GEP20135731B - Trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-n,n-dimethyl carbamoyl-cyclohexylamine for acute mania treatment - Google Patents

Trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-n,n-dimethyl carbamoyl-cyclohexylamine for acute mania treatment

Info

Publication number
GEP20135731B
GEP20135731B GEAP200811619A GEAP2008011619A GEP20135731B GE P20135731 B GEP20135731 B GE P20135731B GE AP200811619 A GEAP200811619 A GE AP200811619A GE AP2008011619 A GEAP2008011619 A GE AP2008011619A GE P20135731 B GEP20135731 B GE P20135731B
Authority
GE
Georgia
Prior art keywords
cyclohexylamine
piperazin
dichlorophenyl
trans
ethyl
Prior art date
Application number
GEAP200811619A
Other languages
English (en)
Inventor
Istvan Laszlovszky
Gyoergy Nemeth
Gyoergy Andor
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of GEP20135731B publication Critical patent/GEP20135731B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GEAP200811619A 2007-05-24 2008-05-19 Trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-n,n-dimethyl carbamoyl-cyclohexylamine for acute mania treatment GEP20135731B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0700370A HUP0700370A2 (en) 2007-05-24 2007-05-24 Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania

Publications (1)

Publication Number Publication Date
GEP20135731B true GEP20135731B (en) 2013-01-25

Family

ID=89987541

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP200811619A GEP20135731B (en) 2007-05-24 2008-05-19 Trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-n,n-dimethyl carbamoyl-cyclohexylamine for acute mania treatment

Country Status (26)

Country Link
US (1) US20100197704A1 (OSRAM)
EP (1) EP2164572B2 (OSRAM)
JP (1) JP2010527985A (OSRAM)
KR (1) KR20150076266A (OSRAM)
CN (2) CN101678212A (OSRAM)
AU (1) AU2008252621B2 (OSRAM)
CA (1) CA2687528C (OSRAM)
CY (1) CY1113566T1 (OSRAM)
DK (1) DK2164572T4 (OSRAM)
EA (1) EA021936B1 (OSRAM)
ES (1) ES2397962T5 (OSRAM)
GE (1) GEP20135731B (OSRAM)
HR (1) HRP20130092T4 (OSRAM)
HU (1) HUP0700370A2 (OSRAM)
IL (1) IL202048A (OSRAM)
MX (1) MX2009012752A (OSRAM)
MY (1) MY148955A (OSRAM)
NZ (1) NZ582284A (OSRAM)
PL (1) PL2164572T5 (OSRAM)
PT (1) PT2164572E (OSRAM)
RS (1) RS52613B2 (OSRAM)
SI (1) SI2164572T2 (OSRAM)
TW (1) TWI428130B (OSRAM)
UA (1) UA101323C2 (OSRAM)
WO (1) WO2008142463A2 (OSRAM)
ZA (1) ZA200908283B (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
WO2009104739A1 (ja) * 2008-02-21 2009-08-27 田辺三菱製薬株式会社 経口投与用固形製剤
UA104869C2 (uk) 2008-07-16 2014-03-25 Ріхтер Гедеон Нірт. Фармацевтичні композиції, що містять ліганди рецептора дофаміну
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
US9610274B2 (en) * 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
WO2014031162A1 (en) 2012-08-20 2014-02-27 Forest Laboratories Holdings Limited Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0207832A (pt) * 2001-02-27 2004-06-22 Ortho Mcneil Pharm Inc Compostos de carbamato para uso na prevenção ou tratamento de distúrbio bipolar
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
HUE033357T2 (en) 2007-05-11 2017-11-28 Richter Gedeon Nyrt Crystalline form of carbamoylcyclohexane derivatives

Also Published As

Publication number Publication date
ES2397962T3 (es) 2013-03-12
US20100197704A1 (en) 2010-08-05
HK1136984A1 (en) 2010-07-16
HRP20130092T1 (en) 2013-02-28
HUP0700370A2 (en) 2009-04-28
SI2164572T1 (sl) 2013-02-28
DK2164572T4 (en) 2016-01-04
SI2164572T2 (sl) 2016-01-29
PT2164572E (pt) 2013-01-28
NZ582284A (en) 2012-07-27
EP2164572B1 (en) 2012-11-14
CN105193807A (zh) 2015-12-30
WO2008142463A3 (en) 2009-03-05
HRP20130092T4 (hr) 2016-01-01
RS52613B2 (sr) 2018-05-31
TW201002326A (en) 2010-01-16
IL202048A (en) 2014-11-30
IL202048A0 (en) 2010-06-16
HU0700370D0 (en) 2007-07-30
PL2164572T3 (pl) 2013-04-30
EA021936B1 (ru) 2015-10-30
AU2008252621A1 (en) 2008-11-27
EP2164572A2 (en) 2010-03-24
RS52613B (sr) 2013-04-30
AU2008252621B2 (en) 2013-09-19
CA2687528A1 (en) 2008-11-27
EP2164572B2 (en) 2015-09-16
ZA200908283B (en) 2010-08-25
JP2010527985A (ja) 2010-08-19
DK2164572T3 (da) 2013-02-11
ES2397962T5 (es) 2016-01-08
EA200971087A1 (ru) 2010-04-30
UA101323C2 (en) 2013-03-25
MY148955A (en) 2013-06-14
PL2164572T5 (pl) 2016-02-29
MX2009012752A (es) 2010-03-15
CA2687528C (en) 2016-07-05
KR20150076266A (ko) 2015-07-06
CY1113566T1 (el) 2016-06-22
TWI428130B (zh) 2014-03-01
WO2008142463A2 (en) 2008-11-27
CN101678212A (zh) 2010-03-24

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