ES2376913T3 - Derivados de triazolopirazina utiles como agentes anticancerosos - Google Patents
Derivados de triazolopirazina utiles como agentes anticancerosos Download PDFInfo
- Publication number
- ES2376913T3 ES2376913T3 ES07734459T ES07734459T ES2376913T3 ES 2376913 T3 ES2376913 T3 ES 2376913T3 ES 07734459 T ES07734459 T ES 07734459T ES 07734459 T ES07734459 T ES 07734459T ES 2376913 T3 ES2376913 T3 ES 2376913T3
- Authority
- ES
- Spain
- Prior art keywords
- membered
- triazolo
- pyrazin
- nr10r11
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79996606P | 2006-05-11 | 2006-05-11 | |
US799966P | 2006-05-11 | ||
US89323107P | 2007-03-06 | 2007-03-06 | |
US893231P | 2007-03-06 | ||
PCT/IB2007/001142 WO2007132308A1 (en) | 2006-05-11 | 2007-04-30 | Triazolopyrazine derivatives useful as anti-cancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2376913T3 true ES2376913T3 (es) | 2012-03-20 |
Family
ID=38441445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07734459T Active ES2376913T3 (es) | 2006-05-11 | 2007-04-30 | Derivados de triazolopirazina utiles como agentes anticancerosos |
Country Status (32)
Country | Link |
---|---|
US (2) | US7732604B2 (zh) |
EP (1) | EP2018383B1 (zh) |
JP (1) | JP4377962B2 (zh) |
KR (1) | KR101099161B1 (zh) |
CN (1) | CN101443331A (zh) |
AP (1) | AP2008004674A0 (zh) |
AR (1) | AR060994A1 (zh) |
AT (1) | ATE532785T1 (zh) |
AU (1) | AU2007251283A1 (zh) |
BR (1) | BRPI0711809A2 (zh) |
CA (1) | CA2651363C (zh) |
CR (1) | CR10383A (zh) |
EA (1) | EA016204B1 (zh) |
EC (1) | ECSP088871A (zh) |
ES (1) | ES2376913T3 (zh) |
GE (1) | GEP20115174B (zh) |
GT (1) | GT200700039A (zh) |
HN (1) | HN2007015177A (zh) |
IL (1) | IL194813A0 (zh) |
MA (1) | MA30411B1 (zh) |
ME (1) | MEP36508A (zh) |
MX (1) | MX2008014399A (zh) |
NL (1) | NL2000613C2 (zh) |
NO (1) | NO20085060L (zh) |
NZ (1) | NZ572361A (zh) |
PE (1) | PE20080067A1 (zh) |
RS (1) | RS20080533A (zh) |
TN (1) | TNSN08445A1 (zh) |
TW (1) | TWI346115B (zh) |
UY (1) | UY30334A1 (zh) |
WO (1) | WO2007132308A1 (zh) |
ZA (1) | ZA200809020B (zh) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
US8198448B2 (en) * | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
US20110039856A1 (en) * | 2007-11-29 | 2011-02-17 | Pfizer Inc. | Polymorphs of a c-met/hgfr inhibitor |
DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
WO2009107391A1 (ja) * | 2008-02-27 | 2009-09-03 | 武田薬品工業株式会社 | 6員芳香環含有化合物 |
WO2009106577A1 (en) * | 2008-02-28 | 2009-09-03 | Novartis Ag | Imidazo [1,2-b] pyridazine derivatives for the treatment of c-met tyrosine kinase mediated disease |
EP2247185B1 (en) * | 2008-03-03 | 2014-04-16 | Tiger Pharmatech | Tyrosine kinase inhibitors |
DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
WO2009157196A1 (ja) * | 2008-06-25 | 2009-12-30 | 武田薬品工業株式会社 | アミド化合物 |
DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
US8592448B2 (en) | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
EP2381777A4 (en) | 2008-12-12 | 2012-08-08 | Ariad Pharma Inc | AZAINDOL DERIVATIVES AS KINASEHEMMER |
KR101663335B1 (ko) | 2008-12-22 | 2016-10-06 | 메르크 파텐트 게엠베하 | 6-(1-메틸-1h-피라졸-4-일)-2-{3-[5-(2-모르폴린-4-일-에톡시)-피리미딘-2-일]-벤질}-2h-피리다진-3-온디히드로겐포스페이트의 신규한 다형체 및 이의 제조 방법 |
JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
JP5686796B2 (ja) * | 2009-05-28 | 2015-03-18 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | c−Metタンパク質キナーゼのアミノピラゾールトリアゾロチアジアゾール阻害剤 |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
MX2012001838A (es) * | 2009-08-12 | 2012-02-29 | Novartis Ag | Compuestos de hidrazona heterociclico y sus usos para tratar cancer e inflamacion. |
IN2012DN01453A (zh) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
DE102009056886A1 (de) * | 2009-12-03 | 2011-06-09 | Bayer Schering Pharma Aktiengesellschaft | cMet-Inhibitoren zur Behandlung der Endometriose |
PT3795573T (pt) | 2009-12-31 | 2022-09-15 | Hutchison Medipharma Ltd | Certas triazolopirazinas, suas composições e seus métodos de utilização |
TWI423974B (zh) * | 2010-02-11 | 2014-01-21 | Hutchison Medipharma Ltd | 三氮唑並吡啶和三氮唑並吡嗪化合物及其組合物和應用 |
EP2569315A1 (en) | 2010-05-14 | 2013-03-20 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
EA025281B9 (ru) | 2010-05-17 | 2017-08-31 | Инкозен Терапьютикс Пвт. Лтд. | СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ |
US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
CN102532141A (zh) | 2010-12-08 | 2012-07-04 | 中国科学院上海药物研究所 | [1,2,4]三唑并[4,3-b][1,2,4]三嗪类化合物、其制备方法和用途 |
US20140088114A1 (en) | 2011-05-16 | 2014-03-27 | OSI Pharmaceuticals ,LLC | Fused bicyclic kinase inhibitors |
EP2755976B1 (en) | 2011-09-15 | 2018-07-18 | Novartis AG | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors |
CN102503959B (zh) * | 2011-10-25 | 2015-04-08 | 南方医科大学 | 一种稠三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用 |
CN102516263B (zh) * | 2011-10-25 | 2015-04-08 | 南方医科大学 | 一种螺三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用 |
CN103204844A (zh) * | 2012-01-17 | 2013-07-17 | 上海艾力斯医药科技有限公司 | 氨基杂芳基化合物及其制备方法与应用 |
JP6192708B2 (ja) | 2012-03-30 | 2017-09-06 | ライゼン・ファーマシューティカルズ・エスアー | C−metプロテインキナーゼ調節物質としての新規3,5−二置換−3h−イミダゾ[4,5−b]ピリジン化合物および3,5−二置換−3h−[1,2,3]トリアゾロ[4,5−b]ピリジン化合物 |
CN104245701A (zh) | 2012-04-03 | 2014-12-24 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
AU2013243737B2 (en) | 2012-04-03 | 2016-06-30 | Novartis Ag | Tyrosine kinase inhibitor combinations and their use |
CN107312009B (zh) * | 2013-04-17 | 2022-09-20 | 上海医药集团股份有限公司 | 喹啉类化合物、其制备方法、中间体、药物组合物和应用 |
WO2014174478A1 (en) | 2013-04-26 | 2014-10-30 | Novartis Ag | Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor |
RU2643361C2 (ru) * | 2013-09-30 | 2018-02-01 | Кореа Рисёч Инститьют Оф Кемикал Текнолоджи | Новые производные триазолопиразина и их применение |
EP3229836B1 (en) | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
JP2018123059A (ja) * | 2015-06-10 | 2018-08-09 | 石原産業株式会社 | 1−シクロプロピルエチルアミン又はその塩の製造方法 |
BR112018001017B1 (pt) * | 2015-07-20 | 2024-02-15 | Genzyme Corporation | Inibidores do receptor de fator-1 de estimulação de colônia (csf-1r), composição farmacêutica e seu uso |
CN105272995B (zh) | 2015-09-24 | 2017-10-27 | 上海海聚生物科技有限公司 | 喹啉类衍生物、其药物组合物、制备方法及应用 |
DK3398951T3 (da) * | 2015-12-31 | 2021-07-12 | Shanghai Pharmaceuticals Holding Co Ltd | Salt af quinolonforbindelse, polymorfer deraf, fremgangsmåde til fremstilling deraf, sammensætning og anvendelser |
IL261721B (en) | 2016-03-15 | 2022-07-01 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for use in the treatment of solid tumors |
IL263429B (en) | 2016-06-20 | 2022-08-01 | Novartis Ag | Crystalline forms of a triazolopyrimidine compound |
KR20180092096A (ko) * | 2017-02-08 | 2018-08-17 | 에이비온 주식회사 | 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법 |
CN108570053A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元并六元杂环化合物、制备方法、中间体、组合和应用 |
CN108276418A (zh) * | 2018-03-20 | 2018-07-13 | 北京凯恩梅格医药科技有限公司 | 化合物、含有该化合物的药用组合物及其用途 |
AU2019395282A1 (en) | 2018-12-14 | 2021-07-08 | Beta Pharma, Inc. | Organophosphorus-substituted compounds as c-MET inhibitors and therapeutic uses thereof |
EP4267573A1 (en) | 2020-12-23 | 2023-11-01 | Genzyme Corporation | Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
DE69334255D1 (de) | 1992-02-06 | 2009-02-12 | Novartis Vaccines & Diagnostic | Marker für Krebs und biosynthetisches Bindeprotein dafür |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
ID19609A (id) | 1996-07-13 | 1998-07-23 | Glaxo Group Ltd | Senyawa-senyawa heterosiklik |
DE69718472T2 (de) | 1996-07-13 | 2003-11-06 | Glaxo Group Ltd | Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren |
RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
DK1212327T3 (da) * | 1999-09-17 | 2003-12-15 | Abbott Gmbh & Co Kg | Pyrazolopyrimidiner som terapeutiske midler |
US7250417B2 (en) * | 2003-07-02 | 2007-07-31 | Sugen Inc. | Arylmethyl triazolo- and imidazopyrazines as c-Met inhibitors |
AU2004274403A1 (en) | 2003-09-03 | 2005-03-31 | Aventis Pharmaceuticals Inc. | 5-aryl-Pyrazolo(4,3-d)pyrimidines, pyridines, and pyrazines and related compounds |
US9697529B2 (en) | 2012-03-13 | 2017-07-04 | American Express Travel Related Services Company, Inc. | Systems and methods for tailoring marketing |
US10884952B2 (en) | 2016-09-30 | 2021-01-05 | Intel Corporation | Enforcing memory operand types using protection keys |
-
2007
- 2007-04-26 NL NL2000613A patent/NL2000613C2/nl not_active IP Right Cessation
- 2007-04-30 EA EA200870423A patent/EA016204B1/ru not_active IP Right Cessation
- 2007-04-30 CA CA2651363A patent/CA2651363C/en not_active Expired - Fee Related
- 2007-04-30 WO PCT/IB2007/001142 patent/WO2007132308A1/en active Application Filing
- 2007-04-30 JP JP2009508530A patent/JP4377962B2/ja not_active Expired - Fee Related
- 2007-04-30 NZ NZ572361A patent/NZ572361A/en not_active IP Right Cessation
- 2007-04-30 AT AT07734459T patent/ATE532785T1/de active
- 2007-04-30 BR BRPI0711809-0A patent/BRPI0711809A2/pt not_active IP Right Cessation
- 2007-04-30 EP EP07734459A patent/EP2018383B1/en active Active
- 2007-04-30 GE GEAP200710971A patent/GEP20115174B/en unknown
- 2007-04-30 CN CNA2007800170852A patent/CN101443331A/zh active Pending
- 2007-04-30 AU AU2007251283A patent/AU2007251283A1/en not_active Abandoned
- 2007-04-30 ME MEP-365/08A patent/MEP36508A/xx unknown
- 2007-04-30 KR KR1020087027474A patent/KR101099161B1/ko not_active IP Right Cessation
- 2007-04-30 ES ES07734459T patent/ES2376913T3/es active Active
- 2007-04-30 AP AP2008004674A patent/AP2008004674A0/xx unknown
- 2007-04-30 RS RSP-2008/0533A patent/RS20080533A/sr unknown
- 2007-04-30 MX MX2008014399A patent/MX2008014399A/es active IP Right Grant
- 2007-05-08 US US11/745,921 patent/US7732604B2/en not_active Expired - Fee Related
- 2007-05-09 AR ARP070102012A patent/AR060994A1/es not_active Application Discontinuation
- 2007-05-09 HN HN2007015177A patent/HN2007015177A/es unknown
- 2007-05-09 GT GT200700039A patent/GT200700039A/es unknown
- 2007-05-09 UY UY30334A patent/UY30334A1/es unknown
- 2007-05-09 PE PE2007000559A patent/PE20080067A1/es not_active Application Discontinuation
- 2007-05-10 TW TW096116645A patent/TWI346115B/zh not_active IP Right Cessation
-
2008
- 2008-10-21 CR CR10383A patent/CR10383A/es not_active Application Discontinuation
- 2008-10-21 ZA ZA2008/09020A patent/ZA200809020B/en unknown
- 2008-10-22 IL IL194813A patent/IL194813A0/en unknown
- 2008-11-06 TN TNP2008000445A patent/TNSN08445A1/fr unknown
- 2008-11-07 EC EC2008008871A patent/ECSP088871A/es unknown
- 2008-11-11 MA MA31378A patent/MA30411B1/fr unknown
- 2008-12-03 NO NO20085060A patent/NO20085060L/no not_active Application Discontinuation
-
2010
- 2010-01-04 US US12/651,984 patent/US20100105656A1/en not_active Abandoned
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