ES2676542T3 - Composiciones de CDV recombinante y usos de las mismas - Google Patents
Composiciones de CDV recombinante y usos de las mismas Download PDFInfo
- Publication number
- ES2676542T3 ES2676542T3 ES11707047T ES11707047T ES2676542T3 ES 2676542 T3 ES2676542 T3 ES 2676542T3 ES 11707047 T ES11707047 T ES 11707047T ES 11707047 T ES11707047 T ES 11707047T ES 2676542 T3 ES2676542 T3 ES 2676542T3
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- ES
- Spain
- Prior art keywords
- alvac
- polynucleotide
- compositions
- locus
- promoter
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/175—Canine distemper virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/205—Rhabdoviridae, e.g. rabies virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18471—Demonstrated in vivo effect
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Abstract
Una composición que comprende: a) un vector de expresión del virus de la viruela del canario, en la que el vector de expresión del virus de la viruela del canario es ALVAC, en la que el vector ALVAC comprende: i) un primer polinucleótido que codifica un polipéptido de HA de CDV que tiene al menos el 80 % de identidad con la secuencia que se expone en SEQ ID NO: 2, en el que dicho primer polinucleótido se inserta en el locus C5 de ALVAC bajo el control del promotor H6 de la variolovacuna; y ii) un segundo polinucleótido que codifica un polipéptido de GM-CSF que tiene al menos el 80 % de identidad con la secuencia que se expone en SEQ ID NO: 4, en el que dicho segundo polinucleótido se inserta en el locus C3 de ALVAC y está operativamente unido al promotor H6 de la variolovacuna; y b) un vehículo farmacéutica o veterinariamente aceptable, adyuvante, diluyente o excipiente
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30862010P | 2010-02-26 | 2010-02-26 | |
PCT/US2011/026378 WO2011106743A1 (en) | 2010-02-26 | 2011-02-25 | Recombinant cdv compositions and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2676542T3 true ES2676542T3 (es) | 2018-07-20 |
Family
ID=44022809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11707047T Active ES2676542T3 (es) | 2010-02-26 | 2011-02-25 | Composiciones de CDV recombinante y usos de las mismas |
Country Status (23)
Country | Link |
---|---|
US (3) | US20130197612A1 (es) |
EP (1) | EP2538972B1 (es) |
JP (1) | JP5898632B2 (es) |
KR (1) | KR20130036209A (es) |
CN (1) | CN102971010A (es) |
AR (1) | AR080313A1 (es) |
AU (1) | AU2011220410B9 (es) |
BR (1) | BR112012021545B1 (es) |
CA (1) | CA2791787C (es) |
CY (1) | CY1120430T1 (es) |
DK (1) | DK2538972T3 (es) |
ES (1) | ES2676542T3 (es) |
HR (1) | HRP20181188T1 (es) |
HU (1) | HUE039735T2 (es) |
LT (1) | LT2538972T (es) |
NZ (1) | NZ602077A (es) |
PL (1) | PL2538972T3 (es) |
PT (1) | PT2538972T (es) |
RS (1) | RS57759B1 (es) |
RU (1) | RU2567337C2 (es) |
SI (1) | SI2538972T1 (es) |
WO (1) | WO2011106743A1 (es) |
ZA (1) | ZA201206209B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103525776A (zh) * | 2013-10-23 | 2014-01-22 | 华中农业大学 | 一种重组狂犬病病毒口服疫苗株及其制备方法 |
CN104164409A (zh) * | 2014-07-18 | 2014-11-26 | 中国人民解放军军事医学科学院军事兽医研究所 | 含有犬gmcsf基因的重组犬瘟热病毒及其制备方法 |
US10081796B2 (en) * | 2015-01-12 | 2018-09-25 | International Aids Vaccine Initiative | Neutralization-resistant CDV mutants and viral vectors |
CN109715204B (zh) | 2016-09-20 | 2023-08-22 | 勃林格殷格翰动物保健有限公司 | 新的ehv插入位点orf70 |
TW201823467A (zh) | 2016-09-20 | 2018-07-01 | 德商百靈佳殷格翰維美迪加股份有限公司 | 犬腺病毒載體 |
AR109540A1 (es) | 2016-09-20 | 2018-12-19 | Boehringer Ingelheim Vetmedica Gmbh | Moléculas promotoras para expresar antígenos virales |
EP3515480A1 (en) | 2016-09-20 | 2019-07-31 | Boehringer Ingelheim Vetmedica GmbH | New swine influenza vaccine |
CN109265522B (zh) * | 2018-09-29 | 2022-03-04 | 东北农业大学 | 用于检测犬瘟热病毒血凝蛋白h抗体的致敏聚苯乙烯纳米微球及其制备方法和应用 |
WO2020086939A1 (en) * | 2018-10-26 | 2020-04-30 | The Wistar Institute Of Anatomy And Biology | Canine distemper vaccines and methods of treatment using the same |
RU2768749C1 (ru) * | 2021-06-07 | 2022-03-24 | Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") | Средство специфической профилактики covid-19 для плотоядных животных |
CN114480441B (zh) * | 2021-12-21 | 2023-03-21 | 长春维石检测技术服务有限公司 | 一段核苷酸序列及其表达重组蛋白纳米颗粒在犬瘟热病毒疫苗的应用 |
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US7682619B2 (en) * | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
WO2009124309A2 (en) * | 2008-04-04 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same |
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2011
- 2011-02-08 US US13/023,110 patent/US20130197612A1/en not_active Abandoned
- 2011-02-25 EP EP11707047.4A patent/EP2538972B1/en active Active
- 2011-02-25 US US13/035,904 patent/US9327137B2/en active Active
- 2011-02-25 SI SI201131495T patent/SI2538972T1/en unknown
- 2011-02-25 DK DK11707047.4T patent/DK2538972T3/en active
- 2011-02-25 RU RU2012140741/10A patent/RU2567337C2/ru active
- 2011-02-25 CN CN2011800165009A patent/CN102971010A/zh active Pending
- 2011-02-25 KR KR1020127025110A patent/KR20130036209A/ko active Search and Examination
- 2011-02-25 BR BR112012021545-0A patent/BR112012021545B1/pt not_active IP Right Cessation
- 2011-02-25 PL PL11707047T patent/PL2538972T3/pl unknown
- 2011-02-25 HU HUE11707047A patent/HUE039735T2/hu unknown
- 2011-02-25 WO PCT/US2011/026378 patent/WO2011106743A1/en active Application Filing
- 2011-02-25 AR ARP110100587A patent/AR080313A1/es active IP Right Grant
- 2011-02-25 JP JP2012555204A patent/JP5898632B2/ja active Active
- 2011-02-25 PT PT117070474T patent/PT2538972T/pt unknown
- 2011-02-25 AU AU2011220410A patent/AU2011220410B9/en not_active Ceased
- 2011-02-25 ES ES11707047T patent/ES2676542T3/es active Active
- 2011-02-25 LT LTEP11707047.4T patent/LT2538972T/lt unknown
- 2011-02-25 CA CA2791787A patent/CA2791787C/en active Active
- 2011-02-25 NZ NZ602077A patent/NZ602077A/en not_active IP Right Cessation
- 2011-02-25 RS RS20180845A patent/RS57759B1/sr unknown
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2012
- 2012-08-17 ZA ZA2012/06209A patent/ZA201206209B/en unknown
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2016
- 2016-03-29 US US15/084,108 patent/US10076566B2/en active Active
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2018
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US20160199483A1 (en) | 2016-07-14 |
NZ602077A (en) | 2014-08-29 |
JP2013521234A (ja) | 2013-06-10 |
LT2538972T (lt) | 2018-07-25 |
BR112012021545A2 (pt) | 2018-09-04 |
RU2012140741A (ru) | 2014-04-10 |
US10076566B2 (en) | 2018-09-18 |
AU2011220410B9 (en) | 2015-07-30 |
WO2011106743A1 (en) | 2011-09-01 |
KR20130036209A (ko) | 2013-04-11 |
CA2791787C (en) | 2019-03-26 |
CA2791787A1 (en) | 2011-09-01 |
DK2538972T3 (en) | 2018-07-30 |
RS57759B1 (sr) | 2018-12-31 |
CN102971010A (zh) | 2013-03-13 |
EP2538972B1 (en) | 2018-04-25 |
US20110236419A1 (en) | 2011-09-29 |
AU2011220410A1 (en) | 2012-09-20 |
HUE039735T2 (hu) | 2019-01-28 |
SI2538972T1 (en) | 2018-07-31 |
CY1120430T1 (el) | 2019-07-10 |
US9327137B2 (en) | 2016-05-03 |
RU2567337C2 (ru) | 2015-11-10 |
HRP20181188T1 (hr) | 2018-10-05 |
JP5898632B2 (ja) | 2016-04-06 |
AR080313A1 (es) | 2012-03-28 |
AU2011220410B2 (en) | 2015-04-02 |
BR112012021545B1 (pt) | 2020-11-03 |
ZA201206209B (en) | 2013-06-26 |
EP2538972A1 (en) | 2013-01-02 |
PT2538972T (pt) | 2018-07-30 |
PL2538972T3 (pl) | 2018-09-28 |
US20130197612A1 (en) | 2013-08-01 |
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