ES2637497T3 - Procedimientos y composiciones para la mejora de la función cognitiva - Google Patents
Procedimientos y composiciones para la mejora de la función cognitiva Download PDFInfo
- Publication number
- ES2637497T3 ES2637497T3 ES09748527.0T ES09748527T ES2637497T3 ES 2637497 T3 ES2637497 T3 ES 2637497T3 ES 09748527 T ES09748527 T ES 09748527T ES 2637497 T3 ES2637497 T3 ES 2637497T3
- Authority
- ES
- Spain
- Prior art keywords
- butanamide
- oxo
- azepanyl
- azepanil
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title abstract description 3
- 238000000034 method Methods 0.000 title description 2
- 230000003920 cognitive function Effects 0.000 title 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 abstract 1
- 229960004002 levetiracetam Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 description 18
- -1 iodomethyl Chemical group 0.000 description 10
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10584708P | 2008-10-16 | 2008-10-16 | |
| US105847P | 2008-10-16 | ||
| US15263109P | 2009-02-13 | 2009-02-13 | |
| US152631P | 2009-02-13 | ||
| US17553609P | 2009-05-05 | 2009-05-05 | |
| US175536P | 2009-05-05 | ||
| PCT/US2009/005647 WO2010044878A1 (en) | 2008-10-16 | 2009-10-16 | Methods and compositions for improving cognitive function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2637497T3 true ES2637497T3 (es) | 2017-10-13 |
Family
ID=41403972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09748527.0T Active ES2637497T3 (es) | 2008-10-16 | 2009-10-16 | Procedimientos y composiciones para la mejora de la función cognitiva |
| ES17167125T Active ES2865504T3 (es) | 2008-10-16 | 2009-10-16 | Procedimientos y composiciones para la mejora de la función cognitiva |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17167125T Active ES2865504T3 (es) | 2008-10-16 | 2009-10-16 | Procedimientos y composiciones para la mejora de la función cognitiva |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20100099735A1 (enExample) |
| EP (2) | EP3260118B1 (enExample) |
| JP (3) | JP5917148B2 (enExample) |
| CN (2) | CN102227217A (enExample) |
| AU (1) | AU2009303834B2 (enExample) |
| BR (1) | BRPI0920342A2 (enExample) |
| CA (1) | CA2740610C (enExample) |
| DK (2) | DK3260118T3 (enExample) |
| EA (1) | EA033130B1 (enExample) |
| ES (2) | ES2637497T3 (enExample) |
| HK (1) | HK1245099A1 (enExample) |
| WO (1) | WO2010044878A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009303834B2 (en) | 2008-10-16 | 2016-08-11 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| CN109662961A (zh) * | 2011-02-09 | 2019-04-23 | 约翰斯霍普金斯大学 | 用于改善认知功能的方法和组合物 |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| EP2968237A4 (en) * | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| US20160030391A1 (en) * | 2013-03-15 | 2016-02-04 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| JP6433482B2 (ja) | 2013-03-15 | 2018-12-05 | エージンバイオ, インコーポレイテッド | 認知機能を改善するための方法および組成物 |
| BR112017025031B1 (pt) * | 2015-05-22 | 2023-03-21 | Agenebio, Inc | Composições farmacêuticas de liberação prolongada de levetiracetam |
| MA50634A (fr) * | 2015-05-22 | 2021-04-28 | Agenebio Inc | Compositions pharmaceutiques à libération prolongée comportant du lévétiracétam |
| CN109069480A (zh) | 2015-12-30 | 2018-12-21 | 阿达玛斯医药公司 | 用于治疗与癫痫相关的病症的方法和组合物 |
| EP3458049B1 (en) * | 2016-05-20 | 2025-03-05 | Institut Pasteur | Levetiracetam, brivaracetam or selectracetam for use in treating sepsis induced acute brain dysfunction |
| US10370561B2 (en) | 2016-06-28 | 2019-08-06 | Prc-Desoto International, Inc. | Urethane/urea-containing bis(alkenyl) ethers, prepolymers prepared using urethane/urea-containing bis(alkenyl) ethers, and uses thereof |
| US11098222B2 (en) | 2018-07-03 | 2021-08-24 | Prc-Desoto International, Inc. | Sprayable polythioether coatings and sealants |
| CN109892247B (zh) * | 2019-04-19 | 2023-08-18 | 桂林医学院 | 一种猫参与的检测大鼠认知功能的实验装置 |
| US20220354807A1 (en) * | 2019-09-30 | 2022-11-10 | Xiamen University | Use of valeric acid derivative in treatment of down's syndrome |
| IL299754A (en) * | 2020-07-10 | 2023-03-01 | Agenebio Inc | Combinations of gaba alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment |
| JP2024508052A (ja) * | 2021-02-26 | 2024-02-21 | シンデシ セラピューティクス ソシエテ アノニム | 認知障害の治療のための化合物 |
| IL319072A (en) | 2022-08-19 | 2025-04-01 | Agenebio Inc | History of Benzazepine, Compositions and Methods for Treating Cognitive Impairment |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1309692A (en) | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
| GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
| IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
| IT1075280B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
| BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
| DE2960194D1 (en) * | 1978-05-08 | 1981-04-16 | Ucb Sa | Lactam-n-acetic acids, their amides, process for their preparation and therapeutic compositions containing them |
| US4654370A (en) | 1979-03-12 | 1987-03-31 | Abbott Laboratories | Glyceryl valproates |
| US4372960A (en) * | 1980-12-12 | 1983-02-08 | Warner-Lambert Company | Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators |
| FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
| IL67623A (en) | 1983-01-05 | 1984-09-30 | Teva Pharma | 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it |
| IL72381A (en) * | 1983-07-20 | 1988-03-31 | Sanofi Sa | Pharmaceutical composition based on valproic acid |
| US4558070A (en) | 1983-10-26 | 1985-12-10 | Abbott Laboratories | Acid salts of valproic acid |
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| US4913906B1 (en) * | 1985-02-28 | 2000-06-06 | Yissum Res Dev Co | Controlled release dosage form of valproic acid |
| JPS6222785A (ja) * | 1985-07-23 | 1987-01-30 | Sanwa Kagaku Kenkyusho:Kk | 新規な2−オキソピロリジン化合物及びその塩、その製法並びにこれらを有効成分とする脳機能障害の予防及び治療剤 |
| IT1190133B (it) * | 1986-06-19 | 1988-02-10 | Chiesi Farma Spa | Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| DE3709230A1 (de) * | 1987-03-20 | 1988-10-06 | Desitin Arzneimittel Gmbh | Neues calciumsalz der valproinsaeure |
| JPS6422883A (en) * | 1987-07-17 | 1989-01-25 | Sanwa Kagaku Kenkyusho Co | 1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient |
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| AU625157B2 (en) | 1989-01-17 | 1992-07-02 | F. Hoffmann-La Roche Ag | Cyclohexaneacetamide derivatives |
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| IT1231477B (it) * | 1989-07-12 | 1991-12-07 | Sigma Tau Ind Farmaceuti | (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
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| ES2311537T3 (es) * | 2001-08-22 | 2009-02-16 | Hamilton Pharmaceuticals, Inc. | Utilizacion de nefiracetam en el tratamiento de la neurodegeneracion postquemica. |
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| ITMI20030573A1 (it) * | 2003-03-24 | 2004-09-25 | Nikem Research Srl | Composti ad azione nootropica, loro preparazione, |
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| MX2010009222A (es) * | 2008-03-03 | 2010-09-28 | Ucb Pharma Sa | Soluciones farmaceuticas, proceso de preparacion y usos terapeuticos. |
| JP2010024156A (ja) | 2008-07-16 | 2010-02-04 | Ucb Pharma Sa | レベチラセタムを含む医薬組成物 |
| WO2010015029A1 (en) | 2008-08-06 | 2010-02-11 | Gosforth Centre (Holdings) Pty Ltd | Compositions and methods for treating psychiatric disorders |
| AU2009303834B2 (en) | 2008-10-16 | 2016-08-11 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US9125898B2 (en) * | 2008-11-14 | 2015-09-08 | Neurotune Ag | Acetam derivatives for pain relief |
| BRPI0921313A2 (pt) | 2008-11-18 | 2015-12-29 | Ucb Pharma Sa | composição farmaucêutica |
| PL2391351T3 (pl) | 2009-01-29 | 2015-02-27 | Ucb Pharma Sa | Kompozycje farmaceutyczne zawierające pochodne 2-okso-1-pirolidyny |
| EP2393483B1 (en) | 2009-02-09 | 2017-06-28 | UCB Biopharma SPRL | Pharmaceutical compositions comprising brivaracetam |
| EP2461808A2 (en) | 2009-08-07 | 2012-06-13 | UCB Pharma S.A. | Methods for enhancing the cognitive function |
| BR112017025031B1 (pt) * | 2015-05-22 | 2023-03-21 | Agenebio, Inc | Composições farmacêuticas de liberação prolongada de levetiracetam |
-
2009
- 2009-10-16 AU AU2009303834A patent/AU2009303834B2/en active Active
- 2009-10-16 ES ES09748527.0T patent/ES2637497T3/es active Active
- 2009-10-16 CA CA2740610A patent/CA2740610C/en active Active
- 2009-10-16 CN CN2009801474233A patent/CN102227217A/zh active Pending
- 2009-10-16 CN CN201710440380.4A patent/CN107243007A/zh active Pending
- 2009-10-16 WO PCT/US2009/005647 patent/WO2010044878A1/en not_active Ceased
- 2009-10-16 ES ES17167125T patent/ES2865504T3/es active Active
- 2009-10-16 BR BRPI0920342-7A patent/BRPI0920342A2/pt not_active Application Discontinuation
- 2009-10-16 JP JP2011532085A patent/JP5917148B2/ja active Active
- 2009-10-16 EP EP17167125.8A patent/EP3260118B1/en active Active
- 2009-10-16 EP EP09748527.0A patent/EP2346500B1/en active Active
- 2009-10-16 DK DK17167125.8T patent/DK3260118T3/da active
- 2009-10-16 US US12/580,464 patent/US20100099735A1/en not_active Abandoned
- 2009-10-16 DK DK09748527.0T patent/DK2346500T3/en active
- 2009-10-16 EA EA201170571A patent/EA033130B1/ru not_active IP Right Cessation
-
2011
- 2011-11-02 US US13/287,531 patent/US8604075B2/en active Active
-
2014
- 2014-04-25 US US14/261,962 patent/US20150094352A1/en not_active Abandoned
- 2014-06-24 JP JP2014129145A patent/JP2014169339A/ja not_active Withdrawn
-
2016
- 2016-05-25 JP JP2016103917A patent/JP6271641B2/ja active Active
-
2018
- 2018-04-06 HK HK18104537.2A patent/HK1245099A1/zh unknown
-
2021
- 2021-08-17 US US17/404,124 patent/US20220218665A1/en not_active Abandoned
-
2023
- 2023-10-03 US US18/376,127 patent/US20240293363A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2740610A1 (en) | 2010-04-22 |
| EP2346500A1 (en) | 2011-07-27 |
| JP6271641B2 (ja) | 2018-01-31 |
| HK1248543A1 (en) | 2018-10-19 |
| JP2012505883A (ja) | 2012-03-08 |
| EP2346500B1 (en) | 2017-05-17 |
| HK1245099A1 (zh) | 2018-08-24 |
| ES2865504T3 (es) | 2021-10-15 |
| AU2009303834A1 (en) | 2010-04-22 |
| DK3260118T3 (da) | 2021-04-19 |
| DK2346500T3 (en) | 2017-07-17 |
| EA033130B1 (ru) | 2019-08-30 |
| JP2014169339A (ja) | 2014-09-18 |
| JP5917148B2 (ja) | 2016-05-11 |
| US20100099735A1 (en) | 2010-04-22 |
| AU2009303834B2 (en) | 2016-08-11 |
| US8604075B2 (en) | 2013-12-10 |
| WO2010044878A1 (en) | 2010-04-22 |
| CN102227217A (zh) | 2011-10-26 |
| JP2016147915A (ja) | 2016-08-18 |
| BRPI0920342A2 (pt) | 2020-06-23 |
| CA2740610C (en) | 2020-01-07 |
| CN107243007A (zh) | 2017-10-13 |
| US20240293363A1 (en) | 2024-09-05 |
| EA201170571A1 (ru) | 2011-12-30 |
| EP3260118B1 (en) | 2021-03-24 |
| EP3260118A1 (en) | 2017-12-27 |
| US20220218665A1 (en) | 2022-07-14 |
| US20150094352A1 (en) | 2015-04-02 |
| US20120046336A1 (en) | 2012-02-23 |
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