ES2392247T3 - Compuesto inmunizante y método para inducir una respuesta inmune contra el sitio de escisión de la beta-secretasa de la proteína precursora de amiloide - Google Patents

Compuesto inmunizante y método para inducir una respuesta inmune contra el sitio de escisión de la beta-secretasa de la proteína precursora de amiloide Download PDF

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Publication number
ES2392247T3
ES2392247T3 ES03744143T ES03744143T ES2392247T3 ES 2392247 T3 ES2392247 T3 ES 2392247T3 ES 03744143 T ES03744143 T ES 03744143T ES 03744143 T ES03744143 T ES 03744143T ES 2392247 T3 ES2392247 T3 ES 2392247T3
Authority
ES
Spain
Prior art keywords
secretase
cleavage site
molecule
immunizing
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03744143T
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English (en)
Spanish (es)
Inventor
Beka Solomon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ramot at Tel Aviv University Ltd
Original Assignee
Ramot at Tel Aviv University Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ramot at Tel Aviv University Ltd filed Critical Ramot at Tel Aviv University Ltd
Application granted granted Critical
Publication of ES2392247T3 publication Critical patent/ES2392247T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645—Dendrimers; Multiple antigen peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES03744143T 2002-03-05 2003-03-04 Compuesto inmunizante y método para inducir una respuesta inmune contra el sitio de escisión de la beta-secretasa de la proteína precursora de amiloide Expired - Lifetime ES2392247T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36134402P 2002-03-05 2002-03-05
US361344P 2002-03-05
PCT/US2003/006388 WO2003076455A2 (en) 2002-03-05 2003-03-04 Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein

Publications (1)

Publication Number Publication Date
ES2392247T3 true ES2392247T3 (es) 2012-12-07

Family

ID=27805031

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03744143T Expired - Lifetime ES2392247T3 (es) 2002-03-05 2003-03-04 Compuesto inmunizante y método para inducir una respuesta inmune contra el sitio de escisión de la beta-secretasa de la proteína precursora de amiloide

Country Status (8)

Country Link
US (3) US7494655B2 (https=)
EP (2) EP2292247A3 (https=)
JP (3) JP2005532276A (https=)
AU (1) AU2003225636A1 (https=)
CA (1) CA2477675C (https=)
ES (1) ES2392247T3 (https=)
IL (3) IL163812A0 (https=)
WO (1) WO2003076455A2 (https=)

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Also Published As

Publication number Publication date
IL212752A (en) 2014-01-30
IL163812A (en) 2011-06-30
EP2292247A3 (en) 2011-10-05
EP1480666B1 (en) 2012-06-13
JP2013181034A (ja) 2013-09-12
JP5717210B2 (ja) 2015-05-13
US20070172484A1 (en) 2007-07-26
WO2003076455A2 (en) 2003-09-18
EP1480666A4 (en) 2006-06-07
WO2003076455A3 (en) 2004-04-08
AU2003225636A1 (en) 2003-09-22
US7494655B2 (en) 2009-02-24
CA2477675A1 (en) 2003-09-18
US20060034855A1 (en) 2006-02-16
AU2003225636A8 (en) 2003-09-22
US20110070249A1 (en) 2011-03-24
JP2005532276A (ja) 2005-10-27
EP2292247A2 (en) 2011-03-09
EP1480666A2 (en) 2004-12-01
IL212752A0 (en) 2011-07-31
US8613928B2 (en) 2013-12-24
JP2010248197A (ja) 2010-11-04
CA2477675C (en) 2013-05-21
IL163812A0 (en) 2005-12-18
US7854931B2 (en) 2010-12-21

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