ES2360841T3 - Derivados de 1,3-dihidroimidazol-2-tiona como inhibidores de dopamina-beta-hidroxilasa. - Google Patents

Derivados de 1,3-dihidroimidazol-2-tiona como inhibidores de dopamina-beta-hidroxilasa. Download PDF

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Publication number
ES2360841T3
ES2360841T3 ES08741778T ES08741778T ES2360841T3 ES 2360841 T3 ES2360841 T3 ES 2360841T3 ES 08741778 T ES08741778 T ES 08741778T ES 08741778 T ES08741778 T ES 08741778T ES 2360841 T3 ES2360841 T3 ES 2360841T3
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ES
Spain
Prior art keywords
inhibitors
antagonists
compound
agonists
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08741778T
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English (en)
Spanish (es)
Inventor
Patrício Manuel Vieira Araújo SOARES DA SILVA
David Alexander Learmonth
Alexander Beliaev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bial Portela and Cia SA
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Bial Portela and Cia SA
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Publication date
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Application filed by Bial Portela and Cia SA filed Critical Bial Portela and Cia SA
Application granted granted Critical
Publication of ES2360841T3 publication Critical patent/ES2360841T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES08741778T 2007-05-08 2008-05-06 Derivados de 1,3-dihidroimidazol-2-tiona como inhibidores de dopamina-beta-hidroxilasa. Active ES2360841T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0708818.0A GB0708818D0 (en) 2007-05-08 2007-05-08 Compounds
GB0708818 2007-05-08

Publications (1)

Publication Number Publication Date
ES2360841T3 true ES2360841T3 (es) 2011-06-09

Family

ID=38198874

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08741778T Active ES2360841T3 (es) 2007-05-08 2008-05-06 Derivados de 1,3-dihidroimidazol-2-tiona como inhibidores de dopamina-beta-hidroxilasa.

Country Status (29)

Country Link
US (5) US8481582B2 (OSRAM)
EP (1) EP2155731B1 (OSRAM)
JP (1) JP5559677B2 (OSRAM)
KR (1) KR101598482B1 (OSRAM)
CN (1) CN101687858B (OSRAM)
AR (2) AR066457A1 (OSRAM)
AT (1) ATE499367T1 (OSRAM)
AU (1) AU2008246443B2 (OSRAM)
BR (1) BRPI0811275B8 (OSRAM)
CA (1) CA2686387C (OSRAM)
CL (1) CL2008001321A1 (OSRAM)
CY (1) CY1111517T1 (OSRAM)
DE (1) DE602008005141D1 (OSRAM)
DK (1) DK2155731T3 (OSRAM)
ES (1) ES2360841T3 (OSRAM)
GB (1) GB0708818D0 (OSRAM)
HR (1) HRP20110253T1 (OSRAM)
IL (1) IL201921A (OSRAM)
MX (1) MX2009012041A (OSRAM)
NO (1) NO20093275L (OSRAM)
NZ (1) NZ580962A (OSRAM)
PL (1) PL2155731T3 (OSRAM)
RS (1) RS51692B (OSRAM)
RU (1) RU2501796C2 (OSRAM)
SI (1) SI2155731T1 (OSRAM)
TW (1) TWI458722B (OSRAM)
UA (1) UA104844C2 (OSRAM)
WO (1) WO2008136695A1 (OSRAM)
ZA (1) ZA200908612B (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0708818D0 (en) 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
WO2012020742A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 新規複素環誘導体およびそれらを含有する医薬組成物
RU2604734C2 (ru) * 2010-12-22 2016-12-10 БИАЛ-ПОРТЕЛА энд КА., С.А. Кристаллическая форма и способ ее очистки
WO2013002660A2 (en) * 2011-06-29 2013-01-03 BIAL - PORTELA & Cª, S.A. Process
KR102259938B1 (ko) * 2012-11-14 2021-06-03 바이알 - 포르텔라 앤드 씨에이 에스에이 폐동맥 고혈압 및 폐 손상의 치료에 이용하기 위한 1,3-디히드로이미다졸-2-티온 유도체
CN103356671B (zh) * 2013-06-24 2015-11-25 顾祥茂 Houttuynoid C在制备治疗或预防慢性心衰的药物中的应用
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
JOP20190049A1 (ar) * 2016-09-23 2019-03-20 Bial Portela & C? S A مثبطات دوبامين-b-هيدروكسيلاز
CA3075669A1 (en) 2017-09-13 2019-03-21 Amgen Inc. Bisamide sarcomere activating compounds and uses thereof
EP3720856A1 (en) 2017-12-04 2020-10-14 BIAL - PORTELA & Cª, S.A. Dopamine-& x392;-hydroxylase inhibitors
GB201810395D0 (en) 2018-06-25 2018-08-08 Bial Portela & Ca Sa Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation
SG11202104423XA (en) * 2018-11-12 2021-05-28 Immunogen Inc Methods of preparing cytotoxic benzodiazepine derivatives
GB201908044D0 (en) 2019-06-05 2019-07-17 Bial Portela & Ca Sa Dopamine-B-Hydroxylase inhibitors
US20250134870A1 (en) * 2021-01-26 2025-05-01 Jiangsu Yahong Meditech Co., Ltd. Pathway modulator, pharmaceutical composition having same, use thereof, and therapeutic method using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217347A (en) * 1977-12-27 1980-08-12 E. R. Squibb & Sons, Inc. Method of treating hypertension and medicaments therefor
US4962128A (en) * 1989-11-02 1990-10-09 Pfizer Inc. Method of treating anxiety-related disorders using sertraline
US5298497A (en) * 1990-05-15 1994-03-29 E. R. Squibb & Sons, Inc. Method for preventing onset of hypertension employing a cholesterol lowering drug
BR9507517A (pt) * 1994-04-26 1997-09-16 Syntex Inc Derivados de benzocicloalquilazotetiona
AR032711A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
US7125904B2 (en) * 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
GB2393958A (en) * 2002-10-11 2004-04-14 Portela & Ca Sa Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase
GB0708818D0 (en) 2007-05-08 2007-06-13 Portela & Ca Sa Compounds

Also Published As

Publication number Publication date
CN101687858A (zh) 2010-03-31
ZA200908612B (en) 2010-11-24
RS51692B (sr) 2011-10-31
EP2155731A1 (en) 2010-02-24
US9630951B2 (en) 2017-04-25
ATE499367T1 (de) 2011-03-15
EP2155731B1 (en) 2011-02-23
US20170369478A1 (en) 2017-12-28
IL201921A0 (en) 2010-06-16
RU2501796C2 (ru) 2013-12-20
JP5559677B2 (ja) 2014-07-23
US20190322648A1 (en) 2019-10-24
PL2155731T3 (pl) 2011-07-29
IL201921A (en) 2013-11-28
CL2008001321A1 (es) 2008-12-26
SI2155731T1 (sl) 2011-05-31
CA2686387C (en) 2015-06-30
KR20100017546A (ko) 2010-02-16
TW200918525A (en) 2009-05-01
HK1142898A1 (en) 2010-12-17
US20210261533A1 (en) 2021-08-26
AU2008246443A8 (en) 2010-01-07
GB0708818D0 (en) 2007-06-13
MX2009012041A (es) 2010-02-18
TWI458722B (zh) 2014-11-01
WO2008136695A1 (en) 2008-11-13
BRPI0811275A2 (pt) 2014-12-23
DE602008005141D1 (de) 2011-04-07
BRPI0811275B8 (pt) 2021-05-25
NO20093275L (no) 2010-02-04
AR066457A1 (es) 2009-08-19
HRP20110253T1 (hr) 2011-05-31
NZ580962A (en) 2012-05-25
KR101598482B1 (ko) 2016-02-29
DK2155731T3 (da) 2011-05-02
AR112789A2 (es) 2019-12-11
CY1111517T1 (el) 2015-08-05
US20130345275A1 (en) 2013-12-26
RU2009145270A (ru) 2011-06-20
US20100137390A1 (en) 2010-06-03
UA104844C2 (uk) 2014-03-25
AU2008246443B2 (en) 2013-07-11
US8481582B2 (en) 2013-07-09
CA2686387A1 (en) 2008-11-13
JP2010526136A (ja) 2010-07-29
BRPI0811275B1 (pt) 2020-01-07
CN101687858B (zh) 2012-12-26
AU2008246443A1 (en) 2008-11-13

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