ES2587591T3 - Método para la predicción de recurrencia del cáncer de mama bajo tratamiento endocrino - Google Patents

Método para la predicción de recurrencia del cáncer de mama bajo tratamiento endocrino Download PDF

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Publication number
ES2587591T3
ES2587591T3 ES14188791.9T ES14188791T ES2587591T3 ES 2587591 T3 ES2587591 T3 ES 2587591T3 ES 14188791 T ES14188791 T ES 14188791T ES 2587591 T3 ES2587591 T3 ES 2587591T3
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breast cancer
cancer recurrence
patient
endocrine treatment
predicting breast
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Inventor
Christoph Petry
Inke Sabine Feder
Mathias Gehrmann
Guido Henning
Karsten Weber
Christian VON TÖRNE
Ralf Kronenwett
Mareike Dartmann
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Sividon Diagnostics GmbH
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Sividon Diagnostics GmbH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Un método para predecir el resultado del cáncer de mama en un tumor positivo para receptores de estrógeno y negativo para HER2 de un paciente con cáncer de mama, comprendiendo dicho método: (a) determinar en una muestra tumoral de dicho paciente los niveles de expresión de ARN de los siguientes 8 genes: UBE2C, RACGAP1, DHCR7, STC2, AZGP1, RBBP8, IL6ST, y MGP (b) combinar matemáticamente los valores de los niveles de expresión para los genes de dicho conjunto cuyos valores se determinaron en la muestra tumoral para proporcionar una puntuación combinada, en donde dicha puntuación combinada es indicativa de una prognosis de dicho paciente.
ES14188791.9T 2010-03-31 2011-03-29 Método para la predicción de recurrencia del cáncer de mama bajo tratamiento endocrino Active ES2587591T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10158561 2010-03-31
EP10158561 2010-03-31

Publications (1)

Publication Number Publication Date
ES2587591T3 true ES2587591T3 (es) 2016-10-25

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ES14188791.9T Active ES2587591T3 (es) 2010-03-31 2011-03-29 Método para la predicción de recurrencia del cáncer de mama bajo tratamiento endocrino
ES11710526.2T Active ES2525382T3 (es) 2010-03-31 2011-03-29 Método para la predicción de recurrencia del cáncer de mama bajo tratamiento endocrino

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US (4) US20130065786A1 (es)
EP (2) EP2845911B1 (es)
JP (2) JP5940517B2 (es)
KR (1) KR101864855B1 (es)
CN (2) CN102971435B (es)
BR (2) BR112012024718A2 (es)
CA (1) CA2793133C (es)
ES (2) ES2587591T3 (es)
HK (1) HK1181817A1 (es)
HU (1) HUE030164T2 (es)
MX (1) MX2012011167A (es)
PL (2) PL2553118T3 (es)
PT (2) PT2553118E (es)
RU (1) RU2654587C2 (es)
UA (1) UA110790C2 (es)
WO (1) WO2011120984A1 (es)
ZA (1) ZA201207229B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030198972A1 (en) 2001-12-21 2003-10-23 Erlander Mark G. Grading of breast cancer
PT2553118E (pt) 2010-03-31 2014-12-17 Sividon Diagnostics Gmbh Método para previsão da recorrência de cancro da mama em tratamento endócrino
PT2737081T (pt) 2011-07-28 2016-12-23 Sividon Diagnostics Gmbh Método para prever a resposta a quimioterapia num doente que sofre de ou em risco de desenvolver cancro de mama recorrente
SG10202010758SA (en) * 2011-11-08 2020-11-27 Genomic Health Inc Method of predicting breast cancer prognosis
ES2763931T3 (es) * 2012-05-22 2020-06-01 Nanostring Technologies Inc Genes Nano46 y métodos para predecir el resultado del cáncer de mama
WO2013188600A1 (en) * 2012-06-12 2013-12-19 Washington University Copy number aberration driven endocrine response gene signature
WO2013190081A1 (en) * 2012-06-22 2013-12-27 Proyecto De Biomedicina Cima, S.L. Methods and reagents for the prognosis of cancer
ES2654469T3 (es) 2013-02-01 2018-02-13 Sividon Diagnostics Gmbh Procedimiento de predicción del beneficio de la inclusión de taxano en un régimen de quimioterapia en pacientes con cáncer de mama
KR20160005731A (ko) * 2013-05-07 2016-01-15 국립연구개발법인 고쿠리츠간켄큐센터 위암의 재발을 예측하는 방법
AU2014265623A1 (en) * 2013-05-13 2015-11-26 Nanostring Technologies, Inc. Methods to predict risk of recurrence in node-positive early breast cancer
WO2015015000A1 (en) * 2013-08-02 2015-02-05 Université Catholique de Louvain Signature of cycling hypoxia and use thereof for the prognosis of cancer
JP2016536004A (ja) * 2013-09-11 2016-11-24 バイオ セラノスティックス，インコーポレイテッド 乳癌再発の予測
CA2958290A1 (en) * 2013-09-23 2015-03-26 The University Of Chicago Methods and compositions relating to cancer therapy with dna damaging agents
KR101548830B1 (ko) * 2013-12-30 2015-08-31 가천대학교 산학협력단 줄기세포 배양방법을 이용하여 발굴된 유방암 줄기세포 마커를 이용한 유방암 예후 예측용 조성물
WO2015110440A1 (en) * 2014-01-22 2015-07-30 Koninklijke Philips N.V. Improved stratification of patients for assessing the suitability of a therapy
RU2566732C1 (ru) * 2014-07-08 2015-10-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт онкологии" Сибирского отделения Российской академии медицинских наук (ФГБУ "НИИ онкологии" СО РАМН) Способ прогнозирования лимфогенного метастазирования при инвазивной карциноме неспецифического типа молочной железы
CN104263815B (zh) * 2014-08-25 2017-01-25 复旦大学附属肿瘤医院 一组用于激素受体阳性乳腺癌预后的基因及其应用
WO2016092299A1 (en) * 2014-12-09 2016-06-16 Medical Research Council Methods and kits for predicting the response to therapy of cancer
EP3274476B1 (en) 2015-03-25 2023-06-07 The General Hospital Corporation Digital analysis of circulating tumor cells in blood samples
EP3426797A1 (en) 2016-03-09 2019-01-16 Myriad International GmbH Method for determining the risk of recurrence of an estrogen receptor-positive and her2-negative primary mammary carcinoma under an endocrine therapy
JP6938536B2 (ja) * 2016-04-14 2021-09-22 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 新規のｖｅｇｆｒ２コレセプターであるｓｃｕｂｅ２の阻害による、腫瘍血管新生の抑制
JP7131773B2 (ja) * 2016-04-29 2022-09-06 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ホルモン受容体に関連する転写活性の標的尺度
CN106480201A (zh) * 2016-10-26 2017-03-08 北京鑫诺美迪基因检测技术有限公司 乳腺癌转移评估试剂盒
EP3985127A1 (en) * 2016-10-27 2022-04-20 The General Hospital Corporation Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers
KR101950717B1 (ko) * 2016-11-23 2019-02-21 주식회사 젠큐릭스 유방암 환자의 화학치료 유용성 예측 방법
KR101896545B1 (ko) * 2016-11-25 2018-09-07 주식회사 젠큐릭스 유방암 환자의 예후 예측 방법
RU2671557C1 (ru) * 2017-07-10 2018-11-02 Александр Григорьевич Тоневицкий Набор реагентов для определения риска возникновения рецидива онкологических заболеваний молочной железы
WO2019051266A2 (en) 2017-09-08 2019-03-14 Myriad Genetics, Inc. METHOD OF USING BIOMARKERS AND CLINICAL VARIABLES TO PREDICT THE INTEREST OF CHEMOTHERAPY
CN108441559B (zh) * 2018-02-27 2021-01-05 海门善准生物科技有限公司 一种免疫相关基因群作为标志物在制备评估高增殖性乳腺癌远处转移风险的产品中的应用
JP7199045B2 (ja) * 2018-04-13 2023-01-05 国立大学法人大阪大学 乳癌の予後に関する情報の取得方法、乳癌の予後の判定装置及びコンピュータプログラム
CN108715804A (zh) * 2018-05-14 2018-10-30 浙江大学 一种群智能寻优的肺癌癌细胞检测仪
CN108424969B (zh) * 2018-06-06 2022-07-15 深圳市颐康生物科技有限公司 一种生物标志物、诊断或预估死亡风险的方法
JP2020028278A (ja) * 2018-08-24 2020-02-27 国立大学法人九州大学 被検体に生じるイベントを予測するための判別器の生成方法、及び前記判別器を用いた被検体の層別化方法
WO2020118245A1 (en) * 2018-12-06 2020-06-11 Georgia State University Research Foundation, Inc. Quantitative centrosomal amplification score to predict local recurrence of ductal carcinoma in situ
US20220333193A1 (en) * 2019-07-05 2022-10-20 Intellexon Gmbh Determining individual hla patterns, use as prognosticators, target genes and therapeutic agents
CA3151330A1 (en) * 2019-09-16 2021-03-25 Christina CURTIS Methods of treatments based upon molecular characterization of breast cancer
KR102325945B1 (ko) * 2020-04-22 2021-11-12 아주대학교산학협력단 두경부암 예후 예측용 바이오마커 조성물
CN112852968A (zh) * 2021-04-08 2021-05-28 杨文琳 基于免疫相关lncRNA构建三阴性乳腺癌风险预测方法
CN114480652A (zh) * 2022-02-21 2022-05-13 深圳市陆为生物技术有限公司 评价乳腺癌患者对于辅助内分泌治疗的响应性的产品

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686446B2 (en) 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
JP4277452B2 (ja) 2000-02-25 2009-06-10 ソニー株式会社 記録装置、再生装置
EA006512B1 (ru) * 2001-04-27 2005-12-29 Институт молекулярной биологии им. В.А.Энгельгардта РАН Способы анализа последовательностей нуклеиновых кислот с использованием биологического олигонуклеотидного микрочипа и наборы для их осуществления
US7297480B2 (en) 2001-06-28 2007-11-20 Dermtech International Method for detection of melanoma
US20040002067A1 (en) 2001-12-21 2004-01-01 Erlander Mark G. Breast cancer progression signatures
US20060024692A1 (en) * 2002-09-30 2006-02-02 Oncotherapy Science, Inc. Method for diagnosing non-small cell lung cancers
FR2863275B1 (fr) * 2003-12-09 2007-08-10 Biomerieux Sa Procede pour le diagnostic/pronostic du cancer du sein
MXPA06009545A (es) * 2004-02-20 2007-03-07 Johnson & Johnson Pronosticos del cancer de mama.
ATE520988T1 (de) * 2004-09-22 2011-09-15 Tripath Imaging Inc Verfahren und zusammensetzungen zur bewertung einer brustkrebsprognose
CA2585561C (en) 2004-11-05 2018-07-17 Genomic Health, Inc. Esr1, pgr, bcl2 and scube2 group score as indicators of breast cancer prognosis and prediction of treatment response
CA2596640A1 (en) 2005-02-04 2006-08-10 Rosetta Inpharmatics Llc Methods of predicting chemotherapy responsiveness in breast cancer patients
JP2008539737A (ja) * 2005-05-13 2008-11-20 ユニヴェルシテ リブル ドゥ ブリュッセル 遺伝子に基づくアルゴリズム的ガン予後
EP1907858A4 (en) 2005-06-13 2009-04-08 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
GB0512299D0 (en) 2005-06-16 2005-07-27 Bayer Healthcare Ag Diagnosis prognosis and prediction of recurrence of breast cancer
US20070134688A1 (en) * 2005-09-09 2007-06-14 The Board Of Regents Of The University Of Texas System Calculated index of genomic expression of estrogen receptor (er) and er-related genes
US20090239223A1 (en) * 2006-07-13 2009-09-24 Siemens Healthcare Diagnostics Inc. Prediction of Breast Cancer Response to Taxane-Based Chemotherapy
CA2699434A1 (en) * 2006-09-15 2008-04-24 Mcgill University Stroma derived predictor of breast cancer
JP2010511630A (ja) 2006-12-01 2010-04-15 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 自己組織化ブロックコポリマーのベシクル、ならびにその生成および使用法
US9353415B2 (en) * 2006-12-19 2016-05-31 Thomson Reuters (Scientific) Llc Methods for functional analysis of high-throughput experimental data and gene groups identified therefrom
EP2592156B1 (en) 2007-06-08 2016-04-20 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
EP2036988A1 (en) 2007-09-12 2009-03-18 Siemens Healthcare Diagnostics GmbH A method for predicting the response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent
WO2009095319A1 (en) 2008-01-28 2009-08-06 Siemens Healthcare Diagnostics Gmbh Cancer prognosis by majority voting
WO2009114836A1 (en) 2008-03-14 2009-09-17 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
WO2009132928A2 (en) * 2008-05-02 2009-11-05 Siemens Healthcare Diagnostics Gmbh Molecular markers for cancer prognosis
ES2457534T3 (es) * 2008-05-30 2014-04-28 The University Of North Carolina At Chapel Hill Perfiles de expresión génica para predecir desenlaces en cáncer de mama
US20110166838A1 (en) * 2008-06-16 2011-07-07 Sividon Diagnostics Algorithms for outcome prediction in patients with node-positive chemotherapy-treated breast cancer
RU2011101382A (ru) 2008-06-16 2012-07-27 Сайвидон Дайагностикс Гмбх (De) Молекулярные маркеры для прогноза развития рака
EP2163649A1 (en) * 2008-09-11 2010-03-17 Fédération Nationale des Centres de Lutte Contre le Cancer Molecular classifier for evaluating the risk of metastasic relapse in breast cancer
KR101192297B1 (ko) 2008-12-10 2012-10-17 한국생명공학연구원 간암에 대한 신규 바이오마커 및 그의 용도
WO2010076322A1 (en) * 2008-12-30 2010-07-08 Siemens Healthcare Diagnostics Inc. Prediction of response to taxane/anthracycline-containing chemotherapy in breast cancer
US20120065084A1 (en) 2009-04-17 2012-03-15 Universite Libre De Bruxelles Methods and tools for predicting the efficiency of anthracyclines in cancer
WO2010135671A1 (en) 2009-05-22 2010-11-25 The Usa, As Represented By The Secretary, Dpt Of Health And Human Services Akt phosphorylation at ser473 as an indicator for taxane-based chemotherapy
EP2553119B1 (en) 2010-03-30 2016-03-30 Ralph Wirtz Algorithm for prediction of benefit from addition of taxane to standard chemotherapy in patients with breast cancer
PT2553118E (pt) 2010-03-31 2014-12-17 Sividon Diagnostics Gmbh Método para previsão da recorrência de cancro da mama em tratamento endócrino
US20130042333A1 (en) 2011-05-06 2013-02-14 Jean-Gabriel JUDDE Markers for cancer prognosis and therapy and methods of use
PT2737081T (pt) 2011-07-28 2016-12-23 Sividon Diagnostics Gmbh Método para prever a resposta a quimioterapia num doente que sofre de ou em risco de desenvolver cancro de mama recorrente
CA2857191A1 (en) 2011-11-28 2013-06-06 National Research Council Of Canada Paclitaxel response markers for cancer
WO2013188600A1 (en) 2012-06-12 2013-12-19 Washington University Copy number aberration driven endocrine response gene signature
WO2015121300A1 (en) 2014-02-12 2015-08-20 Sividon Diagnostics Gmbh Method for predicting the response and survival from chemotherapy in patients with breast cancer
CN106480201A (zh) 2016-10-26 2017-03-08 北京鑫诺美迪基因检测技术有限公司 乳腺癌转移评估试剂盒

Also Published As

Publication number Publication date
ES2525382T3 (es) 2014-12-23
PT2553118E (pt) 2014-12-17
CN105821125A (zh) 2016-08-03
EP2845911A1 (en) 2015-03-11
CA2793133C (en) 2019-08-20
BR122020016370B1 (pt) 2021-05-11
RU2654587C2 (ru) 2018-05-21
JP2013523105A (ja) 2013-06-17
UA110790C2 (uk) 2016-02-25
KR101864855B1 (ko) 2018-07-13
RU2012146343A (ru) 2014-05-10
PT2845911T (pt) 2016-08-25
KR20130010048A (ko) 2013-01-24
CN102971435B (zh) 2016-05-11
WO2011120984A1 (en) 2011-10-06
HK1181817A1 (en) 2013-11-15
EP2553118A1 (en) 2013-02-06
JP2016189781A (ja) 2016-11-10
BR112012024718A2 (pt) 2017-01-10
US20170067118A1 (en) 2017-03-09
US20200224281A1 (en) 2020-07-16
EP2845911B1 (en) 2016-05-18
PL2845911T3 (pl) 2017-01-31
ZA201207229B (en) 2013-06-26
US20210123107A1 (en) 2021-04-29
CA2793133A1 (en) 2011-10-06
CN102971435A (zh) 2013-03-13
AU2011234573B2 (en) 2015-10-01
HUE030164T2 (en) 2017-05-29
JP5940517B2 (ja) 2016-06-29
EP2553118B1 (en) 2014-10-15
PL2553118T3 (pl) 2015-03-31
AU2011234573A1 (en) 2012-09-20
MX2012011167A (es) 2013-02-07
US20130065786A1 (en) 2013-03-14
US10851427B2 (en) 2020-12-01
US11913078B2 (en) 2024-02-27
US10577661B2 (en) 2020-03-03

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