ES2630015T3 - Un método para mantener una concentración de proteína deseada en la superficie de membrana - Google Patents

Un método para mantener una concentración de proteína deseada en la superficie de membrana Download PDF

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Publication number
ES2630015T3
ES2630015T3 ES12153005.9T ES12153005T ES2630015T3 ES 2630015 T3 ES2630015 T3 ES 2630015T3 ES 12153005 T ES12153005 T ES 12153005T ES 2630015 T3 ES2630015 T3 ES 2630015T3
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Spain
Prior art keywords
maintain
protein concentration
concentration
membrane surface
desired protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12153005.9T
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English (en)
Inventor
Anthony Dileo
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EMD Millipore Corp
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EMD Millipore Corp
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Application filed by EMD Millipore Corp filed Critical EMD Millipore Corp
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/14—Safety devices specially adapted for filtration; Devices for indicating clogging
    • B01D35/143—Filter condition indicators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/60—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor integrally combined with devices for controlling the filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/10—Testing of membranes or membrane apparatus; Detecting or repairing leaks
    • B01D65/104—Detection of leaks in membrane apparatus or modules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/0606—Investigating concentration of particle suspensions by collecting particles on a support
    • G01N15/0618—Investigating concentration of particle suspensions by collecting particles on a support of the filter type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7509—General characteristics of the apparatus with filters for virus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2201/00—Details relating to filtering apparatus
    • B01D2201/29—Filter cartridge constructions
    • B01D2201/291—End caps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/08—Specific process operations in the concentrate stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/14—Pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/24—Quality control
    • B01D2311/246—Concentration control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N2015/084—Testing filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00792—Type of components bearing the codes, other than sample carriers
    • G01N2035/00811—Type of components bearing the codes, other than sample carriers consumable or exchangeable components other than sample carriers, e.g. detectors, flow cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S210/00—Liquid purification or separation
    • Y10S210/902—Materials removed
    • Y10S210/903—Nitrogenous
    • Y10S210/905—Protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Filtering Of Dispersed Particles In Gases (AREA)

Abstract

Un método para mantener una concentración de proteína deseada en la superficie de membrana en un sistema, comprendiendo dicho sistema un filtro de flujo tangencial (TFF) (10) que comprende una membrana a través de la cual puede pasar un filtrado, un sensor de concentración (30) situado en el filtro capaz de medir la concentración de soluto, y un transmisor (40) situado cerca y en comunicación con dicho sensor, comprendiendo el método: utilizar dicho sensor para medir una concentración de una proteína en una superficie de membrana de dicho filtro; almacenar un conjunto de dichas concentraciones medidas en un elemento de almacenamiento (50); utilizar dicho transmisor para retransmitir dicha concentración medida a un receptor externo (60), donde dicho transmisor utiliza comunicación inalámbrica; usar un bucle de control para calcular una presión transmembrana deseada actualizada basada en dicha concentración recibida y una presión transmembrana actual; y aplicar dicha presión transmembrana deseada a dicho sistema para mantener dicha concentración de proteína deseada.

Description

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Claims (1)

  1. imagen1
ES12153005.9T 2006-04-12 2007-03-28 Un método para mantener una concentración de proteína deseada en la superficie de membrana Active ES2630015T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US402437 1995-03-10
US11/402,437 US20070243113A1 (en) 2006-04-12 2006-04-12 Filter with memory, communication and concentration sensor

Publications (1)

Publication Number Publication Date
ES2630015T3 true ES2630015T3 (es) 2017-08-17

Family

ID=38191859

Family Applications (4)

Application Number Title Priority Date Filing Date
ES10168357T Active ES2384314T3 (es) 2006-04-12 2007-03-28 Procedimiento para garantizar la integridad de un elemento filtrante
ES12153005.9T Active ES2630015T3 (es) 2006-04-12 2007-03-28 Un método para mantener una concentración de proteína deseada en la superficie de membrana
ES08153281T Active ES2376140T3 (es) 2006-04-12 2007-03-28 Procedimiento para garantizar la integridad de un elemento de filtrado.
ES07251310T Active ES2372312T3 (es) 2006-04-12 2007-03-28 Filtro con memoria, sensor de comunicaciones y de concentración.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES10168357T Active ES2384314T3 (es) 2006-04-12 2007-03-28 Procedimiento para garantizar la integridad de un elemento filtrante

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES08153281T Active ES2376140T3 (es) 2006-04-12 2007-03-28 Procedimiento para garantizar la integridad de un elemento de filtrado.
ES07251310T Active ES2372312T3 (es) 2006-04-12 2007-03-28 Filtro con memoria, sensor de comunicaciones y de concentración.

Country Status (7)

Country Link
US (6) US20070243113A1 (es)
EP (5) EP2463005B1 (es)
JP (2) JP2007283295A (es)
CN (3) CN101073731A (es)
AT (2) ATE526068T1 (es)
ES (4) ES2384314T3 (es)
SG (4) SG171618A1 (es)

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EP1935470A1 (en) 2008-06-25
SG136866A1 (en) 2007-11-29
US8147757B2 (en) 2012-04-03
US8137983B2 (en) 2012-03-20
EP1935470B1 (en) 2011-11-23
SG171618A1 (en) 2011-06-29
US20070243113A1 (en) 2007-10-18
EP1844835A2 (en) 2007-10-17
ES2384314T3 (es) 2012-07-03
CN101653673A (zh) 2010-02-24
US20110020181A1 (en) 2011-01-27
EP2463005B1 (en) 2017-06-07
JP2011237450A (ja) 2011-11-24
EP1844835A3 (en) 2007-11-28
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US20090098021A1 (en) 2009-04-16
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EP2236184B1 (en) 2012-05-23
EP2236184A1 (en) 2010-10-06
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SG171619A1 (en) 2011-06-29
ES2372312T3 (es) 2012-01-18
EP1935469B1 (en) 2013-06-19
US20110084024A1 (en) 2011-04-14
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US8084259B2 (en) 2011-12-27
CN101653672B (zh) 2012-06-20
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EP2463005A1 (en) 2012-06-13
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ATE526068T1 (de) 2011-10-15
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US7901627B2 (en) 2011-03-08
US20120031839A1 (en) 2012-02-09
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ATE534445T1 (de) 2011-12-15
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