ES2525953R1 - Método de obtención de un extracto rico en ácidos triterpénicos de corteza de eucalipto - Google Patents

Método de obtención de un extracto rico en ácidos triterpénicos de corteza de eucalipto Download PDF

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Publication number
ES2525953R1
ES2525953R1 ES201490120A ES201490120A ES2525953R1 ES 2525953 R1 ES2525953 R1 ES 2525953R1 ES 201490120 A ES201490120 A ES 201490120A ES 201490120 A ES201490120 A ES 201490120A ES 2525953 R1 ES2525953 R1 ES 2525953R1
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Prior art keywords
eucalyptus
obtaining
filtration
courtes
trucker
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ES201490120A
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English (en)
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ES2525953A2 (es
ES2525953A9 (es
ES2525953B2 (es
Inventor
Rui Miguel DE ANDRADE DOMINGUES
Carmen Sofia DA ROCHA FREIRE BARROS
Armando Jorge DOMINGUES SILVESTRE
Carlos DE PASCOAL NETO
Carlos Manuel SANTOS SILVA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Raiz-Instituto De Investigacao Da Floresta E Do Papel
RAIZ INST DE INVESTIGAS O DA FLORESTA E DO PAPEL
Universidade de Aveiro
Original Assignee
Raiz-Instituto De Investigacao Da Floresta E Do Papel
RAIZ INST DE INVESTIGAS O DA FLORESTA E DO PAPEL
Universidade de Aveiro
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Application filed by Raiz-Instituto De Investigacao Da Floresta E Do Papel, RAIZ INST DE INVESTIGAS O DA FLORESTA E DO PAPEL, Universidade de Aveiro filed Critical Raiz-Instituto De Investigacao Da Floresta E Do Papel
Publication of ES2525953A2 publication Critical patent/ES2525953A2/es
Publication of ES2525953A9 publication Critical patent/ES2525953A9/es
Publication of ES2525953R1 publication Critical patent/ES2525953R1/es
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Publication of ES2525953B2 publication Critical patent/ES2525953B2/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B01D11/0284—Multistage extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

La presente invención se refiere a un método de obtención de extractos que tienen contenidos muy altos (de hasta el 98%) de ácidos triterpénicos, principalmente ácido oleanólico y ácido ursólico, de corteza de eucalipto. El método implica la extracción sólido-líquido de la corteza con disolventes orgánicos, preferentemente hexano, y el fraccionamiento del extracto en bruto por medio de un tratamiento sencillo con una solución alcalina, seguido de la separación de la fase acuosa, su filtración, acidificación y, finalmente, el aislamiento de la fracción enriquecida en ácidos triterpénicos por medio de filtración, centrifugación o extracción con un disolvente orgánico, preferentemente hexano, seguida de la eliminación del disolvente. La presente invención tiene aplicación en las industrias farmacéutica, nutracéutica, cosmética y de alimentos funcionales.
ES201490120A 2012-04-26 2013-04-26 Método de obtención de un extracto rico en ácidos triterpénicos de corteza de eucalipto Active ES2525953B2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT106278A PT106278B (pt) 2012-04-26 2012-04-26 Método para a obtenção de um extrato rico em ácidos triterpénicos a partir da casca de eucalipto
PT106278 2012-04-26
PCT/IB2013/053318 WO2013160881A1 (en) 2012-04-26 2013-04-26 Method for obtaining an extract rich in triterpenic acids from eucalyptus barks

Publications (4)

Publication Number Publication Date
ES2525953A2 ES2525953A2 (es) 2015-01-02
ES2525953A9 ES2525953A9 (es) 2015-03-23
ES2525953R1 true ES2525953R1 (es) 2015-03-24
ES2525953B2 ES2525953B2 (es) 2017-06-14

Family

ID=48626489

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201490120A Active ES2525953B2 (es) 2012-04-26 2013-04-26 Método de obtención de un extracto rico en ácidos triterpénicos de corteza de eucalipto

Country Status (3)

Country Link
ES (1) ES2525953B2 (es)
PT (1) PT106278B (es)
WO (1) WO2013160881A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112021339A (zh) * 2019-06-03 2020-12-04 南京臻旸生物科技有限公司 一种桉树叶和桉树皮制生物农药和生物肥料的方法及产品
PT117613A (pt) * 2021-11-30 2023-05-30 Univ Aveiro Processo integrado de extracção de compostos bioactivos a partir de biomassa de eucalipto

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2108803C1 (ru) * 1997-04-08 1998-04-20 Новосибирский институт органической химии Сибирского отделения РАН Способ получения биологически активной суммы тритерпеновых кислот
RU2151139C1 (ru) * 1999-08-02 2000-06-20 Открытое акционерное общество "ЭЛХА" Способ получения биологически активной суммы тритерпеновых кислот
CN1521182A (zh) * 2003-01-28 2004-08-18 中国人民解放军第二军医大学 一种桉属植物提取物及其用途
US20060198910A1 (en) * 2003-06-06 2006-09-07 Roschin Viktor I Method for processing vegetable raw materials
EP2286678A1 (en) * 2008-06-17 2011-02-23 Lotte Co., Ltd. Process for preparing a eucalyptus extract

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Publication number Priority date Publication date Assignee Title
RU2108107C1 (ru) 1997-03-06 1998-04-10 Новосибирский институт органической химии СО РАН Способ получения биологически активной суммы солей тритерпеновых кислот
FR2802818B1 (fr) * 1999-12-24 2002-08-30 Greentech Sa Procede d'obtention d'un extrait d'ecorce de bouleau, betula alba, et especes apparentees
EP1161879B1 (en) 2000-06-05 2005-11-09 Loders Croklaan B.V. Blends of ursolic acid/oleanolic acid
EP1310478A4 (en) 2000-08-08 2009-10-21 Nisshin Oillio Group Ltd PROCESS FOR PRODUCING OLEANOLIC ACID AND / OR MASLINIC ACID
EP1250852B1 (en) 2001-04-09 2005-05-11 Loders Croklaan B.V. Concentrate of triterpenes
WO2003011891A1 (en) 2001-08-03 2003-02-13 Council Of Scientific And Industrial Research A process for the isolation of betulinic acid from nelumbo nucifera gaertn rhizomes
JP2006506679A (ja) * 2002-11-15 2006-02-23 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 光学的異方性体
US20050014730A1 (en) * 2003-04-02 2005-01-20 Carlson Robert M. Anti-fungal formulation of triterpene and essential oil
EP1687326A2 (en) 2003-11-10 2006-08-09 Regents Of The University Of Minnesota Method for obtaining natural products from plant material
ES2238183B1 (es) 2004-02-09 2006-12-16 Consejo Sup. Investig. Cientificas Procedimiento para obtener compuestos de alto valor añadido a partir de hoja de olivo.
US20060140883A1 (en) * 2004-12-29 2006-06-29 Colgate-Palmolive Company Oral care compositions containing a eucalyptus extract
RO120950B1 (ro) 2005-02-18 2006-10-30 Biotehnos S.A. Complex bioactiv de acizi triterpenici, procedeu de obţinere şi produse medicamentoase cu utilizări terapeutice
RO122244B1 (ro) 2006-05-04 2009-03-30 Biotehnos S.A. Procedeu de obţinere a acidului oleanolic în stare pură, din herba viscum album
FR2904557B1 (fr) * 2006-08-01 2010-04-30 Pf Medicament Nouvel extrait d'eucalyptus, son procede de preparation et ses utilisations therapeutiques
JP2008255085A (ja) 2007-04-04 2008-10-23 Tokiwa Shokubutsu Kagaku Kenkyusho:Kk 枇杷葉からの高純度コロソリン酸及び高純度ウルソール酸の製造方法
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2108803C1 (ru) * 1997-04-08 1998-04-20 Новосибирский институт органической химии Сибирского отделения РАН Способ получения биологически активной суммы тритерпеновых кислот
RU2151139C1 (ru) * 1999-08-02 2000-06-20 Открытое акционерное общество "ЭЛХА" Способ получения биологически активной суммы тритерпеновых кислот
CN1521182A (zh) * 2003-01-28 2004-08-18 中国人民解放军第二军医大学 一种桉属植物提取物及其用途
US20060198910A1 (en) * 2003-06-06 2006-09-07 Roschin Viktor I Method for processing vegetable raw materials
EP2286678A1 (en) * 2008-06-17 2011-02-23 Lotte Co., Ltd. Process for preparing a eucalyptus extract

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOMINGUES R. M. A.; PATINHA D. J. S.; SOUSA G. D. A.; VILLAVERDE J. J.; SILVA C. M.; FREIRE C. S. R.; SILVESTRE A. J. D.; NETO C. P. Eucalyptus globulus biomass residues *
DOMINGUES R. M. A.; SOUSA G. D. A.; FREIRE C. S. R.; SILVESTRE A. J. D.; NETO C. P. Eucalyptus globulus biomass residues *
DOMINGUES R. M. A.; SOUSA G. D. A.; SILVA C. M.; FREIRE C. S. R.; SILVESTRE A. J. D.; NETO C. P. High value triterpenic compoundsDOMINGUES R. M. A.; SOUSA G. D. A.; SILVA C. M.; FREIRE C. S. R.; SILVESTRE A. J. D.; NETO C. P. High value triterpenic compounds *

Also Published As

Publication number Publication date
WO2013160881A1 (en) 2013-10-31
PT106278B (pt) 2018-01-03
ES2525953A2 (es) 2015-01-02
PT106278A (pt) 2013-10-28
ES2525953A9 (es) 2015-03-23
ES2525953B2 (es) 2017-06-14

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Effective date: 20160706