ES2415166T3 - Polímorfos de sales de Donepezilo, métodos de preparación y usos de los mismos - Google Patents
Polímorfos de sales de Donepezilo, métodos de preparación y usos de los mismos Download PDFInfo
- Publication number
- ES2415166T3 ES2415166T3 ES08800639T ES08800639T ES2415166T3 ES 2415166 T3 ES2415166 T3 ES 2415166T3 ES 08800639 T ES08800639 T ES 08800639T ES 08800639 T ES08800639 T ES 08800639T ES 2415166 T3 ES2415166 T3 ES 2415166T3
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- Prior art keywords
- donepezil
- compound
- formula
- solution
- polymorph
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- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229910017604 nitric acid Inorganic materials 0.000 claims abstract description 30
- 229960003530 donepezil Drugs 0.000 claims description 498
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710061212 | 2007-09-28 | ||
| CN200710061212 | 2007-09-28 | ||
| CN200810052067 | 2008-01-15 | ||
| CN200810052067 | 2008-01-15 | ||
| PCT/CN2008/001646 WO2009049479A1 (en) | 2007-09-28 | 2008-09-24 | Polymorphs of donepezil salts, preparation methods and uses thereof |
| CN200810211731 | 2008-09-24 | ||
| CN2008102117315A CN101397270B (zh) | 2007-09-28 | 2008-09-24 | 多奈哌齐盐的多晶型物及其制备和应用 |
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| ES2415166T3 true ES2415166T3 (es) | 2013-07-24 |
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| ES08800639T Active ES2415166T3 (es) | 2007-09-28 | 2008-09-24 | Polímorfos de sales de Donepezilo, métodos de preparación y usos de los mismos |
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| Country | Link |
|---|---|
| US (2) | US8501779B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2204364B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5426554B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101397270B (cg-RX-API-DMAC7.html) |
| DK (1) | DK2204364T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2415166T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009049479A1 (cg-RX-API-DMAC7.html) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007108011A2 (en) * | 2006-03-20 | 2007-09-27 | Ind-Swift Laboratories Limited | Process for the preparation of highly pure donepezil |
| JP5563841B2 (ja) * | 2010-02-05 | 2014-07-30 | 沢井製薬株式会社 | 薬物の不快な味をマスキングした経口医薬組成物 |
| GB201411802D0 (en) * | 2014-07-02 | 2014-08-13 | Univ Bradford | Effervescent compositions |
| CN104958254A (zh) * | 2015-06-27 | 2015-10-07 | 万特制药(海南)有限公司 | 一种盐酸多奈哌齐口服溶液及其制备方法 |
| EP3888636A4 (en) * | 2018-11-26 | 2022-08-17 | Ebabio Inc. | EUTECTIC MIXTURE OF DONEPEZIL AND ITS USE |
| KR102318249B1 (ko) * | 2018-11-26 | 2021-10-27 | 에바바이오 주식회사 | 도네페질 이온성 액체 및 이의 용도 |
| US20230054895A1 (en) * | 2020-01-10 | 2023-02-23 | President And Fellows Of Harvard College | Methods for inducing biostasis in a cell, tissue or organ |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| RU2190603C2 (ru) * | 1996-06-07 | 2002-10-10 | Эйсай Ко., Лтд. | Полиморфные модификации донепезила гидрохлорида, способы их получения и способ лечения заболевания, сопровождающегося активностью ацетилхолинэстеразы |
| JPH1053576A (ja) * | 1996-06-07 | 1998-02-24 | Eisai Co Ltd | 塩酸ドネペジルの多形結晶およびその製造法 |
| US7439365B2 (en) | 2003-11-17 | 2008-10-21 | Usv, Ltd. | Pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (Donepezil) |
| US20050288330A1 (en) * | 2004-06-29 | 2005-12-29 | Avinash Naidu | Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) |
| HUP0401850A3 (en) * | 2004-09-15 | 2008-03-28 | Egis Gyogyszergyar Nyilvanosan | Donepezil salts for producing pharmaceutical composition |
| DE102004046497A1 (de) * | 2004-09-23 | 2006-04-06 | Helm Ag | Donepezil-Salze |
| KR20070083679A (ko) * | 2004-09-29 | 2007-08-24 | 케마지스 리미티드 | 약학적으로 순수한 비정질 도네페닐 염산염의 제조를 위한정제된 도네페질 말레산염의 용도 |
| CN1759836A (zh) * | 2004-10-12 | 2006-04-19 | 天津和美生物技术有限公司 | 多奈哌齐及其衍生物的舌下含片 |
| US20090171094A1 (en) * | 2005-07-15 | 2009-07-02 | Kazuhide Ashizawa | 1-benzyl-4-[(5, 6-dimethoxy- 1- indanon)- 2- yl]-methyl piperidine p-toluenesulfonate or crystal thereof |
| HU227474B1 (en) * | 2005-12-20 | 2011-07-28 | Richter Gedeon Nyrt | Process for industrial scale production of high purity donepezil hydrochloride polymorph i. |
-
2008
- 2008-09-24 EP EP08800639A patent/EP2204364B1/en not_active Not-in-force
- 2008-09-24 CN CN2008102117315A patent/CN101397270B/zh active Active
- 2008-09-24 JP JP2010526129A patent/JP5426554B2/ja not_active Expired - Fee Related
- 2008-09-24 WO PCT/CN2008/001646 patent/WO2009049479A1/zh not_active Ceased
- 2008-09-24 DK DK08800639.0T patent/DK2204364T3/da active
- 2008-09-24 CN CN2012100165448A patent/CN102603612A/zh active Pending
- 2008-09-24 ES ES08800639T patent/ES2415166T3/es active Active
-
2010
- 2010-03-26 US US12/748,248 patent/US8501779B2/en not_active Expired - Fee Related
-
2013
- 2013-07-05 US US13/935,927 patent/US20130296283A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20130296283A1 (en) | 2013-11-07 |
| WO2009049479A1 (en) | 2009-04-23 |
| CN101397270B (zh) | 2012-03-28 |
| JP2010540470A (ja) | 2010-12-24 |
| DK2204364T3 (da) | 2013-06-03 |
| JP5426554B2 (ja) | 2014-02-26 |
| CN101397270A (zh) | 2009-04-01 |
| CN102603612A (zh) | 2012-07-25 |
| US8501779B2 (en) | 2013-08-06 |
| EP2204364A4 (en) | 2011-08-10 |
| US20100311793A1 (en) | 2010-12-09 |
| EP2204364A1 (en) | 2010-07-07 |
| EP2204364B1 (en) | 2013-03-20 |
| HK1146047A1 (en) | 2011-05-13 |
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