ATE429925T1 - Methoden und pharmazeutische zusammensetzungen zur wundheilung - Google Patents

Methoden und pharmazeutische zusammensetzungen zur wundheilung

Info

Publication number
ATE429925T1
ATE429925T1 AT01963344T AT01963344T ATE429925T1 AT E429925 T1 ATE429925 T1 AT E429925T1 AT 01963344 T AT01963344 T AT 01963344T AT 01963344 T AT01963344 T AT 01963344T AT E429925 T1 ATE429925 T1 AT E429925T1
Authority
AT
Austria
Prior art keywords
methods
pharmaceutical compositions
wound healing
pharmaceutical composition
wound
Prior art date
Application number
AT01963344T
Other languages
English (en)
Inventor
Tamar Tennenbaum
Sanford Sampson
Toshio Kuroki
Addy Alt
Shlomzion Shen
Original Assignee
Univ Bar Ilan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bar Ilan filed Critical Univ Bar Ilan
Application granted granted Critical
Publication of ATE429925T1 publication Critical patent/ATE429925T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01963344T 2000-07-31 2001-07-23 Methoden und pharmazeutische zusammensetzungen zur wundheilung ATE429925T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62997000A 2000-07-31 2000-07-31
PCT/IL2001/000675 WO2002009639A2 (en) 2000-07-31 2001-07-23 Methods and pharmaceutical compositions for healing wounds

Publications (1)

Publication Number Publication Date
ATE429925T1 true ATE429925T1 (de) 2009-05-15

Family

ID=24525225

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01963344T ATE429925T1 (de) 2000-07-31 2001-07-23 Methoden und pharmazeutische zusammensetzungen zur wundheilung

Country Status (12)

Country Link
US (2) US7402571B2 (de)
EP (1) EP1383540B1 (de)
JP (2) JP2004536018A (de)
AT (1) ATE429925T1 (de)
AU (2) AU2001284364B2 (de)
CA (1) CA2416788A1 (de)
DE (1) DE60138572D1 (de)
DK (1) DK1383540T3 (de)
HK (1) HK1059738A1 (de)
IL (1) IL154210A0 (de)
WO (1) WO2002009639A2 (de)
ZA (1) ZA200300708B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148924A1 (en) * 2002-07-09 2003-08-07 Tamar Tennenbaum Methods and pharmaceutical compositions of healing wounds
US20060258562A1 (en) * 2000-07-31 2006-11-16 Healor Ltd. Methods and pharmaceutical compositions for healing wounds
EP1383540B1 (de) 2000-07-31 2009-04-29 Bar-Ilan University Methoden und pharmazeutische zusammensetzungen zur wundheilung
US20100129332A1 (en) * 2000-07-31 2010-05-27 Tamar Tennenbaum Methods and pharmaceutical compositions for healing wounds
US20040037828A1 (en) * 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
CA2455990A1 (en) * 2001-09-06 2003-03-20 The General Hospital Corporation Methods for diagnosing and treating diseases and conditions associated with protein kinase c.lambda.
JP4790609B2 (ja) * 2003-07-15 2011-10-12 バーイラン ユニバーシティー 創傷治癒のための方法及び薬剤組成物
JP4668902B2 (ja) 2003-08-07 2011-04-13 ヒーラー リミテッド 創傷治癒を促進するための薬剤組成物及び方法
WO2005120554A1 (en) 2004-06-14 2005-12-22 Cognis France S.A.S. Cosmetic preparations containing pth fragments
NZ566083A (en) 2005-08-29 2012-11-30 Healor Ltd Methods and compositions for prevention and treatment of diabetic and aged skin
FR2907683A1 (fr) * 2006-10-27 2008-05-02 De Potter Philippe Viseux Composition medicale pour cicatrisation des plaies et pansements permettant son application
US20100310542A1 (en) * 2007-07-30 2010-12-09 Healor Ltd. Pharmaceutical Compositions for treating wouds and related methods
WO2011083481A2 (en) 2010-01-11 2011-07-14 Healor Ltd. Method for treatment of inflammatory disease and disorder
EA032501B9 (ru) * 2013-04-18 2019-11-29 Qbiotics Ltd Способы и композиции для содействия заживлению острой раны и хронической раны
US9604957B2 (en) 2014-02-20 2017-03-28 University Of Notre Dame Du Lac Selective matrix metalloproteinase inhibitors
US10357546B2 (en) 2014-09-19 2019-07-23 University Of Notre Dame Du Lac Acceleration of diabetic wound healing
WO2016149187A1 (en) * 2015-03-13 2016-09-22 Joslin Diabetes Center, Inc. Methods to accelerate wound healing in diabetic subjects
US20180256537A1 (en) * 2015-09-23 2018-09-13 Tapan K. Khan Methods for survival and rejuvenation of dermal fibroblasts using pkc activators
WO2018170394A1 (en) * 2017-03-17 2018-09-20 Rutgers, The State University Of New Jersey Compositions and methods for wound healing
CN115531415B (zh) * 2022-12-01 2023-03-28 山东大学 一种i-CS/HAp-NK复合体及其制备方法和应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US119914A (en) * 1871-10-17 Improvement in harness-trimmings
US4673649A (en) 1983-07-15 1987-06-16 University Patents, Inc. Process and defined medium for growth of human epidermal keratinocyte cells
EP0178321A1 (de) 1984-04-30 1986-04-23 The Trustees Of Columbia University In The City Of New York Topische behandlung von diabetes mit insulin und mit einem auf die haut verabreichten und mit einem pflaster bedeckten penetrationsverbesserer
EP0223977B1 (de) 1985-11-25 1990-10-10 Wako Pure Chemical Industries, Ltd. Farbentwicklungsmethode in klinischen Untersuchungen
US4833257A (en) 1986-07-28 1989-05-23 Arizona Board Of Regents Compositions of matter and methods of using same
JPS63303929A (ja) * 1987-06-04 1988-12-12 Kanji Izumi 創傷治療剤
US5700450A (en) 1988-03-30 1997-12-23 The Trustees Of Boston University Methods for enhancing melanin synthesis in melanocytes using diacyglycerols and uses thereof
US5137734A (en) 1989-03-22 1992-08-11 Dana Farber Cancer Institute Angiogenic monoglycerides
US5145679A (en) * 1989-10-05 1992-09-08 Hinson Joan B Topical emollient for prevention and treatment of circulatory induced lesions
US5423778A (en) 1989-12-14 1995-06-13 Elof Eriksson System and method for transplantation of cells
EP0580778B1 (de) 1991-04-19 1999-08-11 LDS Technologies, Inc. Konvertierbare mikroemulsionsverbindungen
JPH0543453A (ja) * 1991-08-20 1993-02-23 Sumitomo Pharmaceut Co Ltd 創傷治癒促進用局所用徐放性製剤
HUT67319A (en) 1991-08-30 1995-03-28 Life Medical Sciences Inc Compositions for treating wounds
US5591709A (en) * 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
AU3062392A (en) 1991-11-04 1993-06-07 Novo Nordisk A/S Pdgf gel formulation
DE4208552A1 (de) * 1992-03-17 1993-09-23 Liedtke Pharmed Gmbh Topische arzneiformen mit insulin
EP0679402B1 (de) * 1994-04-25 2003-09-10 Japan Science and Technology Corporation Hybridgel, das eine biologisch aktive Substanz sekretiert
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
JP3091113B2 (ja) * 1994-11-22 2000-09-25 科学技術振興事業団 生理活性物質分泌性のハイブリッド型ゲル
DK0871474T4 (da) 1994-12-29 2012-01-09 Ferring Int Ct Sa Fremstilling af human insulin
AUPN089295A0 (en) 1995-02-02 1995-03-02 International Diabetes Institute Treatment of diabetic neuropathy
JP2000504220A (ja) 1996-01-23 2000-04-11 ライガル ファーマシューティカルズ インコーポレイテッド トランス支配性細胞内作用因子ペプチドおよびｒｎａ分子のスクリーニング方法
US5869037A (en) 1996-06-26 1999-02-09 Cornell Research Foundation, Inc. Adenoviral-mediated gene transfer to adipocytes
GB9702943D0 (en) * 1997-02-13 1997-04-02 Univ Manchester Wound healing
JPH10265405A (ja) * 1997-03-19 1998-10-06 Masaaki Nanbara インスリン含有の皮膚外用製剤
JP2002509855A (ja) 1997-10-16 2002-04-02 ズー、デグアン 皮膚、頭皮もしくは創傷への局所施用のための組成物及びその製造方法
AU3635099A (en) 1997-12-15 1999-07-26 Beth Israel Deaconess Medical Center Methods and reagents for modulating cell motility
FR2773075B1 (fr) 1997-12-31 2000-05-05 Cird Galderma Utilisation d'activateurs de ppar-gamma en dermatologie
DE69924232D1 (de) * 1998-01-09 2005-04-21 Novo Nordisk As Stabilisierte insulin-zubereitungen
US6096288A (en) 1998-10-12 2000-08-01 Mobil Oil Corporation Synthesis of the cubic mesoporous molecular sieve MCM-48
US6541447B1 (en) 1999-09-01 2003-04-01 B & M Healthcare Technologies, Inc. Wound healing composition and method for use thereof
WO2001076650A1 (en) 2000-04-06 2001-10-18 University Technology Corporation Compositions and methods for promoting wound healing
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
EP1383540B1 (de) 2000-07-31 2009-04-29 Bar-Ilan University Methoden und pharmazeutische zusammensetzungen zur wundheilung
US6673603B2 (en) 2000-09-01 2004-01-06 Modex Therapeutiques, S.A. Cell paste comprising keratinocytes and fibroblasts
US20020119914A1 (en) 2000-12-26 2002-08-29 Deguang Zhu New uses of insulin and pancreatin
US6750234B2 (en) 2001-03-08 2004-06-15 University Of Kentucky Research Foundation Methods for increasing leptin levels using nicotinic acid compounds

Also Published As

Publication number Publication date
WO2002009639A3 (en) 2003-11-06
JP2011140505A (ja) 2011-07-21
AU8436401A (en) 2002-02-13
DK1383540T3 (da) 2009-08-24
IL154210A0 (en) 2003-07-31
HK1059738A1 (en) 2004-07-16
ZA200300708B (en) 2005-02-23
EP1383540A4 (de) 2004-06-30
US20030017969A1 (en) 2003-01-23
CA2416788A1 (en) 2002-02-07
JP5385321B2 (ja) 2014-01-08
EP1383540A2 (de) 2004-01-28
DE60138572D1 (de) 2009-06-10
AU2001284364B2 (en) 2006-09-28
JP2004536018A (ja) 2004-12-02
EP1383540B1 (de) 2009-04-29
US7402571B2 (en) 2008-07-22
US20030144180A1 (en) 2003-07-31
WO2002009639A2 (en) 2002-02-07

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