AU2003225636A1 - Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein - Google Patents

Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein

Info

Publication number
AU2003225636A1
AU2003225636A1 AU2003225636A AU2003225636A AU2003225636A1 AU 2003225636 A1 AU2003225636 A1 AU 2003225636A1 AU 2003225636 A AU2003225636 A AU 2003225636A AU 2003225636 A AU2003225636 A AU 2003225636A AU 2003225636 A1 AU2003225636 A1 AU 2003225636A1
Authority
AU
Australia
Prior art keywords
inducing
immune response
cleavage site
response against
precursor protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003225636A
Other languages
English (en)
Other versions
AU2003225636A8 (en
Inventor
Beka Solomon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ramot at Tel Aviv University Ltd
Original Assignee
Ramot at Tel Aviv University Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ramot at Tel Aviv University Ltd filed Critical Ramot at Tel Aviv University Ltd
Publication of AU2003225636A1 publication Critical patent/AU2003225636A1/en
Publication of AU2003225636A8 publication Critical patent/AU2003225636A8/xx
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0007Nervous system antigens; Prions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/64Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645Dendrimers; Multiple antigen peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2003225636A 2002-03-05 2003-03-04 Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein Abandoned AU2003225636A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36134402P 2002-03-05 2002-03-05
US60/361,344 2002-03-05
PCT/US2003/006388 WO2003076455A2 (en) 2002-03-05 2003-03-04 Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein

Publications (2)

Publication Number Publication Date
AU2003225636A1 true AU2003225636A1 (en) 2003-09-22
AU2003225636A8 AU2003225636A8 (en) 2003-09-22

Family

ID=27805031

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003225636A Abandoned AU2003225636A1 (en) 2002-03-05 2003-03-04 Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein

Country Status (8)

Country Link
US (3) US7494655B2 (https=)
EP (2) EP2292247A3 (https=)
JP (3) JP2005532276A (https=)
AU (1) AU2003225636A1 (https=)
CA (1) CA2477675C (https=)
ES (1) ES2392247T3 (https=)
IL (3) IL163812A0 (https=)
WO (1) WO2003076455A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1398019A1 (de) 2002-09-13 2004-03-17 Cognis France S.A. Verfahren zum Schutz und zur Modulation von Dermal Epidermal Junctions
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
WO2005033278A2 (en) * 2003-09-30 2005-04-14 Ludwig Institute For Cancer Research In vivo efficacy of ny-eso-1 plus iscom
MX2007005053A (es) * 2004-10-28 2007-06-19 Eisai R&D Man Co Ltd Metodo para evaluar la enfermedad de alzheimer y reactivo de diagnostico.
PL1937284T3 (pl) 2005-10-18 2016-05-31 Starpharma Pty Ltd System podawania kompozycji bakteriobójczego dendymeru
ES2625109T3 (es) 2005-10-25 2017-07-18 Starpharma Pty Limited Compuestos macromoleculares que tienen estequiometría controlada
HRP20140240T4 (hr) 2005-11-30 2017-02-24 Abbvie Inc. Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
JP5989294B2 (ja) * 2006-01-20 2016-09-07 スターファーマ・プロプライエタリー・リミテッドStarpharma Pty Ltd 修飾高分子
EP1996209B1 (en) 2006-03-22 2015-11-04 Starpharma Pty Limited Contraceptive composition
AU2007275258A1 (en) * 2006-07-21 2008-01-24 Ramot At Tel Aviv University Ltd. Use of a phage displaying a peptide from an adhesion protein for treating a disease associated with intracellular formation of protein fibrillar inclusions or aggregates
US8420067B2 (en) 2006-08-11 2013-04-16 Starpharma Pty Ltd Targeted polylysine dendrimer therapeutic agent
US8492341B2 (en) 2006-11-28 2013-07-23 Alzyme Pty Ltd. Amyloid-β binding peptides
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
CN101809153B (zh) 2007-09-27 2014-01-01 日本烟草产业株式会社 参与疱疹病毒的潜伏感染的因子及其利用
GB0720912D0 (en) 2007-10-25 2007-12-05 Univ Cardiff Monoclonal Anitbody for APP
KR101397554B1 (ko) * 2007-11-09 2014-05-21 재단법인서울대학교산학협력재단 치매(알츠하이머 병)의 진단, 예방, 치료제 및 이들의스크리닝 방법
US8921523B2 (en) 2007-12-11 2014-12-30 Glaxo Group Limited Humanized anti-beta-amyloid antibodies
WO2009124119A2 (en) * 2008-04-01 2009-10-08 The Trustes of Columbia University in the City of New York Phosphodiesterase inhibitors and uses thereof
WO2009155538A1 (en) * 2008-06-20 2009-12-23 Merck & Co., Inc. Compositions and methods of depleting amyloid-beta peptides from cerebrospinal fluid to treat alzheimer's disease
AR073295A1 (es) 2008-09-16 2010-10-28 Genentech Inc Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion.
NZ592928A (en) * 2008-11-24 2012-12-21 Univ Ramot Method for treating parkinson' s disease using filamentous bacteriophage
JP2012513464A (ja) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク ホスホジエステラーゼ阻害剤及びその使用
WO2011031720A1 (en) * 2009-09-11 2011-03-17 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Bispecific nanobodies as a therapeutic for alzheimer's disease
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
EP3533803B1 (en) 2010-08-14 2021-10-27 AbbVie Inc. Anti-amyloid-beta antibodies
WO2015199247A1 (ja) * 2014-06-27 2015-12-30 日本たばこ産業株式会社 気分障害を診断、治療又は予防する方法
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN106349334A (zh) * 2015-07-15 2017-01-25 韩震 一种多肽化合物及其制备方法与应用
CN108431046A (zh) 2015-12-28 2018-08-21 日本烟草产业株式会社 诊断、治疗或预防心境障碍的方法
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
WO2020160156A2 (en) 2019-01-30 2020-08-06 Immutics, Inc. Anti-gal3 antibodies and uses thereof
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376861A (en) 1976-06-23 1983-03-15 The Dow Chemical Company Method for preparing 2-alkenyl-2-oxazolines
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4600535A (en) 1982-02-12 1986-07-15 The Dow Chemical Company Cyclic peptides
US4517122A (en) 1982-02-12 1985-05-14 The Dow Chemical Company Cyclic peptides
US4558120A (en) 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4568737A (en) 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4507466A (en) 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4515920A (en) 1984-04-30 1985-05-07 The Rockefeller University Synthesis of peptides and proteins
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
US4587329A (en) 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US4599400A (en) 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5229490A (en) * 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5096815A (en) 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
CA2017507C (en) 1989-05-25 1996-11-12 Gary Van Nest Adjuvant formulation comprising a submicron oil droplet emulsion
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
ES2217250T3 (es) * 1990-06-15 2004-11-01 Scios Inc. Mamifero transgenico, no humano que muestra la patologia de formacion amiloides de la enfermedad de alzheimer.
US5222982A (en) 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
US5441870A (en) * 1992-04-15 1995-08-15 Athena Neurosciences, Inc. Methods for monitoring cellular processing of β-amyloid precursor protein
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
US5716614A (en) 1994-08-05 1998-02-10 Molecular/Structural Biotechnologies, Inc. Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
JPH11507538A (ja) 1995-06-07 1999-07-06 アテナ ニューロサイエンシズ インコーポレイティド β−セクレターゼ、β−セクレターゼに対する抗体、及びβ−セクレターゼ阻害を検出するためのアッセイ
US6221645B1 (en) 1995-06-07 2001-04-24 Elan Pharmaceuticals, Inc. β-secretase antibody
US5744346A (en) 1995-06-07 1998-04-28 Athena Neurosciences, Inc. β-secretase
US5719867A (en) 1995-06-30 1998-02-17 Scientific-Atlanta, Inc. Plural telephony channel baseband signal demodulator for a broadband communications system
WO1998021589A1 (en) 1996-11-15 1998-05-22 The Trustees Of The University Of Pennsylvania Screening for modulators of amyloid processing
DK1005368T3 (da) 1997-03-10 2010-01-04 Ottawa Hospital Res Inst Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer
US6703015B1 (en) * 1999-09-03 2004-03-09 Ramot At Tel-Aviv University Ltd. Filamentous bacteriophage displaying an β-amyloid epitope
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6313268B1 (en) 1998-10-16 2001-11-06 Vivian Y. H. Hook Secretases related to Alzheimer's dementia
GB2364059B (en) 1999-02-10 2004-01-14 Elan Pharm Inc Beta-Secretase enzyme compositions and methods
WO2001014579A2 (en) * 1999-08-26 2001-03-01 Vion Pharmaceuticals, Inc. Compositions and methods for delivery of an agent using attenuated salmonella containing phage
US20040013647A1 (en) * 1999-09-03 2004-01-22 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating a plaque-forming disease
AU784568B2 (en) * 1999-09-03 2006-05-04 Ramot At Tel-Aviv University Ltd Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases
US20020052311A1 (en) * 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
WO2001053457A2 (en) * 2000-01-21 2001-07-26 University Of Connecticut Health Center Vaccines against neurodegenerative disorders
WO2003000719A2 (en) * 2001-06-20 2003-01-03 Ramot At Tel Aviv University Ltd. Multiple antigenic peptide displaying multiple copies of an epitope of plaque-forming polypeptide and methods of using same
AU2003226356A1 (en) * 2002-04-12 2003-10-27 Ramot At Tel Aviv University Ltd. Prevention of brain inflammation as a result of induced autoimmune response
GB0720912D0 (en) * 2007-10-25 2007-12-05 Univ Cardiff Monoclonal Anitbody for APP

Also Published As

Publication number Publication date
IL212752A (en) 2014-01-30
IL163812A (en) 2011-06-30
EP2292247A3 (en) 2011-10-05
EP1480666B1 (en) 2012-06-13
JP2013181034A (ja) 2013-09-12
JP5717210B2 (ja) 2015-05-13
US20070172484A1 (en) 2007-07-26
ES2392247T3 (es) 2012-12-07
WO2003076455A2 (en) 2003-09-18
EP1480666A4 (en) 2006-06-07
WO2003076455A3 (en) 2004-04-08
US7494655B2 (en) 2009-02-24
CA2477675A1 (en) 2003-09-18
US20060034855A1 (en) 2006-02-16
AU2003225636A8 (en) 2003-09-22
US20110070249A1 (en) 2011-03-24
JP2005532276A (ja) 2005-10-27
EP2292247A2 (en) 2011-03-09
EP1480666A2 (en) 2004-12-01
IL212752A0 (en) 2011-07-31
US8613928B2 (en) 2013-12-24
JP2010248197A (ja) 2010-11-04
CA2477675C (en) 2013-05-21
IL163812A0 (en) 2005-12-18
US7854931B2 (en) 2010-12-21

Similar Documents

Publication Publication Date Title
AU2003225636A1 (en) Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein
WO2003072035A8 (en) Compositions and methods for the treatment of immune related diseases
WO2004041170A9 (en) Compositions and methods for the treatment of immune related diseases
WO2004024097A9 (en) Compositions and methods for the treatment of immune related diseases
AU2003211625A1 (en) Method of modifying protein properties
EP1614389A4 (en) Ultrasonic vibrator and method of producing the same
AU2001297856A1 (en) Method for determining homeostasis of the skin
AU2003299823A1 (en) Methods of inducing and maintaining immune tolerance
AU2003205707A1 (en) Method for the preparation of highly branched polypeptides
AU2003213718A1 (en) Method of producing antigens
AU2003237482A1 (en) Methods and devices for facilitating the formation of connections between tissue structures
AU2003300324A1 (en) Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
WO2004024076A8 (en) Novel compositions and methods for the treatment of immune related diseases
EP1308542A3 (en) Method and apparatus for crystallization of proteins and the like
AU2003242614A1 (en) Method for the preparation of halogenated benzonitriles
AU2002246950A1 (en) Hydrocapsules and method of preparation
AU2003276844A1 (en) Formulations of modified antibodies and methods of making the same
AU2003260251A1 (en) Piezoactuator and method for production of the piezoactuator
AU2003230004A1 (en) Methods of therapy for inducing tolerance
AU2002354363A1 (en) Method of activating protein
AU2003276825A1 (en) Method of immunotherapy
WO2004096848A8 (en) Novel composition and methods for the treatment of immune disorders
AU2003228597A1 (en) ANTIBODIES FOR ENZYMES OF THE Omega-OXIDATION PATHWAY AND METHODS RELATING THERETO
GB0205894D0 (en) Method and apparatus for the administration of benefits
AU2003268688A1 (en) Method of inducing immune responses

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase