ES2636239T3 - Generación de moléculas de unión - Google Patents

Generación de moléculas de unión Download PDF

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Publication number
ES2636239T3
ES2636239T3 ES12186010.0T ES12186010T ES2636239T3 ES 2636239 T3 ES2636239 T3 ES 2636239T3 ES 12186010 T ES12186010 T ES 12186010T ES 2636239 T3 ES2636239 T3 ES 2636239T3
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Prior art keywords
cells
antibodies
sequences
antigen
dna
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ES12186010.0T
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English (en)
Spanish (es)
Inventor
Mark Throsby
Ton Logtenberg
Cornelis Adriaan De Kruif
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Merus BV
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Merus BV
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Application filed by Merus BV filed Critical Merus BV
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    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018Orthomyxoviridae, e.g. influenza virus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES12186010.0T 2011-09-26 2012-09-26 Generación de moléculas de unión Active ES2636239T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161539116P 2011-09-26 2011-09-26
US201161539116P 2011-09-26

Publications (1)

Publication Number Publication Date
ES2636239T3 true ES2636239T3 (es) 2017-10-05

Family

ID=47010271

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12186010.0T Active ES2636239T3 (es) 2011-09-26 2012-09-26 Generación de moléculas de unión

Country Status (16)

Country Link
US (5) US9145588B2 (zh)
EP (3) EP3263597A1 (zh)
AU (4) AU2012233037B2 (zh)
CA (1) CA2791109C (zh)
CY (1) CY1119717T1 (zh)
DK (1) DK2604625T3 (zh)
ES (1) ES2636239T3 (zh)
HK (1) HK1247938A1 (zh)
HR (1) HRP20171193T1 (zh)
HU (1) HUE034386T2 (zh)
LT (1) LT2604625T (zh)
ME (1) ME02817B (zh)
PL (1) PL2604625T3 (zh)
PT (1) PT2604625T (zh)
RS (1) RS56302B1 (zh)
SI (1) SI2604625T1 (zh)

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Publication number Publication date
US20160130367A1 (en) 2016-05-12
US20130096020A1 (en) 2013-04-18
AU2012233037A1 (en) 2013-04-11
US20200247908A1 (en) 2020-08-06
EP2604625B1 (en) 2017-06-28
EP3263597A1 (en) 2018-01-03
RS56302B1 (sr) 2017-12-29
CA2791109A1 (en) 2013-03-26
LT2604625T (lt) 2017-09-25
PL2604625T3 (pl) 2017-12-29
DK2604625T3 (en) 2017-08-21
PT2604625T (pt) 2017-08-11
US10647781B2 (en) 2020-05-12
AU2016200316B2 (en) 2017-11-23
CY1119717T1 (el) 2018-09-05
US9908946B2 (en) 2018-03-06
AU2018201328B2 (en) 2020-07-02
US11408095B2 (en) 2022-08-09
AU2016200316A1 (en) 2016-02-11
AU2018201328A1 (en) 2018-03-15
US20230160105A1 (en) 2023-05-25
US20180179300A1 (en) 2018-06-28
EP2604625A1 (en) 2013-06-19
US9145588B2 (en) 2015-09-29
AU2020244368A1 (en) 2020-10-29
EP4086282A1 (en) 2022-11-09
CA2791109C (en) 2021-02-16
SI2604625T1 (sl) 2017-11-30
ME02817B (me) 2018-01-20
HRP20171193T1 (hr) 2017-12-01
HUE034386T2 (en) 2018-02-28
HK1247938A1 (zh) 2018-10-05
AU2012233037B2 (en) 2015-10-29

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