ES2544315T3 - Espectrometría de masas de resistencias por betalactamasas - Google Patents

Espectrometría de masas de resistencias por betalactamasas Download PDF

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Publication number
ES2544315T3
ES2544315T3 ES14179917.1T ES14179917T ES2544315T3 ES 2544315 T3 ES2544315 T3 ES 2544315T3 ES 14179917 T ES14179917 T ES 14179917T ES 2544315 T3 ES2544315 T3 ES 2544315T3
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ES
Spain
Prior art keywords
beta
mass spectrometry
microbes
lactamase resistance
lactamases
Prior art date
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Active
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ES14179917.1T
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English (en)
Inventor
Markus Kostrzewa
Karsten Michelmann
Katrin Sparbier
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Bruker Daltonics GmbH and Co KG
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Bruker Daltonik GmbH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G01N2333/986—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides (3.5.2), e.g. beta-lactamase (penicillinase, 3.5.2.6), creatinine amidohydrolase (creatininase, EC 3.5.2.10), N-methylhydantoinase (3.5.2.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/44—Multiple drug resistance

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Método para la determinación de resistencia a antibióticos betalactámicos de microbios basada en la síntesis microbiana de betalactamasas, en el cual se añaden los microbios a un sustrato y se mide la degradación hidrolítica del sustrato causada por las betalactamasas de los microbios mediante espectrometría de masas.

Description

DESCRIPCIÓN
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Claims (1)

  1. imagen1
ES14179917.1T 2010-06-11 2011-06-10 Espectrometría de masas de resistencias por betalactamasas Active ES2544315T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010023452A DE102010023452B4 (de) 2010-06-11 2010-06-11 Massenspektrometrische Messung von β-Lactamase-Resistenzen
DE102010023452 2010-06-11

Publications (1)

Publication Number Publication Date
ES2544315T3 true ES2544315T3 (es) 2015-08-28

Family

ID=44387449

Family Applications (2)

Application Number Title Priority Date Filing Date
ES14179917.1T Active ES2544315T3 (es) 2010-06-11 2011-06-10 Espectrometría de masas de resistencias por betalactamasas
ES11728209.5T Active ES2515466T3 (es) 2010-06-11 2011-06-10 Espectrometria de masas de resistencias por betalactamasas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES11728209.5T Active ES2515466T3 (es) 2010-06-11 2011-06-10 Espectrometria de masas de resistencias por betalactamasas

Country Status (11)

Country Link
US (1) US20130095511A1 (es)
EP (2) EP2806032B1 (es)
JP (2) JP6055762B2 (es)
CN (1) CN103003699B (es)
AU (1) AU2011263694B2 (es)
BR (1) BR112012031558B8 (es)
CA (1) CA2791627C (es)
DE (1) DE102010023452B4 (es)
DK (1) DK2580598T3 (es)
ES (2) ES2544315T3 (es)
WO (1) WO2011154517A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010023452B4 (de) * 2010-06-11 2012-11-08 Bruker Daltonik Gmbh Massenspektrometrische Messung von β-Lactamase-Resistenzen
CA2808485C (en) 2010-08-19 2019-02-26 Erasmus University Medical Center Rotterdam Methods and means for characterizing antibiotic resistance in microorganisms
CA2851984C (en) * 2011-10-14 2020-10-27 Universite De Liege Method for measuring beta-lactam antibiotics
EA028467B1 (ru) 2012-06-06 2017-11-30 Идмик Са Способ определения чувствительности микроорганизмов к химическим агентам
EP2778232A1 (en) * 2013-03-12 2014-09-17 Universität Heidelberg Method for the detection of multiresistant gram-negative bacteria
WO2014163487A1 (en) 2013-04-04 2014-10-09 Erasmus University Medical Center Rotterdam Mass spectrometric determination of drug resistance
EP2806275B1 (de) * 2013-05-23 2015-07-01 Bruker Daltonik GmbH Massenspektrometrische Resistenzbestimmung durch Wachstums-Messung
CZ304833B6 (cs) 2013-06-20 2014-11-26 Univerzita Karlova v Praze, Lékařská fakulta v Plzni Způsob detekce beta-laktamáz gramnegativních bakterií hmotnostní spektrometrií
CN103645273B (zh) * 2013-12-12 2015-12-30 宁波诺威医疗器械有限公司 β-内酰胺类抗生素耐药性的检测方法、系统及其应用
DE102014000646B4 (de) 2014-01-17 2023-05-11 Bruker Daltonics GmbH & Co. KG Massenspektrometrische Resistenzbestimmung durch Metabolismus-Messung
FR3024465B1 (fr) * 2014-07-30 2018-03-23 Biomerieux Caracterisation de micro-organismes par maldi-tof
EP3081652B1 (de) * 2015-04-13 2017-06-28 Bruker Daltonik GmbH Massenspektrometrischer schnelltest von resistenzen
CN105403640A (zh) * 2015-12-29 2016-03-16 杭州迪安生物技术有限公司 一种细菌氨苄西林耐药的检测方法及检测试剂盒
WO2018183675A1 (en) * 2017-03-29 2018-10-04 Specific Technologies, LLC Susceptibility and resistance of microorganisms
FR3103197A1 (fr) 2019-11-15 2021-05-21 bioMérieux Determination par spectrometrie de masse de la sensibilite ou de la resistance de bacteries a un antibiotique
FR3119459A1 (fr) 2021-02-04 2022-08-05 bioMérieux Plaque pour une analyse par spectrometrie de masse utilisant une technique d’ionisation maldi
DE102021130356B3 (de) 2021-11-19 2023-04-20 Bruker Daltonics GmbH & Co. KG Referenzdatensatz-basiertes, spektrometrisches Charakterisieren von Zellsubstraten unter Verwendung von Teilbibliotheken
CN115561355B (zh) * 2022-09-26 2024-04-30 重庆迪纳利医药科技有限责任公司 羧肽酶g2的中和抗体检测方法以及基于lc-ms/ms的检测系统

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641623A (en) * 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
US7291480B2 (en) * 2002-03-13 2007-11-06 Black Jennifer A Device and method for detecting antibiotic-inactivating enzymes
NZ538235A (en) * 2005-02-15 2008-07-31 Syft Technologies Ltd Evaluation of bacterial growth and antibiotic sensitivity in blood cultures using selected ion flow tube mass spectrometry
DE102006021493B4 (de) * 2006-05-09 2010-04-01 Bruker Daltonik Gmbh Massenspektrometrische Messung mikrobieller Resistenzen
EP2370812A2 (en) * 2008-12-08 2011-10-05 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Methods and kits for direct detection and susceptibility profiling of beta-lactam resistant bacteria
DE102009032649B4 (de) 2009-07-10 2017-12-21 Bruker Daltonik Gmbh Massenspektrometrische Identifizierung von Mikroben nach Unterarten
DE102009033368B4 (de) 2009-07-16 2023-01-26 Bruker Daltonics GmbH & Co. KG Massenspektrometrische Sepsisdiagnose
DE102010023452B4 (de) * 2010-06-11 2012-11-08 Bruker Daltonik Gmbh Massenspektrometrische Messung von β-Lactamase-Resistenzen
CN102033102A (zh) * 2010-10-13 2011-04-27 中国科学院上海有机化学研究所 高通量基质辅助激光解析-质谱法筛查奶类制品中β-内酰胺酶类解抗剂

Also Published As

Publication number Publication date
EP2806032A1 (en) 2014-11-26
JP6055762B2 (ja) 2016-12-27
EP2580598B1 (en) 2014-08-06
CA2791627C (en) 2018-09-11
JP2013529458A (ja) 2013-07-22
AU2011263694B2 (en) 2014-08-28
DK2580598T3 (da) 2014-11-17
EP2580598A1 (en) 2013-04-17
ES2515466T3 (es) 2014-10-29
BR112012031558B1 (pt) 2020-12-08
DE102010023452A1 (de) 2011-12-15
US20130095511A1 (en) 2013-04-18
BR112012031558A2 (pt) 2016-10-25
CN103003699B (zh) 2015-04-29
DE102010023452B4 (de) 2012-11-08
CA2791627A1 (en) 2011-12-15
JP6286406B2 (ja) 2018-02-28
JP2016039814A (ja) 2016-03-24
WO2011154517A1 (en) 2011-12-15
CN103003699A (zh) 2013-03-27
BR112012031558B8 (pt) 2023-03-21
EP2806032B1 (en) 2015-07-29

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