JP5917148B2 - 認知機能を改善するための方法および組成物 - Google Patents
認知機能を改善するための方法および組成物 Download PDFInfo
- Publication number
- JP5917148B2 JP5917148B2 JP2011532085A JP2011532085A JP5917148B2 JP 5917148 B2 JP5917148 B2 JP 5917148B2 JP 2011532085 A JP2011532085 A JP 2011532085A JP 2011532085 A JP2011532085 A JP 2011532085A JP 5917148 B2 JP5917148 B2 JP 5917148B2
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- methyl
- hydrogen
- alkyl
- butanamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *c1c(*)c(*)c(*)c2c1NC(I)=I2 Chemical compound *c1c(*)c(*)c(*)c2c1NC(I)=I2 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10584708P | 2008-10-16 | 2008-10-16 | |
| US61/105,847 | 2008-10-16 | ||
| US15263109P | 2009-02-13 | 2009-02-13 | |
| US61/152,631 | 2009-02-13 | ||
| US17553609P | 2009-05-05 | 2009-05-05 | |
| US61/175,536 | 2009-05-05 | ||
| PCT/US2009/005647 WO2010044878A1 (en) | 2008-10-16 | 2009-10-16 | Methods and compositions for improving cognitive function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014129145A Division JP2014169339A (ja) | 2008-10-16 | 2014-06-24 | 認知機能を改善するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505883A JP2012505883A (ja) | 2012-03-08 |
| JP2012505883A5 JP2012505883A5 (enExample) | 2012-11-29 |
| JP5917148B2 true JP5917148B2 (ja) | 2016-05-11 |
Family
ID=41403972
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532085A Active JP5917148B2 (ja) | 2008-10-16 | 2009-10-16 | 認知機能を改善するための方法および組成物 |
| JP2014129145A Withdrawn JP2014169339A (ja) | 2008-10-16 | 2014-06-24 | 認知機能を改善するための方法および組成物 |
| JP2016103917A Active JP6271641B2 (ja) | 2008-10-16 | 2016-05-25 | 認知機能を改善するための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014129145A Withdrawn JP2014169339A (ja) | 2008-10-16 | 2014-06-24 | 認知機能を改善するための方法および組成物 |
| JP2016103917A Active JP6271641B2 (ja) | 2008-10-16 | 2016-05-25 | 認知機能を改善するための方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20100099735A1 (enExample) |
| EP (2) | EP3260118B1 (enExample) |
| JP (3) | JP5917148B2 (enExample) |
| CN (2) | CN102227217A (enExample) |
| AU (1) | AU2009303834B2 (enExample) |
| CA (1) | CA2740610C (enExample) |
| DK (2) | DK2346500T3 (enExample) |
| EA (1) | EA033130B1 (enExample) |
| ES (2) | ES2637497T3 (enExample) |
| HK (1) | HK1245099A1 (enExample) |
| WO (1) | WO2010044878A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3260118B1 (en) | 2008-10-16 | 2021-03-24 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| WO2012109491A1 (en) * | 2011-02-09 | 2012-08-16 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014144663A1 (en) * | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US20160030391A1 (en) * | 2013-03-15 | 2016-02-04 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| EP2968220B1 (en) | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| NZ738682A (en) | 2015-05-22 | 2022-01-28 | Agenebio Inc | Extended release pharmaceutical compositions of levetiracetam |
| EP3297611B1 (en) * | 2015-05-22 | 2019-07-03 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| EP3397253A1 (en) | 2015-12-30 | 2018-11-07 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of seizure-related disorders |
| HRP20250410T1 (hr) * | 2016-05-20 | 2025-05-23 | Institut Pasteur | Levetiracetam, brivaracetam ili seletracetam, namijenjeni upotrebi u liječenju akutne disfunkcije mozga uzrokovane sepsom |
| US10370561B2 (en) | 2016-06-28 | 2019-08-06 | Prc-Desoto International, Inc. | Urethane/urea-containing bis(alkenyl) ethers, prepolymers prepared using urethane/urea-containing bis(alkenyl) ethers, and uses thereof |
| US11098222B2 (en) | 2018-07-03 | 2021-08-24 | Prc-Desoto International, Inc. | Sprayable polythioether coatings and sealants |
| CN109892247B (zh) * | 2019-04-19 | 2023-08-18 | 桂林医学院 | 一种猫参与的检测大鼠认知功能的实验装置 |
| CN112569216B (zh) * | 2019-09-30 | 2022-02-15 | 厦门大学 | 戊酸衍生物在治疗唐氏综合征中的应用 |
| WO2022011318A1 (en) * | 2020-07-10 | 2022-01-13 | Agenebio, Inc. | Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment |
| CN117177746A (zh) * | 2021-02-26 | 2023-12-05 | 辛德斯治疗股份公司 | 用于治疗认知病症的化合物 |
| US20240132513A1 (en) | 2022-08-19 | 2024-04-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
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| GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
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| IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
| IT1075280B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
| BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
| ATE27T1 (de) * | 1978-05-08 | 1981-04-15 | Ucb Sa | Lactam-n-essigsaeuren und ihre amide, verfahren zu ihrer herstellung und heilmittel, die sie enthalten |
| US4654370A (en) | 1979-03-12 | 1987-03-31 | Abbott Laboratories | Glyceryl valproates |
| US4372960A (en) * | 1980-12-12 | 1983-02-08 | Warner-Lambert Company | Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators |
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| EP3260118B1 (en) | 2008-10-16 | 2021-03-24 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
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| WO2011015349A2 (en) | 2009-08-07 | 2011-02-10 | Ucb Pharma, S.A. | Methods for enhancing the cognitive function |
| NZ738682A (en) * | 2015-05-22 | 2022-01-28 | Agenebio Inc | Extended release pharmaceutical compositions of levetiracetam |
-
2009
- 2009-10-16 EP EP17167125.8A patent/EP3260118B1/en active Active
- 2009-10-16 CN CN2009801474233A patent/CN102227217A/zh active Pending
- 2009-10-16 JP JP2011532085A patent/JP5917148B2/ja active Active
- 2009-10-16 AU AU2009303834A patent/AU2009303834B2/en active Active
- 2009-10-16 CN CN201710440380.4A patent/CN107243007A/zh active Pending
- 2009-10-16 US US12/580,464 patent/US20100099735A1/en not_active Abandoned
- 2009-10-16 DK DK09748527.0T patent/DK2346500T3/en active
- 2009-10-16 DK DK17167125.8T patent/DK3260118T3/da active
- 2009-10-16 ES ES09748527.0T patent/ES2637497T3/es active Active
- 2009-10-16 EA EA201170571A patent/EA033130B1/ru not_active IP Right Cessation
- 2009-10-16 EP EP09748527.0A patent/EP2346500B1/en active Active
- 2009-10-16 ES ES17167125T patent/ES2865504T3/es active Active
- 2009-10-16 CA CA2740610A patent/CA2740610C/en active Active
- 2009-10-16 WO PCT/US2009/005647 patent/WO2010044878A1/en not_active Ceased
-
2011
- 2011-11-02 US US13/287,531 patent/US8604075B2/en active Active
-
2014
- 2014-04-25 US US14/261,962 patent/US20150094352A1/en not_active Abandoned
- 2014-06-24 JP JP2014129145A patent/JP2014169339A/ja not_active Withdrawn
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2016
- 2016-05-25 JP JP2016103917A patent/JP6271641B2/ja active Active
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2018
- 2018-04-06 HK HK18104537.2A patent/HK1245099A1/zh unknown
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2021
- 2021-08-17 US US17/404,124 patent/US20220218665A1/en not_active Abandoned
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2023
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| Publication number | Publication date |
|---|---|
| EP2346500B1 (en) | 2017-05-17 |
| JP2012505883A (ja) | 2012-03-08 |
| EP3260118B1 (en) | 2021-03-24 |
| AU2009303834B2 (en) | 2016-08-11 |
| EA201170571A1 (ru) | 2011-12-30 |
| EP3260118A1 (en) | 2017-12-27 |
| CN107243007A (zh) | 2017-10-13 |
| US20120046336A1 (en) | 2012-02-23 |
| CN102227217A (zh) | 2011-10-26 |
| HK1245099A1 (zh) | 2018-08-24 |
| US8604075B2 (en) | 2013-12-10 |
| JP2014169339A (ja) | 2014-09-18 |
| EP2346500A1 (en) | 2011-07-27 |
| HK1248543A1 (en) | 2018-10-19 |
| WO2010044878A1 (en) | 2010-04-22 |
| ES2637497T3 (es) | 2017-10-13 |
| DK2346500T3 (en) | 2017-07-17 |
| EA033130B1 (ru) | 2019-08-30 |
| US20220218665A1 (en) | 2022-07-14 |
| CA2740610A1 (en) | 2010-04-22 |
| ES2865504T3 (es) | 2021-10-15 |
| AU2009303834A1 (en) | 2010-04-22 |
| DK3260118T3 (da) | 2021-04-19 |
| JP2016147915A (ja) | 2016-08-18 |
| US20150094352A1 (en) | 2015-04-02 |
| JP6271641B2 (ja) | 2018-01-31 |
| CA2740610C (en) | 2020-01-07 |
| US20100099735A1 (en) | 2010-04-22 |
| BRPI0920342A2 (pt) | 2020-06-23 |
| US20240293363A1 (en) | 2024-09-05 |
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