ES2521515T3 - Compuestos cíclicos peptidomiméticos con giro beta para tratar el ojo seco - Google Patents
Compuestos cíclicos peptidomiméticos con giro beta para tratar el ojo seco Download PDFInfo
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- ES2521515T3 ES2521515T3 ES09726969.0T ES09726969T ES2521515T3 ES 2521515 T3 ES2521515 T3 ES 2521515T3 ES 09726969 T ES09726969 T ES 09726969T ES 2521515 T3 ES2521515 T3 ES 2521515T3
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- dry eye
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- C—CHEMISTRY; METALLURGY
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Landscapes
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- Medicinal Chemistry (AREA)
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| US208873P | 2009-02-27 | ||
| PCT/US2009/002121 WO2009123761A1 (en) | 2008-04-04 | 2009-04-03 | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
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| AU2009232352B2 (en) * | 2008-04-04 | 2013-09-05 | Mimetogen Pharmaceuticals Inc. | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
| JP6248103B2 (ja) * | 2012-06-22 | 2017-12-13 | ミメトゲン ファーマシュウティカルズ インコーポレイテッドＭｉｍｅｔｏｇｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | β−ターン環式ペプチド模倣化合物の合成 |
| KR20150004652A (ko) | 2013-07-03 | 2015-01-13 | 삼성디스플레이 주식회사 | 표시 패널, 이를 포함하는 표시 장치 및 이를 이용하는 영상 표시 방법 |
| JP6267003B2 (ja) * | 2014-02-27 | 2018-01-24 | 参天製薬株式会社 | ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤 |
| KR101984116B1 (ko) | 2015-01-12 | 2019-05-31 | 켄달리온 테라퓨틱스 인코포레이티드 | 마이크로-액적 전달 장치 및 방법 |
| WO2016164830A1 (en) | 2015-04-10 | 2016-10-13 | Lagunita Llc | Piezoelectric dispenser with replaceable ampoule |
| CN114874288A (zh) | 2015-07-09 | 2022-08-09 | 米梅奥亨制药公司 | β-转角环状模拟肽盐的溶液相合成和结晶 |
| KR101718733B1 (ko) | 2015-08-21 | 2017-03-22 | 국제약품 주식회사 | 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제 |
| JP2019507193A (ja) | 2016-03-04 | 2019-03-14 | ジェームズ・エム・ライナーソン | 細菌のバイオフィルム形成を阻止又は妨害することによって眼障害を治療する方法 |
| CA3039106A1 (en) | 2017-01-20 | 2018-07-26 | Kedalion Therapeutics, Inc. | Piezoelectric fluid dispenser |
| JP7436363B2 (ja) | 2017-12-08 | 2024-02-21 | ノバルティス アーゲー | 流体送達アライメントシステム |
| CN110092799B (zh) * | 2018-01-29 | 2021-11-12 | 广州丹康医药生物有限公司 | 一种环状化合物、其制备方法和应用 |
| US20190314197A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| CA3102410A1 (en) | 2018-07-03 | 2020-01-09 | Kedalion Therapeutics, Inc. | Topical ocular delivery devices and methods for using the same |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| US12496218B1 (en) | 2019-11-12 | 2025-12-16 | Bausch + Lomb Ireland Limited | Fractionated topical ocular drug delivery methods and devices for use in the same |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| WO2021212038A1 (en) | 2020-04-17 | 2021-10-21 | Kedalion Therapeutics, Inc. | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| JP7711090B2 (ja) | 2020-04-17 | 2025-07-22 | ボシュ ＋ ロム アイルランド リミテッド | 流体力学的に起動される防腐剤無添加分注システム |
| IL308909A (en) * | 2021-06-02 | 2024-01-01 | The Texas A& M Univ System | Selective small molecule agonists and partial agonists of TRK receptors |
| WO2023069255A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
| EP4419123A1 (en) * | 2021-10-20 | 2024-08-28 | Stealth BioTherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
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| GB8917217D0 (en) * | 1989-07-27 | 1989-09-13 | Smith & Nephew | Ophthalmic compositions |
| US5545617A (en) * | 1993-11-12 | 1996-08-13 | The Schepens Eye Research Institute, Inc. | Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion |
| KR20010033484A (ko) * | 1997-12-22 | 2001-04-25 | 휴먼 게놈 사이언시즈, 인크. | 각질세포 성장 인자-2 제제 |
| JP2001064198A (ja) | 1999-08-24 | 2001-03-13 | Teika Seiyaku Kk | 角膜疾患治療剤 |
| WO2001052843A1 (en) * | 2000-01-18 | 2001-07-26 | Mcgill University | β-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS |
| EP1734052B1 (en) * | 2005-06-13 | 2009-02-18 | Primm S.R.L. | Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders |
| EP1921087A1 (en) | 2006-11-10 | 2008-05-14 | Primm S.R.L. | Process for the preparation of cyclic peptides |
| AU2007327990A1 (en) | 2006-12-05 | 2008-06-12 | The Royal Institution For The Advancement Of Learning/ Mcgill University | Methods of use of TRK receptor modulators |
| AU2009232352B2 (en) * | 2008-04-04 | 2013-09-05 | Mimetogen Pharmaceuticals Inc. | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
| WO2010099436A1 (en) * | 2009-02-27 | 2010-09-02 | Mimetogen Pharmaceuticals, Inc. | Methods of treating retinitis pigmentosa |
| JP6248103B2 (ja) * | 2012-06-22 | 2017-12-13 | ミメトゲン ファーマシュウティカルズ インコーポレイテッドＭｉｍｅｔｏｇｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | β−ターン環式ペプチド模倣化合物の合成 |
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- 2009-04-03 JP JP2011502992A patent/JP5480242B2/ja active Active
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| KR101565185B1 (ko) | 2015-11-02 |
| US20110105410A1 (en) | 2011-05-05 |
| JP5480242B2 (ja) | 2014-04-23 |
| EP2271337A1 (en) | 2011-01-12 |
| US20160082072A1 (en) | 2016-03-24 |
| US20120322747A1 (en) | 2012-12-20 |
| KR20110010712A (ko) | 2011-02-07 |
| US9707267B2 (en) | 2017-07-18 |
| AU2009232352B2 (en) | 2013-09-05 |
| JP5870348B2 (ja) | 2016-02-24 |
| CA2720141A1 (en) | 2009-10-08 |
| CA2720141C (en) | 2014-01-28 |
| US8748391B2 (en) | 2014-06-10 |
| AU2009232352A1 (en) | 2009-10-08 |
| HK1152898A1 (en) | 2012-03-16 |
| EP2271337B1 (en) | 2014-09-03 |
| WO2009123761A1 (en) | 2009-10-08 |
| US20140274910A1 (en) | 2014-09-18 |
| JP2014080447A (ja) | 2014-05-08 |
| CN102046166B (zh) | 2012-10-17 |
| CN102046166A (zh) | 2011-05-04 |
| US9156882B2 (en) | 2015-10-13 |
| US8293713B2 (en) | 2012-10-23 |
| JP2011516477A (ja) | 2011-05-26 |
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