ES2371658T3 - Uso combinado de compuesto de prostaglandina e inhibidor de la bomba de protones para el tratamiento de trastornos gastrointestinales. - Google Patents
Uso combinado de compuesto de prostaglandina e inhibidor de la bomba de protones para el tratamiento de trastornos gastrointestinales. Download PDFInfo
- Publication number
- ES2371658T3 ES2371658T3 ES06731937T ES06731937T ES2371658T3 ES 2371658 T3 ES2371658 T3 ES 2371658T3 ES 06731937 T ES06731937 T ES 06731937T ES 06731937 T ES06731937 T ES 06731937T ES 2371658 T3 ES2371658 T3 ES 2371658T3
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- Prior art keywords
- branched
- linear
- compound
- prostaglandin
- alkyl
- Prior art date
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
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- DSDAICPXUXPBCC-MWDJDSKUSA-N trimethyl-β-cyclodextrin Chemical compound COC[C@H]([C@H]([C@@H]([C@H]1OC)OC)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O3)[C@H](OC)[C@H]2OC)COC)O[C@@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@@H]3O[C@@H]1COC DSDAICPXUXPBCC-MWDJDSKUSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67023805P | 2005-04-12 | 2005-04-12 | |
| US670238P | 2005-04-12 |
Publications (1)
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|---|---|
| ES2371658T3 true ES2371658T3 (es) | 2012-01-05 |
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| EP (1) | EP1871380B1 (enExample) |
| JP (2) | JP5711442B2 (enExample) |
| KR (2) | KR20140069182A (enExample) |
| CN (1) | CN101198334B (enExample) |
| AU (1) | AU2006234632B2 (enExample) |
| BR (1) | BRPI0610557A2 (enExample) |
| CA (1) | CA2602812C (enExample) |
| DK (1) | DK1871380T3 (enExample) |
| ES (1) | ES2371658T3 (enExample) |
| IL (1) | IL186374A (enExample) |
| NO (1) | NO20075764L (enExample) |
| NZ (1) | NZ562763A (enExample) |
| PL (1) | PL1871380T3 (enExample) |
| PT (1) | PT1871380E (enExample) |
| RU (1) | RU2468800C2 (enExample) |
| WO (1) | WO2006109881A1 (enExample) |
| ZA (1) | ZA200709072B (enExample) |
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| US8114911B2 (en) * | 2002-10-23 | 2012-02-14 | Sucampo Ag | Prostaglandin compounds for the treatment of obesity |
| US7868045B2 (en) * | 2006-09-06 | 2011-01-11 | Sucampo Ag | Method for promoting gastrointestinal bicarbonate secretion |
| US20090012165A1 (en) * | 2007-07-03 | 2009-01-08 | Sucampo Ag | Pharmaceutical combination of nsaid and prostaglandin compound |
| WO2009157397A1 (ja) * | 2008-06-23 | 2009-12-30 | 日本新薬株式会社 | 非ステロイド性抗炎症剤投与に伴う腸管傷害治療剤 |
| US20110034424A1 (en) * | 2009-06-30 | 2011-02-10 | Sucampo Ag | Method for the long term nsaid use |
| RU2013151166A (ru) * | 2011-04-19 | 2015-05-27 | Сукампо Аг | Способ модуляции активности цитокинов |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| KR20160015100A (ko) | 2014-07-30 | 2016-02-12 | 미래파인켐 주식회사 | 프로스타글란딘 중간체의 제조방법 |
| KR20170025682A (ko) | 2015-08-31 | 2017-03-08 | 미래파인켐 주식회사 | 프로스타글란딘 유도체의 신규한 제조방법 |
| CN107582556A (zh) * | 2017-09-15 | 2018-01-16 | 成都泠汐尚品科技有限公司 | 一种治疗消化性溃疡的药物复方制剂 |
| CN108051553A (zh) * | 2017-12-29 | 2018-05-18 | 武汉轻工大学 | 一种仔猪肠道功能保护剂的筛选方法 |
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| US5428062A (en) | 1987-01-28 | 1995-06-27 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| JPH0688966B2 (ja) * | 1987-01-28 | 1994-11-09 | 株式会社アールテック・ウエノ | プロスタグランジンｅ類およびそれを含む抗潰瘍剤 |
| US5225439A (en) | 1987-01-28 | 1993-07-06 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| CA1322749C (en) | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
| US5221763A (en) | 1987-04-30 | 1993-06-22 | R-Tech Ueno, Ltd. | Prostaglandins of the F series |
| US5317032A (en) | 1987-10-02 | 1994-05-31 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Prostaglandin cathartic |
| CA2039420C (en) | 1990-04-04 | 1996-12-10 | Ryuji Ueno | Treatment of cataract with 15-keto-prostaglandin compounds |
| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| DK0857718T3 (da) | 1996-06-10 | 2002-12-16 | Sucampo Ag | Endothelinantagonist |
| SE9804314D0 (sv) * | 1998-12-14 | 1998-12-14 | Astra Ab | New pharmaceutical formulation |
| PT1220849E (pt) | 1999-10-15 | 2004-10-29 | Sucampo Ag | Composicao de compostos biciclicos e metodo para a sua estabilizacao |
| DE60139002D1 (de) * | 2000-04-06 | 2009-07-30 | Sucampo Ag | Gallensäurefördernde zusammensetzung für lebertransplantation welche ein 15-keto prostaglandin enthält |
| US6414016B1 (en) | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
| TWI302100B (en) * | 2001-05-02 | 2008-10-21 | Sucampo Ag | Composition for treating drug-induced constipation |
| MXPA04002006A (es) | 2001-08-31 | 2004-06-07 | Sucampo Ag | Analogos de prostagladina como abridor del canal de cloruro. |
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| US7732487B2 (en) | 2001-11-19 | 2010-06-08 | Sucampo Ag | Method for treating a disease or condition responsive to opening of C1C-2 channel |
| ES2591252T3 (es) * | 2002-12-27 | 2016-11-25 | Sucampo Ag | Derivados de prostaglandinas para tratar el síndrome de colon irritable y/o la dispepsia funcional |
| US9060959B2 (en) * | 2003-01-24 | 2015-06-23 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Synergistic compositions and method for potentiating anti-oxidative activity |
| CA2517005A1 (en) * | 2003-02-20 | 2004-09-02 | Santarus, Inc. | A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
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2006
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2007
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101198334A (zh) | 2008-06-11 |
| CA2602812A1 (en) | 2006-10-19 |
| CN101198334B (zh) | 2013-02-06 |
| KR20070119753A (ko) | 2007-12-20 |
| US8962688B2 (en) | 2015-02-24 |
| JP2008535774A (ja) | 2008-09-04 |
| US20070276006A1 (en) | 2007-11-29 |
| ZA200709072B (en) | 2008-11-26 |
| EP1871380A1 (en) | 2008-01-02 |
| IL186374A0 (en) | 2008-03-20 |
| DK1871380T3 (da) | 2011-11-21 |
| CA2602812C (en) | 2014-11-18 |
| RU2007141655A (ru) | 2009-05-20 |
| KR20140069182A (ko) | 2014-06-09 |
| RU2468800C2 (ru) | 2012-12-10 |
| BRPI0610557A2 (pt) | 2010-06-29 |
| WO2006109881A1 (en) | 2006-10-19 |
| AU2006234632B2 (en) | 2011-10-27 |
| IL186374A (en) | 2013-05-30 |
| NZ562763A (en) | 2010-12-24 |
| NO20075764L (no) | 2008-01-14 |
| KR101466980B1 (ko) | 2014-12-01 |
| PL1871380T3 (pl) | 2012-03-30 |
| JP5711442B2 (ja) | 2015-04-30 |
| EP1871380B1 (en) | 2011-10-19 |
| PT1871380E (pt) | 2011-11-21 |
| AU2006234632A1 (en) | 2006-10-19 |
| JP2013121972A (ja) | 2013-06-20 |
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