ES2539353T3 - Nuevos agonistas sintéticos de TLR9 - Google Patents
Nuevos agonistas sintéticos de TLR9 Download PDFInfo
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- ES2539353T3 ES2539353T3 ES13171674.8T ES13171674T ES2539353T3 ES 2539353 T3 ES2539353 T3 ES 2539353T3 ES 13171674 T ES13171674 T ES 13171674T ES 2539353 T3 ES2539353 T3 ES 2539353T3
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| US8883174B2 (en) | 2009-03-25 | 2014-11-11 | The Board Of Regents, The University Of Texas System | Compositions for stimulation of mammalian innate immune resistance to pathogens |
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| JP6991857B2 (ja) * | 2014-10-10 | 2022-01-13 | イデラ ファーマシューティカルズ インコーポレイテッド | Ｔｌｒ９アゴニストをチェックポイント阻害剤と共に用いるがんの治療 |
| WO2016081911A2 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| WO2017052403A1 (ru) * | 2015-09-25 | 2017-03-30 | Анатолий Викторович ЗАЗУЛЯ | Изготовление таблетки с механизмом повышения терапевтической эффективности лекарственного средства нанодозой микрорнк |
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| CA3036978A1 (en) | 2016-09-15 | 2018-03-22 | Idera Pharmaceuticals, Inc. | Immune modulation with tlr9 agonists for cancer treatment |
| US20180193003A1 (en) | 2016-12-07 | 2018-07-12 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3046019A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a tlr modulator |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
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| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| ATE432348T1 (de) * | 1997-06-06 | 2009-06-15 | Univ California | Inhibitoren von immunstimulatorischen dna sequenz aktivität |
| US6562798B1 (en) * | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
| US6503734B1 (en) * | 2000-07-26 | 2003-01-07 | Cognis Corporation | Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto |
| US6673613B2 (en) * | 2000-07-26 | 2004-01-06 | Cognis Corporation | Use of CYP52A2A promoter to increase gene expression in yeast |
| RU2194502C2 (ru) * | 2000-12-27 | 2002-12-20 | Наровлянский Александр Наумович | Иммуномодулятор - метаболик - детоксикант - адаптоген - радиопротектор |
| JP4188687B2 (ja) * | 2000-12-27 | 2008-11-26 | ダイナバックス テクノロジーズ コーポレイション | 免疫変調ポリヌクレオチド及びその使用法 |
| CN100334228C (zh) * | 2001-06-21 | 2007-08-29 | 戴纳瓦克斯技术公司 | 嵌合免疫调制化合物及其使用方法 |
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| KR101178816B1 (ko) * | 2002-12-23 | 2012-09-07 | 다이나박스 테크놀로지 코퍼레이션 | 면역자극성 서열 올리고뉴클레오타이드 및 이의 이용방법 |
| EP1620070A2 (en) * | 2003-04-29 | 2006-02-01 | Centocor, Inc. | Toll-like receptor 9 effector agents and uses thereof |
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| US20050244410A1 (en) * | 2004-04-29 | 2005-11-03 | Ashlyn Bassiri | Toll-like receptor 9 effector agents and uses thereof |
| RU2007101039A (ru) * | 2004-06-15 | 2008-07-20 | Айдера Фармасьютикалз | Иммуностимулирующие олигонуклеотидные мультимеры |
| WO2007047396A2 (en) * | 2005-10-12 | 2007-04-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| EP2371956A3 (en) * | 2005-11-07 | 2012-01-04 | Idera Pharmaceuticals | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| US7786089B2 (en) * | 2005-12-20 | 2010-08-31 | Idera Pharmaceuticals, Inc. | Immunostimulatory activity of immune modulatory oligonucleotides (IMO™) containing different lengths of palindromic segments |
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| WO2008131074A1 (en) * | 2007-04-19 | 2008-10-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders |
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2008
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