CN103539769B - 用作激酶抑制剂和hsp90抑制剂的大环化合物 - Google Patents
用作激酶抑制剂和hsp90抑制剂的大环化合物 Download PDFInfo
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- CN103539769B CN103539769B CN201310414870.9A CN201310414870A CN103539769B CN 103539769 B CN103539769 B CN 103539769B CN 201310414870 A CN201310414870 A CN 201310414870A CN 103539769 B CN103539769 B CN 103539769B
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- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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- C07D493/04—Ortho-condensed systems
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83715406P | 2006-08-11 | 2006-08-11 | |
| US60/837,154 | 2006-08-11 | ||
| US85873106P | 2006-11-13 | 2006-11-13 | |
| US60/858,731 | 2006-11-13 | ||
| CN2007800381410A CN101588799B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800381410A Division CN101588799B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103539769A CN103539769A (zh) | 2014-01-29 |
| CN103539769B true CN103539769B (zh) | 2016-03-16 |
Family
ID=39082315
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310414870.9A Active CN103539769B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
| CN2007800381410A Active CN101588799B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800381410A Active CN101588799B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8067412B2 (OSRAM) |
| EP (1) | EP2136799B1 (OSRAM) |
| JP (1) | JP5465006B2 (OSRAM) |
| CN (2) | CN103539769B (OSRAM) |
| CA (1) | CA2696021C (OSRAM) |
| ES (1) | ES2651019T3 (OSRAM) |
| WO (1) | WO2008021213A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8212012B2 (en) * | 2004-11-03 | 2012-07-03 | University Of Kansas | Novobiocin analogues having modified sugar moieties |
| US9120774B2 (en) | 2004-11-03 | 2015-09-01 | University Of Kansas | Novobiocin analogues having modified sugar moieties |
| CA2696021C (en) | 2006-08-11 | 2015-09-29 | Nicolas Winssinger | Macrocyclic compounds useful as inhibitors of kinases and hsp90 |
| US7960353B2 (en) * | 2007-05-10 | 2011-06-14 | University Of Kansas | Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders |
| JP5496908B2 (ja) | 2007-12-07 | 2014-05-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ゼラレノンマクロライドアナログを作製するための中間体および方法 |
| US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
| MX2010007755A (es) * | 2008-01-15 | 2010-12-21 | Univ Strasbourg | Sintesis de lactonas de acido resorcilico utiles como agentes terapeuticos. |
| US20100022635A1 (en) * | 2008-07-28 | 2010-01-28 | University Of Kansas | Heat shock protein 90 inhibitor dosing methods |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| US20110082098A1 (en) * | 2009-09-30 | 2011-04-07 | University Of Kansas | Novobiocin analogues and treatment of polycystic kidney disease |
| US9120768B2 (en) | 2010-08-20 | 2015-09-01 | The Hospital For Sick Children | Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing |
| BR112013009614A2 (pt) * | 2010-10-22 | 2016-07-19 | Centre Nat Rech Scient | conjugados de pochoxime úteis para o tratamento de patologias relacionadas à hsp90 |
| US8987274B2 (en) | 2011-10-28 | 2015-03-24 | Merck Sharp & Dohme Corp | Macrocycles that increase p53 activity and the uses thereof |
| US9993460B2 (en) | 2013-07-26 | 2018-06-12 | Race Oncology Ltd. | Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof |
| WO2016196256A2 (en) * | 2015-06-04 | 2016-12-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
| WO2022089449A1 (zh) * | 2020-10-26 | 2022-05-05 | 山东大学 | 一种特异性热休克蛋白90α亚型抑制剂制备及其应用 |
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| US3196019A (en) | 1964-04-06 | 1965-07-20 | Purdue Research Foundation | Anabolic and estrogenic compound and process of making |
| US3239346A (en) * | 1965-02-15 | 1966-03-08 | Commercial Solvents Corp | Estrogenic compounds and animal growth promoters |
| FR96016E (fr) | 1966-06-29 | 1972-05-19 | Commercial Solvents Corp | Composé utilisable comme supplément alimentaire pour les animaux. |
| US3453367A (en) | 1966-06-29 | 1969-07-01 | Commercial Solvents Corp | Methods for treating inflammation with estrogenic compounds |
| NL131183C (OSRAM) | 1966-12-13 | |||
| US3758511A (en) | 1967-01-18 | 1973-09-11 | Merck & Co Inc | Preparation of d,1-zearalenones |
| US3551454A (en) | 1967-07-26 | 1970-12-29 | Merck & Co Inc | Preparation of optically active (-)-zearalenone and intermediates therefor |
| US3586701A (en) | 1967-08-24 | 1971-06-22 | Commercial Solvents Corp | Norzearalane and its production |
| US3887583A (en) | 1968-05-15 | 1975-06-03 | Commercial Solvents Corp | Products and process |
| US3591608A (en) * | 1968-11-15 | 1971-07-06 | Ayerst Mckenna & Harrison | Macrocyclic ketolactones |
| US3621036A (en) | 1969-02-27 | 1971-11-16 | Merck & Co Inc | Derivatives of zearalane |
| US3860616A (en) | 1969-05-01 | 1975-01-14 | Merck & Co Inc | Synthesis of d,1-zearalanol |
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| BE757082A (fr) | 1970-02-16 | 1971-03-16 | Commercial Solvents Corp | Procede de preparation de nouveaux produits a activite antibacterienne |
| BE757083A (fr) | 1970-02-16 | 1971-03-16 | Commercial Solvents Corp | Nouveaux produits a activite antibacterienne |
| US3687982A (en) | 1971-03-09 | 1972-08-29 | Commercial Solvents Corp | Separation of mixed diastereoisomers of zearalanol |
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- 2007-08-10 US US11/891,652 patent/US8067412B2/en active Active
- 2007-08-10 CN CN201310414870.9A patent/CN103539769B/zh active Active
- 2007-08-10 JP JP2009523852A patent/JP5465006B2/ja not_active Expired - Fee Related
- 2007-08-10 CN CN2007800381410A patent/CN101588799B/zh active Active
- 2007-08-10 ES ES07811232.3T patent/ES2651019T3/es active Active
- 2007-08-10 EP EP07811232.3A patent/EP2136799B1/en active Active
- 2007-08-10 WO PCT/US2007/017754 patent/WO2008021213A1/en not_active Ceased
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2011
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2010501478A (ja) | 2010-01-21 |
| US20080146545A1 (en) | 2008-06-19 |
| JP5465006B2 (ja) | 2014-04-09 |
| ES2651019T3 (es) | 2018-01-23 |
| CN101588799A (zh) | 2009-11-25 |
| EP2136799A1 (en) | 2009-12-30 |
| CN101588799B (zh) | 2013-09-11 |
| EP2136799B1 (en) | 2017-10-04 |
| CA2696021C (en) | 2015-09-29 |
| US8450305B2 (en) | 2013-05-28 |
| WO2008021213A1 (en) | 2008-02-21 |
| US8067412B2 (en) | 2011-11-29 |
| CN103539769A (zh) | 2014-01-29 |
| CA2696021A1 (en) | 2008-02-21 |
| US20120077775A1 (en) | 2012-03-29 |
| EP2136799A4 (en) | 2010-10-27 |
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