EA033130B1 - Способы и композиции для улучшения когнитивной функции - Google Patents
Способы и композиции для улучшения когнитивной функцииInfo
- Publication number
- EA033130B1 EA033130B1 EA201170571A EA201170571A EA033130B1 EA 033130 B1 EA033130 B1 EA 033130B1 EA 201170571 A EA201170571 A EA 201170571A EA 201170571 A EA201170571 A EA 201170571A EA 033130 B1 EA033130 B1 EA 033130B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- levetiracetam
- subject
- pharmaceutically acceptable
- acceptable salt
- cognitive function
- Prior art date
Links
- 230000003920 cognitive function Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000028698 Cognitive impairment Diseases 0.000 abstract 3
- 101710084141 Synaptic vesicle glycoprotein 2A Proteins 0.000 abstract 3
- 208000010877 cognitive disease Diseases 0.000 abstract 3
- 229960004002 levetiracetam Drugs 0.000 abstract 3
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical group CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 2
- 229960002161 brivaracetam Drugs 0.000 abstract 1
- MSYKRHVOOPPJKU-BDAKNGLRSA-N brivaracetam Chemical compound CCC[C@H]1CN([C@@H](CC)C(N)=O)C(=O)C1 MSYKRHVOOPPJKU-BDAKNGLRSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- ANWPENAPCIFDSZ-BQBZGAKWSA-N seletracetam Chemical compound CC[C@@H](C(N)=O)N1C[C@@H](C=C(F)F)CC1=O ANWPENAPCIFDSZ-BQBZGAKWSA-N 0.000 abstract 1
- 229950000852 seletracetam Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10584708P | 2008-10-16 | 2008-10-16 | |
| US15263109P | 2009-02-13 | 2009-02-13 | |
| US17553609P | 2009-05-05 | 2009-05-05 | |
| PCT/US2009/005647 WO2010044878A1 (en) | 2008-10-16 | 2009-10-16 | Methods and compositions for improving cognitive function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201170571A1 EA201170571A1 (ru) | 2011-12-30 |
| EA033130B1 true EA033130B1 (ru) | 2019-08-30 |
Family
ID=41403972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201170571A EA033130B1 (ru) | 2008-10-16 | 2009-10-16 | Способы и композиции для улучшения когнитивной функции |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20100099735A1 (enExample) |
| EP (2) | EP3260118B1 (enExample) |
| JP (3) | JP5917148B2 (enExample) |
| CN (2) | CN107243007A (enExample) |
| AU (1) | AU2009303834B2 (enExample) |
| BR (1) | BRPI0920342A2 (enExample) |
| CA (1) | CA2740610C (enExample) |
| DK (2) | DK2346500T3 (enExample) |
| EA (1) | EA033130B1 (enExample) |
| ES (2) | ES2865504T3 (enExample) |
| HK (1) | HK1245099A1 (enExample) |
| WO (1) | WO2010044878A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0920342A2 (pt) | 2008-10-16 | 2020-06-23 | The Johns Hopkins University | Uso de um inibidor da proteína vesicular sináptica 2a (sv2a) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica para melhora da função cognitiva, uso de levitiracetam ou um sal farmaceuticamente aceitável do mesmo, uso de brivaracetam ou um sal farmaceuticamente aceitável do mesmo, uso do seletracetam ou um sal farmaceuticamente aceitável do mesmo |
| EP2672822A4 (en) * | 2011-02-09 | 2014-08-27 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTIONS |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
| EP2968237A4 (en) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| EP2968257A4 (en) * | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| EP3590506A1 (en) * | 2015-05-22 | 2020-01-08 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| CN107810002B (zh) | 2015-05-22 | 2021-01-05 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
| EP3397253A1 (en) | 2015-12-30 | 2018-11-07 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of seizure-related disorders |
| ES3015257T3 (en) * | 2016-05-20 | 2025-04-30 | Pasteur Institut | Levetiracetam, brivaracetam or selectracetam for use in treating sepsis induced acute brain dysfunction |
| US10370561B2 (en) | 2016-06-28 | 2019-08-06 | Prc-Desoto International, Inc. | Urethane/urea-containing bis(alkenyl) ethers, prepolymers prepared using urethane/urea-containing bis(alkenyl) ethers, and uses thereof |
| US11098222B2 (en) | 2018-07-03 | 2021-08-24 | Prc-Desoto International, Inc. | Sprayable polythioether coatings and sealants |
| CN109892247B (zh) * | 2019-04-19 | 2023-08-18 | 桂林医学院 | 一种猫参与的检测大鼠认知功能的实验装置 |
| WO2021063414A1 (zh) * | 2019-09-30 | 2021-04-08 | 厦门大学 | 戊酸衍生物在治疗唐氏综合征中的应用 |
| IL299754A (en) * | 2020-07-10 | 2023-03-01 | Agenebio Inc | Combinations of gaba alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment |
| EP4572852A1 (en) | 2022-08-19 | 2025-06-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5886023A (en) * | 1991-05-02 | 1999-03-23 | Daiichi Pharmaceutical Co., Ltd. | Agent for improving dementia |
| US20060063707A1 (en) * | 2004-09-17 | 2006-03-23 | Lifelike Biomatic, Inc. | Compositions for enhancing memory and methods therefor |
| EP1731149A1 (en) * | 2005-06-08 | 2006-12-13 | Ucb S.A. | Use of 2-oxo-1-pyrrolidone derivatives for the treatment of diseases characterized by progressive myoclonic epilepsy |
| US20070244143A1 (en) * | 2006-03-08 | 2007-10-18 | Braincells, Inc | Modulation of neurogenesis by nootropic agents |
| US20070298098A1 (en) * | 2005-02-16 | 2007-12-27 | Elan Pharma International Limited | Controlled Release Compositions Comprising Levetiracetam |
| US20080076820A1 (en) * | 2001-08-22 | 2008-03-27 | Eiichi Otomo | Method for treating neurodegeneration |
| WO2009109547A1 (en) * | 2008-03-03 | 2009-09-11 | Ucb Pharma, S.A. | Pharmaceutical solutions, process of preparation and therapeutic uses |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
| GB1309692A (en) | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
| IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
| IT1075280B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
| BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
| EP0005689B1 (fr) * | 1978-05-08 | 1981-03-18 | U C B, S.A. | Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques |
| US4654370A (en) * | 1979-03-12 | 1987-03-31 | Abbott Laboratories | Glyceryl valproates |
| US4372960A (en) * | 1980-12-12 | 1983-02-08 | Warner-Lambert Company | Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators |
| FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
| IL67623A (en) * | 1983-01-05 | 1984-09-30 | Teva Pharma | 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it |
| IL72381A (en) * | 1983-07-20 | 1988-03-31 | Sanofi Sa | Pharmaceutical composition based on valproic acid |
| US4558070A (en) | 1983-10-26 | 1985-12-10 | Abbott Laboratories | Acid salts of valproic acid |
| GB8412358D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| US4913906B1 (en) | 1985-02-28 | 2000-06-06 | Yissum Res Dev Co | Controlled release dosage form of valproic acid |
| JPS6222785A (ja) * | 1985-07-23 | 1987-01-30 | Sanwa Kagaku Kenkyusho:Kk | 新規な2−オキソピロリジン化合物及びその塩、その製法並びにこれらを有効成分とする脳機能障害の予防及び治療剤 |
| IT1190133B (it) * | 1986-06-19 | 1988-02-10 | Chiesi Farma Spa | Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| DE3709230A1 (de) * | 1987-03-20 | 1988-10-06 | Desitin Arzneimittel Gmbh | Neues calciumsalz der valproinsaeure |
| JPS6422883A (en) * | 1987-07-17 | 1989-01-25 | Sanwa Kagaku Kenkyusho Co | 1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient |
| DE3773926D1 (de) | 1987-07-22 | 1991-11-21 | Farvalsa Ag | Feuchtigkeitsstabile feste valproinsaeure-zubereitung und verfahren zu ihrer herstellung. |
| CA2007732A1 (en) | 1989-01-17 | 1990-07-17 | Gary L. Olson | Cyclohexaneacetamide derivatives |
| FR2643556B1 (fr) * | 1989-02-27 | 1993-03-05 | Sanofi Sa | Composition pharmaceutique a liberation prolongee d'acide valproique |
| IT1231477B (it) * | 1989-07-12 | 1991-12-07 | Sigma Tau Ind Farmaceuti | (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
| US5439930A (en) * | 1992-04-14 | 1995-08-08 | Russian-American Institute For New Drug Development | Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects |
| US5440023A (en) * | 1992-09-18 | 1995-08-08 | Beckman Instruments, Inc. | Method for making valproic acid derivatives |
| GB9319732D0 (en) * | 1993-09-24 | 1993-11-10 | Ucb Sa | Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety |
| US5468733A (en) | 1993-09-30 | 1995-11-21 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5516759A (en) | 1994-12-08 | 1996-05-14 | Tap Holdings Inc. | LHRH antagonists having lactam groups at the N-terminus |
| IT1285801B1 (it) * | 1996-10-10 | 1998-06-24 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione dell'acido valproico |
| US6131106A (en) * | 1998-01-30 | 2000-10-10 | Sun Microsystems Inc | System and method for floating-point computation for numbers in delimited floating point representation |
| US6620802B1 (en) * | 1999-11-23 | 2003-09-16 | Corcept Therapeutics, Inc. | Methods of treating mild cognitive impairment using a glucocorticoid-specific receptor antagonist |
| TWI238062B (en) | 1999-12-01 | 2005-08-21 | Ucb Sa | A pyrrolidineacetamide derivative alone or in combination for treatment of CNS disorders |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| EP1356812B1 (en) * | 2000-12-28 | 2009-05-13 | Hamilton Pharmaceuticals, Inc. | Medicines for treatment and prevention of neurogenic pain |
| US6610326B2 (en) | 2001-02-16 | 2003-08-26 | Andrx Corporation | Divalproex sodium tablets |
| EP1379236A4 (en) * | 2001-02-23 | 2009-01-21 | Ucb Sa | TREATMENT OF TICS, TREMOR AND RELATED DISORDER |
| WO2002094787A1 (en) | 2001-05-23 | 2002-11-28 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
| AU2002335015B8 (en) | 2001-10-16 | 2006-11-30 | Memory Pharmaceuticals Corporation | 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes |
| US20040116506A1 (en) * | 2002-06-20 | 2004-06-17 | Krusz John Claude | Use of levetiracetam for treating or preventing acute headaches |
| US7557137B2 (en) * | 2002-08-05 | 2009-07-07 | Bristol-Myers Squibb Company | Gamma-lactams as beta-secretase inhibitors |
| US7090985B2 (en) * | 2002-12-03 | 2006-08-15 | Ucb, S.A. | Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases |
| US20070135514A1 (en) * | 2002-12-03 | 2007-06-14 | Berkley Lynch | Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases |
| ITMI20030573A1 (it) * | 2003-03-24 | 2004-09-25 | Nikem Research Srl | Composti ad azione nootropica, loro preparazione, |
| TW200508197A (en) | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
| ES2323313T3 (es) * | 2003-12-02 | 2009-07-13 | Ucb Pharma, S.A. | Derivados de imidazol, procedimientos para prepararlos y sus usos. |
| US7618978B2 (en) | 2004-04-22 | 2009-11-17 | Eli Lilly And Company | Amides as BACE inhibitors |
| EP1758855B1 (en) | 2004-06-11 | 2007-11-21 | UCB Pharma, S.A. | Process for preparing 2-oxo-1-pyrrolidine derivatives by intramolecular allylation |
| MX2007009088A (es) * | 2005-01-27 | 2007-09-13 | Alembic Ltd | Formulacion de liberacion extendida de levetiracetam. |
| AU2006228947A1 (en) * | 2005-03-30 | 2006-10-05 | Mylan Pharmaceuticals Ulc | Combined-step process for pharmaceutical compositions |
| WO2006128693A2 (en) | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2 -oxo-i -pyrrolidine derivatives/ processes for preparing them and their therapeutic use on the central nervous system |
| GB0517740D0 (en) | 2005-08-31 | 2005-10-12 | Novartis Ag | Organic compounds |
| CA2631885A1 (en) | 2005-12-07 | 2007-06-14 | Ucb Pharma, S.A. | Xanthine derivatives, processes for preparing them and their uses |
| US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7858611B2 (en) * | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
| US7678808B2 (en) * | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| US20080014264A1 (en) * | 2006-07-13 | 2008-01-17 | Ucb, S.A. | Novel pharmaceutical compositions comprising levetiracetam |
| EP2051696A2 (en) * | 2006-08-18 | 2009-04-29 | Morton Grove Pharmaceuticals, Inc. | Stable liquid levetiracetam compositions and methods |
| AU2007346591A1 (en) * | 2007-02-07 | 2008-08-14 | Gosforth Centre (Holdings) Pty Ltd | Treatment of ADHD |
| WO2008132142A2 (en) | 2007-04-27 | 2008-11-06 | Ucb Pharma S.A. | New heterocyclic derivatives useful for the treatment of cns disorders |
| WO2009038412A2 (en) | 2007-09-21 | 2009-03-26 | Lg Life Sciences, Ltd. | Beta-secretase inhibiting compounds |
| US20090176740A1 (en) | 2007-11-30 | 2009-07-09 | Phillips Ii Dauglas James | Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine |
| JP2010024156A (ja) | 2008-07-16 | 2010-02-04 | Ucb Pharma Sa | レベチラセタムを含む医薬組成物 |
| JP2011529923A (ja) | 2008-08-06 | 2011-12-15 | ゴスフォース センター(ホールディングス)プロプライエタリー リミテッド | 精神障害(psychiatricdisorder)を治療するための組成物および方法 |
| BRPI0920342A2 (pt) | 2008-10-16 | 2020-06-23 | The Johns Hopkins University | Uso de um inibidor da proteína vesicular sináptica 2a (sv2a) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica para melhora da função cognitiva, uso de levitiracetam ou um sal farmaceuticamente aceitável do mesmo, uso de brivaracetam ou um sal farmaceuticamente aceitável do mesmo, uso do seletracetam ou um sal farmaceuticamente aceitável do mesmo |
| US9125898B2 (en) * | 2008-11-14 | 2015-09-08 | Neurotune Ag | Acetam derivatives for pain relief |
| AU2009317280B2 (en) | 2008-11-18 | 2014-03-06 | Ucb Pharma, S.A. | Prolonged release formulations comprising an 2 -oxo- 1 -pyrrolidine derivative |
| CA2747396C (en) | 2009-01-29 | 2015-12-08 | Serge Cuypers | Pharmaceutical compositions comprising 2-oxo-1-pyrrolidine derivatives |
| US8563036B2 (en) | 2009-02-09 | 2013-10-22 | Ucb Pharma, S.A. | Pharmaceutical compositions comprising Brivaracetam |
| EP2461808A2 (en) | 2009-08-07 | 2012-06-13 | UCB Pharma S.A. | Methods for enhancing the cognitive function |
-
2009
- 2009-10-16 BR BRPI0920342-7A patent/BRPI0920342A2/pt not_active Application Discontinuation
- 2009-10-16 ES ES17167125T patent/ES2865504T3/es active Active
- 2009-10-16 DK DK09748527.0T patent/DK2346500T3/en active
- 2009-10-16 ES ES09748527.0T patent/ES2637497T3/es active Active
- 2009-10-16 CA CA2740610A patent/CA2740610C/en active Active
- 2009-10-16 DK DK17167125.8T patent/DK3260118T3/da active
- 2009-10-16 EP EP17167125.8A patent/EP3260118B1/en active Active
- 2009-10-16 EP EP09748527.0A patent/EP2346500B1/en active Active
- 2009-10-16 AU AU2009303834A patent/AU2009303834B2/en active Active
- 2009-10-16 CN CN201710440380.4A patent/CN107243007A/zh active Pending
- 2009-10-16 JP JP2011532085A patent/JP5917148B2/ja active Active
- 2009-10-16 CN CN2009801474233A patent/CN102227217A/zh active Pending
- 2009-10-16 US US12/580,464 patent/US20100099735A1/en not_active Abandoned
- 2009-10-16 EA EA201170571A patent/EA033130B1/ru not_active IP Right Cessation
- 2009-10-16 WO PCT/US2009/005647 patent/WO2010044878A1/en not_active Ceased
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2011
- 2011-11-02 US US13/287,531 patent/US8604075B2/en active Active
-
2014
- 2014-04-25 US US14/261,962 patent/US20150094352A1/en not_active Abandoned
- 2014-06-24 JP JP2014129145A patent/JP2014169339A/ja not_active Withdrawn
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2016
- 2016-05-25 JP JP2016103917A patent/JP6271641B2/ja active Active
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2018
- 2018-04-06 HK HK18104537.2A patent/HK1245099A1/zh unknown
-
2021
- 2021-08-17 US US17/404,124 patent/US20220218665A1/en not_active Abandoned
-
2023
- 2023-10-03 US US18/376,127 patent/US20240293363A1/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5886023A (en) * | 1991-05-02 | 1999-03-23 | Daiichi Pharmaceutical Co., Ltd. | Agent for improving dementia |
| US20080076820A1 (en) * | 2001-08-22 | 2008-03-27 | Eiichi Otomo | Method for treating neurodegeneration |
| US20060063707A1 (en) * | 2004-09-17 | 2006-03-23 | Lifelike Biomatic, Inc. | Compositions for enhancing memory and methods therefor |
| US20070298098A1 (en) * | 2005-02-16 | 2007-12-27 | Elan Pharma International Limited | Controlled Release Compositions Comprising Levetiracetam |
| EP1731149A1 (en) * | 2005-06-08 | 2006-12-13 | Ucb S.A. | Use of 2-oxo-1-pyrrolidone derivatives for the treatment of diseases characterized by progressive myoclonic epilepsy |
| US20070244143A1 (en) * | 2006-03-08 | 2007-10-18 | Braincells, Inc | Modulation of neurogenesis by nootropic agents |
| WO2009109547A1 (en) * | 2008-03-03 | 2009-09-11 | Ucb Pharma, S.A. | Pharmaceutical solutions, process of preparation and therapeutic uses |
Non-Patent Citations (4)
| Title |
|---|
| "P.5.017 Use of valproate in treatment of behavioural and psychological disturbances of dementia", EUROPEAN NEUROPSYCHOPHARMACOLOGY., ELSEVIER SCIENCE PUBLISHERS BV, AMSTERDAM., NL, vol. 15, 1 January 2005 (2005-01-01), NL, pages S565, XP025327109, ISSN: 0924-977X * |
| LIPPA CAROL; REVUELTA GONZALO; GLIEBUS GEDIMINAS; IRWIN DAVID; TOWNSHIP HADDON; HEPLER MARJORIE; ROSSO ANDREA: "Levetiracetam: Seizure management for elderly patients with cognitive impairment", NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA, US, vol. 70, no. 11, suppl. 1, 11 March 2008 (2008-03-11), US, pages A97, XP009127253, ISSN: 0028-3878 * |
| MARINI G; CARATTI C; PELUFFO F; CELASCO G; GASPARRO M G: "PLACEBO-CONTROLLED DOUBLE-BLIND STUDY OF PRAMIRACETAM CI-879 IN THE TREATMENT OF ELDERLY SUBJECTS WITH MEMORY IMPAIRMENT", ADVANCES IN THERAPY., HEALTH COMMUNICATIONS, METUCHEN, NJ., US, vol. 9, no. 3, 1 January 1992 (1992-01-01), US, pages 136 - 146, XP009127252, ISSN: 0741-238X * |
| ROZZINI R; ZANETTI O; BIANCHETTI A: "Treatment of cognitive impairment secondary to degenerative dementia. Effectiveness of oxiracetam therapy.", ACTA NEUROLOGICA, CHIRURGIA, NAPLES, IT, vol. 15, no. 1, 1 February 1993 (1993-02-01), IT, pages 44 - 52, XP009127254, ISSN: 0001-6276 * |
Also Published As
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|---|---|
| CA2740610C (en) | 2020-01-07 |
| JP2012505883A (ja) | 2012-03-08 |
| AU2009303834B2 (en) | 2016-08-11 |
| AU2009303834A1 (en) | 2010-04-22 |
| JP2016147915A (ja) | 2016-08-18 |
| EP3260118A1 (en) | 2017-12-27 |
| CA2740610A1 (en) | 2010-04-22 |
| DK3260118T3 (da) | 2021-04-19 |
| US20100099735A1 (en) | 2010-04-22 |
| EP2346500B1 (en) | 2017-05-17 |
| JP6271641B2 (ja) | 2018-01-31 |
| US20150094352A1 (en) | 2015-04-02 |
| JP5917148B2 (ja) | 2016-05-11 |
| US20220218665A1 (en) | 2022-07-14 |
| BRPI0920342A2 (pt) | 2020-06-23 |
| HK1245099A1 (zh) | 2018-08-24 |
| ES2637497T3 (es) | 2017-10-13 |
| US8604075B2 (en) | 2013-12-10 |
| DK2346500T3 (en) | 2017-07-17 |
| CN107243007A (zh) | 2017-10-13 |
| US20120046336A1 (en) | 2012-02-23 |
| JP2014169339A (ja) | 2014-09-18 |
| EA201170571A1 (ru) | 2011-12-30 |
| CN102227217A (zh) | 2011-10-26 |
| HK1248543A1 (en) | 2018-10-19 |
| WO2010044878A1 (en) | 2010-04-22 |
| EP2346500A1 (en) | 2011-07-27 |
| EP3260118B1 (en) | 2021-03-24 |
| US20240293363A1 (en) | 2024-09-05 |
| ES2865504T3 (es) | 2021-10-15 |
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