ES2611984T3 - Preparaciones cosméticas que contienen fragmentos de PTH - Google Patents
Preparaciones cosméticas que contienen fragmentos de PTH Download PDFInfo
- Publication number
- ES2611984T3 ES2611984T3 ES05758418.7T ES05758418T ES2611984T3 ES 2611984 T3 ES2611984 T3 ES 2611984T3 ES 05758418 T ES05758418 T ES 05758418T ES 2611984 T3 ES2611984 T3 ES 2611984T3
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- Prior art keywords
- oil
- acid
- increase
- preparations containing
- cosmetic preparations
- Prior art date
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- POIARNZEYGURDG-UHFFFAOYSA-N beta-damascenone Natural products CC=CC(=O)C1=C(C)C=CCC1(C)C POIARNZEYGURDG-UHFFFAOYSA-N 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- FZJUFJKVIYFBSY-UHFFFAOYSA-N bourgeonal Chemical compound CC(C)(C)C1=CC=C(CCC=O)C=C1 FZJUFJKVIYFBSY-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 239000010628 chamomile oil Substances 0.000 description 1
- 235000019480 chamomile oil Nutrition 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- MXOAEAUPQDYUQM-UHFFFAOYSA-N chlorphenesin Chemical compound OCC(O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-UHFFFAOYSA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- 229930186364 cyclamen Natural products 0.000 description 1
- 229940019836 cyclamen aldehyde Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- XSNQECSCDATQEL-UHFFFAOYSA-N dihydromyrcenol Chemical compound C=CC(C)CCCC(C)(C)O XSNQECSCDATQEL-UHFFFAOYSA-N 0.000 description 1
- 229930008394 dihydromyrcenol Natural products 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000002329 esterase inhibitor Substances 0.000 description 1
- VQNUNMBDOKEZHS-UHFFFAOYSA-N ethoxymethoxycyclododecane Chemical compound CCOCOC1CCCCCCCCCCC1 VQNUNMBDOKEZHS-UHFFFAOYSA-N 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 239000001148 ferula galbaniflua oil terpeneless Substances 0.000 description 1
- YSFTYXKQUONNFY-NQXPEFQPSA-N fgf2 Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H]1NCCC1)C1=CC=CC=C1 YSFTYXKQUONNFY-NQXPEFQPSA-N 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 239000010648 geranium oil Substances 0.000 description 1
- 235000019717 geranium oil Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 229930002839 ionone Natural products 0.000 description 1
- 150000002499 ionone derivatives Chemical class 0.000 description 1
- 239000001851 juniperus communis l. berry oil Substances 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- KVWWIYGFBYDJQC-UHFFFAOYSA-N methyl dihydrojasmonate Chemical compound CCCCCC1C(CC(=O)OC)CCC1=O KVWWIYGFBYDJQC-UHFFFAOYSA-N 0.000 description 1
- AUYPHISUPZUIJS-UHFFFAOYSA-N n-decyl-2-hydroxybenzamide Chemical compound CCCCCCCCCCNC(=O)C1=CC=CC=C1O AUYPHISUPZUIJS-UHFFFAOYSA-N 0.000 description 1
- 239000000025 natural resin Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- 229960003656 ricinoleic acid Drugs 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229940082569 selenite Drugs 0.000 description 1
- MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 description 1
- 229960002718 selenomethionine Drugs 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- KWVISVAMQJWJSZ-VKROHFNGSA-N solasodine Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)CC4=CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@@H](C)CN1 KWVISVAMQJWJSZ-VKROHFNGSA-N 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- ARCJQKUWGAZPFX-UHFFFAOYSA-N stilbene oxide Chemical compound O1C(C=2C=CC=CC=2)C1C1=CC=CC=C1 ARCJQKUWGAZPFX-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- FQAZRHVERGEKOS-UHFFFAOYSA-N tripropan-2-yl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CC(C)OC(=O)CC(O)(C(=O)OC(C)C)CC(=O)OC(C)C FQAZRHVERGEKOS-UHFFFAOYSA-N 0.000 description 1
- ODHUFJLMXDXVRC-UHFFFAOYSA-N tripropyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CCCOC(=O)CC(O)(C(=O)OCCC)CC(=O)OCCC ODHUFJLMXDXVRC-UHFFFAOYSA-N 0.000 description 1
- 239000010679 vetiver oil Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N xi-3-(4-Isopropylphenyl)-2-methylpropanal Chemical compound O=CC(C)CC1=CC=C(C(C)C)C=C1 ZFNVDHOSLNRHNN-UHFFFAOYSA-N 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229940071566 zinc glycinate Drugs 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
Abstract
Uso cosmético de un fragmento peptídico de hormona paratiroidea de acuerdo con la fórmula (I) y/o sales del fragmento peptídico de hormona paratiroidea de acuerdo con la fórmula (I) R1-NH-AA-R2 (fórmula (I)) donde R1 es un grupo acetilo, donde R2 es -OH, en donde AA es la secuencia Gln-Asp-Val-His correspondiente a las posiciones 2 a 5 de la SEQ ID No. 1, para estimular la producción de proteínas de matriz seleccionadas del grupo que consiste en colágeno, elastina y proteoglicanos.
Description
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selenita y los derivados de la misma (por ejemplo, seleno-metionina), estilbeno y sus derivados (por ejemplo, óxido de estilbeno, óxido trans-estilbeno) y derivados apropiados de acuerdo con la presente invención (sales, ésteres, éteres, azúcar, nucleótidos, nucleósidos, péptidos y lípidos) de las sustancias activas mencionadas.
Desodorantes y sustancias que inhiben los gérmenes
Los desodorantes cosméticos (agentes desodorantes) actúan contra los olores corporales, los ocultan o los eliminan. Los olores corporales resultan de la influencia de bacterias presentes en la piel sobre la transpiración apocrina, y se forman productos de descomposición que tienen el olor desagradable. Algunos desodorantes contienen en consecuencia ingredientes activos que actúan como agentes inhibidores de gérmenes, inhibidores enzimáticos, agentes que absorben olores o que los ocultan.
Agentes que inhiben gérmenes
Todas las sustancias que son eficaces contra bacterias gram-positivas son particularmente apropiadas como agentes para inhibir gérmenes, por ejemplo, ácido 4-hidroxibenzoico y las sales de los mismos y ésteres, N-(4-clorofenil)-N'-(3, 4-diclorofenil) urea, 2,4,4'-tricloro-2'-hidroxidifenil(triclosan)éter, 4-cloro-3,5-dimetilfenol, 2,2-metilen-bis(6-bromo-4clorofenol), 3-metil-4-(1-metiletil)fenol, 2-bencil-4-clorofenol, 3-(4-clorofenoxi)-1,2-propanodiol, 3-yodo-2propinilbutilcarbamato, clorohexidina, 3,4,4'-triclorocarbanilida (TTC), sustancias olfativas antibacterianas, timol, aceite de timina, eugenol, aceite de clavo, metanol, aceite de menta, farnesol, fenoxietanol, monocaprinato de glicerol, monocaprilato de glicerol, monolaurato de glicerol (GML), monocaprinato de diglicerol (DMC) N-alquilamida del ácido salicílico, tal como, por ejemplo, n-octilamida del ácido salicílico o n-decilamida del ácido salicílico.
Inhibidores de enzimas
Los inhibidores de la esterasa son particularmente apropiados como inhibidores enzimáticos. En este caso, se trata preferiblemente de citratos de trialquilo, por ejemplo, citrato de trimetilo, citrato de tripropilo, citrato de triisopropilo, citrato de tributilo y, en particular, citrato de trietilo (Hydagen® CAT). Las sustancias inhiben la actividad enzimática y consecuentemente reducen la formación de olores. Otras sustancias que pueden ser consideradas como inhibidores de esterasa son el sulfato de esterol o el fosfato de esterol tales como, por ejemplo, el sulfato o fosfato de lanosterina, cloesterina, campesterina, estigmasterina, sistosterina, ácidos dicarbónicos y el ésterde los mismos, tales como, por ejemplo, ácido glutárico, el éster monoetílico del ácido glutárico, el éster dietílico del ácido glutárico, ácido adípico, el éster monoetílico del ácido adípico, el éster dietílico del ácido adípico, ácido malónico y el éster dietílico del ácido malónico, ácido hidroxicarbónico y los ésteres de los mismos, así como, por ejemplo, ácido cítrico, ácido maleico, ácido tartárico o el éster dietílico del ácido tartárico así como glicinato de zinc.
Agentes absorbentes de olores
Las sustancias apropiadas para actuar como agentes absorbentes de olores son aquellas que admiten compuestos que forman olores y que se pueden fijar adicionalmente. Reducen la presión parcial de los diversos componentes y, por consiguiente, reducen su velocidad de propagación. Por consiguiente, es importante que los perfumes permanezcan sin cambios. Los agentes que absorben los olores no tienen ninguna eficacia antibacteriana. Contienen, por ejemplo, como componente principal, un complejo de sal de zinc del ácido ricinoleico y, en particular, sustancias olfativas neutras que son conocidas para el experto en el arte como agentes de fijación, tales como, por ejemplo, extractos de labdanum, por ejemplo, o extractos de styrax o derivados específicos del ácido abiético. Las sustancias olfativas o aceites de perfume se utilizan como productos que enmascaran los olores y que confieren a los desodorantes, además de su función como productos que enmascaran los olores, un aroma. Los aceites de perfume pueden incluir, por ejemplo, mezclas de sustancias olfativas naturales y sintéticas. Las sustancias olfativas naturales son extractos de plantas, tallos y hojas, frutos, corteza de fruta, raíces, madera, hierbas y plantas aromáticas, agujas, ramas, así como resinas y bálsamos naturales. También es posible utilizar materias primas de origen animal, tales como, por ejemplo, civeta y castor. Los compuestos olfativos sintéticos típicos son productos del tipo éster, éter, aldehído, cetona, alcohol e hidrocarburo. Los compuestos de sustancias olfativas del tipo éster son, por ejemplo, acetato de bencilo, acetato de p-tert-butilciclohexilo, acetato de linalilo, acetato de feniletilo, benzoato de linalilo, formiato de bencilo, propionato de alilciclohexilo, propionato de estirilo y salicilato de bencilo. Los éteres incluyen, por ejemplo, éter benciletílico y aldehídos incluyen, por ejemplo, alcanales lineales que tienen de 8 a 18 átomos de carbono, citral, citronelal, citroneliloxiacetalaldehído, ciclamen aldehído, hidroxicitronelal, lilial y bourgeonal; las cetonas incluyen iononas y metilcedrilcetona, los alcoholes incluyen anetol, citronelol, eugenol, isoeugenol, geraniol, linalol, alcohol feniletílico y terpineol; los hidrocarburos incluyen principalmente los terpenos y balsámicos naturales. Preferiblemente, sin embargo, se utilizan mezclas de diversas sustancias olfativas y juntas producen un aroma intenso. Los aceites esenciales que tienen una volatilidad relativamente baja y que se utilizan principalmente como compuestos aromáticos también son apropiados como aceites de perfume, por ejemplo, aceite de salvia, aceite de manzanilla, aceite de clavo, aceite de bálsamo, aceite de menta, aceite de hoja de canela, aceite de flor lima, aceite de baya de enebro, aceite de vetiver, aceite de oliban, aceite de galbanum, aceite de labolanum y aceite de lavanda. Se utilizan preferiblemente aceite de bergamota, dihidromircenol, lilial, liral, citronelol, alcohol feniletílico, aldehído α-hexilcinámico, geraniol, bencil acetona, aldehído ciclamen, linalol, boisambrene-forte, ambroxano, indol, hedione, sandelice, aceite de limón, aceite de mandarina, aceite de naranja, glicolato de alilamilo, ciclovertal, aceite de lavanda, muscat, aceite de salvia, β-damascona, aceite de geranio bourbon, salicilato de
11
El fragmento de PTH (29-32) correspondiente a las posiciones 2 a 5 de la SEQ ID No: 1 (Gln-Asp-Val-His) estimula el crecimiento de fibroblastos humanos de la dermis cultivados a partir de biopsias de sujetos adultos sanos. La actividad es todavía detectable después de 6 días, incluso sin ningún cambio en el medio de cultivo celular.
5 Ejemplo 2: Efecto en los perfiles de ARNm de fibroblastos humanos de la dermis
El objetivo de este estudio es detectar la variación del perfil de ARNm del fibroblasto humano de la dermis, inducida por tratamiento con el fragmento peptídico PTH (29-32).
Los fibroblastos humanos de la dermis, normales se cultivaron en medio estándar suplementado con suero fetal de ternera (FCS) durante tres días en una atmósfera de CO2 al 5%. Después de los cultivos, el medio se cambió por ya sea
10 un medio estándar suplementado con fragmento peptídico de PTH (29-32) a 5 µg/mL o no. Después de una incubación de ya sea 3 o 24 horas, se detuvieron los cultivos y se extrajeron los ARN totales de los diferentes cultivos. Los ADNc obtenidos a partir de ARN tratados con péptidos o de ARN no tratados se marcaron con cianina-3 y cianina-5, respectivamente.
La mezcla de ADNc tratados y no tratados se hibridó en una matriz de ADNc comercialmente Panhuman® 10K (MW
15 Biotech, Roissy Charles-de-Gaulle, Francia) que permite estudiar cerca de 10.000 expresiones génicas. Después de un lavado altamente riguroso, se midieron las fluorescencias de cianina-3 y cianina-5, permitiendo evaluar una relación de expresión no tratada frente a la tratada de cada gen analizado.
La Tabla 2 muestra el análisis de genes relevantes de dos ensayos independientes. Los resultados se expresan como Log2 de la relación entre la expresión medida de genes en las condiciones tratadas vs no tratadas.
20 Tabla 2: Análisis de la expresión génica en la matriz de ADNc
- Descripción
- Análisis después de 3 h de incubación Análisis después de 24 h de incubación
- Familia
- gen nombre Log2 (tratado/no tratado) Evolución de la expresión Log2 (tratado/no tratado) Evolución de la expresión
- Señal TGF
- tgfbr3 Factor de crecimiento transformante, beta receptor III (betaglicano,); 2,00 aumento 1,54 aumento
- Factor de crecimiento
- ctgf Factor de crecimiento del tejido conjuntivo 0,77 aumento 0,74 aumento
- Factor de crecimiento
- fgf2 Factor de crecimiento de fibroblastos 2; 0,86 aumento ND ND
- Matriz extracelular
- colla1 Colágeno alfa 1 tipo I 0,93 aumento ND ND
- Matriz extracelular
- itgb5 Integrina, beta 5 0,05 sin variación 0,68 aumento
- Matriz extracelular
- itgb4 Integrina, beta 4 ND ND 1,15 aumento
- Matriz extracelular
- itga2b Integrina alfa 2b; 0,50 aumento 0,15 sin variación
- Control de la matriz extracelular
- timp1 Inhibidor tisular de la metaloproteinasa 1 0,15 aumento -0,25 sin variación
- Proteoglicano
- cspg2 Sulfato de condroitina 2 (versican) 1,32 aumento 1,20 aumento
- Proteoglicano
- bgn Biglicano 2,16 aumento 0,66 aumento
15
Claims (1)
-
imagen1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04291496 | 2004-06-14 | ||
| EP04291496 | 2004-06-14 | ||
| PCT/EP2005/006261 WO2005120554A1 (en) | 2004-06-14 | 2005-06-06 | Cosmetic preparations containing pth fragments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2611984T3 true ES2611984T3 (es) | 2017-05-11 |
Family
ID=34971962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05758418.7T Active ES2611984T3 (es) | 2004-06-14 | 2005-06-06 | Preparaciones cosméticas que contienen fragmentos de PTH |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9387235B2 (es) |
| EP (1) | EP1755651B1 (es) |
| JP (1) | JP5324781B2 (es) |
| KR (1) | KR101240695B1 (es) |
| ES (1) | ES2611984T3 (es) |
| WO (1) | WO2005120554A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101594032B1 (ko) | 2012-08-23 | 2016-02-15 | 강원대학교산학협력단 | 염증 또는 피부노화의 예방 또는 치료용 약학 조성물 및 염증 또는 피부노화 개선용 화장료 조성물 |
| RU2709778C2 (ru) * | 2014-12-23 | 2019-12-20 | Эйвон Продактс, Инк. | Пептиды и их применение в уходе за кожей |
| FR3049859B1 (fr) | 2016-04-12 | 2023-11-03 | Basf Beauty Care Solutions France Sas | Utilisation cosmetique d'un extrait de khaya senegalensis |
| FR3055799B1 (fr) | 2016-09-15 | 2020-06-19 | Basf Beauty Care Solutions France Sas | Nouvelle utilisation cosmetique et/ou nutraceutique ou dermatologique d'un extrait de levure |
| FR3058641B1 (fr) | 2016-11-17 | 2019-11-01 | Basf Beauty Care Solutions France Sas | Utilisation cosmetique, nutraceutique ou pharmaceutique preferentiellement dermatologique d'un extrait de feuilles de la plante lansium domesticum pour diminuer la pigmentation de la peau et/ou des annexes cutanees |
| FR3061015B1 (fr) | 2016-12-23 | 2019-09-20 | Basf Beauty Care Solutions France Sas | Utilisation cosmetique d'un extrait de corchorus olitorius |
| KR102007077B1 (ko) * | 2017-03-24 | 2019-08-06 | (주)셀아이콘랩 | 피부 노화 방지 및 피부 주름 예방용 펜타펩타이드와 펜타펩타이드 다이머의 제조방법과 이를 포함하는 화장료 조성물 |
| KR102007079B1 (ko) * | 2017-03-24 | 2019-10-02 | (주)셀아이콘랩 | 펩타이드를 활용한 피부의 노화 억제용 조성물 및 세포노화 억제와 주름개선을 위한 화장품 조성물 |
| KR102007078B1 (ko) * | 2017-03-24 | 2019-08-05 | (주)셀아이콘랩 | 콜라겐 생성을 촉진시키는 신규한 헵타펩타이드 단량체 및 이량체를 포함하는 피부 노화 방지를 위한 화장품 조성물 |
| KR101989666B1 (ko) * | 2017-03-24 | 2019-06-17 | (주)셀아이콘랩 | 신규한 헵타펩타이드 단량체 및 이량체를 포함하는 피부노화 또는 피부주름 예방, 개선을 위한 화장료 조성물 |
| FR3065876B1 (fr) | 2017-05-05 | 2020-08-14 | Basf Beauty Care Solutions France Sas | Utilisation d'un extrait de nephelium lappaceum pour augmenter la fermete de la peau et/ou des muqueuses |
| FR3069162A1 (fr) | 2017-07-24 | 2019-01-25 | Basf Beauty Care Solutions France Sas | Extrait aqueux de momordica cochinchinensis pour maintenir et/ou augmenter l'expression des kindlines de la peau et des muqueuses |
| FR3071742B1 (fr) | 2017-10-03 | 2020-07-10 | Basf Beauty Care Solutions France Sas | Procede d'utilisation d'un inhibiteur de let-7b en cosmetique et/ou en nutraceutique |
| FR3097127B1 (fr) | 2017-10-03 | 2022-09-16 | Basf Beauty Care Solutions France Sas | Procédé d’utilisation d’un inhibiteur de Let-7b en cosmétique et/ou en nutraceutique |
| JP2021516222A (ja) * | 2018-03-16 | 2021-07-01 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法 |
| KR20210137373A (ko) * | 2019-03-08 | 2021-11-17 | 안야 바이오팜 인코포레이티드 | 부갑상샘 호르몬 유사체의 경구 제제 및 치료 |
| CN114736265A (zh) * | 2022-04-20 | 2022-07-12 | 广州市乾相生物科技有限公司 | 一种四肽-9的合成方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4172887A (en) * | 1973-11-30 | 1979-10-30 | L'oreal | Hair conditioning compositions containing crosslinked polyaminopolyamides |
| LU68901A1 (es) | 1973-11-30 | 1975-08-20 | ||
| GB8806893D0 (en) * | 1988-03-23 | 1988-04-27 | Unilever Plc | Cosmetic composition |
| JPH06239815A (ja) * | 1993-02-16 | 1994-08-30 | Teijin Ltd | ２―アミノエトキシベンゼン誘導体及び医薬組成物 |
| US6110892A (en) * | 1994-06-20 | 2000-08-29 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| US5744128A (en) * | 1995-05-03 | 1998-04-28 | Holick; Michael F. | Use of emu oil for stimulating skin and hair growth |
| FR2738746B1 (fr) * | 1995-09-19 | 1997-11-14 | Oreal | Utilisation d'au moins un peptide dans une composition cosmetique ou pour la preparation d'un medicament |
| DE19756377A1 (de) | 1997-12-18 | 1999-06-24 | Beiersdorf Ag | Verwendung von C¶1¶¶8¶-¶3¶¶8¶-Alkylhydroxystearoylstearat zur Verstärkung der UV-A-Schutzleistung kosmetischer oder dermatologischer Formulierungen |
| FR2781157B1 (fr) * | 1998-07-15 | 2000-08-25 | Oreal | Composition anti-inflammatoire |
| FR2781231B1 (fr) | 1998-07-17 | 2002-01-25 | Sederma Sa | Compositions cosmetiques amincissantes |
| FR2788058B1 (fr) * | 1998-12-30 | 2002-01-25 | Sederma Sa | Compositions cosmetiques amincissantes |
| US6890904B1 (en) * | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| JP2001287013A (ja) | 2000-04-10 | 2001-10-16 | Yazaki Corp | ダイカスト鋳造における湯流れ確認方法 |
| US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| ATE429925T1 (de) | 2000-07-31 | 2009-05-15 | Univ Bar Ilan | Methoden und pharmazeutische zusammensetzungen zur wundheilung |
| FR2827170B1 (fr) * | 2001-07-13 | 2004-07-16 | Soc Extraction Principes Actif | Utilisation de peptides pour augmenter l'adhesion cellulaire |
| JP2003300823A (ja) | 2002-04-09 | 2003-10-21 | Nonogawa Shoji Kk | 皮膚外用剤 |
| JP4196605B2 (ja) | 2002-07-29 | 2008-12-17 | 王子製紙株式会社 | コラーゲン産生促進剤 |
| AU2002951372A0 (en) * | 2002-09-13 | 2002-09-26 | St Vincent's Institute Of Medical Research | Parathyroid hormone-like polypeptides |
| JP2009124502A (ja) | 2007-11-15 | 2009-06-04 | Toshiba Corp | フレーム補間装置 |
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2005
- 2005-06-06 WO PCT/EP2005/006261 patent/WO2005120554A1/en active Application Filing
- 2005-06-06 EP EP05758418.7A patent/EP1755651B1/en active Active
- 2005-06-06 ES ES05758418.7T patent/ES2611984T3/es active Active
- 2005-06-06 KR KR1020067026289A patent/KR101240695B1/ko active IP Right Grant
- 2005-06-06 JP JP2007515837A patent/JP5324781B2/ja active Active
- 2005-06-06 US US11/570,614 patent/US9387235B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008502624A (ja) | 2008-01-31 |
| KR20070018120A (ko) | 2007-02-13 |
| JP5324781B2 (ja) | 2013-10-23 |
| US9387235B2 (en) | 2016-07-12 |
| EP1755651A1 (en) | 2007-02-28 |
| KR101240695B1 (ko) | 2013-03-11 |
| US20110059892A1 (en) | 2011-03-10 |
| WO2005120554A1 (en) | 2005-12-22 |
| EP1755651B1 (en) | 2016-10-12 |
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