ES2408932T3 - Síntesis y uso de agentes antibacterianos heterocíclicos - Google Patents
Síntesis y uso de agentes antibacterianos heterocíclicos Download PDFInfo
- Publication number
- ES2408932T3 ES2408932T3 ES09770902T ES09770902T ES2408932T3 ES 2408932 T3 ES2408932 T3 ES 2408932T3 ES 09770902 T ES09770902 T ES 09770902T ES 09770902 T ES09770902 T ES 09770902T ES 2408932 T3 ES2408932 T3 ES 2408932T3
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- compound
- substituted
- formula
- ethynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7538308P | 2008-06-25 | 2008-06-25 | |
| US75383 | 2008-06-25 | ||
| PCT/US2009/048368 WO2009158369A1 (en) | 2008-06-25 | 2009-06-24 | Synthesis and use of heterocyclic antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2408932T3 true ES2408932T3 (es) | 2013-06-24 |
Family
ID=41059643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09770902T Active ES2408932T3 (es) | 2008-06-25 | 2009-06-24 | Síntesis y uso de agentes antibacterianos heterocíclicos |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110212078A1 (OSRAM) |
| EP (1) | EP2307365B1 (OSRAM) |
| JP (1) | JP2011525927A (OSRAM) |
| CA (1) | CA2728210A1 (OSRAM) |
| ES (1) | ES2408932T3 (OSRAM) |
| WO (1) | WO2009158369A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101765585B (zh) | 2007-06-12 | 2017-03-15 | 尔察祯有限公司 | 抗菌剂 |
| US9738604B2 (en) | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
| EP2847168A1 (en) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| AU2014306451B2 (en) | 2013-08-16 | 2019-01-17 | Duke University | Substituted hydroxamic acid compounds |
| WO2015024021A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Antibacterial compounds |
| US9908851B2 (en) | 2013-08-16 | 2018-03-06 | Duke University | 2-piperidinyl substituted N,3-dihydroxybutanamides |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| WO2017030892A1 (en) | 2015-08-14 | 2017-02-23 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
| TW201803847A (zh) | 2016-06-23 | 2018-02-01 | 美商爾察禎有限公司 | 抗菌劑 |
| GB2562777A (en) * | 2017-05-25 | 2018-11-28 | Taisho Pharmaceutical Co Ltd | Novel alpha-amino amide derivatives |
| AR113299A1 (es) | 2017-06-02 | 2020-04-08 | Hoffmann La Roche | Compuestos de isoindolina |
| ES2927480T3 (es) * | 2017-06-02 | 2022-11-07 | Hoffmann La Roche | Compuestos de isoindolina-acetileno para el tratamiento del cáncer |
| EP3814351A1 (en) | 2018-06-29 | 2021-05-05 | F. Hoffmann-La Roche AG | Compounds |
| MX2021015889A (es) | 2019-06-21 | 2022-02-03 | Hoffmann La Roche | Nuevos inhibidores de egfr. |
| WO2020254572A1 (en) | 2019-06-21 | 2020-12-24 | F. Hoffmann-La Roche Ag | Egfr inhibitors for the treatment of cancer |
| CN110498783A (zh) * | 2019-08-02 | 2019-11-26 | 成都蓝蜻蜓生物技术有限公司 | 一种合成罗沙司他中间体的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925659A (en) | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
| WO1999041246A1 (en) | 1998-02-11 | 1999-08-19 | Du Pont Pharmaceuticals Company | Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors |
| KR20010040939A (ko) * | 1998-02-12 | 2001-05-15 | 몰레큐메틱스 리미티드 | β-시트 미메틱 및 이의 사용과 관련된 방법 |
| JP4020290B2 (ja) * | 2000-09-14 | 2007-12-12 | 独立行政法人科学技術振興機構 | 光学活性ヒドロキサム酸 |
| DE10227464A1 (de) | 2002-06-20 | 2004-01-08 | Technische Universität Braunschweig | Glaszusammensetzung zur Herstellung von optischen Übertragungselementen |
| CA2512582C (en) | 2003-01-08 | 2014-07-08 | University Of Washington | Antibacterial agents |
| US7553864B2 (en) | 2005-12-01 | 2009-06-30 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| CA2661605A1 (en) * | 2006-08-31 | 2008-03-06 | Schering Corporation | Hydantoin derivatives useful as antibacterial agents |
| CN101765585B (zh) * | 2007-06-12 | 2017-03-15 | 尔察祯有限公司 | 抗菌剂 |
-
2009
- 2009-06-24 EP EP09770902A patent/EP2307365B1/en not_active Not-in-force
- 2009-06-24 JP JP2011516551A patent/JP2011525927A/ja active Pending
- 2009-06-24 CA CA2728210A patent/CA2728210A1/en not_active Abandoned
- 2009-06-24 ES ES09770902T patent/ES2408932T3/es active Active
- 2009-06-24 WO PCT/US2009/048368 patent/WO2009158369A1/en not_active Ceased
- 2009-06-24 US US13/000,428 patent/US20110212078A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2728210A1 (en) | 2009-12-30 |
| EP2307365A1 (en) | 2011-04-13 |
| JP2011525927A (ja) | 2011-09-29 |
| US20110212078A1 (en) | 2011-09-01 |
| WO2009158369A1 (en) | 2009-12-30 |
| EP2307365B1 (en) | 2013-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2408932T3 (es) | Síntesis y uso de agentes antibacterianos heterocíclicos | |
| EP2057127B1 (en) | Hydantoin derivatives useful as antibacterial agents | |
| US20110212080A1 (en) | Urea derivatives as antibacterial agents | |
| EP0303697B1 (en) | Derivatives of physiologically active substance k-252 | |
| RU2536865C2 (ru) | Производные тиофена | |
| ES2359467T3 (es) | Compuestos útiles como inhibidores de proteína quinasas. | |
| PT931063E (pt) | Indol-3-glioxilamidas n-substituídas com efeito anti-asmático, anti-alérgico e imunossupressor/imunomodulador | |
| CN110770242B (zh) | 作为vanin抑制剂的杂芳族化合物 | |
| WO2007064732A1 (en) | Compounds for the treatment of inflammatory disorders and microbial diseases | |
| ES2881681T3 (es) | 3,4-Dihidro-1H-[1,8]naftiridinonas sustituidas con piperidinilo antibacterianas | |
| BRPI0719861A2 (pt) | Compostos heteroaromáticos bicíclicos | |
| KR20030083755A (ko) | 동통 치료를 위한 바닐로이드 수용체 길항제로서의 용도를위한 융합 피리딘 유도체 | |
| ES2776145T3 (es) | 3,4-Dihidro-1h-[1,8]naftiridinonas sustituidas con homopiperidinilo antibacterianas | |
| JP6434528B2 (ja) | 置換ピリドン及びピラジノン、並びに好中球エラスターゼ活性の阻害剤としてのその使用 | |
| ES2303532T3 (es) | Nuevos derivados de indol y su uso como medicamentos. | |
| CN103242210B (zh) | 含有取代方酸的乙酸妙林酯及其应用 | |
| US5574039A (en) | Antiproliferative compounds having nitrogen-containing tricyclic ring systems and phenyl substituents | |
| WO2018041260A1 (zh) | 一类溴结构域识别蛋白抑制剂及其制备方法和用途 | |
| KR20100132553A (ko) | 신규한 ｎ-(2-아미노-페닐)-아크릴아미드 | |
| ES2251234T3 (es) | Nuevos derivados de pirimidina y proceso para su preparacion. | |
| ES2981840T3 (es) | Derivados de isoquinolina para su uso en el tratamiento del síndrome de deficiencia de GLUT1 | |
| PT2094653E (pt) | Derivados de o-substituído-dibenzilureia como antagonistas do receptor trpv1 | |
| JP2018517720A (ja) | 新規ホスホジエステラーゼ５阻害剤とその使用 | |
| CS214797B2 (cs) | Způsob výroby nových derivátů 4-amino-2-piperidinochinazolinu | |
| JPH0812672A (ja) | チアジアジノン誘導体 |