ES2521515T3 - Compuestos cíclicos peptidomiméticos con giro beta para tratar el ojo seco - Google Patents
Compuestos cíclicos peptidomiméticos con giro beta para tratar el ojo seco Download PDFInfo
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- ES2521515T3 ES2521515T3 ES09726969.0T ES09726969T ES2521515T3 ES 2521515 T3 ES2521515 T3 ES 2521515T3 ES 09726969 T ES09726969 T ES 09726969T ES 2521515 T3 ES2521515 T3 ES 2521515T3
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- dry eye
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- C—CHEMISTRY; METALLURGY
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Landscapes
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- Medicinal Chemistry (AREA)
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| US208873P | 2009-02-27 | ||
| PCT/US2009/002121 WO2009123761A1 (en) | 2008-04-04 | 2009-04-03 | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
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| US8293713B2 (en) | 2008-04-04 | 2012-10-23 | Mimetogen Pharmaceuticals, Inc. | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
| US9115179B2 (en) * | 2012-06-22 | 2015-08-25 | Mimetogen Pharmaceuticals Inc. | Synthesis of beta-turn peptidomimetic cyclic compounds |
| KR20150004652A (ko) | 2013-07-03 | 2015-01-13 | 삼성디스플레이 주식회사 | 표시 패널, 이를 포함하는 표시 장치 및 이를 이용하는 영상 표시 방법 |
| JP6267003B2 (ja) * | 2014-02-27 | 2018-01-24 | 参天製薬株式会社 | ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤 |
| WO2016115050A1 (en) | 2015-01-12 | 2016-07-21 | Lagunita Llc | Micro-droplet delivery device and methods |
| CN107530509A (zh) | 2015-04-10 | 2018-01-02 | 科达莱昂治疗公司 | 具有可替换安瓿的压电分配器 |
| JP6801835B2 (ja) | 2015-07-09 | 2020-12-16 | ミメトゲン ファーマシュウティカルズ インコーポレイテッドＭｉｍｅｔｏｇｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | β−ターンペプチド模倣環状塩の液相合成及び結晶化 |
| KR101718733B1 (ko) | 2015-08-21 | 2017-03-22 | 국제약품 주식회사 | 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제 |
| JP2019507193A (ja) | 2016-03-04 | 2019-03-14 | ジェームズ・エム・ライナーソン | 細菌のバイオフィルム形成を阻止又は妨害することによって眼障害を治療する方法 |
| KR102866401B1 (ko) | 2017-01-20 | 2025-10-01 | 보슈 롬 아일랜드 리미티드 | 압전 유체 분배기 |
| CA3083219A1 (en) | 2017-12-08 | 2019-06-13 | Reynaldo Quintana | Fluid delivery alignment system |
| CN110092799B (zh) * | 2018-01-29 | 2021-11-12 | 广州丹康医药生物有限公司 | 一种环状化合物、其制备方法和应用 |
| US20190314196A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| AU2019297326B2 (en) | 2018-07-03 | 2025-01-09 | Bausch + Lomb Ireland Limited | Topical ocular delivery devices and methods for using the same |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US12090087B2 (en) | 2020-04-17 | 2024-09-17 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| IL297215A (en) | 2020-04-17 | 2022-12-01 | Kedallon Therapeutics Inc | A hydrodynamically activated preservative free distribution system |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| IL308909A (en) * | 2021-06-02 | 2024-01-01 | The Texas A& M Univ System | Selective small molecule agonists and partial agonists of TRK receptors |
| WO2023069255A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
| CA3234071A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
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| GB8917217D0 (en) * | 1989-07-27 | 1989-09-13 | Smith & Nephew | Ophthalmic compositions |
| US5545617A (en) | 1993-11-12 | 1996-08-13 | The Schepens Eye Research Institute, Inc. | Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion |
| CA2316015A1 (en) * | 1997-12-22 | 1999-07-01 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
| JP2001064198A (ja) | 1999-08-24 | 2001-03-13 | Teika Seiyaku Kk | 角膜疾患治療剤 |
| EP1265605B1 (en) | 2000-01-18 | 2006-09-27 | McGILL UNIVERSITY | Pharmaceutical compositions comprising beta-turn peptidomimetic cyclic compounds |
| ATE423135T1 (de) | 2005-06-13 | 2009-03-15 | Primm Srl | Heterodimere peptide mit ngf aktivität und deren verwendung zur behandlung von neurodegenerativen krankheiten |
| EP1921087A1 (en) | 2006-11-10 | 2008-05-14 | Primm S.R.L. | Process for the preparation of cyclic peptides |
| CA2671613C (en) * | 2006-12-05 | 2018-07-03 | The Royal Institution For The Advancement Of Learning/Mcgill University | Methods of use of trk receptor modulators |
| US8293713B2 (en) | 2008-04-04 | 2012-10-23 | Mimetogen Pharmaceuticals, Inc. | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
| ES2512717T3 (es) * | 2009-02-27 | 2014-10-24 | Mimetogen Pharmaceuticals Inc. | Compuestos cíclicos peptidomiméticos para el tratamiento de la retinitis pigmentosa |
| US9115179B2 (en) * | 2012-06-22 | 2015-08-25 | Mimetogen Pharmaceuticals Inc. | Synthesis of beta-turn peptidomimetic cyclic compounds |
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Also Published As
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| KR101565185B1 (ko) | 2015-11-02 |
| JP2011516477A (ja) | 2011-05-26 |
| US20160082072A1 (en) | 2016-03-24 |
| JP2014080447A (ja) | 2014-05-08 |
| KR20110010712A (ko) | 2011-02-07 |
| US20140274910A1 (en) | 2014-09-18 |
| US9707267B2 (en) | 2017-07-18 |
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| US8748391B2 (en) | 2014-06-10 |
| CN102046166A (zh) | 2011-05-04 |
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| JP5480242B2 (ja) | 2014-04-23 |
| US8293713B2 (en) | 2012-10-23 |
| US9156882B2 (en) | 2015-10-13 |
| HK1152898A1 (en) | 2012-03-16 |
| CA2720141A1 (en) | 2009-10-08 |
| EP2271337A1 (en) | 2011-01-12 |
| CN102046166B (zh) | 2012-10-17 |
| US20120322747A1 (en) | 2012-12-20 |
| CA2720141C (en) | 2014-01-28 |
| JP5870348B2 (ja) | 2016-02-24 |
| EP2271337B1 (en) | 2014-09-03 |
| AU2009232352B2 (en) | 2013-09-05 |
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