ES2501646T3 - Elemento de sellado para anastomosis - Google Patents
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- ES2501646T3 ES2501646T3 ES11165760.7T ES11165760T ES2501646T3 ES 2501646 T3 ES2501646 T3 ES 2501646T3 ES 11165760 T ES11165760 T ES 11165760T ES 2501646 T3 ES2501646 T3 ES 2501646T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/115—Staplers for performing anastomosis in a single operation
- A61B17/1152—Staplers for performing anastomosis in a single operation applying the staples on the outside of the lumen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07292—Reinforcements for staple line, e.g. pledgets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/115—Staplers for performing anastomosis in a single operation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/115—Staplers for performing anastomosis in a single operation
- A61B17/1155—Circular staplers comprising a plurality of staples
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B2017/07214—Stapler heads
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Abstract
Elemento de sellado (10) para colocación entre secciones tubulares de tejido que han de unirse, comprendiendo el elemento de sellado (10): un primer material (12) que promueve el crecimiento interior del tejido; y un segundo material (14) que comprende un sellante que rodea al menos parcialmente el primer material, en el que el segundo material (14) es compresible hasta el punto en que cuando se comprime entre el tejido tubular conectado sirve como una junta de sellado para impedir el escape de fluido, caracterizado porque el primer material (12) es relativamente delgado comparado con el segundo material y porque el segundo material se sobremoldea sobre el primer material.
Description
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DESCRIPCIÓN
Elemento de sellado para anastomosis.
Referencia cruzada a solicitud relacionada
La presente solicitud reivindica el beneficio y la prioridad respecto a la solicitud provisional de EE.UU. Nº 60/619.238, presentada el 15 de octubre de 2004.
Antecedentes
Campo técnico
La presente descripción se refiere a dispositivos para sujetar dos tejidos tubulares. Más particularmente, se describen juntas de sellado para su uso en relación con procedimientos de anastomosis. Antecedentes de la técnica relacionada.
Un método para realizar una anastomosis gastrointestinal implica el uso de un aparato grapador circular. Por ejemplo, un aparato conocido como el CEEA® (marca de United States Surgical, una división de Tyco Hëalthcare Group LP) se utiliza después de la resección de una porción de intestino enferma. La grapadora de anastomosis circular se utiliza para aproximar las porciones de intestino restantes, graparlas entre sí y cortar el exceso de tejido en la junta anastomótica.
Se describen dispositivos de grapado circulares ilustrativos en ciertas realizaciones del documento DE19924311 y las solicitudes de patente de EE.UU. Nos 4.354.628; 5.014.899; 5.040.715; y 5.392.979. Otros métodos de realización de anastomosis, utilizando técnicas de unión distintas del grapado que se han contemplado incluyen, por ejemplo, el uso de aplicadores de pinzas, disectores y tijeras, y adhesivos.
El documento DE19924311 desvela las características del preámbulo de la reivindicación 1 y describe una grapadora quirúrgica que incluye un material de apoyo que ha de sujetarse al tejido en cualquier lado de la unión de tejido.
El documento EP1256317 desvela un dispositivo para sujeción de un material de apoyo a un dispositivo de sujeción quirúrgica. El material de apoyo se conecta al lado marchito del tejido de la unión de tejido.
El documento WO031105698 desvela estructuras de soporte anulares. Un anillo de refuerzo está diseñado para mantener el tamaño del lumen en el sitio de anastomosis y se coloca en un lado de la unión entre las secciones tubulares de tejido. El anillo de refuerzo comprende un anillo exterior rígido.
Aunque los dispositivos y procedimientos de anastomosis actuales responden satisfactoriamente, sería ventajoso promover el crecimiento tisular y un buen sellado en un sitio de anastomosis.
Sumario
En esta solicitud se describe un elemento de sellado de material compuesto para uso en anastomosis. El elemento de sellado puede disponerse entre dos porciones de tejido tubular que han de unirse para promover el crecimiento tisular y reducir la aparición de fugas. En las anastomosis grapadas, el elemento de sellado se dispone entre los extremos proximal y distal de una anastomosis antes de que se aproxime el tejido y se disparen las grapas. El elemento de sellado permanece en su sitio durante el proceso de cicatrización y después, en ciertas realizaciones, es absorbido por el cuerpo. En las reivindicaciones adjuntas se define un elemento de sellado según la invención.
Un aspecto de la presente descripción es la reivindicación 1. El primer material comprende un material poroso para permitir el crecimiento interior del tejido. El segundo material comprende un sellante.
El segundo material comprende un material compresible que, cuando se comprime entre un primer lumen de tejido y un segundo lumen de tejido, actúa como una junta de sellado para impedir el escape del contenido de los lúmenes de tejido. Con preferencia, el primer material, y el segundo material son materiales biodegradables, bioabsorbibles, o biorreabsorbibles.
En ciertas realizaciones, el elemento de sellado comprende un elemento anular y el segundo material se dispone hacia fuera del primer material. El primer y el segundo materiales pueden adherirse uno a otro, con un adhesivo biocompatible, y se unen utilizando un proceso de sobremoldeo.
Otro aspecto de la presente descripción es la reivindicación 14.
El segundo material comprende un material compresible que, cuando se comprime entre un primer lumen de tejido y
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un segundo lumen de tejido, actúa como una junta de sellado para impedir el escape del contenido de los lúmenes de tejido. Con preferencia, el primer material y el segundo material son materiales biodegradables, bioabsorbibles o biorreabsorbibles.
El elemento de sellado tiene deseablemente una abertura situada generalmente en el centro para disponerse en uno del primer vástago y el segundo vástago del dispositivo de grapado quirúrgico circular.
Breve descripción de los dibujos.
Los dibujos adjuntos, que se incorporan a esta memoria descriptiva y constituyen una parte de la misma, ilustran realizaciones de la descripción y, junto con una descripción general de la descripción ofrecida anteriormente y la descripción detallada de las realizaciones ofrecidas a continuación, sirven para explicar los principios de la descripción, en los que:
la figura 1 es una vista en perspectiva de un elemento de sellado de acuerdo con una realización de la presente descripción, mostrado en una condición no desplegada;
la figura 2 es una vista en perspectiva de un dispositivo de grapado quirúrgico anular ejemplar;
la figura 3 es una vista longitudinal, parcialmente en sección transversal, que ilustra la varilla de yunque montada en el dispositivo de grapado anular dentro de un sitio quirúrgico y el elemento de sellado de la figura 1 en una condición no desplegada, dispuesto entre las superficies yuxtapuestas del tejido; y
la figura 4 es una vista en perspectiva, en sección transversal del elemento de sellado de la figura 1 mostrado en una condición desplegada.
Descripción detallada de las realizaciones preferidas
Como se muestra en la figura 1, un elemento de sellado 10 de acuerdo con la presente descripción puede ser un material compuesto de un primer material 12 y un segundo material 14, e incluye una abertura central 15.
El primer material 12 es relativamente delgado (comparado con el segundo material) promueve el crecimiento interior del tejido y, opcionalmente, es un material bioabsorbible. En ciertas realizaciones preferidas, el primer material 12 puede ser de aproximadamente 0,000254 m (0,010 pulgadas) a aproximadamente 0,000508 m (0,020 pulgadas) de grosor, aunque pueden usarse otros espesores. Como apreciarán los expertos en la materia, el crecimiento interior del tejido es promovido más fácilmente por materiales que tienen poros formados en ellos. Así, por ejemplo, el primer material 12 puede ser cualquier material poroso biocompatible, opcionalmente bioabsorbible, tal como, por ejemplo, una espuma, una malla, una estructura no tejida o una lámina perforada. En ciertas realizaciones preferidas, el primer material 12 tiene poros comprendidos entre aproximadamente 50 µm y aproximadamente 200 µm. Los ejemplos ilustrativos de materiales porosos bioabsorbibles adecuados incluyen una malla de hernia absorbible tal como Dexon, un fieltro absorbible tal como Polysorb, o una espuma porosa de celdas abiertas tal como poliuretano, homopolímeros adecuados, glicolida, lactida, caprolactona, carbonato de trimetileno, dioxanona, óxidos de polialquileno, etc. Otros materiales adecuados se desvelan en ciertas realizaciones de las patentes de EE.UU. Nos 4.655.221; 4.788.979; 5.543.218; 5.716.376; 5.423.859; y 5.124.103. Sin limitarse a una teoría de funcionamiento particular, hay una cantidad considerable de cicatrización que tiene lugar en esta zona. Por lo tanto, este material es deseablemente lo suficientemente poroso como para permitir que el tejido crezca a través del mismo.
El segundo material 14 forma una junta de sellado. Así, el segundo material 14 puede ser, por ejemplo, un material comprensible o expandible opcionalmente bioabsorbible. En uso, los segundos materiales compresibles 14, cuando se comprimen, actúan como una junta de sellado para impedir el escape de fluido del tejido tubular conectado. En algunas realizaciones, el segundo material 14 es un material blando y dúctil que se comprime entre los extremos proximal 16 y distal 18 de la anastomosis y es capturado por las grapas 33, 35. Véase, por ejemplo, la figura 4. La compresión de este material puede servir, por ejemplo, como empaquetadura para impedir que el contenido del intestino se salga al interior del peritoneo. Los ejemplos ilustrativos de materiales compresibles incluyen, pero no están limitados a, espuma de poliuretano, carboximetilcelulosa (“CMC”) e hidrogeles.
Para los segundos materiales expandibles 14, el material puede expandirse en respuesta al contacto con fluidos, tales como los fluidos naturalmente presentes en el cuerpo. En algunas formas de realización, el segundo material 14 puede ser un material deshidratado que se hincha tras el contacto con la humedad. Por ejemplo, el segundo material 14 puede ser un biomaterial hidrófilo. Ejemplos ilustrativos de biomateriales hidrófilos adecuados incluyen, pero no están limitados a polímeros formados a partir de uno o más de los siguientes monómeros: ácido metacrílico, ácido acrílico, n-vinilpirrolidona, sulfopropilacrilato de potasio, sulfopropilmetacrilato de potasio, acrilamida, dimetilacrilamida, 2-metacriloiloxietilfosforilcolina, 2-hidroxietilmetacrilato o monómeros de vinilo solubles en agua biocompatibles similares. En una realización particularmente útil, el segundo material 14 está formado de poli(2hidroxietilmetacrilato). Cuando el elemento de sellado 10 incluye un biomaterial hidrófilo como segundo material 14,
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el elemento de sellado 10 se puede preparar usando técnicas dentro del ámbito de los expertos en la materia. Por ejemplo, el elemento de sellado se puede formar llenando un molde con una composición que contiene el (los) monómero(s) y, si se desea o es necesario, el iniciador, el reticulador, el plastificante y/o el agente biológico, y polimerizando la composición dentro del molde. La elección de iniciadores, reticuladores, etc. particulares estará
5 determinada por la elección específica de monómero(s) y puede determinarse por los expertos en la materia. Un biomaterial hidrófilo particularmente útil es el poli(2hidroxietilmetacrilato) (“PHEMA”). El contenido de agua en equilibrio (EWC), el hinchamiento y las propiedades mecánicas de la parte de PHEMA del elemento de sellado 10 pueden controlarse por la densidad de reticulación (por ejemplo, la densidad de reticulación puede controlarse por las condiciones de radiación o por el agente reticulante, tal como la concentración de dimetacrilato de di(etilenglicol) (DEGDMA). El espesor del elemento de sellado 10 se controla por el volumen de la composición de monómero polimerizada en el molde. La parte de PHEMA del elemento de sellado 10 también puede modificarse en su superficie después de la formación. Por ejemplo, la parte de PHEMA del elemento de sellado 10 puede modificarse en su superficie con fosfolípidos poliméricos para una hemocompatibilidad y una interacción tisular mejoradas usando injerto por radiación gamma.
15 En las realizaciones, la superficie de la parte del elemento de sellado realizada del segundo material 14 se puede modelar o aplantillar a nano-meso-microescala para acomodar la interacción tisular preferencial en la superficie de contacto del tejido con la junta de sellado. Tales arquitecturas o patrones pueden impedir o minimizar las adhesiones de tejido y la deposición de colágeno superflua postoperatorias, pero ofrecen soporte mecánico y biofísico deseado para la cicatrización de la herida.
O bien cualquiera o bien ambos del primer material 12 y el segundo material 14 de los que está hecho el elemento de sellado 10 pueden contener también una o más sustancias médica y/o quirúrgicamente útiles tales como fármacos, enzimas, factores de crecimiento, péptidos, proteínas, tintes, agentes de diagnóstico o agentes de 25 hemostasia o cualquier otro producto farmacéutico usado en la prevención de estenosis. Ejemplos no limitativos de sustancias médica y/o quirúrgicamente útiles incluyen: antimicrobianos, antibióticos, antifúngicos, antivirales, anticuerpos monoclonales, anticuerpos policlonales, proteínas/péptidos antimicrobianos (enteros y fragmentos), enzimas, terapia genética, partículas virales, quimioterapéuticos, antiinflamatorios, NSAIDS, esteroides, inhibidores de telomerasa, factores de crecimiento (familia TGF, superfamilia de interleucina, GF derivados de fibroblastos, GF derivados de macrófagos, etc.), moléculas de matriz extracelular (laminina, trombospondina, colágeno, fibronectina, ECM sintético, etc.), moléculas de adhesión celular, polisacáridos (ácido hialurónico, carboximetilcelulosa, alginato, dextrano sulfonado, sulfato de heparina, quitosano, etc.) y otros. Estos agentes pueden incorporarse in situ ya sea en uno o tanto en el primer material 12 como en el segundo material 14 de los que está hecho el elemento de sellado 10, o se pueden cargar posteriormente sobre el elemento de sellado 10 usando técnicas dentro del ámbito
35 de los expertos en la materia. Por ejemplo, las sustancias médica y/o quirúrgicamente útiles se pueden mezclar o cargar libremente, ligar electrónica o iónicamente, inmovilizar de manera covalente, quelar o encapsular en partículas, micelas, agregados o cualquier nano-meso-microsólido de variada dimensión, morfología de forma y capacidad de dispersión/suspensión.
El segundo material 14 se sujeta al primer material 12 mediante un proceso de sobremoldeo.
El elemento de sellado 10 tiene deseablemente una abertura situada generalmente en el centro 15 para disponerse en uno del primer vástago y el segundo vástago de un dispositivo de grapado quirúrgico circular. El elemento de sellado es capturado entre los extremos proximal y distal de una anastomosis circular grapada para reducir fugas en
45 el sitio de anastomosis.
Las dimensiones del elemento de sellado 10 pueden variar, según la aplicación particular. En ciertas realizaciones, el diámetro exterior es ligeramente mayor que el diámetro de la fila exterior de grapas del aparato de grapado circular. El diámetro interior será ligeramente mayor que el diámetro del bisturí del aparato de grapado circular. Con preferencia, el diámetro interior puede ser de aproximadamente el tamaño del vástago 38 del conjunto de yunque 40 con el fin de centrar el elemento de sellado 10 sobre el conjunto de yunque 40.
Haciendo referencia ahora a la figura 2, un dispositivo de grapado quirúrgico anular para su uso con las estructuras anulares desveladas en esta solicitud está designado en general como 20. El dispositivo de grapado quirúrgico
55 incluye un conjunto de mango 22 que tiene al menos un elemento de mango de accionamiento pivotante 24 y un elemento de avance 26. Extendiéndose desde el elemento de mango 22, está provista una parte de cuerpo tubular 30 que puede estar construida para que tenga una forma curvada a lo largo de su longitud. La parte de cuerpo 30 termina en un conjunto de cartucho 32 de grapas que incluye un par de agrupaciones anulares de ranuras 46 de recepción de grapas que tienen una grapa (no mostrada) dispuesta en cada una de las ranuras 46 de recepción de grapas. Colocado distalmente del conjunto de cartucho 32 de grapas está provisto un conjunto de yunque 40 que incluye un elemento de yunque 36 y un vástago 38 asociado operativamente con el mismo para conectar de manera desmontable el conjunto de yunque 40 a una parte de extremo distal del dispositivo de grapado.
El conjunto de cartucho 32 de grapas se puede conectar fijamente al extremo distal de la parte de cuerpo tubular 30
65 o se puede configurar para encajar concéntricamente dentro del extremo distal de la parte de cuerpo tubular 30. Típicamente, el conjunto de cartucho 32 de grapas incluye un empujador de grapas (no mostrado) que incluye una
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parte proximal que tiene una forma generalmente troncocónica y una parte distal que define dos anillos concéntricos de dedos separados periféricamente (no mostrados), cada uno de los cuales es recibido dentro de una ranura 46 de recepción de grapas respectiva.
5 Típicamente, un bisturí (no mostrado), sustancialmente en forma de una copa abierta con el reborde de la misma definiendo un borde del bisturí, está dispuesto dentro del conjunto de cartucho 32 de grapas y montado en una superficie distal del empujador de grapas (no mostrado). El borde del bisturí está dispuesto radialmente hacia el interior del par de agrupaciones anulares de grapas. Por consiguiente, en uso, a medida que se hace avanzar el empujador de grapas, el bisturí también se hace avanzar axialmente hacia fuera.
10 Puede hacerse referencia a la patente de EE.UU. Nº 5.915.616 de Viola y col. para una exposición detallada de un dispositivo de grapado anular adecuado. Aunque el dispositivo de grapado mostrado en las figuras. 2-3 es un dispositivo de grapado circular, el elemento de sellado desvelado en esta solicitud puede usarse con grapadoras de otras formas o configuraciones, tales como, por ejemplo, grapadoras lineales o grapadoras anulares que no sean
15 circulares. Además, el elemento de sellado se puede colocar usando suturas, adhesivos, etc.
Volviendo ahora a la figura 3, se ilustra el uso del dispositivo de grapado quirúrgico 20 y el conjunto de yunque 40 separable en un procedimiento de anastomosis para efectuar la unión de secciones intestinales 66 y 68. En el punto del procedimiento mostrado en la figura 3, una sección intestinal enferma ha sido extirpada previamente, el conjunto 20 de yunque 40 ha sido aplicado al sitio operatorio a través de una incisión quirúrgica o transanalmente y ha sido colocado dentro de la sección intestinal 66, y la parte de cuerpo tubular 30 del dispositivo de grapado quirúrgico ha sido insertada transanalmente en la sección intestinal 68. Las secciones intestinales 66 y 68 también se muestran aseguradas temporalmente alrededor de sus componentes respectivos (por ejemplo, el vástago 38 del conjunto de yunque 40 y el extremo distal de la parte de cuerpo tubular 30) por medios convencionales tales como una sutura en
25 bolsa de tabaco “P”.
Según un método, como se observa en la figura 3, si se desea o si el procedimiento quirúrgico lo requiere, el elemento de sellado 10 puede colocarse sobre el vástago 38 del conjunto de yunque 40 antes del acoplamiento del conjunto de yunque 40 al extremo distal de la parte de cuerpo tubular 30. Después de la colocación del elemento de 30 sellado 10 sobre el vástago 38 del conjunto de yunque 40, el cirujano maniobra el conjunto de yunque 40 hasta que el extremo proximal del vástago 38 se inserta en el extremo distal de la parte de cuerpo tubular 30 del dispositivo de grapado quirúrgico 20, en el que la estructura de montaje (no mostrada) dentro del extremo distal de la parte de cuerpo tubular 30 se acopla al vástago 38 para efectuar el montaje. Acto seguido, el conjunto de yunque 40 y la parte de cuerpo tubular 30 se aproximan para aproximar las secciones intestinales 66, 68 y capturar el elemento de
35 sellado 10 entre las mismas. El dispositivo de grapado quirúrgico 20 es disparado entonces, grapando de este modo las secciones intestinales 66, 68 una a otra y cortando la parte de tejido y el elemento de sellado 10 dispuestos radialmente hacia el interior del bisturí, para completar la anastomosis.
Como se aprecia en la figura 4, el segundo material de formación de junta de sellado 14 es comprimido entre los
40 extremos proximal 16 y distal 18 de la anastomosis y capturado por las grapas 33, 35. La compresión de este material sirve como empaquetadura para impedir que el contenido del intestino se salga al interior del peritoneo. La parte del elemento de sellado 10 hecha del primer material 12 queda expuesta en el sitio de anastomosis y sirve para promover el crecimiento interior del tejido y ayudar así a la cicatrización del sitio.
45 Aunque se han ilustrado y descrito varias formas particulares de los elementos de sellado, también resultará evidente que pueden realizarse diversas modificaciones sin apartarse del alcance de la presente descripción. Por ejemplo, se contempla que cada uno de los elementos de sellado descritos en esta solicitud se pueda usar con un dispositivo de anastomosis quirúrgico anular, que no incluya ninguna grapa para asegurar el tejido entre sí, que sea capaz de aproximar, adherir y cortar tejido. Así, debería entenderse que pueden realizarse diversos cambios de
50 forma, detalle y aplicación de las estructuras de soporte de la presente descripción sin apartarse del alcance de la presente descripción.
Claims (11)
- E1116576010-09-2014REIVINDICACIONES1. Elemento de sellado (10) para colocación entre secciones tubulares de tejido que han de unirse, comprendiendo el elemento de sellado (10):5 un primer material (12) que promueve el crecimiento interior del tejido; yun segundo material (14) que comprende un sellante que rodea al menos parcialmente el primer material, en el que el segundo material (14) es compresible hasta el punto en que cuando se comprime entre el tejido tubular conectado10 sirve como una junta de sellado para impedir el escape de fluido, caracterizado porque el primer material (12) es relativamente delgado comparado con el segundo material y porque el segundo material se sobremoldea sobre el primer material.
- 2. El elemento de sellado (10) de la reivindicación 1 en el que el primer material (12) es un material poroso. 15
- 3. El elemento de sellado (10) de la reivindicación 1 en el que el primer material (12) se selecciona del grupo constituido por una espuma, una malla, una estructura no tejida, una lámina perforada y combinaciones de las mismas.20 4. El elemento de sellado (10) de la reivindicación 1 en el que el primer material (12) se selecciona de entre el grupo constituido por glicolida, lactida, caprolactona, carbonato de trimetileno, dioxanona, óxidos de polialquileno y combinaciones de los mismos.
- 5. El elemento de sellado (10) de la reivindicación 1 en el que el primer material (12) comprende un material poroso 25 que tiene poros de tamaño comprendido entre aproximadamente 50 µm y aproximadamente 200 µm.
- 6. El elemento de sellado (10) de la reivindicación 1 en el que el primer material (12) tiene un espesor comprendido entre aproximadamente 0,000254m (0,010 pulgadas) y aproximadamente 0,000508m (0,020 pulgadas).30 7. El elemento de sellado (10) de la reivindicación 1 en el que el material compresible (14) se selecciona de espuma de poliuretano, carboximetilcelulosa e hidrogeles.
- 8. El elemento de sellado (10) de la reivindicación 1 en el que el segundo material (14) se deriva de un monómero seleccionado del grupo constituido por ácido metacrílico, ácido acrílico, n-vinilpirrolidona, sulfopropilacrilato de35 potasio, sulfopropilmetacrilato de potasio, acrilamida, dimetilacrilamida, 2-metacriloiloxietilfosforilcolina, hidroxetilmetacrilato, 2-hidroxietilmetacrilato y combinaciones de los mismos.
- 9. El elemento de sellado (10) de la reivindicación 1 en el que el segundo material (14) espoli(2hidroxietilmetacrilato). 40
- 10. El elemento de sellado (10) de la reivindicación 1 en el que el segundo material (14) comprende una superficie que tiene un patrón formado en la misma.
- 11. El elemento de sellado (10) de la reivindicación 1 en el que al menos uno del primer (12) o el segundo (14) 45 materiales comprende además al menos una sustancia médicamente útil.
- 12. El elemento de sellado (10) de la reivindicación 11 en el que la al menos una sustancia médicamente útil se selecciona de entre el grupo constituido por fármacos, enzimas, factores de crecimiento, péptidos, proteínas, tintes, agentes de diagnóstico, agentes de hemostasia, antimicrobianos, antibióticos, antifúngicos, antivirales, anticuerpos50 monoclonales, anticuerpos policlonales, proteínas/péptidos antimicrobianos, enzimas, terapia genética, partículas virales, quimioterapéuticos, antiinflamatorios, NSAIDS, esteroides, inhibidores de telomerasa, factores de crecimiento, moléculas de matriz extracelular, moléculas de adhesión celular, polisacáridos y combinaciones de los mismos.55 13. El elemento de sellado (10) de la reivindicación 1 que comprende además una abertura situada generalmente en el centro.
- 14. Un conjunto para disponer un elemento de sellado entre lúmenes de tejido que comprende:60 un dispositivo de grapado quirúrgico circular que comprende un conjunto de yunque y una parte de cuerpo tubular en el que el conjunto de yunque comprende un elemento de yunque y un primer vástago y la parte de cuerpo tubular comprende una pluralidad de grapas quirúrgicas en una configuración circular y un segundo vástago dispuesto hacia el interior de las grapas quirúrgicas, pudiendo sujetarse el primer vástago al segundo vástago; y65 un elemento de sellado (10) tal como se define en una cualquiera de las reivindicaciones 1 a 13.6
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- 2005-09-29 WO PCT/US2005/035120 patent/WO2006044160A2/en active Application Filing
- 2005-09-29 EP EP05803193A patent/EP1799125B8/en not_active Not-in-force
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- 2011-03-14 JP JP2011055957A patent/JP2011139913A/ja not_active Withdrawn
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2013
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