ES2380654T3 - Tableta de desintegración rápida que comprende un ingrediente activo lábil en medio ácido - Google Patents
Tableta de desintegración rápida que comprende un ingrediente activo lábil en medio ácido Download PDFInfo
- Publication number
- ES2380654T3 ES2380654T3 ES01999360T ES01999360T ES2380654T3 ES 2380654 T3 ES2380654 T3 ES 2380654T3 ES 01999360 T ES01999360 T ES 01999360T ES 01999360 T ES01999360 T ES 01999360T ES 2380654 T3 ES2380654 T3 ES 2380654T3
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- Spain
- Prior art keywords
- active ingredient
- tablet
- labile
- mixture
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000004480 active ingredient Substances 0.000 title claims abstract description 105
- 239000002253 acid Substances 0.000 title claims abstract description 20
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- 239000003112 inhibitor Substances 0.000 claims abstract description 26
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- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 23
- 102000006270 Proton Pumps Human genes 0.000 claims abstract description 22
- 229920002472 Starch Polymers 0.000 claims abstract description 19
- 235000019698 starch Nutrition 0.000 claims abstract description 18
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 17
- 239000000194 fatty acid Substances 0.000 claims abstract description 17
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- 239000011159 matrix material Substances 0.000 claims abstract description 16
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
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- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
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- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00126807 | 2000-12-07 | ||
| EP00126807 | 2000-12-07 | ||
| PCT/EP2001/014340 WO2002045694A1 (en) | 2000-12-07 | 2001-12-06 | Rapidly disintegrating tablet comprising an acid-labile active ingredient |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2380654T3 true ES2380654T3 (es) | 2012-05-17 |
Family
ID=8170591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01999360T Expired - Lifetime ES2380654T3 (es) | 2000-12-07 | 2001-12-06 | Tableta de desintegración rápida que comprende un ingrediente activo lábil en medio ácido |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7147869B2 (pt) |
| EP (1) | EP1341528B1 (pt) |
| JP (1) | JP2004514737A (pt) |
| KR (1) | KR20030072555A (pt) |
| CN (1) | CN100335040C (pt) |
| AT (1) | ATE541564T1 (pt) |
| AU (1) | AU2002221939A1 (pt) |
| BR (1) | BR0115986A (pt) |
| CA (1) | CA2430829C (pt) |
| CY (1) | CY1112615T1 (pt) |
| DK (1) | DK1341528T3 (pt) |
| ES (1) | ES2380654T3 (pt) |
| HK (1) | HK1062264A1 (pt) |
| PT (1) | PT1341528E (pt) |
| SI (1) | SI1341528T1 (pt) |
| WO (1) | WO2002045694A1 (pt) |
Families Citing this family (30)
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| AU2002231654A1 (en) * | 2000-12-07 | 2002-06-18 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Pharmaceutical paste comprising an acid-labile active ingredient |
| KR20030059318A (ko) * | 2000-12-07 | 2003-07-07 | 알타나 파마 아게 | 산 불안정성 활성 성분을 포함하는 현탁액 형태의 약학 제제 |
| UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| HUP0401941A3 (en) * | 2001-07-16 | 2008-04-28 | Astrazeneca Ab | Pharmaceutical formulation comprising a proton pomp inhibitor and antacids and process for its preparation |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| US7470791B2 (en) | 2003-03-10 | 2008-12-30 | Nycomed Gmbh | Process for the preparation of roflumilast |
| CL2004000983A1 (es) | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
| PE20050150A1 (es) | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
| JP5563735B2 (ja) | 2004-06-16 | 2014-07-30 | タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド | Ｐｐｉ多回剤形 |
| US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
| US8057820B2 (en) * | 2004-10-08 | 2011-11-15 | Mcneil-Ppc, Inc. | Enteric coated aspirin granules comingled with binder |
| US8758814B2 (en) | 2004-10-08 | 2014-06-24 | Mcneil-Ppc, Inc. | Chewable enteric coated aspirin tablets |
| ES2421916T3 (es) | 2005-03-16 | 2013-09-06 | Nycomed Gmbh | Forma farmacéutica de sabor enmascarado que contiene roflumilast |
| FR2885526B1 (fr) * | 2005-05-13 | 2007-07-27 | Flamel Technologies Sa | Medicament oral a base d'inhibiteur de pompe a protons |
| CN100431526C (zh) * | 2005-11-07 | 2008-11-12 | 上海艾力斯医药科技有限公司 | 一种酸敏感型药物的快速崩解片剂 |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8425935B2 (en) * | 2005-12-21 | 2013-04-23 | Basf Se | Pharmaceutical formulation for producing rapidly disintegrating tablets |
| CN101707930B (zh) * | 2007-06-06 | 2013-10-30 | 巴斯夫欧洲公司 | 用于制备快速崩解的片剂的药物配制剂 |
| US8568780B2 (en) * | 2007-06-06 | 2013-10-29 | Basf Se | Pharmaceutical formulation for the production of rapidly disintegrating tablets |
| US8173158B2 (en) * | 2007-10-12 | 2012-05-08 | Takeda Pharmaceuticals U.S.A., Inc. | Methods of treating gastrointestinal disorders independent of the intake of food |
| DE102010011421A1 (de) * | 2009-03-19 | 2010-09-30 | Schaeffler Technologies Gmbh & Co. Kg | Schaltbarer Schlepphebel eines Ventiltriebs einer Brennkraftmaschine |
| WO2010122583A2 (en) | 2009-04-24 | 2010-10-28 | Rubicon Research Private Limited | Oral pharmaceutical compositions of acid labile substances |
| WO2010144865A2 (en) | 2009-06-12 | 2010-12-16 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| US20130052278A1 (en) * | 2010-03-11 | 2013-02-28 | Rich Vitamins Llc | Quick dissolve nutritional powder |
| EP2441446A1 (en) * | 2010-10-14 | 2012-04-18 | Deva Holding Anonim Sirketi | Using of superdisintegrants in cetyl myristate and/or cetyl palmitate formulations |
| EP2583673A1 (en) * | 2010-10-14 | 2013-04-24 | Deva Holding Anonim Sirketi | Coating of cetyl myristate and/or cetyl palmitate particles |
| CA2823628A1 (en) | 2011-01-05 | 2012-07-12 | Hospira, Inc. | Spray drying vancomycin |
| CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
| US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065142A (en) * | 1958-07-30 | 1962-11-20 | Armour Pharma | Gastric resistant medicinal preparation |
| US4006227A (en) * | 1973-11-15 | 1977-02-01 | Gallegos Alfred J | Compositions and methods for fertility control |
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
| FI90544C (fi) | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
| US5380535A (en) * | 1991-05-28 | 1995-01-10 | Geyer; Robert P. | Chewable drug-delivery compositions and methods for preparing the same |
| CA2103443C (en) | 1991-05-28 | 1998-12-22 | Robert P. Geyer | Chewable drug-delivery composition |
| PL187160B1 (pl) * | 1994-01-31 | 2004-05-31 | Yamanouchi Pharma Co Ltd | Sposób wytwarzania rozpuszczalnej wewnątrzustnie formowanej tłocznie wypraski |
| SE9402431D0 (sv) | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| PT1078628E (pt) | 1994-07-08 | 2009-01-27 | Astrazeneca Ab | Forma de dosagem em comprimidos com unidades múltiplas |
| SE512835C2 (sv) | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| JP4939680B2 (ja) * | 1997-05-27 | 2012-05-30 | 武田薬品工業株式会社 | 固形製剤 |
| NZ505123A (en) * | 1997-12-19 | 2003-07-25 | Smithkline Beecham Corp | Process for manufacturing bite-dispersion tablets by compressing medicaments and other ingredients into granulates then compressing the granulates and other ingredients into tablets, and the tablets thereof |
| SE9704869D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulaton II |
| CN1195500C (zh) * | 1998-05-18 | 2005-04-06 | 武田药品工业株式会社 | 可口腔崩解的片剂 |
| SI1100469T1 (pt) * | 1998-07-28 | 2005-08-31 | Takeda Pharmaceutical | |
| SE9803240D0 (sv) * | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
| PT1187601E (pt) * | 1999-06-07 | 2005-11-30 | Altana Pharma Ag | Nova forma de preparacao e a administracao compreendendo um inibidor da bomba de protoes instavel em meio acido |
| DE19925710C2 (de) * | 1999-06-07 | 2002-10-10 | Byk Gulden Lomberg Chem Fab | Neue Zubereitung und Darreichungsform enthaltend einen säurelabilen Protonenpumpenhemmer |
-
2001
- 2001-12-06 EP EP01999360A patent/EP1341528B1/en not_active Expired - Lifetime
- 2001-12-06 JP JP2002547480A patent/JP2004514737A/ja active Pending
- 2001-12-06 CA CA2430829A patent/CA2430829C/en not_active Expired - Fee Related
- 2001-12-06 WO PCT/EP2001/014340 patent/WO2002045694A1/en active Application Filing
- 2001-12-06 AT AT01999360T patent/ATE541564T1/de active
- 2001-12-06 SI SI200131011T patent/SI1341528T1/sl unknown
- 2001-12-06 AU AU2002221939A patent/AU2002221939A1/en not_active Abandoned
- 2001-12-06 BR BR0115986-0A patent/BR0115986A/pt not_active Application Discontinuation
- 2001-12-06 US US10/433,397 patent/US7147869B2/en not_active Expired - Fee Related
- 2001-12-06 PT PT01999360T patent/PT1341528E/pt unknown
- 2001-12-06 DK DK01999360.9T patent/DK1341528T3/da active
- 2001-12-06 CN CNB018202594A patent/CN100335040C/zh not_active Expired - Fee Related
- 2001-12-06 KR KR10-2003-7007557A patent/KR20030072555A/ko active Search and Examination
- 2001-12-06 ES ES01999360T patent/ES2380654T3/es not_active Expired - Lifetime
-
2004
- 2004-07-15 HK HK04105201A patent/HK1062264A1/xx not_active IP Right Cessation
-
2012
- 2012-04-09 CY CY20121100345T patent/CY1112615T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN100335040C (zh) | 2007-09-05 |
| CA2430829A1 (en) | 2002-06-13 |
| US20040110661A1 (en) | 2004-06-10 |
| BR0115986A (pt) | 2003-12-23 |
| CA2430829C (en) | 2010-06-22 |
| HK1062264A1 (en) | 2004-10-29 |
| US7147869B2 (en) | 2006-12-12 |
| EP1341528B1 (en) | 2012-01-18 |
| AU2002221939A1 (en) | 2002-06-18 |
| ATE541564T1 (de) | 2012-02-15 |
| CN1479613A (zh) | 2004-03-03 |
| DK1341528T3 (da) | 2012-03-26 |
| SI1341528T1 (sl) | 2012-05-31 |
| JP2004514737A (ja) | 2004-05-20 |
| PT1341528E (pt) | 2012-03-20 |
| WO2002045694A1 (en) | 2002-06-13 |
| CY1112615T1 (el) | 2016-02-10 |
| EP1341528A1 (en) | 2003-09-10 |
| KR20030072555A (ko) | 2003-09-15 |
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