ES2372713T3 - Vacuna antitumoral derivada de celulas cd4+ normales modificadas químicamente. - Google Patents

Vacuna antitumoral derivada de celulas cd4+ normales modificadas químicamente. Download PDF

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Publication number
ES2372713T3
ES2372713T3 ES08701232T ES08701232T ES2372713T3 ES 2372713 T3 ES2372713 T3 ES 2372713T3 ES 08701232 T ES08701232 T ES 08701232T ES 08701232 T ES08701232 T ES 08701232T ES 2372713 T3 ES2372713 T3 ES 2372713T3
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cells
lymphocytes
antigens
tumor
cell
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Spanish (es)
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Alexei Kirkin
Karine Dzhandzhugazyan
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Cytovac AS
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Cytovac AS
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4267Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/06Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121Dendritic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES08701232T 2007-01-03 2008-01-03 Vacuna antitumoral derivada de celulas cd4+ normales modificadas químicamente. Active ES2372713T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0700058 2007-01-03
GBGB0700058.1A GB0700058D0 (en) 2007-01-03 2007-01-03 Anti-tumor vaccine based on normal cells

Publications (1)

Publication Number Publication Date
ES2372713T3 true ES2372713T3 (es) 2012-01-25

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ES08701232T Active ES2372713T3 (es) 2007-01-03 2008-01-03 Vacuna antitumoral derivada de celulas cd4+ normales modificadas químicamente.

Country Status (14)

Country Link
US (2) US10023839B2 (cg-RX-API-DMAC7.html)
EP (1) EP2102331B1 (cg-RX-API-DMAC7.html)
JP (1) JP5452231B2 (cg-RX-API-DMAC7.html)
AT (1) ATE522600T1 (cg-RX-API-DMAC7.html)
AU (1) AU2008203730B2 (cg-RX-API-DMAC7.html)
CY (1) CY1112668T1 (cg-RX-API-DMAC7.html)
DK (1) DK2102331T3 (cg-RX-API-DMAC7.html)
ES (1) ES2372713T3 (cg-RX-API-DMAC7.html)
GB (1) GB0700058D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20110899T1 (cg-RX-API-DMAC7.html)
PL (1) PL2102331T3 (cg-RX-API-DMAC7.html)
PT (1) PT2102331E (cg-RX-API-DMAC7.html)
SI (1) SI2102331T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008081035A1 (cg-RX-API-DMAC7.html)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA011421B1 (ru) * 2008-08-26 2009-02-27 Петр Генриевич ЛОХОВ Способ получения противоопухолевой вакцины
US8467973B2 (en) 2009-07-28 2013-06-18 Promising Future, Llc Pairing processes for preparing alloreactive cytotoxic T cells
US8666674B2 (en) 2009-07-28 2014-03-04 Promising Future, Llc Pairing processes for preparing reactive cytotoxic T cells
US9211321B2 (en) 2009-10-27 2015-12-15 Immunicum Ab Method for proliferation of antigen-specific T cells
GB201013443D0 (en) 2010-08-11 2010-09-22 Cytovac As Compositions and methods for producing dendritic cells
US10426740B1 (en) 2010-08-18 2019-10-01 Avm Biotechnology, Llc Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues
EA201792642A1 (ru) 2015-05-28 2018-10-31 Кайт Фарма, Инк. Способы диагностики для т-клеточной терапии
IL312426B1 (en) 2015-05-28 2025-10-01 Kite Pharma Inc Methods for training patients for T-cell therapy
TW202521141A (zh) 2015-10-20 2025-06-01 美商凱特製藥公司 製備用於t細胞治療之t細胞的方法
UA128781C2 (uk) 2016-04-01 2024-10-23 Кайт Фарма, Інк. Т-клітина, спосіб її отримання та застосування
CU20180121A7 (es) 2016-04-01 2019-05-03 Kite Pharma Inc Receptores de antígenos quiméricos y células t
KR102522622B1 (ko) 2016-04-01 2023-04-18 카이트 파마 인코포레이티드 Bcma 결합 분자 및 그의 사용 방법
WO2018152181A1 (en) 2017-02-14 2018-08-23 Kite Pharma, Inc. Cd70 binding molecules and methods of use thereof
US20180280437A1 (en) 2017-03-13 2018-10-04 Kite Pharma, Inc. Chimeric antigen receptors for melanoma and uses thereof
BR112019020214A2 (pt) 2017-04-01 2020-04-22 Avm Biotechnology Llc substituição do pré-condicionamento citotóxico antes da imunoterapia celular
CN110494158A (zh) 2017-04-03 2019-11-22 凯德药业股份有限公司 使用包含优化的多功能t细胞的嵌合受体t细胞进行治疗
JOP20180042A1 (ar) 2017-04-24 2019-01-30 Kite Pharma Inc نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام
CN110662831A (zh) 2017-05-26 2020-01-07 凯德药业股份有限公司 制备和使用胚胎间充质祖细胞的方法
SG11202002327PA (en) 2017-09-15 2020-04-29 Kite Pharma Inc Methods and systems for performing a patient-specific immunotherapy procedure with chain-of-custody and chain-of-identity biological sample tracking
WO2019060695A1 (en) 2017-09-22 2019-03-28 Kite Pharma, Inc. CHIMERIC POLYPEPTIDES AND USES THEREOF
WO2019079564A1 (en) 2017-10-18 2019-04-25 Kite Pharma, Inc. METHODS OF DELIVERY OF CHIMERIC ANTIGEN RECEPTOR IMMUNOTHERAPY
US11390655B2 (en) 2017-11-16 2022-07-19 Kite Pharma, Inc. Modified chimeric antigen receptors and methods of use
TW201932593A (zh) 2018-01-15 2019-08-16 美商輝瑞大藥廠 合併投與嵌合抗原受體之免疫療法與4-1bb促效劑的方法
US12338459B2 (en) 2018-02-02 2025-06-24 Arizona Board Of Regents On Behalf Of Arizona State University DNA-chimeric antigen receptor T cells for immunotherapy
KR102618231B1 (ko) 2018-02-16 2023-12-28 카이트 파마 인코포레이티드 변형된 만능성 줄기 세포, 및 제조 및 사용 방법
AU2019252944B2 (en) 2018-04-12 2022-12-08 Kite Pharma, Inc. Chimeric receptor T cell treatment using characteristics of the tumor microenvironment
KR102734592B1 (ko) 2018-06-01 2024-11-27 카이트 파마 인코포레이티드 키메라 항원 수용체 t 세포 요법
US20210155941A1 (en) 2018-06-22 2021-05-27 Kite Pharma Eu B.V. Compositions and methods for making engineered t cells
EP3830125A1 (en) 2018-08-02 2021-06-09 Kite Pharma, Inc. Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof
EP3488851A1 (en) 2018-10-03 2019-05-29 AVM Biotechnology, LLC Immunoablative therapies
EP3632446B3 (en) 2018-10-03 2024-01-24 AVM Biotechnology, LLC Immunoablative therapies
MX2021006968A (es) 2018-12-12 2021-10-13 Kite Pharma Inc Antígeno quimérico y receptores de las células t, y métodos de uso.
WO2020208054A1 (en) 2019-04-12 2020-10-15 Cytovac A/S Method for preparation of cancer/testis antigen-specific t-cells
CN118662516A (zh) 2019-05-03 2024-09-20 凯德药业股份有限公司 施用嵌合抗原受体免疫疗法的方法
CN114391021A (zh) 2019-06-21 2022-04-22 凯德药业股份有限公司 TGF-β受体和使用方法
WO2021046134A1 (en) 2019-09-03 2021-03-11 Allogene Therapeutics, Inc. Methods of preparing t cells for t cell therapy
WO2021260675A1 (en) 2020-06-24 2021-12-30 Yeda Research And Development Co. Ltd. Agents for sensitizing solid tumors to treatment
IL299911A (en) 2020-08-14 2023-03-01 Kite Pharma Inc Improving immune cell function
US12152251B2 (en) 2020-08-25 2024-11-26 Kite Pharma, Inc. T cells with improved functionality
AU2021369507B2 (en) 2020-10-28 2025-06-26 Kite Pharma, Inc. Flow cytometric method for characterization of t-cell impurities
CN116745319A (zh) 2020-12-24 2023-09-12 凯德药业股份有限公司 前列腺癌嵌合抗原受体
CA3207182A1 (en) 2021-01-10 2022-07-14 Kite Pharma, Inc. T cell therapy
US20240076616A1 (en) 2021-01-21 2024-03-07 Cytovac A/S Method for t-cell expansion and related medical applications
WO2022178243A1 (en) 2021-02-20 2022-08-25 Kite Pharma, Inc. Gene markers for sellecting immunotherapies
IL305571A (en) 2021-03-11 2023-10-01 Kite Pharma Inc Improving the function of immune system cells
US12337035B2 (en) 2021-04-16 2025-06-24 Kite Pharma, Inc. TACI binding molecules
WO2022221126A1 (en) 2021-04-16 2022-10-20 Kite Pharma, Inc. Methods and systems for scheduling a patient-specific immunotherapy procedure
AU2022274608B2 (en) 2021-05-14 2025-12-11 Kite Pharma, Inc. Chimeric antigen receptor t cell therapy
KR20240013173A (ko) 2021-05-24 2024-01-30 카이트 파마 인코포레이티드 Nkg2d-기초 키메라 항원 수용체
US20230020993A1 (en) 2021-06-08 2023-01-19 Kite Pharma, Inc. Gpc3 binding molecules
WO2022269019A1 (en) 2021-06-25 2022-12-29 Cytovac A/S Method for preparation of cytotoxic t lymphocytes with broad tumour-specific reactivity and characteristics of early differentiation cells
EP4363558A1 (en) 2021-07-01 2024-05-08 Kite Pharma, Inc. Closed-system and method for autologous and allogeneic cell therapy manufacturing
JP2024525485A (ja) 2021-07-02 2024-07-12 カイト ファーマ インコーポレイテッド 細胞療法適用において使用される遺伝子構築物由来の遺伝子産物におけるバリアントを特定するための方法
US20230060292A1 (en) 2021-07-26 2023-03-02 Kite Pharma, Inc. Split chimeric antigen receptors and methods of use
KR20240027077A (ko) 2021-07-30 2024-02-29 카이트 파마 인코포레이티드 세포 요법-유도 독성의 모니터링 및 관리
EP4419559A1 (en) 2021-10-18 2024-08-28 Kite Pharma, Inc. Signaling domains for chimeric antigen receptors
JP2025508376A (ja) 2022-02-15 2025-03-26 カイト ファーマ インコーポレイテッド 免疫療法由来の有害事象の予測
WO2023247324A1 (en) 2022-06-24 2023-12-28 Cytovac A/S Novel combination treatment with adoptive cellular therapy
WO2024044670A1 (en) 2022-08-26 2024-02-29 Kite Pharma, Inc. Improving immune cell function
AU2023367198A1 (en) 2022-10-28 2025-04-17 Kite Pharma, Inc. Improving efficacy and durable response of immunotherapy
US20240158869A1 (en) 2022-10-28 2024-05-16 Kite Pharma, Inc. Factors for optimizing immunotherapy
US20240309428A1 (en) 2023-03-17 2024-09-19 Kite Pharma, Inc. Impact of tumor microenvironment on efficacy of immunotherapy
US20250161361A1 (en) 2023-11-01 2025-05-22 Kite Pharma, Inc. Factors for optimizing immunotherapy efficacy
WO2025174963A1 (en) 2024-02-16 2025-08-21 Kite Pharma, Inc. Systems, methods, and kits for generating and administering engineered t cells and cd38 targeting compounds as a combination therapy
WO2025188561A1 (en) 2024-03-04 2025-09-12 Kite Pharma, Inc. Predictive markers for immunotherapy
WO2025231376A1 (en) 2024-05-03 2025-11-06 Kite Pharma, Inc. Chimeric receptors binding to cll-1 and methods of use thereof
US20250382383A1 (en) 2024-05-31 2025-12-18 Kite Pharma, Inc. Tricistronic constructs for anti-gpc3 car

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003012085A1 (en) * 2001-07-30 2003-02-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Antigen presenting cells, method for their preparation and their use for cancer vaccines

Also Published As

Publication number Publication date
CY1112668T1 (el) 2016-02-10
PL2102331T3 (pl) 2012-01-31
DK2102331T3 (da) 2011-10-17
US20100092498A1 (en) 2010-04-15
EP2102331A1 (en) 2009-09-23
HRP20110899T1 (hr) 2011-12-31
EP2102331B1 (en) 2011-08-31
ATE522600T1 (de) 2011-09-15
SI2102331T1 (sl) 2012-01-31
US20180036397A1 (en) 2018-02-08
US10023839B2 (en) 2018-07-17
JP2010514455A (ja) 2010-05-06
WO2008081035A1 (en) 2008-07-10
PT2102331E (pt) 2011-12-19
JP5452231B2 (ja) 2014-03-26
AU2008203730B2 (en) 2013-11-07
AU2008203730A1 (en) 2008-07-10
GB0700058D0 (en) 2007-02-07

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