ES2348623T3 - Sales y polimorfos de un compuesto de indolinona sustituidos con pirrol. - Google Patents
Sales y polimorfos de un compuesto de indolinona sustituidos con pirrol. Download PDFInfo
- Publication number
- ES2348623T3 ES2348623T3 ES04769435T ES04769435T ES2348623T3 ES 2348623 T3 ES2348623 T3 ES 2348623T3 ES 04769435 T ES04769435 T ES 04769435T ES 04769435 T ES04769435 T ES 04769435T ES 2348623 T3 ES2348623 T3 ES 2348623T3
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- Prior art keywords
- salt
- fluoro
- cancer
- methyl
- hydroxy
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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| WO2007034327A1 (en) * | 2005-09-20 | 2007-03-29 | Pfizer Products Inc. | Dosage forms and methods of treatment using a tyrosine kinase inhibitor |
| TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
| CN101631747B (zh) * | 2007-04-04 | 2012-09-19 | 大塚化学株式会社 | 钛酸钾及其制造方法、以及摩擦材料和树脂组合物 |
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| RU2430361C1 (ru) * | 2010-07-05 | 2011-09-27 | Государственное образовательное учреждение высшего профессионального образования "Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого Министерства здравоохранения и социального развития Российской Федерации" | Способ прогнозирования риска развития диабетической ретинопатии при сахарном диабете типа 2 у якутов |
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| SU1575936A3 (ru) * | 1986-04-10 | 1990-06-30 | Е.И.Дюпон Де Немур Энд Ко.(Фирма) | Способ получени 3,3-дизамещенных индолин-2-ионов или их солей |
| US5534522A (en) * | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| DE19622489A1 (de) * | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| CA2399358C (en) * | 2000-02-15 | 2006-03-21 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| AU2002324684B2 (en) * | 2001-08-15 | 2006-10-05 | Pharmacia And Upjohn Company Llc | Crystals including a malic acid salt of N-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3H-indole-3-ylidene) methyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof |
| YU67702A (sh) | 2001-09-28 | 2004-12-31 | Pfizer Products Inc. | Postupak za dobijanje alkansulfonil piridina |
| TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| EP1476443A2 (en) * | 2002-02-15 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Process for preparing indolinone derivatives |
| HN2003000272A (es) * | 2002-09-10 | 2008-07-29 | Pharmacia Italia Spa | Formulaciones que comprenden un compuesto de indolinona |
-
2004
- 2004-09-20 DE DE602004028028T patent/DE602004028028D1/de not_active Expired - Lifetime
- 2004-09-20 CN CNB2004800287364A patent/CN100432072C/zh not_active Expired - Fee Related
- 2004-09-20 WO PCT/IB2004/003070 patent/WO2005033098A1/en not_active Ceased
- 2004-09-20 RU RU2006110541/04A patent/RU2319702C2/ru not_active IP Right Cessation
- 2004-09-20 PL PL04769435T patent/PL1670785T3/pl unknown
- 2004-09-20 AT AT04769435T patent/ATE473223T1/de active
- 2004-09-20 EP EP04769435A patent/EP1670785B1/en not_active Expired - Lifetime
- 2004-09-20 AU AU2004277464A patent/AU2004277464B2/en not_active Ceased
- 2004-09-20 MX MXPA06003661A patent/MXPA06003661A/es active IP Right Grant
- 2004-09-20 BR BRPI0415022-8A patent/BRPI0415022A/pt not_active IP Right Cessation
- 2004-09-20 NZ NZ546001A patent/NZ546001A/en unknown
- 2004-09-20 KR KR1020067006363A patent/KR20060058728A/ko not_active Ceased
- 2004-09-20 KR KR1020087000428A patent/KR20080007520A/ko not_active Ceased
- 2004-09-20 DK DK04769435.1T patent/DK1670785T3/da active
- 2004-09-20 ES ES04769435T patent/ES2348623T3/es not_active Expired - Lifetime
- 2004-09-20 JP JP2006530728A patent/JP4933259B2/ja not_active Expired - Fee Related
- 2004-09-20 CA CA2540639A patent/CA2540639C/en not_active Expired - Fee Related
- 2004-09-20 PT PT04769435T patent/PT1670785E/pt unknown
- 2004-09-20 SI SI200431486T patent/SI1670785T1/sl unknown
- 2004-09-30 US US10/956,420 patent/US7247627B2/en not_active Expired - Fee Related
- 2004-10-01 AR ARP040103580A patent/AR047762A1/es not_active Application Discontinuation
- 2004-10-01 TW TW093129924A patent/TW200524921A/zh unknown
-
2006
- 2006-03-17 NO NO20061246A patent/NO20061246L/no not_active Application Discontinuation
- 2006-03-20 IL IL174414A patent/IL174414A/en not_active IP Right Cessation
- 2006-03-31 ZA ZA200602691A patent/ZA200602691B/en unknown
-
2010
- 2010-09-03 CY CY20101100810T patent/CY1110771T1/el unknown
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