CA2720141C - Beta-turn peptidomimetic cyclic compounds for treating dry eye - Google Patents
Beta-turn peptidomimetic cyclic compounds for treating dry eye Download PDFInfo
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- CA2720141C CA2720141C CA2720141A CA2720141A CA2720141C CA 2720141 C CA2720141 C CA 2720141C CA 2720141 A CA2720141 A CA 2720141A CA 2720141 A CA2720141 A CA 2720141A CA 2720141 C CA2720141 C CA 2720141C
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- scopolamine
- dry eye
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C07K5/123—Tripeptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12303608P | 2008-04-04 | 2008-04-04 | |
| US61/123,036 | 2008-04-04 | ||
| US20887309P | 2009-02-27 | 2009-02-27 | |
| US61/208,873 | 2009-02-27 | ||
| PCT/US2009/002121 WO2009123761A1 (en) | 2008-04-04 | 2009-04-03 | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2720141A1 CA2720141A1 (en) | 2009-10-08 |
| CA2720141C true CA2720141C (en) | 2014-01-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2720141A Active CA2720141C (en) | 2008-04-04 | 2009-04-03 | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8293713B2 (enExample) |
| EP (1) | EP2271337B1 (enExample) |
| JP (2) | JP5480242B2 (enExample) |
| KR (1) | KR101565185B1 (enExample) |
| CN (1) | CN102046166B (enExample) |
| AU (1) | AU2009232352B2 (enExample) |
| CA (1) | CA2720141C (enExample) |
| ES (1) | ES2521515T3 (enExample) |
| WO (1) | WO2009123761A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8293713B2 (en) | 2008-04-04 | 2012-10-23 | Mimetogen Pharmaceuticals, Inc. | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
| US9115179B2 (en) * | 2012-06-22 | 2015-08-25 | Mimetogen Pharmaceuticals Inc. | Synthesis of beta-turn peptidomimetic cyclic compounds |
| KR20150004652A (ko) | 2013-07-03 | 2015-01-13 | 삼성디스플레이 주식회사 | 표시 패널, 이를 포함하는 표시 장치 및 이를 이용하는 영상 표시 방법 |
| JP6267003B2 (ja) * | 2014-02-27 | 2018-01-24 | 参天製薬株式会社 | ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤 |
| WO2016115050A1 (en) | 2015-01-12 | 2016-07-21 | Lagunita Llc | Micro-droplet delivery device and methods |
| CN107530509A (zh) | 2015-04-10 | 2018-01-02 | 科达莱昂治疗公司 | 具有可替换安瓿的压电分配器 |
| JP6801835B2 (ja) | 2015-07-09 | 2020-12-16 | ミメトゲン ファーマシュウティカルズ インコーポレイテッドＭｉｍｅｔｏｇｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | β−ターンペプチド模倣環状塩の液相合成及び結晶化 |
| KR101718733B1 (ko) | 2015-08-21 | 2017-03-22 | 국제약품 주식회사 | 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제 |
| JP2019507193A (ja) | 2016-03-04 | 2019-03-14 | ジェームズ・エム・ライナーソン | 細菌のバイオフィルム形成を阻止又は妨害することによって眼障害を治療する方法 |
| KR102866401B1 (ko) | 2017-01-20 | 2025-10-01 | 보슈 롬 아일랜드 리미티드 | 압전 유체 분배기 |
| CA3083219A1 (en) | 2017-12-08 | 2019-06-13 | Reynaldo Quintana | Fluid delivery alignment system |
| CN110092799B (zh) * | 2018-01-29 | 2021-11-12 | 广州丹康医药生物有限公司 | 一种环状化合物、其制备方法和应用 |
| US20190314196A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| AU2019297326B2 (en) | 2018-07-03 | 2025-01-09 | Bausch + Lomb Ireland Limited | Topical ocular delivery devices and methods for using the same |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US12090087B2 (en) | 2020-04-17 | 2024-09-17 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| IL297215A (en) | 2020-04-17 | 2022-12-01 | Kedallon Therapeutics Inc | A hydrodynamically activated preservative free distribution system |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| IL308909A (en) * | 2021-06-02 | 2024-01-01 | The Texas A& M Univ System | Selective small molecule agonists and partial agonists of TRK receptors |
| WO2023069255A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
| CA3234071A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
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| GB8917217D0 (en) * | 1989-07-27 | 1989-09-13 | Smith & Nephew | Ophthalmic compositions |
| US5545617A (en) | 1993-11-12 | 1996-08-13 | The Schepens Eye Research Institute, Inc. | Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion |
| CA2316015A1 (en) * | 1997-12-22 | 1999-07-01 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
| JP2001064198A (ja) | 1999-08-24 | 2001-03-13 | Teika Seiyaku Kk | 角膜疾患治療剤 |
| EP1265605B1 (en) | 2000-01-18 | 2006-09-27 | McGILL UNIVERSITY | Pharmaceutical compositions comprising beta-turn peptidomimetic cyclic compounds |
| ATE423135T1 (de) | 2005-06-13 | 2009-03-15 | Primm Srl | Heterodimere peptide mit ngf aktivität und deren verwendung zur behandlung von neurodegenerativen krankheiten |
| EP1921087A1 (en) | 2006-11-10 | 2008-05-14 | Primm S.R.L. | Process for the preparation of cyclic peptides |
| CA2671613C (en) * | 2006-12-05 | 2018-07-03 | The Royal Institution For The Advancement Of Learning/Mcgill University | Methods of use of trk receptor modulators |
| US8293713B2 (en) | 2008-04-04 | 2012-10-23 | Mimetogen Pharmaceuticals, Inc. | Beta-turn peptidomimetic cyclic compounds for treating dry eye |
| ES2512717T3 (es) * | 2009-02-27 | 2014-10-24 | Mimetogen Pharmaceuticals Inc. | Compuestos cíclicos peptidomiméticos para el tratamiento de la retinitis pigmentosa |
| US9115179B2 (en) * | 2012-06-22 | 2015-08-25 | Mimetogen Pharmaceuticals Inc. | Synthesis of beta-turn peptidomimetic cyclic compounds |
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| KR101565185B1 (ko) | 2015-11-02 |
| JP2011516477A (ja) | 2011-05-26 |
| US20160082072A1 (en) | 2016-03-24 |
| JP2014080447A (ja) | 2014-05-08 |
| KR20110010712A (ko) | 2011-02-07 |
| US20140274910A1 (en) | 2014-09-18 |
| US9707267B2 (en) | 2017-07-18 |
| ES2521515T3 (es) | 2014-11-12 |
| AU2009232352A1 (en) | 2009-10-08 |
| WO2009123761A1 (en) | 2009-10-08 |
| US8748391B2 (en) | 2014-06-10 |
| CN102046166A (zh) | 2011-05-04 |
| US20110105410A1 (en) | 2011-05-05 |
| JP5480242B2 (ja) | 2014-04-23 |
| US8293713B2 (en) | 2012-10-23 |
| US9156882B2 (en) | 2015-10-13 |
| HK1152898A1 (en) | 2012-03-16 |
| CA2720141A1 (en) | 2009-10-08 |
| EP2271337A1 (en) | 2011-01-12 |
| CN102046166B (zh) | 2012-10-17 |
| US20120322747A1 (en) | 2012-12-20 |
| JP5870348B2 (ja) | 2016-02-24 |
| EP2271337B1 (en) | 2014-09-03 |
| AU2009232352B2 (en) | 2013-09-05 |
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