ES2637497T3 - Procedimientos y composiciones para la mejora de la función cognitiva - Google Patents
Procedimientos y composiciones para la mejora de la función cognitiva Download PDFInfo
- Publication number
- ES2637497T3 ES2637497T3 ES09748527.0T ES09748527T ES2637497T3 ES 2637497 T3 ES2637497 T3 ES 2637497T3 ES 09748527 T ES09748527 T ES 09748527T ES 2637497 T3 ES2637497 T3 ES 2637497T3
- Authority
- ES
- Spain
- Prior art keywords
- butanamide
- oxo
- azepanyl
- azepanil
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title abstract description 3
- 238000000034 method Methods 0.000 title description 2
- 230000003920 cognitive function Effects 0.000 title 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 abstract 1
- 229960004002 levetiracetam Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 description 18
- -1 iodomethyl Chemical group 0.000 description 10
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10584708P | 2008-10-16 | 2008-10-16 | |
| US105847P | 2008-10-16 | ||
| US15263109P | 2009-02-13 | 2009-02-13 | |
| US152631P | 2009-02-13 | ||
| US17553609P | 2009-05-05 | 2009-05-05 | |
| US175536P | 2009-05-05 | ||
| PCT/US2009/005647 WO2010044878A1 (en) | 2008-10-16 | 2009-10-16 | Methods and compositions for improving cognitive function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2637497T3 true ES2637497T3 (es) | 2017-10-13 |
Family
ID=41403972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09748527.0T Active ES2637497T3 (es) | 2008-10-16 | 2009-10-16 | Procedimientos y composiciones para la mejora de la función cognitiva |
| ES17167125T Active ES2865504T3 (es) | 2008-10-16 | 2009-10-16 | Procedimientos y composiciones para la mejora de la función cognitiva |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17167125T Active ES2865504T3 (es) | 2008-10-16 | 2009-10-16 | Procedimientos y composiciones para la mejora de la función cognitiva |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20100099735A1 (enExample) |
| EP (2) | EP2346500B1 (enExample) |
| JP (3) | JP5917148B2 (enExample) |
| CN (2) | CN107243007A (enExample) |
| AU (1) | AU2009303834B2 (enExample) |
| BR (1) | BRPI0920342A2 (enExample) |
| CA (1) | CA2740610C (enExample) |
| DK (2) | DK3260118T3 (enExample) |
| EA (1) | EA033130B1 (enExample) |
| ES (2) | ES2637497T3 (enExample) |
| HK (1) | HK1245099A1 (enExample) |
| WO (1) | WO2010044878A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107243007A (zh) | 2008-10-16 | 2017-10-13 | 约翰斯.霍普金斯大学 | 改善认知功能的方法和组合物 |
| BR112013020283A2 (pt) * | 2011-02-09 | 2016-07-19 | Univ Johns Hopkins | "uso de inibidor de proteína de vesícula sináptica 2a (sv2a), valproato, levetiracetam, brivarecetam e seletracetam no tratamento de deficiência cognitiva, bem como composição farmacêutica compreendendo os mesmos" |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| US20160030391A1 (en) * | 2013-03-15 | 2016-02-04 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| HK1218623A1 (zh) | 2013-03-15 | 2017-03-03 | 艾吉因生物股份有限公司 | 用於改善認知功能的方法和組合物 |
| EP3297611B1 (en) * | 2015-05-22 | 2019-07-03 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| US10925834B2 (en) * | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| EP3397253A1 (en) | 2015-12-30 | 2018-11-07 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of seizure-related disorders |
| RS66710B1 (sr) * | 2016-05-20 | 2025-05-30 | Pasteur Institut | Levetiracetam, brivaracetam ili selectracetam za upotrebu u lečenju akutne moždane disfunkcije izazvane sepsom |
| US10370561B2 (en) | 2016-06-28 | 2019-08-06 | Prc-Desoto International, Inc. | Urethane/urea-containing bis(alkenyl) ethers, prepolymers prepared using urethane/urea-containing bis(alkenyl) ethers, and uses thereof |
| US11098222B2 (en) | 2018-07-03 | 2021-08-24 | Prc-Desoto International, Inc. | Sprayable polythioether coatings and sealants |
| CN109892247B (zh) * | 2019-04-19 | 2023-08-18 | 桂林医学院 | 一种猫参与的检测大鼠认知功能的实验装置 |
| US20220354807A1 (en) * | 2019-09-30 | 2022-11-10 | Xiamen University | Use of valeric acid derivative in treatment of down's syndrome |
| MX2023000405A (es) * | 2020-07-10 | 2023-05-10 | Agenebio Inc | Combinaciones de agonistas del receptor a del acido gamma aminobutirico (gabaa) alfa 5 e inhibidores de la glicoproteina de vesicula sinaptica 2a (sv2a) y metodos de uso en el tratamiento del deterioro cognitivo. |
| IL305471A (en) * | 2021-02-26 | 2023-10-01 | Syndesi Therapeutics Sa | Compounds for the treatment of cognitive disorders |
| CA3265413A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzoazepine derivatives, compositions and methods of treatment for cognitive impairment |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1309692A (en) | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
| GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
| IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
| IT1075280B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
| BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
| EP0005689B1 (fr) * | 1978-05-08 | 1981-03-18 | U C B, S.A. | Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques |
| US4654370A (en) | 1979-03-12 | 1987-03-31 | Abbott Laboratories | Glyceryl valproates |
| US4372960A (en) * | 1980-12-12 | 1983-02-08 | Warner-Lambert Company | Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators |
| FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
| IL67623A (en) * | 1983-01-05 | 1984-09-30 | Teva Pharma | 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it |
| IL72381A (en) | 1983-07-20 | 1988-03-31 | Sanofi Sa | Pharmaceutical composition based on valproic acid |
| US4558070A (en) * | 1983-10-26 | 1985-12-10 | Abbott Laboratories | Acid salts of valproic acid |
| GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| US4913906B1 (en) * | 1985-02-28 | 2000-06-06 | Yissum Res Dev Co | Controlled release dosage form of valproic acid |
| JPS6222785A (ja) * | 1985-07-23 | 1987-01-30 | Sanwa Kagaku Kenkyusho:Kk | 新規な2−オキソピロリジン化合物及びその塩、その製法並びにこれらを有効成分とする脳機能障害の予防及び治療剤 |
| IT1190133B (it) | 1986-06-19 | 1988-02-10 | Chiesi Farma Spa | Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| DE3709230A1 (de) | 1987-03-20 | 1988-10-06 | Desitin Arzneimittel Gmbh | Neues calciumsalz der valproinsaeure |
| JPS6422883A (en) * | 1987-07-17 | 1989-01-25 | Sanwa Kagaku Kenkyusho Co | 1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient |
| ATE68346T1 (de) * | 1987-07-22 | 1991-11-15 | Farvalsa Ag | Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. |
| HUT53607A (en) | 1989-01-17 | 1990-11-28 | Hoffmann La Roche | Process for production of derivatives of cyclohexan-acetamid |
| FR2643556B1 (fr) | 1989-02-27 | 1993-03-05 | Sanofi Sa | Composition pharmaceutique a liberation prolongee d'acide valproique |
| IT1231477B (it) * | 1989-07-12 | 1991-12-07 | Sigma Tau Ind Farmaceuti | (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
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| US5439930A (en) * | 1992-04-14 | 1995-08-08 | Russian-American Institute For New Drug Development | Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects |
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| WO2002053153A1 (en) * | 2000-12-28 | 2002-07-11 | Daiichi Pharmaceutical Co., Ltd. | Medicines for treatment and prevention of neurogenic pain |
| US6610326B2 (en) | 2001-02-16 | 2003-08-26 | Andrx Corporation | Divalproex sodium tablets |
| AU2002245486B2 (en) * | 2001-02-23 | 2006-11-16 | Ucb Pharma, S.A. | Treatment of tics, tremors and related disorders |
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| US20040192759A1 (en) * | 2001-08-22 | 2004-09-30 | Eiichi Otomo | Use of nefiracetam for treating neurodegeneration |
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| ITMI20030573A1 (it) * | 2003-03-24 | 2004-09-25 | Nikem Research Srl | Composti ad azione nootropica, loro preparazione, |
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| ZA200604410B (en) | 2003-12-02 | 2008-09-25 | Ucb Sa | Imidazole derivatives, processes for preparing them and their uses |
| JP2007533741A (ja) | 2004-04-22 | 2007-11-22 | イーライ リリー アンド カンパニー | Bace阻害剤 |
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| WO2006034196A1 (en) * | 2004-09-17 | 2006-03-30 | Lifelike Biomatic Inc. | Compositions for enhancing memory and methods therefor |
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| US20070298098A1 (en) * | 2005-02-16 | 2007-12-27 | Elan Pharma International Limited | Controlled Release Compositions Comprising Levetiracetam |
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| AU2007346591A1 (en) * | 2007-02-07 | 2008-08-14 | Gosforth Centre (Holdings) Pty Ltd | Treatment of ADHD |
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| KR20090031333A (ko) | 2007-09-21 | 2009-03-25 | 주식회사 엘지생명과학 | 신규한 베타-세크리타제 저해용 화합물 |
| US20090176740A1 (en) | 2007-11-30 | 2009-07-09 | Phillips Ii Dauglas James | Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine |
| AU2009221177B2 (en) * | 2008-03-03 | 2013-05-30 | Ucb Biopharma Sprl | Pharmaceutical solutions, process of preparation and therapeutic uses |
| JP2010024156A (ja) | 2008-07-16 | 2010-02-04 | Ucb Pharma Sa | レベチラセタムを含む医薬組成物 |
| WO2010015029A1 (en) | 2008-08-06 | 2010-02-11 | Gosforth Centre (Holdings) Pty Ltd | Compositions and methods for treating psychiatric disorders |
| CN107243007A (zh) | 2008-10-16 | 2017-10-13 | 约翰斯.霍普金斯大学 | 改善认知功能的方法和组合物 |
| US9125898B2 (en) * | 2008-11-14 | 2015-09-08 | Neurotune Ag | Acetam derivatives for pain relief |
| KR101689688B1 (ko) | 2008-11-18 | 2016-12-26 | 유씨비 파마, 에스.에이. | 2옥소1피롤리딘 유도체를 포함하는 지연 방출형 제형 |
| CN102300562A (zh) | 2009-01-29 | 2011-12-28 | Ucb医药有限公司 | 含有2-氧代-1-吡咯烷衍生物的药物组合物 |
| US8563036B2 (en) | 2009-02-09 | 2013-10-22 | Ucb Pharma, S.A. | Pharmaceutical compositions comprising Brivaracetam |
| WO2011015349A2 (en) | 2009-08-07 | 2011-02-10 | Ucb Pharma, S.A. | Methods for enhancing the cognitive function |
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2009
- 2009-10-16 CN CN201710440380.4A patent/CN107243007A/zh active Pending
- 2009-10-16 ES ES09748527.0T patent/ES2637497T3/es active Active
- 2009-10-16 EP EP09748527.0A patent/EP2346500B1/en active Active
- 2009-10-16 US US12/580,464 patent/US20100099735A1/en not_active Abandoned
- 2009-10-16 DK DK17167125.8T patent/DK3260118T3/da active
- 2009-10-16 EA EA201170571A patent/EA033130B1/ru not_active IP Right Cessation
- 2009-10-16 AU AU2009303834A patent/AU2009303834B2/en active Active
- 2009-10-16 CA CA2740610A patent/CA2740610C/en active Active
- 2009-10-16 EP EP17167125.8A patent/EP3260118B1/en active Active
- 2009-10-16 JP JP2011532085A patent/JP5917148B2/ja active Active
- 2009-10-16 DK DK09748527.0T patent/DK2346500T3/en active
- 2009-10-16 BR BRPI0920342-7A patent/BRPI0920342A2/pt not_active Application Discontinuation
- 2009-10-16 ES ES17167125T patent/ES2865504T3/es active Active
- 2009-10-16 WO PCT/US2009/005647 patent/WO2010044878A1/en not_active Ceased
- 2009-10-16 CN CN2009801474233A patent/CN102227217A/zh active Pending
-
2011
- 2011-11-02 US US13/287,531 patent/US8604075B2/en active Active
-
2014
- 2014-04-25 US US14/261,962 patent/US20150094352A1/en not_active Abandoned
- 2014-06-24 JP JP2014129145A patent/JP2014169339A/ja not_active Withdrawn
-
2016
- 2016-05-25 JP JP2016103917A patent/JP6271641B2/ja active Active
-
2018
- 2018-04-06 HK HK18104537.2A patent/HK1245099A1/zh unknown
-
2021
- 2021-08-17 US US17/404,124 patent/US20220218665A1/en not_active Abandoned
-
2023
- 2023-10-03 US US18/376,127 patent/US20240293363A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EA033130B1 (ru) | 2019-08-30 |
| CA2740610A1 (en) | 2010-04-22 |
| AU2009303834A1 (en) | 2010-04-22 |
| JP2014169339A (ja) | 2014-09-18 |
| JP5917148B2 (ja) | 2016-05-11 |
| CN102227217A (zh) | 2011-10-26 |
| EP3260118B1 (en) | 2021-03-24 |
| JP2016147915A (ja) | 2016-08-18 |
| HK1248543A1 (en) | 2018-10-19 |
| HK1245099A1 (zh) | 2018-08-24 |
| CA2740610C (en) | 2020-01-07 |
| EP3260118A1 (en) | 2017-12-27 |
| US8604075B2 (en) | 2013-12-10 |
| JP2012505883A (ja) | 2012-03-08 |
| EP2346500B1 (en) | 2017-05-17 |
| US20220218665A1 (en) | 2022-07-14 |
| US20100099735A1 (en) | 2010-04-22 |
| DK3260118T3 (da) | 2021-04-19 |
| EP2346500A1 (en) | 2011-07-27 |
| US20240293363A1 (en) | 2024-09-05 |
| EA201170571A1 (ru) | 2011-12-30 |
| CN107243007A (zh) | 2017-10-13 |
| US20150094352A1 (en) | 2015-04-02 |
| AU2009303834B2 (en) | 2016-08-11 |
| JP6271641B2 (ja) | 2018-01-31 |
| BRPI0920342A2 (pt) | 2020-06-23 |
| US20120046336A1 (en) | 2012-02-23 |
| ES2865504T3 (es) | 2021-10-15 |
| DK2346500T3 (en) | 2017-07-17 |
| WO2010044878A1 (en) | 2010-04-22 |
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