ES2590213T3 - Predicción del riesgo a sufrir episodios cardíacos adversos graves - Google Patents
Predicción del riesgo a sufrir episodios cardíacos adversos graves Download PDFInfo
- Publication number
- ES2590213T3 ES2590213T3 ES14177846.4T ES14177846T ES2590213T3 ES 2590213 T3 ES2590213 T3 ES 2590213T3 ES 14177846 T ES14177846 T ES 14177846T ES 2590213 T3 ES2590213 T3 ES 2590213T3
- Authority
- ES
- Spain
- Prior art keywords
- subject
- time
- macers
- level
- probnp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000747 cardiac effect Effects 0.000 title abstract description 11
- 230000002411 adverse Effects 0.000 title abstract description 7
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 abstract description 21
- 102400001263 NT-proBNP Human genes 0.000 abstract description 20
- 238000000034 method Methods 0.000 abstract description 8
- 108020001621 Natriuretic Peptide Proteins 0.000 abstract description 4
- 102000004571 Natriuretic peptide Human genes 0.000 abstract description 4
- 239000000692 natriuretic peptide Substances 0.000 abstract description 4
- 230000000638 stimulation Effects 0.000 abstract 13
- 210000004556 brain Anatomy 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 206010013975 Dyspnoeas Diseases 0.000 description 7
- 238000013517 stratification Methods 0.000 description 7
- 208000000059 Dyspnea Diseases 0.000 description 6
- 206010019280 Heart failures Diseases 0.000 description 6
- 238000005259 measurement Methods 0.000 description 5
- 230000002685 pulmonary effect Effects 0.000 description 5
- 235000009421 Myristica fragrans Nutrition 0.000 description 4
- 239000001115 mace Substances 0.000 description 4
- 238000004393 prognosis Methods 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 206010033307 Overweight Diseases 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000000779 thoracic wall Anatomy 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 1
- 101800002247 Brain natriuretic peptide 45 Proteins 0.000 description 1
- 208000020446 Cardiac disease Diseases 0.000 description 1
- 206010007556 Cardiac failure acute Diseases 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 208000029147 Collagen-vascular disease Diseases 0.000 description 1
- 201000006306 Cor pulmonale Diseases 0.000 description 1
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 description 1
- 206010052337 Diastolic dysfunction Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 1
- 206010027417 Metabolic acidosis Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000010378 Pulmonary Embolism Diseases 0.000 description 1
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 206010057442 Rhinolaryngitis Diseases 0.000 description 1
- 206010071436 Systolic dysfunction Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 208000000122 hyperventilation Diseases 0.000 description 1
- 230000000870 hyperventilation Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 208000018360 neuromuscular disease Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 210000002741 palatine tonsil Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 208000008494 pericarditis Diseases 0.000 description 1
- 206010035653 pneumoconiosis Diseases 0.000 description 1
- 231100000857 poor renal function Toxicity 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Primary Health Care (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4615808P | 2008-04-18 | 2008-04-18 | |
| US46158P | 2008-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2590213T3 true ES2590213T3 (es) | 2016-11-18 |
Family
ID=41199760
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14177846.4T Active ES2590213T3 (es) | 2008-04-18 | 2009-04-17 | Predicción del riesgo a sufrir episodios cardíacos adversos graves |
| ES16166093.1T Active ES2687401T3 (es) | 2008-04-18 | 2009-04-17 | Predicción del riesgo a sufrir episodios cardíacos adversos graves |
| ES09731842.2T Active ES2443125T3 (es) | 2008-04-18 | 2009-04-17 | Predicción del riesgo a sufrir episodios cardíacos adversos graves |
| ES13179055.2T Active ES2525029T3 (es) | 2008-04-18 | 2009-04-17 | Predicción del riesgo de sufrir episodios cardíacos adversos graves |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16166093.1T Active ES2687401T3 (es) | 2008-04-18 | 2009-04-17 | Predicción del riesgo a sufrir episodios cardíacos adversos graves |
| ES09731842.2T Active ES2443125T3 (es) | 2008-04-18 | 2009-04-17 | Predicción del riesgo a sufrir episodios cardíacos adversos graves |
| ES13179055.2T Active ES2525029T3 (es) | 2008-04-18 | 2009-04-17 | Predicción del riesgo de sufrir episodios cardíacos adversos graves |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8090562B2 (enExample) |
| EP (5) | EP3093663B1 (enExample) |
| JP (6) | JP5526122B2 (enExample) |
| AU (3) | AU2009236109B2 (enExample) |
| CA (1) | CA2720674A1 (enExample) |
| DK (4) | DK2269063T3 (enExample) |
| ES (4) | ES2590213T3 (enExample) |
| HR (2) | HRP20131100T1 (enExample) |
| HU (2) | HUE029880T2 (enExample) |
| PL (4) | PL3093663T3 (enExample) |
| PT (4) | PT2827152T (enExample) |
| SI (4) | SI2660599T1 (enExample) |
| WO (1) | WO2009129454A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002038794A2 (en) | 2000-11-09 | 2002-05-16 | The Brigham And Women's Hospital, Inc. | Cardiovascular disease diagnostic and therapeutic targets |
| WO2003094856A2 (en) | 2002-05-09 | 2003-11-20 | The Brigham And Women's Hospital, Inc. | 1l1rl-1 as a cardiovascular disease marker and therapeutic target |
| WO2007127749A2 (en) | 2006-04-24 | 2007-11-08 | Critical Care Diagnostics, Inc. | Predicting mortality and detecting severe disease |
| US20090305265A1 (en) * | 2006-04-27 | 2009-12-10 | Critical Care Diagnostics, Inc. | Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease |
| PL2021796T3 (pl) | 2006-05-01 | 2012-07-31 | Critical Care Diagnostics Inc | Diagnozowanie choroby sercowo-naczyniowej |
| HUE025058T2 (en) * | 2006-05-02 | 2016-01-28 | Critical Care Diagnostics Inc | Differential diagnosis of pulmonary and cardiovascular disease |
| US9968266B2 (en) | 2006-12-27 | 2018-05-15 | Cardiac Pacemakers, Inc. | Risk stratification based heart failure detection algorithm |
| HUE029880T2 (en) | 2008-04-18 | 2017-04-28 | Critical Care Diagnostics Inc | Predicting the risk of serious heart events |
| ES2795003T3 (es) * | 2008-10-07 | 2020-11-20 | Brahms Gmbh | Biomarcador para la predicción de los primeros eventos adversos |
| US9561006B2 (en) * | 2008-10-15 | 2017-02-07 | The United States Of America As Represented By The Secretary Of The Navy | Bayesian modeling of pre-transplant variables accurately predicts kidney graft survival |
| US8417541B1 (en) * | 2009-08-27 | 2013-04-09 | Cerner Innovation, Inc. | Multi-stage model for predicting probabilities of mortality in adult critically ill patients |
| US20130066212A1 (en) * | 2009-09-25 | 2013-03-14 | Volcano Corporation | Device and Method for Determining the Likelihood of a Patient Having a Clinical Event or a Clinically Silent Event Based on Ascertained Physiological Parameters |
| EP3434694B1 (en) | 2010-04-09 | 2020-12-30 | Critical Care Diagnostics, Inc. | Soluble human st-2 antibodies and assays |
| US10943676B2 (en) | 2010-06-08 | 2021-03-09 | Cerner Innovation, Inc. | Healthcare information technology system for predicting or preventing readmissions |
| CN103718046B (zh) * | 2011-03-17 | 2016-10-12 | 重症监护诊断股份有限公司 | 预测不良临床结果的风险的方法 |
| EP2734222B1 (en) | 2011-07-18 | 2016-10-19 | Critical Care Diagnostics, Inc. | Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy |
| EP2637023A1 (en) * | 2012-03-08 | 2013-09-11 | B.R.A.H.M.S GmbH | Prediction of outcome in patients with chronic obstructive pulmonary disease |
| CN104507383B (zh) | 2012-05-18 | 2018-08-28 | 重症监护诊断股份有限公司 | 用于治疗或预报室性快速性心律失常事件风险的方法 |
| CN102830234A (zh) * | 2012-08-10 | 2012-12-19 | 杭州华得森生物技术有限公司 | 一种检测人心力衰竭新型标志物st2的快速诊断试剂盒 |
| CN104737023B (zh) | 2012-08-16 | 2017-07-28 | 重症监护诊断股份有限公司 | 预测患高血压风险的方法 |
| JP6450679B2 (ja) | 2012-08-21 | 2019-01-09 | クリティカル ケア ダイアグノスティクス インコーポレイテッド | マルチマーカーリスク層別化 |
| RU2510505C1 (ru) * | 2012-11-15 | 2014-03-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ определения вероятности выраженной сердечной недостаточности в клинической картине инфаркта миокарда |
| GB201310290D0 (en) * | 2013-06-10 | 2013-07-24 | Univ Manchester | Method for determining a probability of a major adverse cardiac event (MACE) |
| JP6655016B2 (ja) * | 2014-01-10 | 2020-02-26 | クリティカル ケア ダイアグノスティクス インコーポレイテッド | 心不全のリスクを決定するための方法 |
| AU2014407088B2 (en) | 2014-09-26 | 2021-09-23 | Somalogic Operating Co., Inc. | Cardiovascular risk event prediction and uses thereof |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| US10079073B2 (en) | 2014-12-11 | 2018-09-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| WO2016140958A1 (en) * | 2015-03-02 | 2016-09-09 | Estes Edward Harvey | Method and device to predict adverse cardiovascular events and mortality from an electrocardiogram-based validated risk score |
| EP4442200A3 (en) | 2016-04-01 | 2024-12-04 | Cardiac Pacemakers, Inc. | Multi-disease patient management |
| AT518560B1 (de) | 2016-04-18 | 2018-01-15 | Trumpf Maschinen Austria Gmbh & Co Kg | Biegebalken für eine Schwenkbiegemaschine |
| EP4445834A3 (en) | 2017-04-29 | 2024-12-25 | Cardiac Pacemakers, Inc. | Heart failure event rate assessment |
| US20200074313A1 (en) * | 2018-08-29 | 2020-03-05 | Koninklijke Philips N.V. | Determining features to be included in a risk assessment instrument |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| EP4640848A2 (en) | 2019-05-17 | 2025-10-29 | Regeneron Pharmaceuticals, Inc. | Genome-based methods for reducing cardiovascular risk |
| US11551817B2 (en) | 2020-01-14 | 2023-01-10 | International Business Machines Corporation | Assessing unreliability of clinical risk prediction |
| CN117099000A (zh) * | 2021-03-08 | 2023-11-21 | 赛诺菲 | 心血管疾病 |
| WO2023086746A1 (en) * | 2021-11-11 | 2023-05-19 | Beckman Coulter, Inc. | Assessment of risk for major adverse cardiac event |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208479A (en) | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| US5206140A (en) | 1988-06-24 | 1993-04-27 | Research Corporation Technologies, Inc. | Assay for soluble crosslinked fibrin polymers |
| US5217899A (en) | 1990-08-24 | 1993-06-08 | The General Hospital Corporation | Cell stretching apparatus |
| JP2665850B2 (ja) | 1991-11-14 | 1997-10-22 | 塩野義製薬株式会社 | hBNPのC端を認識するモノクロ−ナル抗体 |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| JP2732005B2 (ja) | 1992-12-14 | 1998-03-25 | 眞一 富永 | ヒトst2をコードするdna、該dnaの発現産物、該dnaを発現させることによる発現産物の製造方法 |
| JPH0731479A (ja) | 1993-02-23 | 1995-02-03 | Shinichi Tominaga | マウスst2lをコードするdna、該dnaの発現産物、該dnaを発現させることによる発現産物の製造方法 |
| US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| JP2001500724A (ja) | 1996-08-23 | 2001-01-23 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | T1レセプター様リガンドii |
| WO1998038311A1 (en) | 1997-02-28 | 1998-09-03 | Human Genome Sciences, Inc. | T1/st2-receptor ligand iii |
| DE19711932A1 (de) | 1997-03-21 | 1998-09-24 | Anne Katrin Dr Werenskiold | In vitro-Verfahren zum Prognostizieren des Krankheitsverlaufs von Patienten mit Mammakarzinom und/oder zum Diagnostizieren eines Mammakarzinoms |
| EP1003501B9 (en) | 1997-04-02 | 2005-06-08 | The Brigham And Women's Hospital, Inc. | Use of an agent for lowering the risk of cardiovascular disease |
| CA2293718A1 (en) | 1997-06-10 | 1998-12-17 | Medlyte Diagnostics, Inc. | Methods for early detection of heart disease |
| DE69833118T2 (de) | 1997-09-11 | 2006-08-31 | Shionogi & Co., Ltd. | Immunoassay zum bestimmen von bnp |
| GB9727172D0 (en) | 1997-12-24 | 1998-02-25 | Univ Glasgow | Reagents specific for st2l and uses therefor |
| US6309888B1 (en) | 1998-09-04 | 2001-10-30 | Leuven Research & Development Vzw | Detection and determination of the stages of coronary artery disease |
| GB9827348D0 (en) * | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| WO2000035473A2 (en) | 1998-12-18 | 2000-06-22 | Scios Inc. | Methods for detection and use of differentially expressed genes in disease states |
| AU5309600A (en) | 1999-06-02 | 2000-12-18 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
| FR2795823B1 (fr) | 1999-07-01 | 2001-11-23 | Inst Nat Sante Rech Med | Methodes et kits pour le diagnostic ou le suivi d'une pathologie synoviale ou osteoarticulaire comprenant l'utilisation d'un marqueur specifique de la degradation du tissu synovial |
| AU783855B2 (en) | 1999-08-24 | 2005-12-15 | Medicure International Inc. | Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds |
| US6323334B1 (en) | 1999-09-24 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding a 103 gene product and uses therefor |
| AU2001218871A1 (en) | 2000-03-21 | 2001-10-03 | Takao Arai | Monoclonal antibody and method and kit for the immunoassay of soluble human st2 with the use of the same |
| FR2807170B1 (fr) | 2000-03-30 | 2002-06-28 | Sipal | Charniere elastique a frottement reduit |
| RU2002110275A (ru) | 2000-08-22 | 2004-03-27 | Дзе Брихэм Энд Уимен'З Хоспитал, Инк. (Us) | Диагностика и лечение сердечно-сосудистых состояний |
| WO2002038794A2 (en) | 2000-11-09 | 2002-05-16 | The Brigham And Women's Hospital, Inc. | Cardiovascular disease diagnostic and therapeutic targets |
| US6537221B2 (en) | 2000-12-07 | 2003-03-25 | Koninklijke Philips Electronics, N.V. | Strain rate analysis in ultrasonic diagnostic images |
| FI20010019A7 (fi) | 2001-01-05 | 2002-07-06 | Biohit Oyj | Menetelmä atrofisen gastriitin diagnostisoimiseksi |
| US20040253637A1 (en) | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| DE60233301D1 (de) | 2001-05-04 | 2009-09-24 | Biosite Inc | Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| WO2003022987A2 (en) | 2001-07-26 | 2003-03-20 | Eos Biotechnology, Inc. | Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection |
| US6810284B1 (en) | 2001-11-21 | 2004-10-26 | Pacesetter, Inc. | Implantable cardiac stimulation system and method for monitoring diastolic function |
| WO2003094856A2 (en) | 2002-05-09 | 2003-11-20 | The Brigham And Women's Hospital, Inc. | 1l1rl-1 as a cardiovascular disease marker and therapeutic target |
| WO2003100000A2 (en) | 2002-05-24 | 2003-12-04 | Tularik Inc. | Amplification and overexpression of oncogenes |
| US8263325B2 (en) | 2002-11-15 | 2012-09-11 | Ottawa Heart Institute Research Corporation | Predicting, detecting and monitoring treatment of cardiomyopathies and myocarditis |
| AU2003302132B2 (en) * | 2002-11-21 | 2008-02-21 | Inverness Medical Switzerland Gmbh | Bodily fluid markers of tissue hypoxia |
| US20070042978A1 (en) | 2002-12-19 | 2007-02-22 | Jean-Philippe Girard | Nf-hev compositions and methods of use |
| US20040133079A1 (en) | 2003-01-02 | 2004-07-08 | Mazar Scott Thomas | System and method for predicting patient health within a patient management system |
| US20040220155A1 (en) | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
| US20060257558A1 (en) | 2003-10-31 | 2006-11-16 | Hiroshi Nomura | Plasma polymerization of atomically modified surfaces |
| EP2186913B1 (en) | 2003-11-26 | 2016-02-10 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| US7781219B2 (en) | 2003-12-05 | 2010-08-24 | The Cleveland Clinic Foundation | Risk markers for cardiovascular disease |
| US20050196817A1 (en) | 2004-01-20 | 2005-09-08 | Molecular Staging Inc. | Biomarkers for sepsis |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| JP2005291899A (ja) | 2004-03-31 | 2005-10-20 | Akira Matsumori | 心疾患の検査法 |
| EP1833766A1 (en) | 2004-12-17 | 2007-09-19 | Clearwater Systems Corp. | Method and apparatus for treating fluids |
| WO2006077265A1 (en) | 2005-01-24 | 2006-07-27 | F. Hoffmann-La Roche Ag | The use of bnp-type peptides and anp-type peptides for assessing the risk of suffering from a cardiovascular complication as a consequence of volume overload |
| EP1731910A1 (en) | 2005-06-07 | 2006-12-13 | F. Hoffmann-La Roche Ag | Use of NT-proANP and NT-proBNP for diagnosing cardiac diseases |
| US20070021977A1 (en) | 2005-07-19 | 2007-01-25 | Witt Biomedical Corporation | Automated system for capturing and archiving information to verify medical necessity of performing medical procedure |
| JP4820192B2 (ja) | 2006-03-17 | 2011-11-24 | 一般財団法人化学及血清療法研究所 | 急性冠症候群でのadamts13の測定と利用 |
| WO2007127749A2 (en) * | 2006-04-24 | 2007-11-08 | Critical Care Diagnostics, Inc. | Predicting mortality and detecting severe disease |
| US20090305265A1 (en) | 2006-04-27 | 2009-12-10 | Critical Care Diagnostics, Inc. | Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease |
| PL2021796T3 (pl) * | 2006-05-01 | 2012-07-31 | Critical Care Diagnostics Inc | Diagnozowanie choroby sercowo-naczyniowej |
| HUE025058T2 (en) | 2006-05-02 | 2016-01-28 | Critical Care Diagnostics Inc | Differential diagnosis of pulmonary and cardiovascular disease |
| US8147817B2 (en) | 2006-05-04 | 2012-04-03 | The Brigham And Women's Hospital, Inc. | IL-33 in the treatment and diagnosis of diseases and disorders |
| EP2302395B1 (en) * | 2006-06-07 | 2015-04-15 | Health Diagnostic Laboratory, Inc. | Markers associated with arteriovascular events and methods of use thereof |
| RU2312591C1 (ru) | 2006-06-14 | 2007-12-20 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ прогнозирования развития риска внезапной смерти у больных с лево- и правожелудочковой экстрасистолией |
| WO2008116083A1 (en) | 2007-03-22 | 2008-09-25 | Cv Therapeutics, Inc. | Use of ranolazine for elevated brain-type natriuretic peptide |
| CA2705500A1 (en) | 2007-05-11 | 2008-11-20 | Tufts Medical Center | Polynucleotides associated with age-related macular degeneration and methods for evaluating patient risk |
| GB0713404D0 (en) | 2007-07-11 | 2007-08-22 | Integra Sp Ipr Ltd | Altio graph |
| US20100267062A1 (en) | 2007-09-26 | 2010-10-21 | Norbert Frey | Osteopontin as Novel Prognostic Biomarker for Heart Failure |
| FR2923029B1 (fr) | 2007-10-26 | 2009-11-20 | Minima | Lunettes de type sans entourage a branches filaires |
| HUE029880T2 (en) | 2008-04-18 | 2017-04-28 | Critical Care Diagnostics Inc | Predicting the risk of serious heart events |
| WO2010025393A2 (en) * | 2008-08-28 | 2010-03-04 | The Regents Of The University Of California | Protein biomarkers and methods for diagnosing kawasaki disease |
| JP5584695B2 (ja) | 2008-11-11 | 2014-09-03 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Adm及びbnpのレベルを決定することによる心疾患に罹患した患者の予後診断及びリスク評価 |
| JP5728488B2 (ja) | 2009-11-13 | 2015-06-03 | ビージー メディシン, インコーポレイテッド | 心筋梗塞のリスクファクターおよび予測 |
| US8258456B2 (en) | 2009-11-27 | 2012-09-04 | Himax Imaging, Inc. | Image sensor |
| EP3434694B1 (en) | 2010-04-09 | 2020-12-30 | Critical Care Diagnostics, Inc. | Soluble human st-2 antibodies and assays |
| RU2017110678A (ru) | 2010-11-01 | 2019-01-24 | Б.Р.А.Х.М.С Гмбх | Оценка прогноза и риска пациентов с неспецифическими жалобами |
| RU2452394C1 (ru) | 2010-11-09 | 2012-06-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Ульяновский государственный университет | Способ прогнозирования риска смерти больных хронической сердечной недостаточностью |
| CN103718046B (zh) | 2011-03-17 | 2016-10-12 | 重症监护诊断股份有限公司 | 预测不良临床结果的风险的方法 |
| US8615387B2 (en) * | 2011-04-07 | 2013-12-24 | Invensys Systems, Inc. | Dynamic simulation of fluid filled vessels |
| EP2734222B1 (en) | 2011-07-18 | 2016-10-19 | Critical Care Diagnostics, Inc. | Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy |
| CN104507383B (zh) | 2012-05-18 | 2018-08-28 | 重症监护诊断股份有限公司 | 用于治疗或预报室性快速性心律失常事件风险的方法 |
| CN104737023B (zh) * | 2012-08-16 | 2017-07-28 | 重症监护诊断股份有限公司 | 预测患高血压风险的方法 |
| JP6450679B2 (ja) * | 2012-08-21 | 2019-01-09 | クリティカル ケア ダイアグノスティクス インコーポレイテッド | マルチマーカーリスク層別化 |
| US9665593B2 (en) * | 2013-03-28 | 2017-05-30 | International Business Machines Corporation | Dynamically synching elements in file |
| JP6178687B2 (ja) | 2013-09-27 | 2017-08-09 | 富士機械工業株式会社 | グラビア塗工装置 |
| JP6655016B2 (ja) | 2014-01-10 | 2020-02-26 | クリティカル ケア ダイアグノスティクス インコーポレイテッド | 心不全のリスクを決定するための方法 |
| USD770057S1 (en) | 2014-04-14 | 2016-10-25 | Critical Care Diagnostics, Inc. | Blood test kit |
| US9934249B2 (en) | 2014-06-03 | 2018-04-03 | Conduent Business Machines Services, Llc | Systems and methods for context-aware and personalized access to visualizations of road events |
| USD800333S1 (en) | 2014-09-23 | 2017-10-17 | Critical Care Diagnostics, Inc. | Blood test kit |
| USD800332S1 (en) | 2014-09-23 | 2017-10-17 | Critical Care Diagnostics, Inc. | Blood test kit |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| US10079073B2 (en) | 2014-12-11 | 2018-09-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
-
2009
- 2009-04-17 HU HUE14177846A patent/HUE029880T2/en unknown
- 2009-04-17 SI SI200931045T patent/SI2660599T1/sl unknown
- 2009-04-17 EP EP16166093.1A patent/EP3093663B1/en not_active Not-in-force
- 2009-04-17 ES ES14177846.4T patent/ES2590213T3/es active Active
- 2009-04-17 EP EP13179055.2A patent/EP2660599B1/en not_active Not-in-force
- 2009-04-17 SI SI200930776T patent/SI2269063T1/sl unknown
- 2009-04-17 EP EP09731842.2A patent/EP2269063B1/en not_active Not-in-force
- 2009-04-17 HR HRP20131100AT patent/HRP20131100T1/hr unknown
- 2009-04-17 PT PT141778464T patent/PT2827152T/pt unknown
- 2009-04-17 HU HUE16166093A patent/HUE039963T2/hu unknown
- 2009-04-17 PL PL16166093T patent/PL3093663T3/pl unknown
- 2009-04-17 ES ES16166093.1T patent/ES2687401T3/es active Active
- 2009-04-17 EP EP18166387.3A patent/EP3378955A1/en not_active Withdrawn
- 2009-04-17 JP JP2011505224A patent/JP5526122B2/ja not_active Expired - Fee Related
- 2009-04-17 EP EP14177846.4A patent/EP2827152B1/en not_active Not-in-force
- 2009-04-17 AU AU2009236109A patent/AU2009236109B2/en not_active Ceased
- 2009-04-17 DK DK09731842.2T patent/DK2269063T3/da active
- 2009-04-17 DK DK16166093.1T patent/DK3093663T3/en active
- 2009-04-17 WO PCT/US2009/040941 patent/WO2009129454A2/en not_active Ceased
- 2009-04-17 ES ES09731842.2T patent/ES2443125T3/es active Active
- 2009-04-17 PL PL14177846.4T patent/PL2827152T3/pl unknown
- 2009-04-17 PT PT131790552T patent/PT2660599E/pt unknown
- 2009-04-17 PT PT16166093T patent/PT3093663T/pt unknown
- 2009-04-17 DK DK14177846.4T patent/DK2827152T3/en active
- 2009-04-17 DK DK13179055.2T patent/DK2660599T3/en active
- 2009-04-17 US US12/425,956 patent/US8090562B2/en active Active
- 2009-04-17 ES ES13179055.2T patent/ES2525029T3/es active Active
- 2009-04-17 PT PT97318422T patent/PT2269063E/pt unknown
- 2009-04-17 SI SI200931872T patent/SI3093663T1/sl unknown
- 2009-04-17 PL PL09731842T patent/PL2269063T3/pl unknown
- 2009-04-17 SI SI200931469A patent/SI2827152T1/sl unknown
- 2009-04-17 PL PL13179055T patent/PL2660599T3/pl unknown
- 2009-04-17 CA CA2720674A patent/CA2720674A1/en not_active Abandoned
-
2011
- 2011-11-18 US US13/299,612 patent/US20120065897A1/en not_active Abandoned
-
2013
- 2013-03-06 US US13/787,137 patent/US9886553B2/en not_active Expired - Fee Related
-
2014
- 2014-04-03 US US14/244,526 patent/US9965593B2/en active Active
- 2014-04-14 JP JP2014082442A patent/JP5873521B2/ja not_active Expired - Fee Related
- 2014-11-03 HR HRP20141056AT patent/HRP20141056T1/hr unknown
-
2016
- 2016-01-15 JP JP2016006007A patent/JP6200975B2/ja not_active Expired - Fee Related
- 2016-02-04 AU AU2016200697A patent/AU2016200697B2/en not_active Ceased
-
2017
- 2017-08-28 JP JP2017162932A patent/JP6484679B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-04 AU AU2018202350A patent/AU2018202350A1/en not_active Abandoned
- 2018-04-12 US US15/951,376 patent/US11170896B2/en active Active
-
2019
- 2019-02-18 JP JP2019026401A patent/JP6788050B2/ja not_active Expired - Fee Related
-
2020
- 2020-10-29 JP JP2020181010A patent/JP2021039108A/ja not_active Ceased
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2590213T3 (es) | Predicción del riesgo a sufrir episodios cardíacos adversos graves | |
| Herdy et al. | Cardiopulmonary exercise test: background, applicability and interpretation | |
| Valente et al. | Rationale and design of an International Multicenter Registry of patients with repaired tetralogy of Fallot to define risk factors for late adverse outcomes: the INDICATOR cohort | |
| Hemilä et al. | Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports | |
| Fernández-Codina et al. | Lung transplantation in systemic sclerosis: a single center cohort study | |
| Vriz et al. | Mitral valve prolapse and sudden cardiac death in athletes at high risk | |
| Kula et al. | A retrospective study on children with pulmonary arterial hypertension: a single-center experience | |
| Nuti | Heart failure: pathophysiology and clinical picture | |
| Ozdemir et al. | Echocardiographic findings in children with Marfan syndrome: cardiovascular topics | |
| Trojnarska et al. | Exercise testing in adults after repair of aortic coarctation: evaluation of cardiopulmonary exercise capacity and B-type natriuretic protein levels | |
| Mishra et al. | Proposed method for evaluation and categorization of functional capacity of children, adolescents, and adults with cardiac diseases to bring them in existing social justice system by creating the cardiac disability criteria | |
| Maisel et al. | Algorithms in heart failure | |
| Paul et al. | Epidemiological study of dilated cardiomyopathy from eastern india with special reference to left atrial size | |
| Vaz et al. | Evaluation of clinical presentation and outcome of patients with respiratory bronchiolitis-associated interstitial lung disease | |
| Kamphuis et al. | The need for cardiac follow-up in adults with mild congenital cardiac disease | |
| Borlaug | Heart failure with preserved ejection fraction | |
| Ashraf et al. | Diagnosing and Managing Pulmonary and Right-Sided Heart Disease: Pulmonary Hypertension, Right Ventricular Outflow Pathology, and Sleep Apnea | |
| Joosen et al. | Does stroke volume limit exercise capacity in TGA patients after the arterial switch operation? | |
| Shin et al. | B-type natriuretic peptide blood concentrations in differential diagnosis of dyspnea and its association to 6 minute walk | |
| Hughes | Validation of submaximal heart rate recovery as a perioperative risk measure | |
| Gorrie et al. | (847) Turning Back The Clock; A Unique Case of Reversible Pulmonary Hypertension | |
| Subramanyam et al. | Preoperative evaluation of the patient with cardiorespiratory diseases | |
| Ciurzyński et al. | Advanced systemic sclerosis complicated by pulmonary hypertension and complete atrioventricular block: a case report. | |
| Vladimirovna et al. | A clinical case of idiopathic pulmonary arterial hypertension in patient with comorbid ischemic heart disease: the key stages of diagnosis | |
| KUMAR | A STUDY ON ECHOCARDIOGRAPHIC PROFILE OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |