ES2395112T3 - Polímeros y copolímeros de ácido poliláctico endurecidos - Google Patents
Polímeros y copolímeros de ácido poliláctico endurecidos Download PDFInfo
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- ES2395112T3 ES2395112T3 ES07763255T ES07763255T ES2395112T3 ES 2395112 T3 ES2395112 T3 ES 2395112T3 ES 07763255 T ES07763255 T ES 07763255T ES 07763255 T ES07763255 T ES 07763255T ES 2395112 T3 ES2395112 T3 ES 2395112T3
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- stents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
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- A61L17/105—Polyesters not covered by A61L17/12
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- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/01—Use of inorganic substances as compounding ingredients characterized by their specific function
- C08K3/014—Stabilisers against oxidation, heat, light or ozone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0016—Plasticisers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/005—Stabilisers against oxidation, heat, light, ozone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0083—Nucleating agents promoting the crystallisation of the polymer matrix
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
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- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
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| US747144P | 2006-05-12 | ||
| PCT/US2007/003100 WO2007092417A1 (en) | 2006-02-07 | 2007-02-06 | Toughened polylactic acid polymers and copolymers |
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Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1617792B1 (de) * | 2003-04-10 | 2009-11-18 | Synthes GmbH | Vorrichtung zur temporären schienung von zehen |
| GB0329654D0 (en) | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| US9452001B2 (en) * | 2005-02-22 | 2016-09-27 | Tecres S.P.A. | Disposable device for treatment of infections of human limbs |
| US8021679B2 (en) | 2005-08-25 | 2011-09-20 | Medtronic Vascular, Inc | Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore |
| BRPI0617325B8 (pt) | 2005-10-13 | 2021-06-22 | Synthes Gmbh | luva biologicamente compatível |
| US9592325B2 (en) | 2006-02-07 | 2017-03-14 | Tepha, Inc. | Polymeric, degradable drug-eluting stents and coatings |
| WO2007092417A1 (en) | 2006-02-07 | 2007-08-16 | Tepha, Inc. | Toughened polylactic acid polymers and copolymers |
| US8979921B2 (en) | 2006-02-07 | 2015-03-17 | Tepha, Inc. | Polymeric, degradable drug-eluting stents and coatings |
| BRPI0600685A (pt) * | 2006-02-24 | 2007-11-20 | Phb Ind Sa | blenda polimérica ambientalmente degradável e seu processo de obtenção |
| US8241619B2 (en) | 2006-05-15 | 2012-08-14 | Medtronic Vascular, Inc. | Hindered amine nitric oxide donating polymers for coating medical devices |
| WO2007140320A2 (en) | 2006-05-26 | 2007-12-06 | Nanyang Technological University | Implantable article, method of forming same and method for reducing thrombogenicity |
| US9089627B2 (en) | 2006-07-11 | 2015-07-28 | Abbott Cardiovascular Systems Inc. | Stent fabricated from polymer composite toughened by a dispersed phase |
| IL177550A0 (en) * | 2006-08-17 | 2006-12-31 | Sialo Technology Israel Ltd | All-in-one optical microscopic handle |
| CN101594831B (zh) | 2006-11-30 | 2011-09-14 | 史密夫和内修有限公司 | 纤维增强的复合材料 |
| US8814930B2 (en) | 2007-01-19 | 2014-08-26 | Elixir Medical Corporation | Biodegradable endoprosthesis and methods for their fabrication |
| NZ588816A (en) | 2007-01-21 | 2011-11-25 | Hemoteq Ag | Medical device for the treatment of stenoses of corporal lumina and for the prevention of impending restenoses |
| US7811600B2 (en) * | 2007-03-08 | 2010-10-12 | Medtronic Vascular, Inc. | Nitric oxide donating medical devices and methods of making same |
| JP5416090B2 (ja) | 2007-04-18 | 2014-02-12 | スミス アンド ネフュー ピーエルシー | 形状記憶ポリマーの膨張成形 |
| AU2008243035B2 (en) | 2007-04-19 | 2013-09-12 | Smith & Nephew, Inc. | Graft fixation |
| JP5520814B2 (ja) | 2007-04-19 | 2014-06-11 | スミス アンド ネフュー インコーポレーテッド | マルチモーダル形状記憶ポリマー |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| US8273828B2 (en) * | 2007-07-24 | 2012-09-25 | Medtronic Vascular, Inc. | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation |
| US20090112259A1 (en) * | 2007-10-31 | 2009-04-30 | Angiotech Pharmaceuticals, Inc. | Recombinant expressed bioadsorbable polyhydroxyalkonate monofilament and multi-filaments self-retaining sutures |
| US20090222088A1 (en) * | 2008-02-29 | 2009-09-03 | Medtronic Vascular, Inc. | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition |
| US20090232863A1 (en) * | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers |
| US20090232868A1 (en) * | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Nitric Oxide Releasing Polymer Composition |
| US10898620B2 (en) | 2008-06-20 | 2021-01-26 | Razmodics Llc | Composite stent having multi-axial flexibility and method of manufacture thereof |
| US8206635B2 (en) * | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
| US8206636B2 (en) | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
| US9216152B2 (en) | 2008-06-27 | 2015-12-22 | Tepha, Inc. | Injectable delivery of microparticles and compositions therefore |
| US8129477B1 (en) * | 2008-08-06 | 2012-03-06 | Medtronic, Inc. | Medical devices and methods including blends of biodegradable polymers |
| US9314999B2 (en) | 2008-08-15 | 2016-04-19 | Toray Plastics (America), Inc. | Biaxially oriented polylactic acid film with high barrier |
| US8158187B2 (en) * | 2008-12-19 | 2012-04-17 | Medtronic Vascular, Inc. | Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices |
| US20100244304A1 (en) * | 2009-03-31 | 2010-09-30 | Yunbing Wang | Stents fabricated from a sheet with increased strength, modulus and fracture toughness |
| US8709465B2 (en) * | 2009-04-13 | 2014-04-29 | Medtronic Vascular, Inc. | Diazeniumdiolated phosphorylcholine polymers for nitric oxide release |
| US9265633B2 (en) | 2009-05-20 | 2016-02-23 | 480 Biomedical, Inc. | Drug-eluting medical implants |
| EP3858299B1 (en) | 2009-05-20 | 2025-10-08 | Lyra Therapeutics, Inc. | Method of loading a self-expanding implant |
| US20110319987A1 (en) | 2009-05-20 | 2011-12-29 | Arsenal Medical | Medical implant |
| US8888840B2 (en) * | 2009-05-20 | 2014-11-18 | Boston Scientific Scimed, Inc. | Drug eluting medical implant |
| US9309347B2 (en) | 2009-05-20 | 2016-04-12 | Biomedical, Inc. | Bioresorbable thermoset polyester/urethane elastomers |
| US8992601B2 (en) | 2009-05-20 | 2015-03-31 | 480 Biomedical, Inc. | Medical implants |
| US9150004B2 (en) * | 2009-06-19 | 2015-10-06 | Toray Plastics (America), Inc. | Biaxially oriented polylactic acid film with improved heat seal properties |
| US20100330382A1 (en) * | 2009-06-26 | 2010-12-30 | Toray Plastics (America), Inc. | Biaxially oriented polylactic acid film with improved moisture barrier |
| US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
| EP2453938B1 (en) | 2009-07-17 | 2015-08-19 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| WO2011031558A2 (en) * | 2009-08-27 | 2011-03-17 | Metabolix, Inc. | Toughened polyhydroxyalkanoate compositions |
| EP2480710B1 (en) | 2009-09-25 | 2018-01-24 | Toray Plastics (America) , Inc. | Multi-layer high moisture barrier polylactic acid film and its method of forming |
| US9221213B2 (en) | 2009-09-25 | 2015-12-29 | Toray Plastics (America), Inc. | Multi-layer high moisture barrier polylactic acid film |
| US8372133B2 (en) | 2009-10-05 | 2013-02-12 | 480 Biomedical, Inc. | Polymeric implant delivery system |
| WO2011123165A1 (en) | 2010-03-31 | 2011-10-06 | Toray Plastics (America), Inc. | Biaxially oriented polyactic acid film with reduced noise level |
| US9492962B2 (en) | 2010-03-31 | 2016-11-15 | Toray Plastics (America), Inc. | Biaxially oriented polylactic acid film with reduced noise level and improved moisture barrier |
| US8981316B2 (en) * | 2010-04-02 | 2015-03-17 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of implantable medical devices |
| EP2425865A1 (en) * | 2010-08-06 | 2012-03-07 | Aesculap AG | Medicinal thread having a polyhydroxyalkanoate coating |
| US10753023B2 (en) | 2010-08-13 | 2020-08-25 | Kimberly-Clark Worldwide, Inc. | Toughened polylactic acid fibers |
| US8936740B2 (en) | 2010-08-13 | 2015-01-20 | Kimberly-Clark Worldwide, Inc. | Modified polylactic acid fibers |
| US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| US8758374B2 (en) | 2010-09-15 | 2014-06-24 | University Of Utah Research Foundation | Method for connecting nerves via a side-to-side epineurial window using artificial conduits |
| ES2644478T3 (es) | 2010-11-09 | 2017-11-29 | Tepha, Inc. | Implantes cocleares liberadores de fármacos |
| WO2012128720A1 (en) * | 2011-03-21 | 2012-09-27 | Nanyang Technological University | A bioabsorbable tracheal stent, and method of manufacturing thereof |
| US8545546B2 (en) | 2011-05-13 | 2013-10-01 | Abbott Cardiovascular Systems Inc. | Bioabsorbable scaffolds made from composites |
| US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| EP3266806A1 (en) * | 2011-09-27 | 2018-01-10 | Tepha, Inc. | A method of making an article comrising poly-4-hydroxybutyrate or a copolymer thereof |
| US9180228B2 (en) | 2011-10-03 | 2015-11-10 | Abbott Cardiovascular Systems Inc. | Rubber toughened bioresorbable polymer peripheral scaffolds |
| US9931121B2 (en) | 2011-10-17 | 2018-04-03 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
| US10842494B2 (en) | 2011-10-17 | 2020-11-24 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
| TWI590843B (zh) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | 膜及其製造方法 |
| US10858762B2 (en) * | 2012-02-10 | 2020-12-08 | Kimberly-Clark Worldwide, Inc. | Renewable polyester fibers having a low density |
| US8975305B2 (en) | 2012-02-10 | 2015-03-10 | Kimberly-Clark Worldwide, Inc. | Rigid renewable polyester compositions having a high impact strength and tensile elongation |
| US8980964B2 (en) | 2012-02-10 | 2015-03-17 | Kimberly-Clark Worldwide, Inc. | Renewable polyester film having a low modulus and high tensile elongation |
| US8637130B2 (en) | 2012-02-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Molded parts containing a polylactic acid composition |
| US9040598B2 (en) | 2012-02-10 | 2015-05-26 | Kimberly-Clark Worldwide, Inc. | Renewable polyester compositions having a low density |
| US9254212B2 (en) | 2012-04-06 | 2016-02-09 | Abbott Cardiovascular Systems Inc. | Segmented scaffolds and delivery thereof for peripheral applications |
| EP3238751B1 (en) * | 2012-05-21 | 2020-07-08 | Tepha, Inc. | Resorbable bioceramic compositions of poly-4-hydroxybutyrate and copolymers |
| US9475930B2 (en) | 2012-08-17 | 2016-10-25 | Metabolix, Inc. | Biobased rubber modifiers for polymer blends |
| KR20150120982A (ko) * | 2013-02-18 | 2015-10-28 | 유.에스. 퍼시픽 논우븐스 인더스트리 리미티드 | 분해성 재생 재료 |
| US10201640B2 (en) | 2013-03-13 | 2019-02-12 | Tepha, Inc. | Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof |
| US9290612B2 (en) | 2013-03-13 | 2016-03-22 | Tepha, Inc. | Compositions and devices of poly-4-hydroxybutyrate |
| WO2014186435A2 (en) | 2013-05-14 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for reducing neointima formation |
| WO2014194220A1 (en) | 2013-05-30 | 2014-12-04 | Metabolix, Inc. | Recyclate blends |
| KR102249720B1 (ko) | 2013-06-21 | 2021-05-11 | 디퍼이 신테스 프로덕츠, 인코포레이티드 | 필름 및 제조 방법 |
| US9717609B2 (en) | 2013-08-01 | 2017-08-01 | Abbott Cardiovascular Systems Inc. | Variable stiffness stent |
| WO2015026964A1 (en) | 2013-08-20 | 2015-02-26 | Tepha, Inc. | Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof |
| US9687585B2 (en) | 2013-08-20 | 2017-06-27 | Tepha, Inc. | Thermoformed poly-4-hydroxybutyrate medical implants |
| US9302029B2 (en) * | 2013-10-31 | 2016-04-05 | Tepha, Inc. | Pultrusion of poly-4-hydroxybutyrate and copolymers thereof |
| US9480780B2 (en) | 2013-11-05 | 2016-11-01 | Tepha, Inc. | Compositions and devices of poly-4-hydroxybutyrate |
| WO2015067817A1 (en) | 2013-11-11 | 2015-05-14 | Styrolution Group Gmbh | Blends of styrene butadiene copolymers with poly(lactic acid) |
| EP3086820B1 (en) | 2013-12-26 | 2020-10-28 | Tepha, Inc. | Medical implants including laminates of poly-4-hydroxybutyrate and copolymers thereof |
| US9457127B2 (en) | 2014-03-18 | 2016-10-04 | Tepha, Inc. | Micro-fiber webs of poly-4-hydroxybutyrate and copolymers thereof produced by centrifugal spinning |
| US10611903B2 (en) | 2014-03-27 | 2020-04-07 | Cj Cheiljedang Corporation | Highly filled polymer systems |
| EP3137015B1 (en) | 2014-04-30 | 2022-01-26 | Tepha, Inc. | Three-dimensional resorbable implants for tissue reinforcement and hernia repair |
| EP3180040B1 (en) | 2014-08-15 | 2020-05-13 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
| US9259339B1 (en) | 2014-08-15 | 2016-02-16 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9730819B2 (en) | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9855156B2 (en) * | 2014-08-15 | 2018-01-02 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9480588B2 (en) | 2014-08-15 | 2016-11-01 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| EP3183012B1 (en) | 2014-08-20 | 2017-12-20 | Tepha, Inc. | Thermoformed poly-4-hydroxybutyrate medical implants |
| EP3197512B1 (en) | 2014-09-22 | 2020-05-06 | Tepha, Inc. | Oriented p4hb implants containing antimicrobial agents |
| US9555155B2 (en) | 2014-12-11 | 2017-01-31 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
| US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
| ES2855006T3 (es) | 2015-04-01 | 2021-09-23 | Univ Yale | Partículas de hierro y platino para la adherencia de productos biológicos en implantes médicos |
| EP4233873A3 (en) | 2015-06-29 | 2023-10-18 | Lyra Therapeutics, Inc. | Implantable scaffolds for treatment of sinusitis |
| US10232082B2 (en) | 2015-06-29 | 2019-03-19 | 480 Biomedical, Inc. | Implantable scaffolds for treatment of sinusitis |
| ES2873887T3 (es) | 2016-05-16 | 2021-11-04 | Elixir Medical Corp | Liberación de stent |
| US11622872B2 (en) | 2016-05-16 | 2023-04-11 | Elixir Medical Corporation | Uncaging stent |
| BR112019002171B1 (pt) | 2016-08-02 | 2023-01-17 | Fitesa Simpsonville, Inc. | Sistema e processo para preparar um tecido não tecido de ácido poliláctico (pla) por fiação contínua |
| US11441251B2 (en) | 2016-08-16 | 2022-09-13 | Fitesa Germany Gmbh | Nonwoven fabrics comprising polylactic acid having improved strength and toughness |
| WO2018170132A1 (en) | 2017-03-14 | 2018-09-20 | University Of Connecticut | Biodegradable pressure sensor |
| WO2018217574A1 (en) | 2017-05-25 | 2018-11-29 | Tepha, Inc. | Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof |
| WO2019050936A1 (en) | 2017-09-06 | 2019-03-14 | Tepha, Inc. | CALANDERATED SURGICAL TRELLIS COMPRISING POLYHYDROXYALKANOATES |
| US12402885B2 (en) | 2017-09-23 | 2025-09-02 | Universität Zürich | Medical occlusion device |
| EP3459469A1 (en) | 2017-09-23 | 2019-03-27 | Universität Zürich | Medical occluder device |
| ES2916298T3 (es) | 2017-12-04 | 2022-06-29 | Tepha Inc | Implantes médicos de poli-4-hidroxibutirato termoformado con membrana al vacío |
| CA3102277C (en) | 2018-06-11 | 2024-11-12 | Tepha Inc | PROCESSES FOR 3D PRINTING POLY-4-HYDROXYBUTYRATE AND COPOLYMERS |
| ES2956815T3 (es) | 2018-10-29 | 2023-12-28 | Tepha Inc | Procedimientos de fabricación de suturas de malla a partir de poli-4-hidroxibutirato y sus copolímeros |
| US11826495B2 (en) | 2019-03-01 | 2023-11-28 | University Of Connecticut | Biodegradable piezoelectric ultrasonic transducer system |
| MX2021014269A (es) | 2019-05-20 | 2022-05-10 | New Wincup Holdings Inc | Aparatos y metodos para fabricar pajillas o popotes para bebidas biodegradables, compostables a partir de material de polihidroxialcanoato. |
| US11944315B2 (en) | 2019-09-26 | 2024-04-02 | Universität Zürich | Left atrial appendage occlusion devices |
| WO2021183626A1 (en) | 2020-03-10 | 2021-09-16 | University Of Connecticut | Therapeutic bandage |
| CN111234490A (zh) * | 2020-03-20 | 2020-06-05 | 珠海麦得发生物科技股份有限公司 | 一种高韧性全降解pha/plla复合材料及其制备方法 |
| DE102020206085B4 (de) * | 2020-05-14 | 2022-08-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Biologisch abbaubare mit Laminin beschichtete Gefäßstützen (Stents) |
| US12491290B2 (en) | 2020-06-08 | 2025-12-09 | University Of Connecticut | Biodegradable piezoelectric composite materials |
| WO2022192168A1 (en) | 2021-03-11 | 2022-09-15 | Tepha, Inc. | Breast reconstruction implant |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3728839A (en) * | 1971-04-29 | 1973-04-24 | American Cyanamid Co | Storage stable surgically absorbable polyglycolic acid products |
| US5527337A (en) * | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
| US5059211A (en) * | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
| JP2561853B2 (ja) * | 1988-01-28 | 1996-12-11 | 株式会社ジェイ・エム・エス | 形状記憶性を有する成形体及びその使用方法 |
| CA2082410C (en) * | 1991-03-08 | 2003-09-23 | Hideo Tamai | Luminal stent, holding structure therefor and device for attaching luminal stent |
| US5939467A (en) * | 1992-06-26 | 1999-08-17 | The Procter & Gamble Company | Biodegradable polymeric compositions and products thereof |
| US5384030A (en) * | 1994-02-15 | 1995-01-24 | General Motors Corporation | Exhaust sensor including a composite tile sensing element and methods of making the same |
| US5629077A (en) * | 1994-06-27 | 1997-05-13 | Advanced Cardiovascular Systems, Inc. | Biodegradable mesh and film stent |
| US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
| DE69615763T2 (de) * | 1995-07-13 | 2002-08-08 | Mitsubishi Gas Chemical Co., Inc. | Polymermischungen aliphatischer Polyester auf Basis von Polylactiden, Verfahren zu deren Herstellung und Verfahren zum Formen diese Mischungen |
| DE19539449A1 (de) * | 1995-10-24 | 1997-04-30 | Biotronik Mess & Therapieg | Verfahren zur Herstellung intraluminaler Stents aus bioresorbierbarem Polymermaterial |
| FR2748422B1 (fr) * | 1996-05-10 | 1998-06-12 | Rollin Sa | Systeme de transfert d'un produit liquide plus ou moins visqueux sur un support, procede de fabrication d'une telle surface et blanchet d'impression offset realise avec cette surface |
| US5670161A (en) * | 1996-05-28 | 1997-09-23 | Healy; Kevin E. | Biodegradable stent |
| US5811272A (en) * | 1996-07-26 | 1998-09-22 | Massachusetts Institute Of Technology | Method for controlling molecular weight of polyhydroxyalkanoates |
| WO1998051812A2 (en) | 1997-05-12 | 1998-11-19 | Metabolix, Inc. | Polyhydroxyalkanoates for in vivo applications |
| US6245103B1 (en) * | 1997-08-01 | 2001-06-12 | Schneider (Usa) Inc | Bioabsorbable self-expanding stent |
| ATE323152T1 (de) * | 1997-09-19 | 2006-04-15 | Metabolix Inc | Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten |
| AU751610B2 (en) | 1997-12-22 | 2002-08-22 | Tepha, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| MXPA00011401A (es) * | 1998-05-22 | 2003-04-22 | Metabolix Inc | Composiciones de biopolimero de polimero de polihidroxialcanoato. |
| DK1163019T3 (da) * | 1999-03-25 | 2008-03-03 | Metabolix Inc | Medicinske indretninger og anvendelser af polyhydroxyalkanoatpolymere |
| US6368346B1 (en) * | 1999-06-03 | 2002-04-09 | American Medical Systems, Inc. | Bioresorbable stent |
| ITTO20010061A1 (it) | 2001-01-25 | 2002-07-25 | Novamont Spa | Miscele binarie di poliesteri alifatici biodegradabili e prodotti da queste ottenuti. |
| US6905987B2 (en) * | 2001-03-27 | 2005-06-14 | The Procter & Gamble Company | Fibers comprising polyhydroxyalkanoate copolymer/polylactic acid polymer or copolymer blends |
| US6607548B2 (en) * | 2001-05-17 | 2003-08-19 | Inion Ltd. | Resorbable polymer compositions |
| US20030069629A1 (en) * | 2001-06-01 | 2003-04-10 | Jadhav Balkrishna S. | Bioresorbable medical devices |
| US7011678B2 (en) * | 2002-01-31 | 2006-03-14 | Radi Medical Systems Ab | Biodegradable stent |
| WO2004038030A2 (en) * | 2002-05-10 | 2004-05-06 | Metabolix, Inc. | Bioabsorbable polymer containing 2-hdroxyacid monomers |
| US20040260386A1 (en) * | 2003-01-31 | 2004-12-23 | Shalaby Shalaby W. | Absorbable / biodegradable tubular stent and methods of making the same |
| US7807722B2 (en) * | 2003-11-26 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Biobeneficial coating compositions and methods of making and using thereof |
| US20050137678A1 (en) * | 2003-12-22 | 2005-06-23 | Medtronic Vascular, Inc. | Low profile resorbable stent |
| US20060018948A1 (en) * | 2004-06-24 | 2006-01-26 | Guire Patrick E | Biodegradable implantable medical devices, methods and systems |
| US20060069629A1 (en) * | 2004-09-30 | 2006-03-30 | Michael Schweitzer | Methods and systems for redeploying stock in a distribution network |
| WO2007092417A1 (en) * | 2006-02-07 | 2007-08-16 | Tepha, Inc. | Toughened polylactic acid polymers and copolymers |
-
2007
- 2007-02-06 WO PCT/US2007/003100 patent/WO2007092417A1/en not_active Ceased
- 2007-02-06 ES ES07763255T patent/ES2395112T3/es active Active
- 2007-02-06 EP EP07763255A patent/EP1993621B1/en active Active
- 2007-02-06 AU AU2007212501A patent/AU2007212501B2/en not_active Ceased
- 2007-02-06 WO PCT/US2007/003101 patent/WO2007092418A2/en not_active Ceased
- 2007-02-06 AT AT07763255T patent/ATE520425T1/de not_active IP Right Cessation
- 2007-02-06 ES ES07763697T patent/ES2395076T3/es active Active
- 2007-02-06 JP JP2008554296A patent/JP5508720B2/ja active Active
- 2007-02-06 US US11/671,632 patent/US7618448B2/en active Active
- 2007-02-06 EP EP07763697A patent/EP1991287B1/en not_active Not-in-force
- 2007-02-06 CA CA2640750A patent/CA2640750C/en not_active Expired - Fee Related
- 2007-02-06 US US11/671,544 patent/US20070182041A1/en not_active Abandoned
-
2016
- 2016-08-22 US US15/242,979 patent/US20160355637A1/en not_active Abandoned
- 2016-08-22 US US15/242,993 patent/US20160355677A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007092417A1 (en) | 2007-08-16 |
| WO2007092418A3 (en) | 2008-08-14 |
| EP1991287A2 (en) | 2008-11-19 |
| WO2007092418A2 (en) | 2007-08-16 |
| US20070182041A1 (en) | 2007-08-09 |
| AU2007212501A1 (en) | 2007-08-16 |
| US20070185561A1 (en) | 2007-08-09 |
| EP1993621A1 (en) | 2008-11-26 |
| EP1991287B1 (en) | 2012-07-04 |
| US7618448B2 (en) | 2009-11-17 |
| US20160355637A1 (en) | 2016-12-08 |
| ES2395076T3 (es) | 2013-02-08 |
| AU2007212501B2 (en) | 2011-03-31 |
| JP5508720B2 (ja) | 2014-06-04 |
| CA2640750C (en) | 2013-12-17 |
| JP2009525812A (ja) | 2009-07-16 |
| ATE520425T1 (de) | 2011-09-15 |
| EP1993621B1 (en) | 2011-08-17 |
| US20160355677A1 (en) | 2016-12-08 |
| CA2640750A1 (en) | 2007-08-16 |
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