jiang
Xuqing Zhang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34964755&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE525354(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE525354T1 publication Critical patent/ATE525354T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05732623T 2004-05-03 2005-04-01 Benzofuranderivate als selektive androgenrezeptormodulatoren (sarms) ATE525354T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56748904P 2004-05-03 2004-05-03
PCT/US2005/011062 WO2005110985A2 (en) 2004-05-03 2005-04-01 Indole, benzofuran and benzothiophene derivatives as selective androgen receptor modulators (sarms)

Publications (1)

Publication Number Publication Date
ATE525354T1 true ATE525354T1 (de) 2011-10-15

Family

ID=34964755

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05732623T ATE525354T1 (de) 2004-05-03 2005-04-01 Benzofuranderivate als selektive androgenrezeptormodulatoren (sarms)

Country Status (12)

Country Link
US (3) US7288553B2 (de)
EP (2) EP2078712B1 (de)
JP (1) JP4917018B2 (de)
CN (2) CN102091068B (de)
AR (1) AR048723A1 (de)
AT (1) ATE525354T1 (de)
AU (1) AU2005243239C1 (de)
CA (1) CA2565205A1 (de)
ES (1) ES2371170T3 (de)
MY (1) MY143211A (de)
TW (1) TWI359138B (de)
WO (1) WO2005110985A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
ATE525354T1 (de) * 2004-05-03 2011-10-15 Janssen Pharmaceutica Nv Benzofuranderivate als selektive androgenrezeptormodulatoren (sarms)
HRP20120837T1 (hr) * 2007-08-31 2012-11-30 Astellas Pharma Inc. Derivati piperidina
PT2222636E (pt) 2007-12-21 2013-07-16 Ligand Pharm Inc Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações
JP2009173594A (ja) * 2008-01-25 2009-08-06 Sumitomo Chemical Co Ltd アミロイドβタンパク質の蓄積を抑制するための医薬組成物
JP5609150B2 (ja) * 2009-02-27 2014-10-22 アステラス製薬株式会社 ピペリジン誘導体
CA2788907A1 (en) * 2010-02-04 2011-08-11 Radius Health, Inc. Selective androgen receptor modulators
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
EP2875013B1 (de) 2012-07-17 2017-11-29 Glaxosmithkline Intellectual Property (No. 2) Limited Indolcarbonitrile als selektive androgenrezeptormodulatoren
US10441567B2 (en) 2014-01-17 2019-10-15 Ligand Pharmaceuticals Incorporated Methods and compositions for modulating hormone levels
RU2769527C2 (ru) 2016-06-22 2022-04-01 Эллипсес Фарма Лтд Способы лечения ar+ рака молочной железы
MX2021012690A (es) 2019-04-19 2022-01-31 Ligand Pharm Inc Formas cristalinas y metodos para producir formas cristalinas de un compuesto.
WO2022070483A1 (ja) * 2020-09-30 2022-04-07 地方独立行政法人東京都健康長寿医療センター 前立腺癌又は乳癌治療用医薬組成物
CN116969876B (zh) * 2023-06-21 2025-09-12 沈阳药科大学 鸦胆子中吲哚生物碱衍生物及其制备方法和抗肿瘤应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1088059B (de) * 1957-07-11 1960-09-01 Ciba Geigy Verfahren zur Herstellung von in 1- und 9-Stellung substituierten, quaternaeren ª†-Carboliniumsalzen
US3326935A (en) * 1964-01-07 1967-06-20 Smith Kline French Lab (2-amino-1-hydroxyethyl)-thianaphthenes
BE663926A (de) 1964-05-20
GB1123974A (en) * 1964-10-05 1968-08-14 Belge Produits Chimiques Sa Benzofuran derivatives and process for preparing the same
US3929836A (en) * 1965-05-11 1975-12-30 Hoffmann La Roche 2-(2-Lower alkylamino-1-hydroxy-ethyl)-substituted benzofurans
GB1174411A (en) * 1966-03-02 1969-12-17 Aspro Nicholas Ltd Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture
TR16784A (tr) * 1971-04-20 1973-05-01 Hoffmann La Roche Sikroplopan tuervleri
GB1346912A (en) * 1973-04-20 1974-02-13 Roche Products Ltd Substituted benzofurans
DE3070865D1 (en) * 1979-11-15 1985-08-14 Beecham Group Plc Secondary ethanol amines, their preparation and their use in pharmaceutical compositions
JPH04139177A (ja) * 1989-12-28 1992-05-13 Dainippon Ink & Chem Inc フラルベンゾキノン誘導体及びその製造方法並びに制癌剤
CA2112890A1 (en) * 1991-07-09 1993-01-21 Shoichi Chokai Benzofuran derivative and pharmaceutical composition
WO1994024117A1 (fr) * 1993-04-22 1994-10-27 Nippon Shinyaku Co., Ltd. Derive de l'acide benzofurancarboxylique et composition pharmaceutique
US6160109A (en) * 1995-10-20 2000-12-12 Isis Pharmaceuticals, Inc. Preparation of phosphorothioate and boranophosphate oligomers
EP0888324A1 (de) * 1996-03-08 1999-01-07 Synthelabo 2-aminoäthyl-benzofuran-derivate, deren herstellung und verwendung in therapie
GB9610813D0 (en) * 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of benzufuran derivatives
JP2000109479A (ja) * 1998-07-30 2000-04-18 Japan Tobacco Inc ジ置換マレイミド化合物及びその医薬用途
JP3714093B2 (ja) * 2000-02-29 2005-11-09 アイシン精機株式会社 燃料電池
AR030414A1 (es) * 2000-04-03 2003-08-20 Astrazeneca Ab Combinacion farmaceutica que comprende un beta bloqueante y un inhibidor de hmg-coa reductasa , formulacion farmaceutica, equipo transportable de partes , uso de esta combinacion y de esta formulacion para preparar medicamentos
CA2420279C (en) * 2000-08-24 2011-07-19 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof
GB0106177D0 (en) * 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
US20030022868A1 (en) * 2001-06-25 2003-01-30 Dalton James T. Selective androgen receptor modulators and methods of use thereof
WO2003070731A2 (en) * 2002-02-19 2003-08-28 Pharmacia & Upjohn Company Azabicyclic compounds for the treatment of disease
HRP20040887A2 (en) 2002-03-26 2005-04-30 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
ES2291981T3 (es) * 2003-11-20 2008-03-01 Eli Lilly And Company Moduladores del receptor de la vitamina d.
JP4717005B2 (ja) * 2003-11-20 2011-07-06 イーライ リリー アンド カンパニー ビタミンｄ受容体モジュレータ
GB0403148D0 (en) * 2004-02-12 2004-03-17 Smithkline Beecham Corp Chemical compounds
ATE525354T1 (de) * 2004-05-03 2011-10-15 Janssen Pharmaceutica Nv Benzofuranderivate als selektive androgenrezeptormodulatoren (sarms)
WO2005111028A1 (en) * 2004-05-03 2005-11-24 Janssen Pharmaceutica N.V. Novel indole derivatives as selective androgen receptor modulators (sarms)

Also Published As

Publication number Publication date
TW200604171A (en) 2006-02-01
EP2078712B1 (de) 2015-06-10
US20110021785A1 (en) 2011-01-27
WO2005110985A2 (en) 2005-11-24
US8394971B2 (en) 2013-03-12
US7288553B2 (en) 2007-10-30
US20080070970A1 (en) 2008-03-20
ES2371170T3 (es) 2011-12-28
MY143211A (en) 2011-03-31
CA2565205A1 (en) 2005-11-24
AR048723A1 (es) 2006-05-17
AU2005243239C1 (en) 2013-10-24
US20050250740A1 (en) 2005-11-10
JP2007536226A (ja) 2007-12-13
US7678926B2 (en) 2010-03-16
JP4917018B2 (ja) 2012-04-18
AU2005243239B2 (en) 2012-04-26
CN1980891A (zh) 2007-06-13
CN1980891B (zh) 2011-03-09
CN102091068A (zh) 2011-06-15
WO2005110985A3 (en) 2006-04-27
EP1771413B1 (de) 2011-09-21
EP1771413A2 (de) 2007-04-11
EP2078712A1 (de) 2009-07-15
AU2005243239A1 (en) 2005-11-24
CN102091068B (zh) 2012-09-19
TWI359138B (en) 2012-03-01

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties