ES2579942T3 - Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma - Google Patents
Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma Download PDFInfo
- Publication number
- ES2579942T3 ES2579942T3 ES11758010.0T ES11758010T ES2579942T3 ES 2579942 T3 ES2579942 T3 ES 2579942T3 ES 11758010 T ES11758010 T ES 11758010T ES 2579942 T3 ES2579942 T3 ES 2579942T3
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- acid
- pharmaceutical compositions
- methyl
- quinazolin
- pyrazol
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3833—Chiral chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37928610P | 2010-09-01 | 2010-09-01 | |
| US37928010P | 2010-09-01 | 2010-09-01 | |
| US379286P | 2010-09-01 | ||
| US379280P | 2010-09-01 | ||
| PCT/US2011/049902 WO2012030917A1 (en) | 2010-09-01 | 2011-08-31 | An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
Publications (1)
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|---|---|
| ES2579942T3 true ES2579942T3 (es) | 2016-08-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES11758010.0T Active ES2579942T3 (es) | 2010-09-01 | 2011-08-31 | Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma |
| ES11758009.2T Active ES2581840T3 (es) | 2010-09-01 | 2011-08-31 | Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11758009.2T Active ES2581840T3 (es) | 2010-09-01 | 2011-08-31 | Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8912324B2 (enExample) |
| EP (2) | EP2611796B1 (enExample) |
| JP (2) | JP5932794B2 (enExample) |
| AR (2) | AR082875A1 (enExample) |
| AU (2) | AU2011296074B2 (enExample) |
| CA (2) | CA2809994A1 (enExample) |
| ES (2) | ES2579942T3 (enExample) |
| TW (2) | TW201305143A (enExample) |
| WO (2) | WO2012030917A1 (enExample) |
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| US8633209B2 (en) * | 2010-09-01 | 2014-01-21 | Ambit Biosciences Corporation | Hydrobromide salts of a pyrazolylaminoquinazoline |
| WO2012030917A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
| US9611253B2 (en) | 2012-02-29 | 2017-04-04 | Ambit Biosciences Corporation | Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith |
| RS62713B1 (sr) | 2014-08-11 | 2022-01-31 | Acerta Pharma Bv | Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora |
| SMT202200285T1 (it) | 2014-08-11 | 2022-09-14 | Acerta Pharma Bv | Combinazioni terapeutiche di un inibitore di btk, un inibitore di pd-1 e/o un inibitore di pd-l1 |
| TW201618773A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | Ｂｔｋ抑制劑、ｐｉ３ｋ抑制劑、ｊａｋ－２抑制劑、及／或ｃｄｋ４／６抑制劑的治療組合物 |
| CN117858709A (zh) * | 2022-08-08 | 2024-04-09 | 石药集团中奇制药技术（石家庄）有限公司 | 一种含有三环杂芳基的化合物的用途 |
| WO2024201533A1 (en) * | 2023-03-31 | 2024-10-03 | Sava Healthcare Limited | A parenteral composition of cinnamic acid |
| CN118239990B (zh) * | 2024-05-28 | 2025-03-14 | 北京元延医药科技股份有限公司 | 不对称氢化催化合成药物的稀有贵金属和手性膦的配合物 |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| HU196714B (en) | 1984-10-04 | 1989-01-30 | Monsanto Co | Process for producing non-aqueous composition comprising somatotropin |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| US5612059A (en) | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| PH30995A (en) | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
| US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
| US5985307A (en) | 1993-04-14 | 1999-11-16 | Emory University | Device and method for non-occlusive localized drug delivery |
| US6087324A (en) | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US6004534A (en) | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
| US5958458A (en) | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US5759542A (en) | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
| US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| US6316652B1 (en) | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
| US5798119A (en) | 1995-06-13 | 1998-08-25 | S. C. Johnson & Son, Inc. | Osmotic-delivery devices having vapor-permeable coatings |
| WO1997001331A2 (en) | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
| TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
| JP2909418B2 (ja) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
| US6039975A (en) | 1995-10-17 | 2000-03-21 | Hoffman-La Roche Inc. | Colon targeted delivery system |
| US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| TW345603B (en) | 1996-05-29 | 1998-11-21 | Gmundner Fertigteile Gmbh | A noise control device for tracks |
| US6264970B1 (en) | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US6419961B1 (en) | 1996-08-29 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Sustained release microcapsules of a bioactive substance and a biodegradable polymer |
| US6375987B1 (en) | 1996-10-01 | 2002-04-23 | Gattefossé, S.A. | Process for the manufacture of pharmaceutical composition with modified release of active principle comprising the matrix |
| HUP0000116A3 (en) | 1996-10-01 | 2000-08-28 | Stanford Res Inst Int | Taste-masked microcapsule compositions and methods of manufacture |
| CA2217134A1 (en) | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
| ES2221019T3 (es) | 1996-10-31 | 2004-12-16 | Takeda Chemical Industries, Ltd. | Preparacion de liberacion mantenida. |
| US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
| DE19648576C2 (de) | 1996-11-23 | 1999-08-12 | Lohmann Therapie Syst Lts | Lutschtablette zur modifizierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt |
| WO1998027980A2 (en) | 1996-12-20 | 1998-07-02 | Takeda Chemical Industries, Ltd. | Method of producing a sustained-release preparation |
| US5891474A (en) | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| US6613358B2 (en) | 1998-03-18 | 2003-09-02 | Theodore W. Randolph | Sustained-release composition including amorphous polymer |
| US6048736A (en) | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
| KR19990085365A (ko) | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
| US7169410B1 (en) | 1998-05-19 | 2007-01-30 | Sdg, Inc. | Targeted liposomal drug delivery system |
| CA2348871C (en) | 1998-11-02 | 2009-04-14 | John G. Devane | Multiparticulate modified release composition |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6271359B1 (en) | 1999-04-14 | 2001-08-07 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
| US6623756B1 (en) | 2000-04-27 | 2003-09-23 | Noveon Ip Holdings Corp. | Directly compressed solid dosage articles |
| MXPA03001771A (es) | 2000-08-30 | 2003-06-04 | Pfizer Prod Inc | Formulaciones de liberacion sostenida para secretagogos de hormona del crecimiento. |
| WO2002068415A1 (en) * | 2000-12-21 | 2002-09-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| PL361452A1 (en) | 2001-07-27 | 2004-10-04 | Yamanouchi Pharmaceutical Co.Ltd. | Compositions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same |
| BR0212951A (pt) | 2001-09-28 | 2004-10-26 | Mcneil Ppc Inc | Formas de dosagens compósitas |
| SI1355633T1 (en) | 2001-12-19 | 2005-06-30 | Astrazeneca Ab | NEW FILM COATING containing an ethyl acrylate/methyl methacrylate copolymer and polyvinyl acetate |
| AR038117A1 (es) * | 2002-01-14 | 2004-12-29 | Upjohn Co | Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida |
| US7112435B1 (en) | 2002-08-07 | 2006-09-26 | Ambit Biosciences Corporation | Uncoupling of DNA insert propagation and expression of protein for phage display |
| US6958161B2 (en) | 2002-04-12 | 2005-10-25 | F H Faulding & Co Limited | Modified release coated drug preparation |
| GB0211019D0 (en) * | 2002-05-14 | 2002-06-26 | Syngenta Ltd | Novel compounds |
| JP2006515847A (ja) * | 2002-12-13 | 2006-06-08 | ニューロジェン・コーポレーション | カプサイシン受容体調節剤としてのカルボン酸、ホスフェート又はホスホネート置換キナゾリン−４−イルアミン類縁体 |
| US7485322B2 (en) | 2002-12-24 | 2009-02-03 | Lek Pharmaceuticals D.D. | Modified release pharmaceutical composition |
| ES2397706T3 (es) | 2005-02-18 | 2013-03-08 | The Hong Kong Polytechnic University | Método para la hidrosililación asimétrica de cetonas |
| WO2006136552A2 (en) * | 2005-06-22 | 2006-12-28 | Nycomed Gmbh | Process for the production of intermadiates for the preparation of tricyclic benzimidazoles |
| US7427414B2 (en) | 2006-01-18 | 2008-09-23 | Astron Research Limited | Modified release oral dosage form using co-polymer of polyvinyl acetate |
| CA2656192C (en) | 2006-06-30 | 2016-05-03 | Ambit Biosciences Corporation | Detectable nucleic acid tag |
| WO2008077560A1 (en) * | 2006-12-22 | 2008-07-03 | Lonza Ag | Process for the preparation of optically active 2-amino-1-phenylethanols |
| EP2134695A4 (en) * | 2007-03-14 | 2011-05-25 | Exelixis Inc | HEMGE OF THE HEDGEHOG SIGNAL PATH |
| KR101174201B1 (ko) * | 2007-08-28 | 2012-08-16 | 아이알엠 엘엘씨 | 키나제 억제제로서의 2-비페닐아미노-4-아미노피리미딘 유도체 |
| MX2010009462A (es) * | 2008-02-29 | 2010-09-24 | Pfizer | Derivados de indazol. |
| SG2014014013A (en) * | 2008-09-22 | 2014-07-30 | Cayman Chemical Co Inc | Multiheteroaryl compounds as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| CN105601619A (zh) * | 2009-02-27 | 2016-05-25 | 埃姆比特生物科学公司 | 调控jak激酶的喹唑啉衍生物和其使用方法 |
| WO2012030917A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
-
2011
- 2011-08-31 WO PCT/US2011/049902 patent/WO2012030917A1/en not_active Ceased
- 2011-08-31 CA CA2809994A patent/CA2809994A1/en not_active Abandoned
- 2011-08-31 CA CA2809993A patent/CA2809993A1/en not_active Abandoned
- 2011-08-31 EP EP11758010.0A patent/EP2611796B1/en not_active Not-in-force
- 2011-08-31 JP JP2013527248A patent/JP5932794B2/ja not_active Expired - Fee Related
- 2011-08-31 US US13/222,963 patent/US8912324B2/en not_active Expired - Fee Related
- 2011-08-31 JP JP2013527249A patent/JP5933554B2/ja not_active Expired - Fee Related
- 2011-08-31 US US13/223,099 patent/US8703943B2/en not_active Expired - Fee Related
- 2011-08-31 AU AU2011296074A patent/AU2011296074B2/en not_active Ceased
- 2011-08-31 AU AU2011296078A patent/AU2011296078B2/en not_active Ceased
- 2011-08-31 WO PCT/US2011/049895 patent/WO2012030913A1/en not_active Ceased
- 2011-08-31 ES ES11758010.0T patent/ES2579942T3/es active Active
- 2011-08-31 ES ES11758009.2T patent/ES2581840T3/es active Active
- 2011-08-31 EP EP11758009.2A patent/EP2611795B1/en not_active Not-in-force
- 2011-09-01 TW TW100131607A patent/TW201305143A/zh unknown
- 2011-09-01 AR ARP110103206A patent/AR082875A1/es unknown
- 2011-09-01 TW TW100131608A patent/TW201302732A/zh unknown
- 2011-09-01 AR ARP110103205A patent/AR082874A1/es unknown
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2014
- 2014-03-11 US US14/204,884 patent/US8952020B2/en not_active Expired - Fee Related
- 2014-11-18 US US14/546,938 patent/US9295672B2/en not_active Expired - Fee Related
-
2015
- 2015-01-12 US US14/595,033 patent/US20150353528A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR082875A1 (es) | 2013-01-16 |
| US20120053194A1 (en) | 2012-03-01 |
| US20140194449A1 (en) | 2014-07-10 |
| US20150141443A1 (en) | 2015-05-21 |
| CA2809993A1 (en) | 2012-03-08 |
| TW201302732A (zh) | 2013-01-16 |
| JP5932794B2 (ja) | 2016-06-08 |
| US9295672B2 (en) | 2016-03-29 |
| JP5933554B2 (ja) | 2016-06-15 |
| EP2611795A1 (en) | 2013-07-10 |
| JP2013536854A (ja) | 2013-09-26 |
| CA2809994A1 (en) | 2012-03-08 |
| AU2011296074A1 (en) | 2013-03-28 |
| WO2012030917A1 (en) | 2012-03-08 |
| JP2013536853A (ja) | 2013-09-26 |
| US20150353528A1 (en) | 2015-12-10 |
| AR082874A1 (es) | 2013-01-16 |
| WO2012030913A1 (en) | 2012-03-08 |
| EP2611796A1 (en) | 2013-07-10 |
| EP2611795B1 (en) | 2016-05-04 |
| EP2611796B1 (en) | 2016-04-20 |
| US8952020B2 (en) | 2015-02-10 |
| ES2581840T3 (es) | 2016-09-07 |
| AU2011296078B2 (en) | 2015-06-18 |
| US20120053193A1 (en) | 2012-03-01 |
| US8703943B2 (en) | 2014-04-22 |
| TW201305143A (zh) | 2013-02-01 |
| US8912324B2 (en) | 2014-12-16 |
| AU2011296078A1 (en) | 2013-03-28 |
| AU2011296074B2 (en) | 2015-06-18 |
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