ATE396998T1 - Tetrazyklische imidazobenzodiazepine als gaba- rezeptormodulatoren - Google Patents

Tetrazyklische imidazobenzodiazepine als gaba- rezeptormodulatoren

Info

Publication number
ATE396998T1
ATE396998T1 AT05825935T AT05825935T ATE396998T1 AT E396998 T1 ATE396998 T1 AT E396998T1 AT 05825935 T AT05825935 T AT 05825935T AT 05825935 T AT05825935 T AT 05825935T AT E396998 T1 ATE396998 T1 AT E396998T1
Authority
AT
Austria
Prior art keywords
imidazobenzodiazepines
tetracyclic
receptor modulators
gaba receptor
gaba
Prior art date
Application number
AT05825935T
Other languages
English (en)
Inventor
Bernd Buettelmann
Henner Knust
Andrew Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE396998T1 publication Critical patent/ATE396998T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05825935T 2004-12-14 2005-12-05 Tetrazyklische imidazobenzodiazepine als gaba- rezeptormodulatoren ATE396998T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04106556 2004-12-14

Publications (1)

Publication Number Publication Date
ATE396998T1 true ATE396998T1 (de) 2008-06-15

Family

ID=36129290

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05825935T ATE396998T1 (de) 2004-12-14 2005-12-05 Tetrazyklische imidazobenzodiazepine als gaba- rezeptormodulatoren

Country Status (17)

Country Link
US (1) US7432256B2 (de)
EP (1) EP1828194B1 (de)
JP (1) JP4783380B2 (de)
KR (1) KR100923393B1 (de)
CN (1) CN101115756B (de)
AR (1) AR055005A1 (de)
AT (1) ATE396998T1 (de)
AU (1) AU2005315913B2 (de)
BR (1) BRPI0515800A (de)
CA (1) CA2590333C (de)
DE (1) DE602005007265D1 (de)
ES (1) ES2307230T3 (de)
MX (1) MX2007007115A (de)
PL (1) PL1828194T3 (de)
RU (1) RU2393161C2 (de)
TW (1) TW200631953A (de)
WO (1) WO2006063708A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008064318A2 (en) * 2006-11-22 2008-05-29 University Of Medicine And Dentistry Of New Jersey Peripheral opioid receptor active compounds
US10206921B2 (en) 2009-06-03 2019-02-19 The Regents Of The University Of California Methods and compositions for treating a subject for central nervous system (CNS) injury
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CA2837818A1 (en) * 2010-06-03 2011-12-08 The Regents Of The University Of California Methods and compositions for treating a subject for central nervous system (cns) injury
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
MX381561B (es) 2013-12-20 2025-03-12 Agenebio Inc Derivados de benzodiazepina, composiciones, y métodos para tratar el deterioro cognitivo.
US10815242B2 (en) 2015-06-19 2020-10-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CA3104478A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20250197390A1 (en) 2022-03-16 2025-06-19 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Fused heterocyclic compound, and preparation method therefor and medical use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
DE3587913D1 (de) * 1984-01-19 1994-10-06 Hoffmann La Roche Imidazodiazepin-Derivate.
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines
TW201311B (de) * 1991-06-17 1993-03-01 Hoffmann La Roche
TWI239333B (en) * 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators
RU2007112940A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные имидазобензодиазепина

Also Published As

Publication number Publication date
TW200631953A (en) 2006-09-16
KR20070089227A (ko) 2007-08-30
AR055005A1 (es) 2007-08-01
AU2005315913B2 (en) 2011-11-24
PL1828194T3 (pl) 2008-11-28
DE602005007265D1 (de) 2008-07-10
EP1828194B1 (de) 2008-05-28
ES2307230T3 (es) 2008-11-16
US7432256B2 (en) 2008-10-07
CA2590333A1 (en) 2006-06-22
CN101115756B (zh) 2010-06-16
WO2006063708A1 (en) 2006-06-22
RU2007121767A (ru) 2009-01-27
MX2007007115A (es) 2007-07-11
KR100923393B1 (ko) 2009-10-23
JP4783380B2 (ja) 2011-09-28
AU2005315913A1 (en) 2006-06-22
RU2393161C2 (ru) 2010-06-27
CA2590333C (en) 2013-01-08
EP1828194A1 (de) 2007-09-05
JP2008523125A (ja) 2008-07-03
CN101115756A (zh) 2008-01-30
BRPI0515800A (pt) 2008-08-05
US20060128691A1 (en) 2006-06-15

Similar Documents

Publication Publication Date Title
DK2653465T3 (da) Opioid-receptormodulatorer
ATE439357T1 (de) Indolylderivate als liver-x-rezeptormodulatoren
DE602007006531D1 (de) Pyrazin-2-carboxamid-derivate als cb2-rezeptormodulatoren
ATE510831T1 (de) Hydrierte benzoäcüthiophenderivate als immunmodulatoren
ATE537157T1 (de) Substituierte phenoxy-n-alkylierte thiazoledindione als östrogenassoziierte rezeptor-alpha-modulatoren
GB0400440D0 (en) Receptor modulators
DK1928845T3 (da) Aminodiazepiner som toll-lignende receptor-modulatorer
ATE538091T1 (de) Tetrahydrocyclopentaäbüindolverbindungen als androgenrezeptormodulatoren
ATE529429T1 (de) Tricyclische spiroderivate als crth2-modulatoren
DE602005014583D1 (de) Fahrradsteuerapparat
DE502005007052D1 (de) Sitzbefestigungsvorrichtung
ATE490251T1 (de) Tricyclische opioidmodulatoren
EP1831743A4 (de) Verstärkungsunterstützte elektroabsorptionsmodulatoren
DE502005005196D1 (de) Direktional verfestigte bauteile
ATE396998T1 (de) Tetrazyklische imidazobenzodiazepine als gaba- rezeptormodulatoren
EP1751115A4 (de) Theramuteinmodulatoren
DE602005021211D1 (de) Befestigungsvorrichtung
EP1915162A4 (de) Modulatoren
ATE537166T1 (de) Piperidylpropanthiole als ccr3-modulatoren
DE602005019719D1 (de) 3-piperidinylisochroman-5-ole als dopaminagonisten
DE602005008596D1 (de) Neue tetracyclische tetrahydrofuranderivate
DE602007008589D1 (de) Pyridooxazepin-progesteronrezeptor-modulatoren
DE602006005138D1 (de) Nichtsteroide glucocorticoid-rezeptormodulatoren
DE602006020489D1 (de) Cb1-rezeptormodulatoren
DE602005003564D1 (de) Progesteronrezeptormodulatoren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1828194

Country of ref document: EP