ES2397962T5 - Carbamoil-ciclohexanos para el tratamiento de la manía aguda - Google Patents
Carbamoil-ciclohexanos para el tratamiento de la manía aguda Download PDFInfo
- Publication number
- ES2397962T5 ES2397962T5 ES08762655.2T ES08762655T ES2397962T5 ES 2397962 T5 ES2397962 T5 ES 2397962T5 ES 08762655 T ES08762655 T ES 08762655T ES 2397962 T5 ES2397962 T5 ES 2397962T5
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- patients
- day
- piperazin
- dichlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000011282 treatment Methods 0.000 title description 12
- 206010026749 Mania Diseases 0.000 title description 8
- PNZXMIKHJXIPEK-UHFFFAOYSA-N cyclohexanecarboxamide Chemical class NC(=O)C1CCCCC1 PNZXMIKHJXIPEK-UHFFFAOYSA-N 0.000 title description 3
- 239000002775 capsule Substances 0.000 description 13
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 5
- -1 2,3-dichlorophenyl Chemical group 0.000 description 4
- 208000020925 Bipolar disease Diseases 0.000 description 4
- 101150049660 DRD2 gene Proteins 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 239000000902 placebo Substances 0.000 description 4
- 229940068196 placebo Drugs 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- PZWXYRDNQYUIIU-UHFFFAOYSA-N 3-cyclohexyl-1,1-dimethylurea Chemical compound CN(C)C(=O)NC1CCCCC1 PZWXYRDNQYUIIU-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000027776 Extrapyramidal disease Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000003001 depressive effect Effects 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 230000003291 dopaminomimetic effect Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 230000002746 orthostatic effect Effects 0.000 description 2
- 239000002464 receptor antagonist Substances 0.000 description 2
- 229940044551 receptor antagonist Drugs 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- CTOLFPPLHXBOTO-UHFFFAOYSA-N 3-cyclohexyl-1,1-dimethylurea;hydrochloride Chemical compound Cl.CN(C)C(=O)NC1CCCCC1 CTOLFPPLHXBOTO-UHFFFAOYSA-N 0.000 description 1
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 description 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 description 1
- 102100024959 5-hydroxytryptamine receptor 2C Human genes 0.000 description 1
- 101710138093 5-hydroxytryptamine receptor 2C Proteins 0.000 description 1
- 108060003345 Adrenergic Receptor Proteins 0.000 description 1
- 102000017910 Adrenergic receptor Human genes 0.000 description 1
- 206010054089 Depressive symptom Diseases 0.000 description 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 description 1
- 101150097070 Drd3 gene Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000000543 Histamine Receptors Human genes 0.000 description 1
- 102000016979 Other receptors Human genes 0.000 description 1
- 102000003946 Prolactin Human genes 0.000 description 1
- 108010057464 Prolactin Proteins 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000028683 bipolar I disease Diseases 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- GPPJWWMREQHLQT-BHQIMSFRSA-N cariprazine hydrochloride Chemical compound Cl.C1C[C@@H](NC(=O)N(C)C)CC[C@@H]1CCN1CCN(C=2C(=C(Cl)C=CC=2)Cl)CC1 GPPJWWMREQHLQT-BHQIMSFRSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229940124301 concurrent medication Drugs 0.000 description 1
- JMMKXVYQBRGGJF-UHFFFAOYSA-N cyclohexanecarbothioamide Chemical class NC(=S)C1CCCCC1 JMMKXVYQBRGGJF-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 125000004188 dichlorophenyl group Chemical group 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000002197 limbic effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 239000004031 partial agonist Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000003518 presynaptic effect Effects 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0700370 | 2007-05-24 | ||
| HU0700370A HUP0700370A2 (en) | 2007-05-24 | 2007-05-24 | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania |
| PCT/HU2008/000052 WO2008142463A2 (en) | 2007-05-24 | 2008-05-19 | Carbamoyl-cyclohexanes for treating acute mania |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2397962T3 ES2397962T3 (es) | 2013-03-12 |
| ES2397962T5 true ES2397962T5 (es) | 2016-01-08 |
Family
ID=89987541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08762655.2T Active ES2397962T5 (es) | 2007-05-24 | 2008-05-19 | Carbamoil-ciclohexanos para el tratamiento de la manía aguda |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20100197704A1 (OSRAM) |
| EP (1) | EP2164572B2 (OSRAM) |
| JP (1) | JP2010527985A (OSRAM) |
| KR (1) | KR20150076266A (OSRAM) |
| CN (2) | CN105193807A (OSRAM) |
| AU (1) | AU2008252621B2 (OSRAM) |
| CA (1) | CA2687528C (OSRAM) |
| CY (1) | CY1113566T1 (OSRAM) |
| DK (1) | DK2164572T4 (OSRAM) |
| EA (1) | EA021936B1 (OSRAM) |
| ES (1) | ES2397962T5 (OSRAM) |
| GE (1) | GEP20135731B (OSRAM) |
| HR (1) | HRP20130092T4 (OSRAM) |
| HU (1) | HUP0700370A2 (OSRAM) |
| IL (1) | IL202048A (OSRAM) |
| MX (1) | MX2009012752A (OSRAM) |
| MY (1) | MY148955A (OSRAM) |
| NZ (1) | NZ582284A (OSRAM) |
| PL (1) | PL2164572T5 (OSRAM) |
| PT (1) | PT2164572E (OSRAM) |
| RS (1) | RS52613B2 (OSRAM) |
| SI (1) | SI2164572T2 (OSRAM) |
| TW (1) | TWI428130B (OSRAM) |
| UA (1) | UA101323C2 (OSRAM) |
| WO (1) | WO2008142463A2 (OSRAM) |
| ZA (1) | ZA200908283B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0700353A2 (en) * | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| US7875610B2 (en) * | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| EP2251011B1 (en) * | 2008-02-21 | 2012-04-04 | Richter Gedeon Nyrt. | Solid preparation for oral administration |
| SI2317852T1 (sl) | 2008-07-16 | 2015-04-30 | Richter Gedeon Nyrt. | Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja |
| HU230067B1 (hu) | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| US9610274B2 (en) * | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| US8912197B2 (en) | 2012-08-20 | 2014-12-16 | Forest Laboratories Holdings Ltd. | Crystalline form of carbamoyl-cyclohexane derivatives |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS50680B (sr) * | 2001-02-27 | 2010-06-30 | Ortho-Mcneil Pharmaceutical Inc. | Karbamatna jedinjenja za upotrebu u sprečavanju i lečenju bipolarnih poremećaja |
| HU227534B1 (en) * | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| CA2756796C (en) * | 2007-05-11 | 2018-05-22 | Forest Laboratories Holdings Limited | Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives |
-
2007
- 2007-05-24 HU HU0700370A patent/HUP0700370A2/hu unknown
-
2008
- 2008-05-19 CN CN201510549993.2A patent/CN105193807A/zh active Pending
- 2008-05-19 WO PCT/HU2008/000052 patent/WO2008142463A2/en not_active Ceased
- 2008-05-19 US US12/601,776 patent/US20100197704A1/en not_active Abandoned
- 2008-05-19 SI SI200830879T patent/SI2164572T2/sl unknown
- 2008-05-19 EA EA200971087A patent/EA021936B1/ru unknown
- 2008-05-19 ES ES08762655.2T patent/ES2397962T5/es active Active
- 2008-05-19 CA CA2687528A patent/CA2687528C/en not_active Expired - Fee Related
- 2008-05-19 RS RS20130009A patent/RS52613B2/sr unknown
- 2008-05-19 CN CN200880017360A patent/CN101678212A/zh active Pending
- 2008-05-19 PT PT87626552T patent/PT2164572E/pt unknown
- 2008-05-19 EP EP08762655.2A patent/EP2164572B2/en active Active
- 2008-05-19 MY MYPI20094808A patent/MY148955A/en unknown
- 2008-05-19 UA UAA200913520A patent/UA101323C2/ru unknown
- 2008-05-19 NZ NZ582284A patent/NZ582284A/xx unknown
- 2008-05-19 PL PL08762655T patent/PL2164572T5/pl unknown
- 2008-05-19 AU AU2008252621A patent/AU2008252621B2/en active Active
- 2008-05-19 HR HRP20130092TT patent/HRP20130092T4/hr unknown
- 2008-05-19 GE GEAP200811619A patent/GEP20135731B/en unknown
- 2008-05-19 MX MX2009012752A patent/MX2009012752A/es active IP Right Grant
- 2008-05-19 DK DK08762655.2T patent/DK2164572T4/en active
- 2008-05-19 JP JP2010508913A patent/JP2010527985A/ja active Pending
- 2008-05-19 KR KR1020157016650A patent/KR20150076266A/ko not_active Ceased
- 2008-07-08 TW TW097125710A patent/TWI428130B/zh active
-
2009
- 2009-11-11 IL IL202048A patent/IL202048A/en active IP Right Grant
- 2009-11-23 ZA ZA200908283A patent/ZA200908283B/xx unknown
-
2013
- 2013-01-25 CY CY20131100073T patent/CY1113566T1/el unknown
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