IL204891A - Soluble portions of the 2pb protein of influenza virus capable of binding to cap - rna - Google Patents

Soluble portions of the 2pb protein of influenza virus capable of binding to cap - rna

Info

Publication number
IL204891A
IL204891A IL204891A IL20489110A IL204891A IL 204891 A IL204891 A IL 204891A IL 204891 A IL204891 A IL 204891A IL 20489110 A IL20489110 A IL 20489110A IL 204891 A IL204891 A IL 204891A
Authority
IL
Israel
Prior art keywords
cap
influenza virus
protein capable
binding rna
soluble fragments
Prior art date
Application number
IL204891A
Other languages
English (en)
Hebrew (he)
Other versions
IL204891A0 (en
Original Assignee
European Molecular Biology Lab Embl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by European Molecular Biology Lab Embl filed Critical European Molecular Biology Lab Embl
Publication of IL204891A0 publication Critical patent/IL204891A0/en
Publication of IL204891A publication Critical patent/IL204891A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2501/00—Containers having bodies formed in one piece
    • B65D2501/0009—Bottles or similar containers with necks or like restricted apertures designed for pouring contents
    • B65D2501/0018—Ribs
    • B65D2501/0036—Hollow circonferential ribs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL204891A 2007-10-09 2010-04-06 Soluble portions of the 2pb protein of influenza virus capable of binding to cap - rna IL204891A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99839807P 2007-10-09 2007-10-09
US7079208P 2008-03-25 2008-03-25
US12345608P 2008-04-08 2008-04-08
PCT/EP2008/008543 WO2009046983A1 (en) 2007-10-09 2008-10-09 Soluble fragments of influenza virus pb2 protein capable of binding rna-cap

Publications (2)

Publication Number Publication Date
IL204891A0 IL204891A0 (en) 2010-11-30
IL204891A true IL204891A (en) 2015-04-30

Family

ID=40364724

Family Applications (3)

Application Number Title Priority Date Filing Date
IL204891A IL204891A (en) 2007-10-09 2010-04-06 Soluble portions of the 2pb protein of influenza virus capable of binding to cap - rna
IL222997A IL222997A0 (en) 2007-10-09 2012-11-12 Soluble fragments of influenza virus pb2 protein capable of binding rna - cap
IL237903A IL237903A (en) 2007-10-09 2015-03-23 An antibody that binds to the 2pb protein of influenza virus and uses it

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL222997A IL222997A0 (en) 2007-10-09 2012-11-12 Soluble fragments of influenza virus pb2 protein capable of binding rna - cap
IL237903A IL237903A (en) 2007-10-09 2015-03-23 An antibody that binds to the 2pb protein of influenza virus and uses it

Country Status (11)

Country Link
US (1) US9045248B2 (enExample)
EP (2) EP2197901B1 (enExample)
JP (3) JP5725861B2 (enExample)
KR (1) KR101672554B1 (enExample)
CN (1) CN101970465B (enExample)
AU (1) AU2008309939B2 (enExample)
CA (1) CA2701362A1 (enExample)
ES (1) ES2454773T3 (enExample)
IL (3) IL204891A (enExample)
SG (1) SG185289A1 (enExample)
WO (1) WO2009046983A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2197901B1 (en) * 2007-10-09 2013-12-11 European Molecular Biology Laboratory (Embl) Soluble fragments of influenza virus pb2 protein capable of binding rna-cap
PL2442809T3 (pl) 2009-06-17 2017-02-28 Vertex Pharmaceuticals Incorporated Inhibitory replikacji wirusów grypy
CN102803288B (zh) * 2010-03-16 2015-09-23 欧洲分子生物学实验室(Embl) 来自甲型流感2009大流行h1n1病毒的rna依赖性rna聚合酶的pa亚基片段及其用途
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
AU2013292617A1 (en) * 2012-07-19 2015-01-22 Zoetis Llc Bovine influenza C virus compositions
LT3068776T (lt) 2013-11-13 2019-08-12 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitoriai
EP3421468B1 (en) 2013-11-13 2020-11-04 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
CN105018441A (zh) * 2014-04-22 2015-11-04 中国科学院生物物理研究所 流感病毒rna聚合酶结晶的方法
CN105002149B (zh) * 2014-04-22 2018-04-06 中国科学院生物物理研究所 流感病毒rna聚合酶纯化或结晶的方法
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
CN107286044B (zh) 2016-04-13 2021-07-13 香港神农有限公司 一种能够抑制流感病毒pb2蛋白与rna帽结合的化合物
CL2018003871A1 (es) 2018-12-28 2021-01-15 Univ Pontificia Catolica Chile Anticuerpos monoclonales específicos para el antígeno pb2 del virus de la influenza humana (flu), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por flu
WO2020239822A1 (en) 2019-05-27 2020-12-03 The European Molecular Biology Laboratory Nucleic acid construct binding to influenza polymerase pb1 rna synthesis active site
CN113234778A (zh) * 2020-08-20 2021-08-10 深圳市瑞吉生物科技有限公司 一种Cap2结构5′帽子类似物及其制备方法和应用
CN114741315B (zh) * 2022-04-28 2023-06-13 深圳市紫光同创电子有限公司 用例更新方法、装置、电子设备及存储介质
CN116024301B (zh) * 2023-01-16 2025-10-28 北京协同创新研究院 一种rna依赖性rna聚合酶截短体的筛选方法、截短体及应用
WO2025055169A1 (en) * 2023-09-12 2025-03-20 The Chinese University Of Hong Kong A fluorescent probe to measure rna binding and elongation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837852A (en) * 1993-10-14 1998-11-17 Bristol-Myers Squibb Company Capped nucleic acid oligomers that inhibit cap-dependent transcription of the influenza virus endonuclease
EP2197901B1 (en) * 2007-10-09 2013-12-11 European Molecular Biology Laboratory (Embl) Soluble fragments of influenza virus pb2 protein capable of binding rna-cap
JP6614523B2 (ja) * 2014-03-28 2019-12-04 地方独立行政法人神奈川県立産業技術総合研究所 インフルエンザウイルスのｒｎａ依存性ｒｎａポリメラーゼのｐｂ２サブユニットに対するモノクローナル抗体

Also Published As

Publication number Publication date
ES2454773T3 (es) 2014-04-11
EP2197901A1 (en) 2010-06-23
IL237903A (en) 2017-10-31
CN101970465B (zh) 2016-03-16
KR20100074212A (ko) 2010-07-01
JP2016176955A (ja) 2016-10-06
WO2009046983A1 (en) 2009-04-16
CN101970465A (zh) 2011-02-09
EP2574619A2 (en) 2013-04-03
SG185289A1 (en) 2012-11-29
IL222997A0 (en) 2012-12-31
JP5937169B2 (ja) 2016-06-22
JP6309563B2 (ja) 2018-04-11
IL204891A0 (en) 2010-11-30
JP5725861B2 (ja) 2015-05-27
AU2008309939A1 (en) 2009-04-16
AU2008309939B2 (en) 2013-11-14
US20110008348A1 (en) 2011-01-13
KR101672554B1 (ko) 2016-11-03
CA2701362A1 (en) 2009-04-16
EP2197901B1 (en) 2013-12-11
JP2015062417A (ja) 2015-04-09
JP2011501942A (ja) 2011-01-20
EP2574619A3 (en) 2013-07-31
US9045248B2 (en) 2015-06-02

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees