ES2375350T3 - Formulaciones líquidas concentradas que comprenden un ingrediente microbicidamente activo. - Google Patents
Formulaciones líquidas concentradas que comprenden un ingrediente microbicidamente activo. Download PDFInfo
- Publication number
- ES2375350T3 ES2375350T3 ES02002043T ES02002043T ES2375350T3 ES 2375350 T3 ES2375350 T3 ES 2375350T3 ES 02002043 T ES02002043 T ES 02002043T ES 02002043 T ES02002043 T ES 02002043T ES 2375350 T3 ES2375350 T3 ES 2375350T3
- Authority
- ES
- Spain
- Prior art keywords
- weight
- active ingredient
- liquid formulations
- concentrated liquid
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000012669 liquid formulation Substances 0.000 title claims abstract description 14
- 239000004480 active ingredient Substances 0.000 title claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- -1 Z is SO2H Chemical group 0.000 claims abstract description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 5
- 239000000460 chlorine Substances 0.000 claims abstract description 5
- 239000004310 lactic acid Substances 0.000 claims abstract description 5
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 5
- 235000013772 propylene glycol Nutrition 0.000 claims abstract description 5
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims abstract description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 3
- 229940071118 cumenesulfonate Drugs 0.000 claims abstract description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 description 16
- 238000009472 formulation Methods 0.000 description 10
- 238000012360 testing method Methods 0.000 description 8
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- 239000004753 textile Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000003641 microbiacidal effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 235000019764 Soybean Meal Nutrition 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 2
- 229960002885 histidine Drugs 0.000 description 2
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 2
- 229940048848 lauryl glucoside Drugs 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000004455 soybean meal Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- KSHRPPASRGMRPU-UHFFFAOYSA-N 2-chlorylphenol Chemical compound OC1=CC=CC=C1Cl(=O)=O KSHRPPASRGMRPU-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical group OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 239000012897 dilution medium Substances 0.000 description 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Natural products C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 230000003165 hydrotropic effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 108010009004 proteose-peptone Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229940079842 sodium cumenesulfonate Drugs 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- QEKATQBVVAZOAY-UHFFFAOYSA-M sodium;4-propan-2-ylbenzenesulfonate Chemical compound [Na+].CC(C)C1=CC=C(S([O-])(=O)=O)C=C1 QEKATQBVVAZOAY-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2041—Dihydric alcohols
- C11D3/2044—Dihydric alcohols linear
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2082—Polycarboxylic acids-salts thereof
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D3/16—Organic compounds
- C11D3/24—Organic compounds containing halogen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/34—Organic compounds containing sulfur
- C11D3/3418—Toluene -, xylene -, cumene -, benzene - or naphthalene sulfonates or sulfates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/26—Organic compounds containing oxygen
- C11D7/261—Alcohols; Phenols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/26—Organic compounds containing oxygen
- C11D7/265—Carboxylic acids or salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/28—Organic compounds containing halogen
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
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- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
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- D06M13/148—Polyalcohols, e.g. glycerol or glucose
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- D06M13/152—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen having a hydroxy group bound to a carbon atom of a six-membered aromatic ring
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- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
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Abstract
Una formulación líquida concentrada (b) que comprende (b1) 10 a 25% en peso de un ingrediente microbicidamente activo de fórmula en donde Y es cloro o bromo, Z es SO2H, NO2 o alquilo C1-C4, r es 0 a 3, o es 0 a 3, p es 0 o 1, m es 0 o 1 y n es 0 o 1, (b2) 10 a 70% en peso de cumenosulfonato, (b3) 10 a 50% en peso de ácido láctico, (b4) 5 a 75% en peso de 1,2-propanodiol y agua hasta completar el 100%.
Description
Formulaciones líquidas concentradas que comprenden un ingrediente microbicidamente activo
La presente invención se refiere a formulaciones líquidas que comprenden ingredientes microbicidamente activos, al uso de estas formulaciones como ingrediente farmacológicamente activo en productos cosméticos, artículos de uso 5 doméstico o desinfectantes para las manos, y al uso como conservantes en artículos de uso doméstico y productos cosméticos.
La US-A-5.403.864 describe una composición antimicrobiana que comprende de 0,5 a 3,0% en peso aproximadamente de triclosan, de 0,5 a 2,0% en peso aproximadamente de cloroxifenol y de 40 a 70% en peso aproximadamente de un alcohol.
10 La EP-A-0.259.249 describe preparados y usos de los mismos para la desinfección de piel y manos. La referencia describe que los hidroxibifeniléteres halogenados con considerados como no solubles en cantidades proporcionalmente pequeñas de etanol, propanol, isopropanol o propilenglicol.
La WO 93/07250 describe una composición de limpieza antiséptica que comprende un alcanol y un concentrado acuoso de un surfactante. La composición puede también comprender un biocida. El surfactante es un componente
15 esencial en esta composición.
La WO 96/06152 describe formulaciones de jabón surfactantes que comprenden (a) 0,01 a 0,2% en peso de una sustancia activa microbicida, (b) 0,1 a 7,5% en peso de uno o más de un agente hidrotrópico, (c) 0 a 2% en peso de uno o más de una sustancia surfactante sintética o de un jabón o de una combinación de dichas sustancias y/o una sal de un ácido graso C8-C22 saturado y/o insaturado; (d) 0 a 10% en peso de un alcohol dihídrico; (e) 0 a 70% en
20 peso de un alcohol monohídrico; y (f) agua de la red o agua desionizada para completar el 100%.
La CH 604523 describe una formulación antimicrobiana sinérgica que comprende o-hidroxidifeniléter, un surfactante solubilizante y opcionalmente un disolvente tal como agua.
La presente invención se refiere a formulaciones líquidas concentradas (b) que comprenden
(b1) 10 a 25% en peso de un ingrediente microbicidamente activo de fórmula (1)
en donde
Y es cloro o bromo,
Z es SO2H, NO2 o alquilo C1-C4,
r es 0 a 3, 30 o es 0 a 3,
p es 0 o 1,
m es 0 o 1 y
n es 0 o 1,
(b2) 10 a 70% en peso de cumenosulfonato, 35 (b3) 10 a 50% en peso de ácido láctico,
(b4) 5 a 75% en peso de 1,2-propanodiol y
agua hasta completar el 100%.
Compuestos especialmente interesantes de fórmula (1) son aquellos en donde
Y es cloro o bromo,
5 m es 0,
n es 0 o 1,
o es 1 o 2,
r es 1 o 2 y
p es 0.
10 Compuestos muy especialmente interesantes de fórmula (1) son aquellos en donde Y es cloro, m es 0, n es 0,
o es 1,
15 r es 2 y p es 0. Muy especialmente preferido es el compuesto de fórmula
El ácido láctico, que se emplea de acuerdo con la invención, puede también emplearse preferentemente en forma de 20 sus sales de metales alcalinos o sales amónicas solubles en agua.
Las formulaciones líquidas de acuerdo con la invención se emplean como ingrediente activo en productos cosméticos, por ejemplo desodorantes, limpiadores, lociones/cremas, en artículos de uso doméstico, por ejemplo como un aditivo en líquidos de lavado, detergentes líquidos de uso doméstico; como un aditivo en productos para la higiene dental, por ejemplo en colutorios o pastas de dientes, o como un ingrediente antimicrobialmente activo para
25 superficies duras y blandas, por ejemplo polímeros, papel, textiles y, en particular, la piel humana.
Las formulaciones líquidas de acuerdo con la invención son además también adecuadas como conservantes para productos cosméticos y artículos de uso doméstico.
Igualmente, también son útiles como desinfectantes para materiales de fibras textiles.
Las formulaciones líquidas de acuerdo con la invención se preparan disolviendo el componente (b1) en el
30 componente (b4), añadiendo los componentes (b2) y (b3) a la solución resultante, con agitación, completando la solución resultante con agua desionizada hasta 90-95% del volumen final, si es adecuado ajustando el pH con una base cosméticamente aceptable, por ejemplo mono- o dietanolamina, y completando la mezcla con agua desionizada hasta un volumen final de 100%.
El ingrediente microbicidamente activo disuelto puede ser incorporado en productos cosméticos y artículos de uso doméstico sin inconveniente alguno. El ingrediente activo, que de por sí es pulverulento, se ofrece al usuario en forma disuelta. De este modo deja de ser ya necesario una predisolución consumidora de tiempo en disolventes adecuados mientras se aporta calor.
Además, las formulaciones líquidas de acuerdo con la invención se distinguen por una acción antimicrobiana 5 sinérgica (véase ejemplo 4) y por una buena estabilidad en almacenamiento.
Los ejemplos, que siguen, ilustran la preparación de las formulaciones líquidas de acuerdo con la invención. Las partes son partes en peso.
Ejemplos de preparación de las formulaciones líquidas concentradas
Ejemplo 1:
10 10 partes del compuesto de fórmula (101) y 5 partes de 1,2-propanodiol se pesan en un recipiente y se agita a temperatura ambiente. 40 partes de ácido láctico se añaden. El pH se lleva a un valor de 3 a 4 por adición de etanolamina. 30 partes de cumenosulfonato sódico y 10 partes de agua desionizada se añaden en la secuencia anterior y se continúa la agitación hasta que se
15 disuelven todos los constituyentes. La mezcla se completa a 100 partes con agua desionizada.
Microorganismos Staphylococcus aureus ATCC 9144
de ensayo:
Enterococcus faecium ATCC 10541
Escherichia coli ATCC 10536 Pseudomonas aeruginosa CIP A-22 Candida albicans ATCC 10231
Medios Caldo de caseína peptona de harina de soja para el crecimiento del inóculo nutrientes: Agar de caseína peptona de harina de soja con 3% de monooleato de polioxietileno
(20) sorbitán; 0,3% de lecitina; 0,1% de L-histidina
Medio de Caldo de tripticasa peptona de harina de soja con 10% de monooleato de polioxietileno dilución: (20) sorbitán; 3% de lecitina; 0,1% de L-histidina y 0,5% de tiosulfato sódico.
a. Uso de la formulación del ejemplo 1 como desinfectante Estos ensayos demuestran que las formulaciones líquidas de acuerdo con la invención presentan una actividad
20 microbicida muy potente, incluso a bajas concentraciones. Estas propiedades son importantes para desinfectantes en general, pero en particular para la desinfección de textiles. Procedimiento: Se diluyen 0,1 ml de la formulación del ejemplo 1 con 8,9 ml de agua y la dilución se trata posteriormente con 1 ml
de una dilución 1:10 de un cultivo de la bacteria de ensayo que se incuba durante 16 a 24 horas a 37º C. 25 La concentración de los organismos de ensayo en el lote es de 108 microorganismos /ml.
El lote se mezcla a fondo y posteriormente se incuba durante 5 minutos a temperatura ambiente con agitación suave. Después de 5 minutos, se separa 1 ml del lote y se determina el recuento de bacterias vivas. Para este fin, se llevan
a cabo diluciones en el medio de dilución y se efectúan deposiciones de 0,1 ml de cada uno de estas diluciones
sobre los medios de agar.
El recuento de bacterias vivas se determina una vez que las placas han sido incubadas durante 24 a 48 horas a 37º
C contando las colonias teniendo en cuenta el factor de dilución.
Los resultados del ensayo se muestran en la tabla 1.
- Tabla 1
- Lote
- Reducción en el recuento bacterial después de 5 minutos (log)
- S. aureus ATCC 9144
- Ent. faecium ATCC 10541 E. coli ATCC 10536 P. aeruginosa CIP A-22
- Agua
- 0 0 0 0
- 1% formulación 6
- > 105 > 105 > 105 > 105
La formulación ensayada del ejemplo 41 muestra una reducción de todos los microorganismos del ensayo de al menos 5 potencias de 10 después de un tiempo tan pequeño como 5 minutos en el ensayo de suspensión.
7% de laurilsulfato sódico
10 7% de miret sulfato sódico 4% de laurilglucósido 1% de cocamidopropilbetaína 1% de la formulación del ejemplo 4 1% de cloruro sódico
15 0,02% de dibromodicianobutano 0,08% de fenoxietanol 78,9% de agua Preparación: Se mezcla laurilsulfato sódico con miret sulfato sódico y laurilglucósido y se disuelve en 30 partes de agua. Se
20 añade la formulación del ejemplo 1 y se homogeniza. Se añaden cocamidopropilbetaína, cloruro sódico, dibromodicianobutano y fenoxietanol. El pH se ajusta a 6,0 con ácido cítrico. Se añade agua para completar 100 partes.
50% de las formulaciones del ejemplo 1
25 10% de poliglicoléter de alcohol laurílico hasta 100% de agua El pH se lleva a 5 con monoetanolamina.
Claims (2)
- REIVINDICACIONES1. Una formulación líquida concentrada (b) que comprende (b1) 10 a 25% en peso de un ingrediente microbicidamente activo de fórmula5 en donde Y es cloro o bromo, Z es SO2H, NO2 o alquilo C1-C4, r es 0 a 3,o es 0 a 3,10 p es 0 o 1, m es 0 o 1 y n es 0 o 1, (b2) 10 a 70% en peso de cumenosulfonato, (b3) 10 a 50% en peso de ácido láctico,15 (b4) 5 a 75% en peso de 1,2-propanodiol y agua hasta completar el 100%.
- 2. Una formulación líquida según la reivindicación 1, en donde el componente (b1) tiene la fórmula
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CH140396 | 1996-06-04 | ||
CH140396 | 1996-06-04 |
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ID=4209620
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ES97923969T Expired - Lifetime ES2182077T3 (es) | 1996-06-04 | 1997-05-22 | Formulaciones liquidas concentradas que comprenden un ingrediente microbicidamente activo. |
ES02002043T Expired - Lifetime ES2375350T3 (es) | 1996-06-04 | 1997-05-22 | Formulaciones líquidas concentradas que comprenden un ingrediente microbicidamente activo. |
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ES97923969T Expired - Lifetime ES2182077T3 (es) | 1996-06-04 | 1997-05-22 | Formulaciones liquidas concentradas que comprenden un ingrediente microbicidamente activo. |
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Country | Link |
---|---|
US (1) | US6358906B1 (es) |
EP (2) | EP0914085B1 (es) |
JP (1) | JP4106091B2 (es) |
CN (1) | CN1133418C (es) |
AR (2) | AR008760A1 (es) |
AU (1) | AU2959497A (es) |
BR (1) | BR9709422A (es) |
CO (1) | CO4850630A1 (es) |
DE (1) | DE69715421T2 (es) |
ES (2) | ES2182077T3 (es) |
ID (1) | ID17019A (es) |
MY (1) | MY126299A (es) |
TW (1) | TW464491B (es) |
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EP0914085B1 (en) | 1996-06-04 | 2002-09-11 | Ciba SC Holding AG | Concentrated liquid accumulations comprising a microbicidally active ingredient |
KR20010013377A (ko) | 1997-06-04 | 2001-02-26 | 데이비드 엠 모이어 | 마일드한 잔류성 항균 조성물 |
ATE246722T1 (de) * | 1997-09-17 | 2003-08-15 | Ciba Sc Holding Ag | Antimikrobieller waschmittelzusatz |
US6107261A (en) | 1999-06-23 | 2000-08-22 | The Dial Corporation | Compositions containing a high percent saturation concentration of antibacterial agent |
WO2000078141A1 (en) * | 1999-06-23 | 2000-12-28 | The Dial Corporation | Antibacterial compositions |
WO2000078275A2 (en) * | 1999-06-23 | 2000-12-28 | The Dial Corporation | Antibacterial compositions |
US6861397B2 (en) | 1999-06-23 | 2005-03-01 | The Dial Corporation | Compositions having enhanced deposition of a topically active compound on a surface |
GB2354771A (en) * | 1999-10-01 | 2001-04-04 | Mcbride Ltd Robert | Bactericide combinations in detergents |
US20020172656A1 (en) | 2000-01-20 | 2002-11-21 | Biedermann Kimberly Ann | Cleansing compositions |
US6362152B1 (en) | 2000-04-07 | 2002-03-26 | The Dow Chemical Company | Low color and low haze formulations of sodium o-phenylphenate |
DE60118148T2 (de) | 2000-06-21 | 2007-03-15 | Ciba Speciality Chemicals Holding Inc. | Tenside Formulierungen |
GB2357968A (en) * | 2000-12-18 | 2001-07-11 | Ciba Sc Holding Ag | Use of hydroxy diphenylethers as disinfectants |
US6616922B2 (en) | 2001-03-27 | 2003-09-09 | The Dial Corporation | Antibacterial compositions |
FR2826572B1 (fr) * | 2001-06-29 | 2005-10-07 | Oreal | Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles |
FR2826571B1 (fr) * | 2001-06-29 | 2005-10-07 | Oreal | Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles |
FR2826570B1 (fr) * | 2001-06-29 | 2005-08-26 | Oreal | Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles |
FR2826573B1 (fr) * | 2001-06-29 | 2005-10-07 | Oreal | Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles |
FR2826574B1 (fr) * | 2001-06-29 | 2005-08-26 | Oreal | Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles |
DE10216368A1 (de) * | 2002-04-12 | 2003-10-16 | Henkel Kgaa | Arylsulfatase-Inhibitoren in Deodorantien und Antitranspirantien |
WO2005011385A1 (en) * | 2003-08-04 | 2005-02-10 | Delaval Holding Ab | Food-grade sanitizing composition |
US7794737B2 (en) * | 2003-10-16 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Odor absorbing extrudates |
US7144846B2 (en) * | 2004-05-11 | 2006-12-05 | Steris, Inc. | Acidic phenolic disinfectant compositions |
EP1830638A2 (en) * | 2004-12-09 | 2007-09-12 | The Dial Corporation | Compositions having a high antiviral and antibacterial efficacy |
US20090012174A1 (en) * | 2004-12-09 | 2009-01-08 | The Dial Corporation | Compositions Having a High Antiviral and Antibacterial Efficacy |
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-
1997
- 1997-05-22 EP EP97923969A patent/EP0914085B1/en not_active Expired - Lifetime
- 1997-05-22 BR BR9709422A patent/BR9709422A/pt not_active Application Discontinuation
- 1997-05-22 CN CNB971950997A patent/CN1133418C/zh not_active Expired - Fee Related
- 1997-05-22 EP EP02002043A patent/EP1201229B1/en not_active Expired - Lifetime
- 1997-05-22 US US09/194,801 patent/US6358906B1/en not_active Expired - Fee Related
- 1997-05-22 DE DE69715421T patent/DE69715421T2/de not_active Expired - Lifetime
- 1997-05-22 AU AU29594/97A patent/AU2959497A/en not_active Abandoned
- 1997-05-22 ES ES97923969T patent/ES2182077T3/es not_active Expired - Lifetime
- 1997-05-22 WO PCT/EP1997/002605 patent/WO1997046218A2/en active IP Right Grant
- 1997-05-22 ES ES02002043T patent/ES2375350T3/es not_active Expired - Lifetime
- 1997-05-22 JP JP50015098A patent/JP4106091B2/ja not_active Expired - Lifetime
- 1997-05-27 CO CO97029078A patent/CO4850630A1/es unknown
- 1997-05-30 MY MYPI97002398A patent/MY126299A/en unknown
- 1997-05-30 ID IDP971830A patent/ID17019A/id unknown
- 1997-06-02 AR ARP970102384A patent/AR008760A1/es active IP Right Grant
- 1997-06-02 TW TW086107514A patent/TW464491B/zh not_active IP Right Cessation
- 1997-06-03 ZA ZA9704871A patent/ZA974871B/xx unknown
-
2010
- 2010-06-10 AR ARP100102051A patent/AR077053A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO4850630A1 (es) | 1999-10-26 |
ES2182077T3 (es) | 2003-03-01 |
JP4106091B2 (ja) | 2008-06-25 |
CN1220597A (zh) | 1999-06-23 |
TW464491B (en) | 2001-11-21 |
JP2000512276A (ja) | 2000-09-19 |
US6358906B1 (en) | 2002-03-19 |
EP0914085B1 (en) | 2002-09-11 |
AR077053A2 (es) | 2011-07-27 |
EP1201229B1 (en) | 2011-11-09 |
EP1201229A1 (en) | 2002-05-02 |
AU2959497A (en) | 1998-01-05 |
WO1997046218A2 (en) | 1997-12-11 |
CN1133418C (zh) | 2004-01-07 |
AR008760A1 (es) | 2000-02-23 |
MY126299A (en) | 2006-09-29 |
ZA974871B (en) | 1998-05-20 |
ID17019A (id) | 1997-12-04 |
DE69715421D1 (de) | 2002-10-17 |
DE69715421T2 (de) | 2003-08-07 |
EP0914085A2 (en) | 1999-05-12 |
BR9709422A (pt) | 1999-08-10 |
WO1997046218A3 (en) | 1998-03-12 |
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