ES2490240T3 - Formulaciones de polvo seco para inhalador que comprenden partículas modificadas en la superficie con aditivos antiadherentes - Google Patents
Formulaciones de polvo seco para inhalador que comprenden partículas modificadas en la superficie con aditivos antiadherentes Download PDFInfo
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- ES2490240T3 ES2490240T3 ES10151576.5T ES10151576T ES2490240T3 ES 2490240 T3 ES2490240 T3 ES 2490240T3 ES 10151576 T ES10151576 T ES 10151576T ES 2490240 T3 ES2490240 T3 ES 2490240T3
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Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61M2202/00—Special media to be introduced, removed or treated
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Landscapes
- Health & Medical Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
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Applications Claiming Priority (2)
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| GB0425758 | 2004-11-23 | ||
| GBGB0425758.0A GB0425758D0 (en) | 2004-11-23 | 2004-11-23 | Preparation of pharmaceutical compositions |
Publications (1)
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| ES10151576.5T Active ES2490240T3 (es) | 2004-11-23 | 2005-11-23 | Formulaciones de polvo seco para inhalador que comprenden partículas modificadas en la superficie con aditivos antiadherentes |
| ES10179073.1T Active ES2548884T3 (es) | 2004-11-23 | 2005-11-23 | Formulaciones de polvo seco para inhalador que comprenden partículas modificadas en la superficie con aditivos antiadherentes |
| ES05808842T Active ES2340599T3 (es) | 2004-11-23 | 2005-11-23 | Formulaciones de polvo seco para inhalador que comprenden particulas modificadas en la superficie con aditivos antiadherentes. |
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| ES10179073.1T Active ES2548884T3 (es) | 2004-11-23 | 2005-11-23 | Formulaciones de polvo seco para inhalador que comprenden partículas modificadas en la superficie con aditivos antiadherentes |
| ES05808842T Active ES2340599T3 (es) | 2004-11-23 | 2005-11-23 | Formulaciones de polvo seco para inhalador que comprenden particulas modificadas en la superficie con aditivos antiadherentes. |
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| EP2283818B1 (en) * | 2000-11-30 | 2017-08-02 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
| WO2004087243A1 (ja) | 2003-03-27 | 2004-10-14 | Bioactis Limited | 鼻腔用粉末薬剤施薬装置 |
| US20120321717A1 (en) * | 2003-04-14 | 2012-12-20 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| GB0321607D0 (en) * | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
| EP1785145A4 (en) * | 2004-08-10 | 2008-08-13 | Translational Res Ltd | TRANSNASAL COMPOSITION WITH IMMEDIATE EFFECT AND HIGH RESORBIBILITY |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| GB0621957D0 (en) * | 2006-11-03 | 2006-12-13 | Vectura Group Plc | Inhaler devices and bespoke pharmaceutical compositions |
| US8337817B2 (en) * | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) * | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| NZ580963A (en) * | 2007-04-11 | 2012-08-31 | Omeros Corp | Compositions and methods for prophylaxis and treatment of addictions |
| GB0712316D0 (en) * | 2007-06-26 | 2007-08-01 | Entripneur Ltd | A novel powder and its method of manufacture |
| EP2230934B8 (en) | 2007-12-14 | 2012-10-24 | AeroDesigns, Inc | Delivering aerosolizable food products |
| BRPI0915803A2 (pt) | 2008-07-18 | 2015-11-10 | Prosonix Ltd | processo para aumentar a cristalinidade de pelo menos um material sólido, partícula, composição farmacêutica, e, inalador |
| EP2410981B2 (en) | 2009-03-26 | 2020-02-26 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| GB0905840D0 (en) * | 2009-04-06 | 2009-05-20 | Sagentia Ltd | Apparatus and methods |
| CN102458372A (zh) * | 2009-04-24 | 2012-05-16 | 先灵公司 | 适用在干粉吸入器中的聚结物制剂 |
| JP2012526726A (ja) * | 2009-05-15 | 2012-11-01 | 株式会社新日本科学 | 薬物動態が改善された鼻腔内用薬学的組成物 |
| GB2472327B (en) | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
| GB0918249D0 (en) | 2009-10-19 | 2009-12-02 | Respivert Ltd | Compounds |
| GB0918431D0 (en) | 2009-10-21 | 2009-12-09 | Prosonix Ltd | Process for improving crystallinity |
| SG184352A1 (en) * | 2010-04-01 | 2012-10-30 | Chiesi Farma Spa | Process for preparing carrier particles for dry powders for inhalation |
| AU2011244384B2 (en) * | 2010-04-21 | 2016-06-23 | Chiesi Farmaceutici S.P.A. | "Process for providing particles with reduced electrostatic charges" |
| CN102309456B (zh) * | 2010-07-02 | 2013-05-01 | 北京化工大学 | 一种厄贝沙坦纳微复合粉体与片剂及其制备方法 |
| US20130164338A1 (en) | 2010-08-30 | 2013-06-27 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| JP5877201B2 (ja) | 2010-08-30 | 2016-03-02 | パルマトリックス，インコーポレイテッド | 肺疾患を治療するための乾燥粉末製剤および方法 |
| RU2017144619A (ru) | 2010-09-29 | 2019-02-20 | Пулмэтрикс, Инк. | Катионы одновалентных металлов сухих порошков для ингаляций |
| WO2012050945A1 (en) * | 2010-09-29 | 2012-04-19 | Pulmatrix, Inc. | Cationic dry powders |
| UY33337A (es) | 2010-10-18 | 2011-10-31 | Respivert Ltd | DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS |
| ITMI20120092A1 (it) * | 2012-01-26 | 2013-07-27 | Micro Macinazione S A | Compositi di inclusione farmaco-carrier preparati con processo di attivazione meccano-chimica mediante mulini a getto di fluido ad alta energia |
| HK1204989A1 (en) * | 2012-02-29 | 2015-12-11 | Pulmatrix Operating Company, Inc. | Inhalable dry powders |
| CN104284679B (zh) | 2012-03-13 | 2017-08-04 | 瑞斯比维特有限公司 | 药物制剂 |
| CA2869849A1 (en) | 2012-04-13 | 2013-10-17 | Glaxosmithkline Intellectual Property Development Limited | Aggregate particles comprising nanoparticulate drug particles of umeclidinium bromide, vilanterol trifenatate and fluticasone furoate |
| CN103570610B (zh) * | 2012-07-18 | 2017-08-11 | 重庆华邦制药有限公司 | 一种罗氟司特微粒的制备方法 |
| CN103588846B (zh) * | 2012-08-15 | 2016-08-03 | 重庆华邦制药有限公司 | 一种丙酸氟替卡松微粒的制备方法及其用途 |
| BR112015010601B1 (pt) * | 2012-11-09 | 2022-07-19 | Civitas Therapeutics, Inc. | Composição farmacêutica e uso da composição |
| JP6116206B2 (ja) * | 2012-11-26 | 2017-04-19 | クリニプロ株式会社 | 吸入用パウダーの製造方法 |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| GB201305825D0 (en) * | 2013-03-28 | 2013-05-15 | Vectura Ltd | New use |
| AU2014248455B2 (en) | 2013-04-01 | 2018-12-06 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| ITMI20130572A1 (it) * | 2013-04-10 | 2014-10-11 | Eratech Srl | Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione |
| EP2991634A1 (en) * | 2013-04-30 | 2016-03-09 | Otitopic Inc. | Dry powder formulations and methods of use |
| PE20160372A1 (es) * | 2013-07-11 | 2016-05-19 | Chiesi Farma Spa | Formulacion en polvo seco que comprende un anticolinergico, un corticosteroide y un beta-adrenergico para administrar por inhalacion |
| EP3738592B1 (en) | 2013-10-08 | 2022-01-26 | AI Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| WO2015089105A1 (en) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| US10307371B2 (en) | 2014-02-11 | 2019-06-04 | AI Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| EP3107548B8 (en) * | 2014-02-20 | 2022-07-20 | Otitopic Inc. | Dry powder formulations for inhalation |
| ES2952025T3 (es) | 2014-04-04 | 2023-10-26 | Ai Therapeutics Inc | Una formulación de rapamicina inhalable para tratar condiciones relacionadas con la edad |
| EA201692456A1 (ru) | 2014-07-09 | 2017-08-31 | Арвен Иладж Санайи Ве Тиджарет А.Ш. | Способ получения составов для ингаляции |
| CN116687887A (zh) * | 2014-07-31 | 2023-09-05 | 维克图拉公司 | 用于吸入的干粉制剂 |
| MA40617B1 (fr) | 2014-09-09 | 2020-05-29 | Vectura Ltd | Formulation comprenant glycopyrrolate, procédé et appareil |
| US20170304276A1 (en) | 2014-10-07 | 2017-10-26 | Lam Therapeutics, Inc. | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
| US20160119692A1 (en) * | 2014-10-24 | 2016-04-28 | Sunshine Partners LLC | Interactive system and method for viewer selection of objects in context while viewing television |
| CN107106641B (zh) | 2014-10-31 | 2021-12-21 | 葛兰素史密斯克莱知识产权发展有限公司 | 粉末制剂 |
| PE20180690A1 (es) * | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
| US9585835B1 (en) * | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
| US10149844B2 (en) | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| US10853435B2 (en) | 2016-06-17 | 2020-12-01 | Axon Enterprise, Inc. | Systems and methods for aligning event data |
| JP7471774B2 (ja) * | 2016-06-30 | 2024-04-22 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチン粒子 |
| UA124535C2 (uk) * | 2016-06-30 | 2021-10-05 | Філіп Морріс Продактс С.А. | Нікотиновмісні частинки та композиції |
| JP7085538B2 (ja) * | 2016-10-14 | 2022-06-16 | パルマトリックス オペレーティング カンパニー，インコーポレイテッド | 抗真菌薬乾燥粉末 |
| EP3592352A1 (en) * | 2017-03-07 | 2020-01-15 | Philip Morris Products S.a.s. | Inhalable nicotine formulations, and methods of making and using thereof |
| CA3067632A1 (en) | 2017-06-02 | 2018-12-06 | Csp Technologies, Inc. | Inhaler and methods of using and making same |
| CN109200034A (zh) * | 2017-06-30 | 2019-01-15 | 正大天晴药业集团股份有限公司 | 一种可吸入干粉形式的组合物及其制备方法 |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| KR102681843B1 (ko) | 2017-09-22 | 2024-07-05 | 벡추라 인코포레이티드 | 스테아르산마그네슘을 갖는 건조 분말 조성물 |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| JP2021509677A (ja) | 2018-01-05 | 2021-04-01 | インペル ニューロファーマ インコーポレイテッド | 精密嗅覚装置によるオランザピンの鼻孔間送達 |
| CN112451509B (zh) * | 2020-12-19 | 2023-03-07 | 沈阳药科大学 | 一种川丁特罗吸入粉雾剂及其制备方法 |
| WO2023069028A1 (en) * | 2021-10-20 | 2023-04-27 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | A process for the preparation of dry powder compositions for inhalation |
| US12005185B2 (en) * | 2021-12-17 | 2024-06-11 | Belhaven BioPharma Inc. | Medical counter measures including dry powder formulations and associated methods |
| WO2023128913A1 (en) * | 2021-12-31 | 2023-07-06 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | A process for the preparation of dry powder compositions for inhalation |
| WO2024009079A1 (en) | 2022-07-04 | 2024-01-11 | Hovione Scientia Limited | Dry powder inhaler pharmaceutical composition of coated crystalline dry powder for inhalation |
| CN115060832B (zh) * | 2022-08-18 | 2022-11-29 | 上海奥科达生物医药科技有限公司 | 奥卡西平口服混悬液中奥卡西平及防腐剂含量检测方法 |
| CN115770221A (zh) * | 2022-12-29 | 2023-03-10 | 浙江上药九旭药业有限公司 | 银杏酮酯粉体、银杏酮酯滴丸剂及其制备方法 |
| GB2633305A (en) | 2023-08-30 | 2025-03-12 | Envirohale Malta Holdings Ltd | Nasal and pulmonary drug delivery |
| CN119055610A (zh) * | 2024-08-27 | 2024-12-03 | 江苏谦仁生物科技有限公司 | 一种阿昔莫司胶囊及其制备方法 |
| CN119371006B (zh) * | 2024-11-06 | 2025-07-04 | 北京城市排水集团有限责任公司 | 一种长效缓释型污泥脱氮菌群调节药剂及制备方法和应用 |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687773A (en) | 1983-03-28 | 1987-08-18 | Mclean Hospital | (+)-N-N-propylnorapomorphine and selective limbic activity |
| ATE224748T1 (de) | 1989-04-28 | 2002-10-15 | Riker Laboratories Inc | Inhalationsvorrichtung für trockenpulver |
| JPH05963A (ja) | 1990-04-13 | 1993-01-08 | Toray Ind Inc | ポリペプチド類組成物 |
| US5292520A (en) | 1990-09-13 | 1994-03-08 | Akzo N.V. | Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| TW402506B (en) | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
| SA95160463B1 (ar) | 1994-12-22 | 2005-10-04 | استرا أكتيبولاج | مساحيق للاستنشاق |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| FR2747311B1 (fr) | 1996-04-10 | 1998-08-14 | Pf Medicament | Inhalateur a poudre et a air comprime |
| ATE287257T1 (de) | 1997-01-16 | 2005-02-15 | Massachusetts Inst Technology | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| US6051257A (en) | 1997-02-24 | 2000-04-18 | Superior Micropowders, Llc | Powder batch of pharmaceutically-active particles and methods for making same |
| EP0931595A1 (en) | 1998-01-26 | 1999-07-28 | Imra Europe S.A. | A device for spraying a liquid |
| US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| CA2347856C (en) | 1998-11-13 | 2009-02-17 | Jago Research Ag | Dry powder for inhalation |
| GB9827145D0 (en) | 1998-12-09 | 1999-02-03 | Co Ordinated Drug Dev | Improvements in or relating to powders |
| TR200102567T2 (tr) | 1999-03-05 | 2002-01-21 | Chiesi Farmaceutici S.P.A. | İnhalasyon için geliştirilmiş toz halindeki farmasötik bileşimler |
| EP1180020B2 (en) | 1999-05-27 | 2009-06-24 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| GB2353222B (en) | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
| US6586008B1 (en) | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| US20010036481A1 (en) | 1999-08-25 | 2001-11-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
| JP2001072586A (ja) | 1999-09-06 | 2001-03-21 | Nikken Chem Co Ltd | 吸入用粉末製剤及びその製造方法 |
| JP2001151673A (ja) | 1999-09-06 | 2001-06-05 | Nikken Chem Co Ltd | 吸入用粉末製剤の製造方法 |
| IL148291A0 (en) | 1999-09-16 | 2002-09-12 | Tanabe Seiyaku Co | Aromatic nitrogen-containing 6-membered cyclic compounds |
| FI20002217L (fi) | 1999-12-30 | 2001-07-01 | Orion Yhtymae Oyj | Inhalaatiopartikkelit |
| GB0008411D0 (en) * | 2000-04-05 | 2000-05-24 | Vectura Ltd | Pharmaceutical preparations and their manufacture |
| GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| CZ20023637A3 (cs) | 2000-04-07 | 2003-02-12 | Tap Pharmaceutical Products, Inc. | Deriváty apomorfinu a způsoby jejich použití |
| JP2004500424A (ja) | 2000-04-17 | 2004-01-08 | ヴェクトゥラ リミテッド | 吸入器で使用するための製剤 |
| GB0009468D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formulations for use in inhaler devices |
| GB0009469D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
| PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| GB0010709D0 (en) | 2000-05-03 | 2000-06-28 | Vectura Ltd | Powders for use a in dry powder inhaler |
| PT1296651E (pt) * | 2000-06-27 | 2008-02-12 | Vectura Ltd | Método para fazer partículas para serem usadas numa composição farmacêutica |
| GB2364919A (en) | 2000-07-21 | 2002-02-13 | Cambridge Consultants | Inhalers |
| WO2002009669A2 (en) | 2000-08-01 | 2002-02-07 | Inhale Therapeutic Systems, Inc. | Apparatus and process to produce particles having a narrow size distribution and particles made thereby |
| US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US20020086876A1 (en) | 2000-11-15 | 2002-07-04 | Ruff Dustin D. | Treatment of anti-depression drug-induced sexual dysfunction with apomorphine |
| MXPA03004288A (es) | 2000-11-15 | 2004-09-10 | Tap Pharmaceutical Prod Inc | Tratamiento de disfuncion sexual inducida por farmaco antidepresivo con apomorfina. |
| EP2283818B1 (en) | 2000-11-30 | 2017-08-02 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| AU2211502A (en) | 2000-11-30 | 2002-06-11 | Vectura Ltd | Method of making particles for use in a pharmaceutical composition |
| EP2292212A3 (en) * | 2000-11-30 | 2012-08-08 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| WO2002043693A2 (en) * | 2000-11-30 | 2002-06-06 | Vectura Limited | Pharmaceutical compositions for inhalation |
| PT1353647E (pt) | 2000-12-27 | 2011-05-24 | Gilead Sciences Inc | Aztreonam inal?vel para tratamento e preven??o de infec??es bacterianas pulmonares |
| GB0109384D0 (en) * | 2001-04-12 | 2001-05-30 | Vectura Ltd | Pharmaceutical products, preparation and uses thereof |
| JP2005506855A (ja) | 2001-05-10 | 2005-03-10 | ベクトゥラ デリバリー デバイシーズ リミテッド | 吸入器 |
| GB2375308A (en) | 2001-05-10 | 2002-11-13 | Cambridge Consultants | Inhalers |
| JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
| US20040028613A1 (en) | 2001-06-25 | 2004-02-12 | Nastech Pharmaceutical Company Inc | Dopamine agonist formulations for enhanced central nervous system delivery |
| WO2003020241A2 (en) * | 2001-09-05 | 2003-03-13 | Vectura Limited | Functional powders for oral delivery |
| EP1490031A1 (en) * | 2002-03-07 | 2004-12-29 | Vectura Limited | Fast melt multiparticulate formulations for oral delivery |
| US20040003341A1 (en) | 2002-06-20 | 2004-01-01 | Koninklijke Philips Electronics N.V. | Method and apparatus for processing electronic forms for use with resource constrained devices |
| US20060127480A1 (en) * | 2002-10-11 | 2006-06-15 | Michael Tobyn | Pharmaceutical excipients comprising inorganic particles in association with an organic polymeric material and forming a solid reticulated matrix, compositions, manufacturing and use thereof |
| US20060147389A1 (en) * | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| WO2004093848A2 (en) * | 2003-04-14 | 2004-11-04 | Vectura Ltd | Dry power inhaler devices and dry power formulations for enhancing dosing efficiency |
| CA2522231A1 (en) | 2003-04-14 | 2004-10-21 | Vectura Ltd | Pharmaceutical compositions comprising apomorphine for pulmonary inhalation |
| US20040204439A1 (en) | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
| WO2005025535A2 (en) * | 2003-09-15 | 2005-03-24 | Vectura Limited | Methods for preparing pharmaceutical compositions |
| GB0321607D0 (en) * | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| GB0330255D0 (en) | 2003-12-31 | 2004-02-04 | Vectura Ltd | Multiparticulate formulations for oral delivery |
| GB0408308D0 (en) | 2004-04-14 | 2004-05-19 | Vectura Ltd | Pharmaceutical compositions |
| GB0409703D0 (en) * | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
| GB0410399D0 (en) | 2004-05-10 | 2004-06-16 | Arakis Ltd | The treatment of respiratory disease |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| GB0426301D0 (en) | 2004-11-30 | 2004-12-29 | Vectura Ltd | Pharmaceutical formulations |
-
2004
- 2004-11-23 GB GBGB0425758.0A patent/GB0425758D0/en not_active Ceased
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- 2005-11-23 HU HUE10179073A patent/HUE027465T2/en unknown
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- 2005-11-23 AT AT05808842T patent/ATE456363T1/de active
- 2005-11-23 US US11/791,385 patent/US20080127972A1/en not_active Abandoned
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-
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