RU2017121910A - Биологически активная композиция из томатов, имеющая уменьшенное содержание ликопина - Google Patents
Биологически активная композиция из томатов, имеющая уменьшенное содержание ликопина Download PDFInfo
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- RU2017121910A RU2017121910A RU2017121910A RU2017121910A RU2017121910A RU 2017121910 A RU2017121910 A RU 2017121910A RU 2017121910 A RU2017121910 A RU 2017121910A RU 2017121910 A RU2017121910 A RU 2017121910A RU 2017121910 A RU2017121910 A RU 2017121910A
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- lycopene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Claims (19)
1. Композиция, содержащая ликопин, один или оба из фитоена и фитофлуена, и фитостеролы, при этом концентрация ликопина находится в диапазоне от 0,3% до 2% (вес./вес.), и при этом весовое соотношение ликопина и одного или обоих из фитоена и фитофлуена находится в диапазоне от 1:1 до 1:2,5.
2. Композиция по п.1, где концентрация фитостеролов составляет, по меньшей мере, 2% (вес./вес.).
3. Композиция по п.1, дополнительно содержащая витамин Е в концентрации, по меньшей мере, 2% (вес./вес.).
4. Композиция по п.1, дополнительно содержащая один или более дополнительных компонентов, выбранных из группы, состоящей из дополнительных каротиноидов, витамина Е, полифенолов и растворимых сухих веществ томатов.
5. Композиция по п.1, дополнительно содержащая бета-каротин.
6. Композиция по п.1, дополнительно содержащая карнозную кислоту.
7. Композиция по п.1, дополнительно содержащая растворимые сухие вещества томатов.
8. Композиция по п.1, где указанную композицию получают из томатов.
9. Способ получения композиции, содержащей ликопин, один или оба из фитоена и фитофлуена, и фитостеролы, по п.1, где указанный способ включает стадии:
a) предоставления томатного продукта, содержащего 5-20% (вес./вес.) ликопина;
b) экстрагирования обогащенного каротиноидами материала из указанного томатного продукта с использованием этанола, изопропанола, этилацетата или ацетона в соотношении более 1:1 (растворитель:томатный экстракт) в качестве экстракционного растворителя;
c) нагревания смеси растворитель/томатный экстракт при температуре около 25-60°C;
d) отделения кристаллического материала от растворителя посредством фильтрации или разделения центрифугированием; и
e) выпаривания супернатанта, полученного на стадии (d), тем самым получая указанную композицию из томатов.
10. Способ по п.9, где растворителем является этанол.
11. Способ по п.9, где томатный продукт представляет собой олеорезин.
12. Способ по п.9, где томатный продукт содержит кожуру томата.
13. Применение композиции по любому из пп.1-8 для получения лекарственного средства.
14. Применение композиции по любому из пп.1-8 для получения косметического или космецевтического средства.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462083909P | 2014-11-25 | 2014-11-25 | |
| US62/083,909 | 2014-11-25 | ||
| PCT/IL2015/051129 WO2016084068A1 (en) | 2014-11-25 | 2015-11-23 | Biologically-active tomato composition having reduced amount of lycopene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017121910A true RU2017121910A (ru) | 2018-12-26 |
| RU2017121910A3 RU2017121910A3 (ru) | 2019-04-17 |
| RU2748400C2 RU2748400C2 (ru) | 2021-05-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017121910A RU2748400C2 (ru) | 2014-11-25 | 2015-11-23 | Биологически активная композиция из томатов, имеющая уменьшенное содержание ликопина |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20170354704A1 (ru) |
| EP (1) | EP3220934B1 (ru) |
| JP (1) | JP6817951B2 (ru) |
| KR (1) | KR102602826B1 (ru) |
| CN (1) | CN107106625A (ru) |
| AU (1) | AU2015351930B2 (ru) |
| ES (1) | ES2742486T3 (ru) |
| RU (1) | RU2748400C2 (ru) |
| WO (1) | WO2016084068A1 (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3824899B1 (en) * | 2018-07-17 | 2024-06-12 | Saisei Pharma Co., Ltd. | Inflammatory cytokine production inhibitor |
| EP3826658A4 (en) * | 2018-07-23 | 2022-04-27 | Lycored Ltd. | LYCOPENE COMPOSITIONS AND METHODS FOR PROTECTING SKIN AGAINST ULTRAVIOLET RADIATION |
| CN110638902A (zh) * | 2019-09-30 | 2020-01-03 | 白冬平 | 番茄提取物在制备降血压药物中的应用及其降血压组合物 |
| CN111840112B (zh) * | 2020-07-23 | 2021-07-20 | 中南大学 | 鼠尾草酸或其衍生物在制备治疗糖尿病并发症药物中的应用 |
| WO2023275329A1 (en) * | 2021-07-01 | 2023-01-05 | Inaturals | Cosmetic use of a solanum lycopersicum fruit (tomato) skin extract |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3445237C1 (de) | 1984-12-12 | 1986-06-05 | R.P. Scherer GmbH, 6930 Eberbach | Weichgelatinekapseln und Verfahren zu ihrer Herstellung |
| US5837311A (en) * | 1993-12-13 | 1998-11-17 | Makhteshim Chemical Works Ltd. | Industrial processing of tomatoes and product thereof |
| IL107999A (en) * | 1993-12-13 | 1998-02-08 | Makhteshim Chem Works Ltd | Efficient process for the manufacture of tomato products |
| DE19603402A1 (de) | 1995-02-24 | 1996-08-29 | Basf Ag | Weichgelatinekapseln |
| WO1996041622A1 (en) | 1995-06-09 | 1996-12-27 | R.P. Scherer Corporation | Soft gelatin capsules containing particulate material |
| IL126076A (en) * | 1998-09-04 | 2005-05-17 | Ibr Ltd | Transparent composition comprising phytoene and phytofluene |
| US6258380B1 (en) | 1999-03-05 | 2001-07-10 | Banner Pharmacaps, Inc. | Chewable soft capsule |
| US6797303B2 (en) * | 2001-09-04 | 2004-09-28 | Lycored Natural Products Industries Ltd. | Carotenoid extraction process |
| RU2008119234A (ru) * | 2005-10-16 | 2009-11-27 | Ликорд Лтд. (Il) | Композиции для лечения глазных заболеваний |
| TW200738227A (en) * | 2006-04-03 | 2007-10-16 | Panatoz Corp | One kind of multi-carotenoids and its administration |
| CN101449801A (zh) * | 2007-11-30 | 2009-06-10 | 天津科技大学 | 从番茄皮渣中提取番茄红素的方法 |
| CN101704703A (zh) * | 2008-07-21 | 2010-05-12 | 聂希刚 | 利用植物产品生产高纯度番茄红素粉的方法 |
| EP2381935B1 (en) * | 2009-01-19 | 2016-06-01 | Lycored Ltd. | Synergistic combinations of carotenoids and polyphenols |
| CN102126911B (zh) * | 2010-12-22 | 2012-08-08 | 晨光生物科技集团股份有限公司 | 一种高效生产番茄红素晶体的工业化方法 |
| US8460718B2 (en) * | 2011-04-07 | 2013-06-11 | Lycored Ltd. | Synergistic compositions and methods |
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- 2015-11-23 WO PCT/IL2015/051129 patent/WO2016084068A1/en active Application Filing
- 2015-11-23 KR KR1020177017557A patent/KR102602826B1/ko active IP Right Grant
- 2015-11-23 CN CN201580073860.0A patent/CN107106625A/zh active Pending
- 2015-11-23 US US15/529,244 patent/US20170354704A1/en active Pending
- 2015-11-23 EP EP15820643.3A patent/EP3220934B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3220934B1 (en) | 2019-06-12 |
| KR20170093166A (ko) | 2017-08-14 |
| US20170354704A1 (en) | 2017-12-14 |
| AU2015351930B2 (en) | 2021-08-12 |
| WO2016084068A1 (en) | 2016-06-02 |
| CN107106625A (zh) | 2017-08-29 |
| AU2015351930A1 (en) | 2017-07-13 |
| RU2017121910A3 (ru) | 2019-04-17 |
| ES2742486T3 (es) | 2020-02-14 |
| JP6817951B2 (ja) | 2021-01-20 |
| KR102602826B1 (ko) | 2023-11-15 |
| JP2018501305A (ja) | 2018-01-18 |
| EP3220934A1 (en) | 2017-09-27 |
| RU2748400C2 (ru) | 2021-05-25 |
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