CA2696021C - Macrocyclic compounds useful as inhibitors of kinases and hsp90 - Google Patents

Macrocyclic compounds useful as inhibitors of kinases and hsp90 Download PDF

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Publication number
CA2696021C
CA2696021C CA2696021A CA2696021A CA2696021C CA 2696021 C CA2696021 C CA 2696021C CA 2696021 A CA2696021 A CA 2696021A CA 2696021 A CA2696021 A CA 2696021A CA 2696021 C CA2696021 C CA 2696021C
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compound
equiv
disease
eomo
hydrogen
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French (fr)
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CA2696021A1 (en
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Nicolas Winssinger
Sofia Barluenga
Martin Karplus
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Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
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  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
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  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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CA2696021A 2006-08-11 2007-08-10 Macrocyclic compounds useful as inhibitors of kinases and hsp90 Active CA2696021C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83715406P 2006-08-11 2006-08-11
US60/837,154 2006-08-11
US85873106P 2006-11-13 2006-11-13
US60/858,731 2006-11-13
PCT/US2007/017754 WO2008021213A1 (en) 2006-08-11 2007-08-10 Macrocyclic compounds useful as inhibitors of kinases and hsp90

Publications (2)

Publication Number Publication Date
CA2696021A1 CA2696021A1 (en) 2008-02-21
CA2696021C true CA2696021C (en) 2015-09-29

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CA2696021A Active CA2696021C (en) 2006-08-11 2007-08-10 Macrocyclic compounds useful as inhibitors of kinases and hsp90

Country Status (7)

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US (2) US8067412B2 (OSRAM)
EP (1) EP2136799B1 (OSRAM)
JP (1) JP5465006B2 (OSRAM)
CN (2) CN101588799B (OSRAM)
CA (1) CA2696021C (OSRAM)
ES (1) ES2651019T3 (OSRAM)
WO (1) WO2008021213A1 (OSRAM)

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US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
US8067412B2 (en) 2006-08-11 2011-11-29 Universite De Strasbourg Macrocyclic compounds useful as inhibitors of kinases and HSP90
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
CN101889006B (zh) 2007-12-07 2013-09-04 卫材R&D管理株式会社 用于制备玉米赤霉烯酮大环内酯类似物的中间物和方法
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
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US20100022635A1 (en) * 2008-07-28 2010-01-28 University Of Kansas Heat shock protein 90 inhibitor dosing methods
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WO2008021213A1 (en) 2008-02-21
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CN103539769B (zh) 2016-03-16
EP2136799A1 (en) 2009-12-30
CN101588799A (zh) 2009-11-25
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