ES2651019T3 - Compuestos macrocíclicos útiles como inhibidores de cinasas y de HSP90 - Google Patents

Compuestos macrocíclicos útiles como inhibidores de cinasas y de HSP90 Download PDF

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Publication number
ES2651019T3
ES2651019T3 ES07811232.3T ES07811232T ES2651019T3 ES 2651019 T3 ES2651019 T3 ES 2651019T3 ES 07811232 T ES07811232 T ES 07811232T ES 2651019 T3 ES2651019 T3 ES 2651019T3
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Prior art keywords
compound
disease
equiv
acid
hsp90
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Spanish (es)
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Nicolas Winssinger
Sofia Barluenga
Martin Karplus
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Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
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Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
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    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
ES07811232.3T 2006-08-11 2007-08-10 Compuestos macrocíclicos útiles como inhibidores de cinasas y de HSP90 Active ES2651019T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83715406P 2006-08-11 2006-08-11
US837154P 2006-08-11
US85873106P 2006-11-13 2006-11-13
US858731P 2006-11-13
PCT/US2007/017754 WO2008021213A1 (en) 2006-08-11 2007-08-10 Macrocyclic compounds useful as inhibitors of kinases and hsp90

Publications (1)

Publication Number Publication Date
ES2651019T3 true ES2651019T3 (es) 2018-01-23

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ES07811232.3T Active ES2651019T3 (es) 2006-08-11 2007-08-10 Compuestos macrocíclicos útiles como inhibidores de cinasas y de HSP90

Country Status (7)

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US (2) US8067412B2 (OSRAM)
EP (1) EP2136799B1 (OSRAM)
JP (1) JP5465006B2 (OSRAM)
CN (2) CN101588799B (OSRAM)
CA (1) CA2696021C (OSRAM)
ES (1) ES2651019T3 (OSRAM)
WO (1) WO2008021213A1 (OSRAM)

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US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
WO2008021213A1 (en) 2006-08-11 2008-02-21 Nicolas Winssinger Macrocyclic compounds useful as inhibitors of kinases and hsp90
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
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KR101835253B1 (ko) * 2008-01-15 2018-03-06 유니베르시떼 드 스트라스부르 치료제로서 유용한 레조르실산 락톤의 합성
WO2010014617A1 (en) * 2008-07-28 2010-02-04 University Of Kansas Heat shock protein 90 inhibitor dosing methods
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WO2011041593A1 (en) * 2009-09-30 2011-04-07 University Of Kansas Novobiocin analogues and treatment of polycystic kidney disease
WO2012021974A1 (en) * 2010-08-20 2012-02-23 The Hospital For Sick Children Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
CN107011311A (zh) * 2010-10-22 2017-08-04 斯特拉斯堡大学 用于治疗HSP90相关病状的Pochoxime缀合物
EP2771008A4 (en) * 2011-10-28 2015-04-08 Merck Sharp & Dohme MACROCYCLES FOR INCREASING P53 ACTIVITY AND USES THEREOF
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EP2136799A1 (en) 2009-12-30
CN101588799A (zh) 2009-11-25
WO2008021213A1 (en) 2008-02-21
CA2696021A1 (en) 2008-02-21
CA2696021C (en) 2015-09-29
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CN103539769A (zh) 2014-01-29
EP2136799A4 (en) 2010-10-27
JP2010501478A (ja) 2010-01-21
JP5465006B2 (ja) 2014-04-09
US20080146545A1 (en) 2008-06-19
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