ES2454773T3 - Fragmentos solubles de la proteína PB2 del virus influenza con capacidad para unirse a un casquete de ARN - Google Patents
Fragmentos solubles de la proteína PB2 del virus influenza con capacidad para unirse a un casquete de ARN Download PDFInfo
- Publication number
- ES2454773T3 ES2454773T3 ES08838119.9T ES08838119T ES2454773T3 ES 2454773 T3 ES2454773 T3 ES 2454773T3 ES 08838119 T ES08838119 T ES 08838119T ES 2454773 T3 ES2454773 T3 ES 2454773T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- polypeptide
- seq
- terminal end
- aligned
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012634 fragment Substances 0.000 title abstract 10
- 108020005161 RNA Caps Proteins 0.000 title abstract 3
- 108700015453 influenza virus PB2 Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 21
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 21
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 21
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 9
- 125000000539 amino acid group Chemical group 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 210000004899 c-terminal region Anatomy 0.000 abstract 3
- DKVRNHPCAOHRSI-KQYNXXCUSA-N 7-methyl-GTP Chemical compound C1=2N=C(N)NC(=O)C=2[N+](C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]1O DKVRNHPCAOHRSI-KQYNXXCUSA-N 0.000 abstract 1
- 108060004795 Methyltransferase Proteins 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
- B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
- B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2501/00—Containers having bodies formed in one piece
- B65D2501/0009—Bottles or similar containers with necks or like restricted apertures designed for pouring contents
- B65D2501/0018—Ribs
- B65D2501/0036—Hollow circonferential ribs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Mechanical Engineering (AREA)
- Ceramic Engineering (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Containers Having Bodies Formed In One Piece (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99839807P | 2007-10-09 | 2007-10-09 | |
| US998398P | 2007-10-09 | ||
| US7079208P | 2008-03-25 | 2008-03-25 | |
| US70792P | 2008-03-25 | ||
| US12345608P | 2008-04-08 | 2008-04-08 | |
| US123456P | 2008-04-08 | ||
| PCT/EP2008/008543 WO2009046983A1 (en) | 2007-10-09 | 2008-10-09 | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2454773T3 true ES2454773T3 (es) | 2014-04-11 |
Family
ID=40364724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08838119.9T Active ES2454773T3 (es) | 2007-10-09 | 2008-10-09 | Fragmentos solubles de la proteína PB2 del virus influenza con capacidad para unirse a un casquete de ARN |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9045248B2 (enExample) |
| EP (2) | EP2197901B1 (enExample) |
| JP (3) | JP5725861B2 (enExample) |
| KR (1) | KR101672554B1 (enExample) |
| CN (1) | CN101970465B (enExample) |
| AU (1) | AU2008309939B2 (enExample) |
| CA (1) | CA2701362A1 (enExample) |
| ES (1) | ES2454773T3 (enExample) |
| IL (3) | IL204891A (enExample) |
| SG (1) | SG185289A1 (enExample) |
| WO (1) | WO2009046983A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2197901B1 (en) * | 2007-10-09 | 2013-12-11 | European Molecular Biology Laboratory (Embl) | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
| PL2442809T3 (pl) | 2009-06-17 | 2017-02-28 | Vertex Pharmaceuticals Incorporated | Inhibitory replikacji wirusów grypy |
| CN102803288B (zh) * | 2010-03-16 | 2015-09-23 | 欧洲分子生物学实验室(Embl) | 来自甲型流感2009大流行h1n1病毒的rna依赖性rna聚合酶的pa亚基片段及其用途 |
| AU2011343642A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| AU2013292617A1 (en) * | 2012-07-19 | 2015-01-22 | Zoetis Llc | Bovine influenza C virus compositions |
| LT3068776T (lt) | 2013-11-13 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Gripo virusų replikacijos inhibitoriai |
| EP3421468B1 (en) | 2013-11-13 | 2020-11-04 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| CN105018441A (zh) * | 2014-04-22 | 2015-11-04 | 中国科学院生物物理研究所 | 流感病毒rna聚合酶结晶的方法 |
| CN105002149B (zh) * | 2014-04-22 | 2018-04-06 | 中国科学院生物物理研究所 | 流感病毒rna聚合酶纯化或结晶的方法 |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| CN107286044B (zh) | 2016-04-13 | 2021-07-13 | 香港神农有限公司 | 一种能够抑制流感病毒pb2蛋白与rna帽结合的化合物 |
| CL2018003871A1 (es) | 2018-12-28 | 2021-01-15 | Univ Pontificia Catolica Chile | Anticuerpos monoclonales específicos para el antígeno pb2 del virus de la influenza humana (flu), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por flu |
| WO2020239822A1 (en) | 2019-05-27 | 2020-12-03 | The European Molecular Biology Laboratory | Nucleic acid construct binding to influenza polymerase pb1 rna synthesis active site |
| CN113234778A (zh) * | 2020-08-20 | 2021-08-10 | 深圳市瑞吉生物科技有限公司 | 一种Cap2结构5′帽子类似物及其制备方法和应用 |
| CN114741315B (zh) * | 2022-04-28 | 2023-06-13 | 深圳市紫光同创电子有限公司 | 用例更新方法、装置、电子设备及存储介质 |
| CN116024301B (zh) * | 2023-01-16 | 2025-10-28 | 北京协同创新研究院 | 一种rna依赖性rna聚合酶截短体的筛选方法、截短体及应用 |
| WO2025055169A1 (en) * | 2023-09-12 | 2025-03-20 | The Chinese University Of Hong Kong | A fluorescent probe to measure rna binding and elongation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837852A (en) * | 1993-10-14 | 1998-11-17 | Bristol-Myers Squibb Company | Capped nucleic acid oligomers that inhibit cap-dependent transcription of the influenza virus endonuclease |
| EP2197901B1 (en) * | 2007-10-09 | 2013-12-11 | European Molecular Biology Laboratory (Embl) | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
| JP6614523B2 (ja) * | 2014-03-28 | 2019-12-04 | 地方独立行政法人神奈川県立産業技術総合研究所 | インフルエンザウイルスのｒｎａ依存性ｒｎａポリメラーゼのｐｂ２サブユニットに対するモノクローナル抗体 |
-
2008
- 2008-10-09 EP EP08838119.9A patent/EP2197901B1/en not_active Not-in-force
- 2008-10-09 CN CN200880119968.9A patent/CN101970465B/zh not_active Expired - Fee Related
- 2008-10-09 WO PCT/EP2008/008543 patent/WO2009046983A1/en not_active Ceased
- 2008-10-09 CA CA2701362A patent/CA2701362A1/en not_active Abandoned
- 2008-10-09 EP EP12175945.0A patent/EP2574619A3/en not_active Withdrawn
- 2008-10-09 KR KR1020107008765A patent/KR101672554B1/ko not_active Expired - Fee Related
- 2008-10-09 JP JP2010528317A patent/JP5725861B2/ja not_active Expired - Fee Related
- 2008-10-09 US US12/681,974 patent/US9045248B2/en not_active Expired - Fee Related
- 2008-10-09 SG SG2012075354A patent/SG185289A1/en unknown
- 2008-10-09 ES ES08838119.9T patent/ES2454773T3/es active Active
- 2008-10-09 AU AU2008309939A patent/AU2008309939B2/en not_active Ceased
-
2010
- 2010-04-06 IL IL204891A patent/IL204891A/en not_active IP Right Cessation
-
2012
- 2012-11-12 IL IL222997A patent/IL222997A0/en unknown
-
2014
- 2014-10-08 JP JP2014207447A patent/JP5937169B2/ja not_active Expired - Fee Related
-
2015
- 2015-03-23 IL IL237903A patent/IL237903A/en not_active IP Right Cessation
-
2016
- 2016-05-10 JP JP2016094331A patent/JP6309563B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2197901A1 (en) | 2010-06-23 |
| IL237903A (en) | 2017-10-31 |
| CN101970465B (zh) | 2016-03-16 |
| KR20100074212A (ko) | 2010-07-01 |
| JP2016176955A (ja) | 2016-10-06 |
| WO2009046983A1 (en) | 2009-04-16 |
| CN101970465A (zh) | 2011-02-09 |
| EP2574619A2 (en) | 2013-04-03 |
| SG185289A1 (en) | 2012-11-29 |
| IL222997A0 (en) | 2012-12-31 |
| JP5937169B2 (ja) | 2016-06-22 |
| JP6309563B2 (ja) | 2018-04-11 |
| IL204891A0 (en) | 2010-11-30 |
| IL204891A (en) | 2015-04-30 |
| JP5725861B2 (ja) | 2015-05-27 |
| AU2008309939A1 (en) | 2009-04-16 |
| AU2008309939B2 (en) | 2013-11-14 |
| US20110008348A1 (en) | 2011-01-13 |
| KR101672554B1 (ko) | 2016-11-03 |
| CA2701362A1 (en) | 2009-04-16 |
| EP2197901B1 (en) | 2013-12-11 |
| JP2015062417A (ja) | 2015-04-09 |
| JP2011501942A (ja) | 2011-01-20 |
| EP2574619A3 (en) | 2013-07-31 |
| US9045248B2 (en) | 2015-06-02 |
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