IN2014KN02993A - - Google Patents

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Publication number
IN2014KN02993A
IN2014KN02993A IN2993KON2014A IN2014KN02993A IN 2014KN02993 A IN2014KN02993 A IN 2014KN02993A IN 2993KON2014 A IN2993KON2014 A IN 2993KON2014A IN 2014KN02993 A IN2014KN02993 A IN 2014KN02993A
Authority
IN
India
Prior art keywords
compounds
modulators
making
methods
relates
Prior art date
Application number
Inventor
Philip Stewart Turnbull
Rodolfo Cadilla
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49117887&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014KN02993(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip No 2 Ltd filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of IN2014KN02993A publication Critical patent/IN2014KN02993A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06Anabolic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
IN2993KON2014 2012-07-17 2013-07-15 IN2014KN02993A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261672455P 2012-07-17 2012-07-17
US201361748874P 2013-01-04 2013-01-04
PCT/IB2013/001530 WO2014013309A1 (en) 2012-07-17 2013-07-15 Indolecarbonitriles as selective androgen receptor modulators

Publications (1)

Publication Number Publication Date
IN2014KN02993A true IN2014KN02993A (en) 2015-05-08

Family

ID=49117887

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2993KON2014 IN2014KN02993A (en) 2012-07-17 2013-07-15

Country Status (39)

Country Link
US (5) US8957104B2 (en)
EP (1) EP2875013B1 (en)
JP (1) JP6106746B2 (en)
KR (1) KR102127939B1 (en)
CN (1) CN104619693B (en)
AR (1) AR091770A1 (en)
AU (1) AU2013291721B2 (en)
BR (1) BR112015000940B1 (en)
CA (1) CA2879104C (en)
CL (1) CL2015000119A1 (en)
CO (1) CO7240378A2 (en)
CR (1) CR20150008A (en)
CY (1) CY1120064T1 (en)
DK (1) DK2875013T3 (en)
DO (1) DOP2015000004A (en)
EA (1) EA026371B8 (en)
ES (1) ES2657912T3 (en)
HK (1) HK1208867A1 (en)
HR (1) HRP20180061T1 (en)
HU (1) HUE036238T2 (en)
IL (1) IL236448A (en)
IN (1) IN2014KN02993A (en)
JO (1) JO3384B1 (en)
LT (1) LT2875013T (en)
ME (1) ME02996B (en)
MX (1) MX349943B (en)
MY (2) MY198512A (en)
NZ (1) NZ703129A (en)
PE (1) PE20150371A1 (en)
PH (1) PH12015500104B1 (en)
PL (1) PL2875013T3 (en)
PT (1) PT2875013T (en)
RS (1) RS56810B1 (en)
SG (1) SG11201408493WA (en)
SI (1) SI2875013T1 (en)
TW (1) TWI574946B (en)
UY (1) UY34911A (en)
WO (1) WO2014013309A1 (en)
ZA (1) ZA201500096B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10155099B2 (en) 2009-09-21 2018-12-18 Cook Regentec Llc Method for infusing stem cells
MY198512A (en) 2012-07-17 2023-09-01 Glaxosmithkline Ip No 2 Ltd Indolecarbonitriles as selective androgen receptor modulators
US9902694B2 (en) * 2014-01-21 2018-02-27 GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No 2) LIMITED Crystalline forms
KR20190077607A (en) * 2014-10-16 2019-07-03 지티엑스, 인코포레이티드 METHODS OF TREATING UROLOGICAL DISORDERS USING SARMs
CN105130872B (en) * 2015-08-25 2018-01-30 江西师范大学 Preparation method of 3-trifluoromethyl substituted indole
CN110437125B (en) * 2019-09-06 2021-03-12 苏州旺山旺水生物医药有限公司 Preparation method of Tezacaftor intermediate II
WO2022204235A1 (en) * 2021-03-23 2022-09-29 Nido Biosciences, Inc. Bicyclic compounds as androgen receptor modulators
CN115010574B (en) * 2022-06-06 2024-01-05 爱斯特(成都)生物制药股份有限公司 Synthesis method of 1-bromo-2-chloro-4-fluoro-2-iodobenzene

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CA2322161A1 (en) 1998-02-25 1999-09-02 Yibin Xiang Inhibitors of phospholipase enzymes
EA005852B1 (en) * 1998-06-19 2005-06-30 Пфайзер Продактс Инк. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
CN100475789C (en) 2002-05-24 2009-04-08 拜尔农作物科学股份公司 Process for the preparation of thioalkylamine derivatives
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
CN1960973A (en) * 2004-03-30 2007-05-09 惠氏公司 1-(1h-indol-1-yl)-3-(4-methylpiperazin-1-yl)-1-phenyl propan-2-ol derivatives and related compounds as modulators of the norepinephrine(NE) and the serotonine(5-HT) activity and the monoamine reuptake
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KR20120083452A (en) * 2009-10-15 2012-07-25 화이자 인코포레이티드 Pyrrolo[2,3-d]pyrimidine compounds
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US9902694B2 (en) * 2014-01-21 2018-02-27 GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No 2) LIMITED Crystalline forms

Also Published As

Publication number Publication date
JO3384B1 (en) 2019-03-13
CL2015000119A1 (en) 2015-04-24
US20170073309A1 (en) 2017-03-16
WO2014013309A1 (en) 2014-01-23
SG11201408493WA (en) 2015-02-27
ME02996B (en) 2018-10-20
CA2879104C (en) 2020-08-25
US20140024694A1 (en) 2014-01-23
JP2015522603A (en) 2015-08-06
AR091770A1 (en) 2015-02-25
ES2657912T3 (en) 2018-03-07
HRP20180061T1 (en) 2018-02-23
US9533948B2 (en) 2017-01-03
PL2875013T3 (en) 2018-06-29
HK1208867A1 (en) 2016-03-18
PT2875013T (en) 2018-02-28
MY173845A (en) 2020-02-24
AU2013291721B2 (en) 2016-02-25
LT2875013T (en) 2018-02-26
CA2879104A1 (en) 2014-01-23
IL236448A (en) 2016-10-31
AU2013291721A1 (en) 2015-02-26
MX349943B (en) 2017-08-21
JP6106746B2 (en) 2017-04-05
PH12015500104A1 (en) 2015-03-02
BR112015000940B1 (en) 2022-05-17
KR102127939B1 (en) 2020-06-29
US20150080449A1 (en) 2015-03-19
US10196353B2 (en) 2019-02-05
SI2875013T1 (en) 2018-03-30
HUE036238T2 (en) 2018-06-28
EA026371B1 (en) 2017-03-31
US20190127326A1 (en) 2019-05-02
DK2875013T3 (en) 2018-01-22
US10710963B2 (en) 2020-07-14
MX2015000825A (en) 2015-07-17
CR20150008A (en) 2015-03-09
RS56810B1 (en) 2018-04-30
US8957104B2 (en) 2015-02-17
NZ703129A (en) 2017-06-30
TW201416349A (en) 2014-05-01
PH12015500104B1 (en) 2015-03-02
MY198512A (en) 2023-09-01
KR20150032333A (en) 2015-03-25
CN104619693B (en) 2019-08-13
ZA201500096B (en) 2017-07-26
UY34911A (en) 2014-02-28
CY1120064T1 (en) 2018-12-12
EA201492237A1 (en) 2015-06-30
EP2875013A1 (en) 2015-05-27
US20200270210A1 (en) 2020-08-27
DOP2015000004A (en) 2015-03-15
CO7240378A2 (en) 2015-04-17
PE20150371A1 (en) 2015-03-27
CN104619693A (en) 2015-05-13
IL236448A0 (en) 2015-02-26
EA026371B8 (en) 2017-06-30
US11299457B2 (en) 2022-04-12
TWI574946B (en) 2017-03-21
EP2875013B1 (en) 2017-11-29
BR112015000940A2 (en) 2017-06-27

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