ES2547349T3 - Proceso de fabricación de salicilamidas N-sustituidas - Google Patents

Proceso de fabricación de salicilamidas N-sustituidas Download PDF

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Publication number
ES2547349T3
ES2547349T3 ES05818421.9T ES05818421T ES2547349T3 ES 2547349 T3 ES2547349 T3 ES 2547349T3 ES 05818421 T ES05818421 T ES 05818421T ES 2547349 T3 ES2547349 T3 ES 2547349T3
Authority
ES
Spain
Prior art keywords
alkyl
formula
ethyl
alkenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05818421.9T
Other languages
English (en)
Spanish (es)
Inventor
Bernhard Riss
Ulrich Meier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34090175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2547349(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2547349T3 publication Critical patent/ES2547349T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES05818421.9T 2004-12-16 2005-12-14 Proceso de fabricación de salicilamidas N-sustituidas Expired - Lifetime ES2547349T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0427603 2004-12-16
GBGB0427603.6A GB0427603D0 (en) 2004-12-16 2004-12-16 Organic compounds
PCT/EP2005/013454 WO2006063821A1 (en) 2004-12-16 2005-12-14 Manufacture process of n-substituted salicylamides

Publications (1)

Publication Number Publication Date
ES2547349T3 true ES2547349T3 (es) 2015-10-05

Family

ID=34090175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05818421.9T Expired - Lifetime ES2547349T3 (es) 2004-12-16 2005-12-14 Proceso de fabricación de salicilamidas N-sustituidas

Country Status (24)

Country Link
US (1) US8461385B2 (enExample)
EP (2) EP1838664B1 (enExample)
JP (1) JP5224816B2 (enExample)
KR (1) KR101287233B1 (enExample)
CN (1) CN101080384B (enExample)
AR (1) AR055007A1 (enExample)
AU (1) AU2005315850B2 (enExample)
BR (1) BRPI0519327A2 (enExample)
CA (1) CA2587213C (enExample)
ES (1) ES2547349T3 (enExample)
GB (1) GB0427603D0 (enExample)
GT (1) GT200500353A (enExample)
IL (1) IL183366A0 (enExample)
MA (1) MA29092B1 (enExample)
MX (1) MX2007007211A (enExample)
NO (1) NO338969B1 (enExample)
PE (1) PE20060740A1 (enExample)
PL (1) PL1838664T3 (enExample)
PT (1) PT1838664E (enExample)
RU (1) RU2404158C2 (enExample)
TN (1) TNSN07229A1 (enExample)
TW (1) TW200635880A (enExample)
WO (1) WO2006063821A1 (enExample)
ZA (1) ZA200703826B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101627011A (zh) 2005-09-19 2010-01-13 爱密斯菲尔科技公司 N-(5-氯水杨酰基)-8-氨基辛酸的二钠盐的晶形
PL2215047T3 (pl) 2007-11-02 2014-05-30 Emisphere Tech Inc Sposób leczenia niedoborów witaminy b12
CN109473182B (zh) * 2018-11-12 2021-10-19 北京北排科技有限公司 一种基于深度信念网络的mbr膜透水率智能检测方法
CA3141383A1 (en) * 2019-05-20 2020-11-26 Lonza Guangzhou Pharmaceutical Ltd. Method for preparation of carsalam
CN115260116B (zh) * 2022-08-19 2024-04-12 株洲壹诺生物技术有限公司 8-(2-羟基苯甲酰胺基)辛酸钠及苯并噁嗪-2,4-二酮和8-溴辛酸乙酯的制法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU382610A1 (ru) * 1968-07-08 1973-05-25 Способ получения амидов карбоновых кислот
DE60017888T2 (de) 1999-04-05 2006-01-19 Emisphere Technologies, Inc. Dinatrium-salze, monohydrate und ethanol-solvate
TR200200619T2 (tr) * 1999-06-25 2003-01-21 The Institutes For Pharmaceutical Discovery, Llc. İkame edilmiş fenoksiasetik asitler.
ES2386263T3 (es) 2000-03-21 2012-08-14 Emisphere Technologies, Inc. Método de preparación de salicilamidas alquiladas mediante un producto intermedio de dicarboxilato
US7262325B2 (en) 2000-06-02 2007-08-28 Emisphere Technologies, Inc. Method of preparing salicylamides
WO2003057650A2 (en) * 2002-01-09 2003-07-17 Emisphere Technologies, Inc. Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate
EP1299348B1 (en) * 2000-06-29 2008-04-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US7495030B2 (en) * 2000-09-06 2009-02-24 Emisphere Technologies, Inc. (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
US7049283B2 (en) * 2000-12-06 2006-05-23 Novartis Ag Pharmaceutical compositions for the oral delivery of pharmacologically active agents
JP4417113B2 (ja) * 2002-02-20 2010-02-17 エミスフェアー・テクノロジーズ・インク Ｇｌｐ−１分子の投与方法
US20050054557A1 (en) * 2002-05-09 2005-03-10 Goldberg Michael M. Compositions for delivering parathyroid hormone and calcitonin

Also Published As

Publication number Publication date
PL1838664T3 (pl) 2016-04-29
CN101080384B (zh) 2011-06-15
NO338969B1 (no) 2016-11-07
AR055007A1 (es) 2007-08-01
NO20073548L (no) 2007-09-17
BRPI0519327A2 (pt) 2009-01-13
TNSN07229A1 (en) 2008-11-21
IL183366A0 (en) 2007-09-20
GB0427603D0 (en) 2005-01-19
RU2404158C2 (ru) 2010-11-20
CN101080384A (zh) 2007-11-28
JP5224816B2 (ja) 2013-07-03
JP2008524142A (ja) 2008-07-10
EP2955171A1 (en) 2015-12-16
GT200500353A (es) 2006-07-17
MX2007007211A (es) 2007-08-15
RU2007126972A (ru) 2009-01-27
EP1838664B1 (en) 2015-07-15
TW200635880A (en) 2006-10-16
ZA200703826B (en) 2008-08-27
US20090253811A1 (en) 2009-10-08
MA29092B1 (fr) 2007-12-03
AU2005315850A1 (en) 2006-06-22
KR20070086276A (ko) 2007-08-27
PE20060740A1 (es) 2006-09-04
CA2587213A1 (en) 2006-06-22
PT1838664E (pt) 2015-10-16
US8461385B2 (en) 2013-06-11
EP1838664A1 (en) 2007-10-03
WO2006063821A1 (en) 2006-06-22
AU2005315850B2 (en) 2009-11-05
KR101287233B1 (ko) 2013-07-17
CA2587213C (en) 2015-05-19

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