CY1112615T1 - Ταχεως διασπωμενο δισκιο το οποιο περιεχει ενα ασταθες σε οξυ δραστικο συστατικο - Google Patents

Ταχεως διασπωμενο δισκιο το οποιο περιεχει ενα ασταθες σε οξυ δραστικο συστατικο

Info

Publication number
CY1112615T1
CY1112615T1 CY20121100345T CY121100345T CY1112615T1 CY 1112615 T1 CY1112615 T1 CY 1112615T1 CY 20121100345 T CY20121100345 T CY 20121100345T CY 121100345 T CY121100345 T CY 121100345T CY 1112615 T1 CY1112615 T1 CY 1112615T1
Authority
CY
Cyprus
Prior art keywords
active ingredient
tablet
instability
oral administration
acid active
Prior art date
Application number
CY20121100345T
Other languages
English (en)
Inventor
Rango Dietrich
Rudolf Linder
Hartmut Ney
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of CY1112615T1 publication Critical patent/CY1112615T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Περιγράφεται ένα ταχέως διασπώμενο δισκίο για στοματική χορήγηση ασταθών σε οξύ δραστικών συστατικών. Το ταχέως διασπώμενο δισκίο για στοματική χορήγηση ενός ασταθούς σε οξύ δραστικού συστατικού περιέχει ένα πλήθος μεμονωμένων μονάδων δραστικού συστατικού μαζί με φαρμακευτικά έκδοχα, όπου το ασταθές σε οξύ δραστικό συστατικό υπάρχει στις μεμονωμένες μονάδες δραστικού συστατικού εντός μήτρας που αποτελείται από μίγμα το οποίο περιέχει τουλάχιστον μια στερεά παραφίνη και μια ή περισσότερες ουσίες από την ομάδα λιπαράς αλκοόλης, τριγλυκεριδίου και εστέρα λιπαρού οξέος, και όπου υπάρχουν έκδοχα τα οποία, με την λήψη από το στόμα του δισκίου, προκαλούν την ταχεία διάσπαση του δισκίου.
CY20121100345T 2000-12-07 2012-04-09 Ταχεως διασπωμενο δισκιο το οποιο περιεχει ενα ασταθες σε οξυ δραστικο συστατικο CY1112615T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00126807 2000-12-07
EP01999360A EP1341528B1 (en) 2000-12-07 2001-12-06 Rapidly disintegrating tablet comprising an acid-labile active ingredient

Publications (1)

Publication Number Publication Date
CY1112615T1 true CY1112615T1 (el) 2016-02-10

Family

ID=8170591

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100345T CY1112615T1 (el) 2000-12-07 2012-04-09 Ταχεως διασπωμενο δισκιο το οποιο περιεχει ενα ασταθες σε οξυ δραστικο συστατικο

Country Status (16)

Country Link
US (1) US7147869B2 (el)
EP (1) EP1341528B1 (el)
JP (1) JP2004514737A (el)
KR (1) KR20030072555A (el)
CN (1) CN100335040C (el)
AT (1) ATE541564T1 (el)
AU (1) AU2002221939A1 (el)
BR (1) BR0115986A (el)
CA (1) CA2430829C (el)
CY (1) CY1112615T1 (el)
DK (1) DK1341528T3 (el)
ES (1) ES2380654T3 (el)
HK (1) HK1062264A1 (el)
PT (1) PT1341528E (el)
SI (1) SI1341528T1 (el)
WO (1) WO2002045694A1 (el)

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UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
US7357943B2 (en) * 2000-12-07 2008-04-15 Nycomed Gmbh Pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient
BR0211117A (pt) * 2001-07-16 2004-06-22 Astrazeneca Ab Tablete multiparticulado, processo para a manufatura e uso do mesmo, e, método e tratamento de distúrbios gastrointestinais
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
ME00524B (me) 2003-03-10 2011-10-10 Astrazeneca Ab Novi postupak za dobijanje roflumilasta
PE20050150A1 (es) 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
CL2004000983A1 (es) 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
CA2570916C (en) 2004-06-16 2013-06-11 Tap Pharmaceutical Products, Inc. Pulsed release dosage form of a ppi
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US8057820B2 (en) * 2004-10-08 2011-11-15 Mcneil-Ppc, Inc. Enteric coated aspirin granules comingled with binder
US8758814B2 (en) * 2004-10-08 2014-06-24 Mcneil-Ppc, Inc. Chewable enteric coated aspirin tablets
CA2601250C (en) 2005-03-16 2014-10-28 Nycomed Gmbh Taste masked dosage form containing roflumilast
FR2885526B1 (fr) * 2005-05-13 2007-07-27 Flamel Technologies Sa Medicament oral a base d'inhibiteur de pompe a protons
CN100431526C (zh) * 2005-11-07 2008-11-12 上海艾力斯医药科技有限公司 一种酸敏感型药物的快速崩解片剂
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
JP5209492B2 (ja) * 2005-12-21 2013-06-12 ビーエーエスエフ ソシエタス・ヨーロピア 速崩性錠剤製造のための医薬製剤
WO2008148731A1 (de) * 2007-06-06 2008-12-11 Basf Se Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten
KR20160083132A (ko) * 2007-06-06 2016-07-11 바스프 에스이 급속 붕해 정제의 제조를 위한 제약 제제
CN102014638A (zh) * 2007-10-12 2011-04-13 武田制药北美公司 与食物摄入无关的治疗胃肠病症的方法
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EP2544665A4 (en) * 2010-03-11 2014-01-01 Rich Vitamins Llc NUTRITIONAL POWDER WITH RAPID DISSOLUTION
EP2441446A1 (en) * 2010-10-14 2012-04-18 Deva Holding Anonim Sirketi Using of superdisintegrants in cetyl myristate and/or cetyl palmitate formulations
EP2441445A1 (en) * 2010-10-14 2012-04-18 Deva Holding Anonim Sirketi Coating of cetyl myristate and/or cetyl palmitate particles
DK2661254T3 (da) 2011-01-05 2017-11-06 Hospira Inc Sprøjtetørring af vancomycin
CN104043104B (zh) 2013-03-15 2018-07-10 浙江创新生物有限公司 含盐酸万古霉素的喷雾干粉及其工业化制备方法
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Also Published As

Publication number Publication date
CA2430829C (en) 2010-06-22
BR0115986A (pt) 2003-12-23
SI1341528T1 (sl) 2012-05-31
ES2380654T3 (es) 2012-05-17
US20040110661A1 (en) 2004-06-10
DK1341528T3 (da) 2012-03-26
WO2002045694A1 (en) 2002-06-13
ATE541564T1 (de) 2012-02-15
AU2002221939A1 (en) 2002-06-18
EP1341528B1 (en) 2012-01-18
JP2004514737A (ja) 2004-05-20
PT1341528E (pt) 2012-03-20
EP1341528A1 (en) 2003-09-10
US7147869B2 (en) 2006-12-12
KR20030072555A (ko) 2003-09-15
HK1062264A1 (en) 2004-10-29
CN100335040C (zh) 2007-09-05
CN1479613A (zh) 2004-03-03
CA2430829A1 (en) 2002-06-13

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