KR20060058728A - 피롤-치환된 인돌리논 화합물의 염 및 다형체 - Google Patents

피롤-치환된 인돌리논 화합물의 염 및 다형체 Download PDF

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Publication number
KR20060058728A
KR20060058728A KR1020067006363A KR20067006363A KR20060058728A KR 20060058728 A KR20060058728 A KR 20060058728A KR 1020067006363 A KR1020067006363 A KR 1020067006363A KR 20067006363 A KR20067006363 A KR 20067006363A KR 20060058728 A KR20060058728 A KR 20060058728A
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KR
South Korea
Prior art keywords
pyrrole
fluoro
salt
methyl
hydroxy
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Ceased
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KR1020067006363A
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English (en)
Korean (ko)
Inventor
안드레이 블라스코
퀸규 진
쿤 루
마이클 안토니 마우라기스
동 송
브렌다 수 본더웰
Original Assignee
파마시아 앤드 업존 캄파니 엘엘씨
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Publication of KR20060058728A publication Critical patent/KR20060058728A/ko
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020067006363A 2003-10-02 2004-09-20 피롤-치환된 인돌리논 화합물의 염 및 다형체 Ceased KR20060058728A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50810403P 2003-10-02 2003-10-02
US60/508,104 2003-10-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020087000428A Division KR20080007520A (ko) 2003-10-02 2004-09-20 피롤-치환된 인돌리논 화합물의 염 및 다형체

Publications (1)

Publication Number Publication Date
KR20060058728A true KR20060058728A (ko) 2006-05-30

Family

ID=34421700

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020067006363A Ceased KR20060058728A (ko) 2003-10-02 2004-09-20 피롤-치환된 인돌리논 화합물의 염 및 다형체
KR1020087000428A Ceased KR20080007520A (ko) 2003-10-02 2004-09-20 피롤-치환된 인돌리논 화합물의 염 및 다형체

Family Applications After (1)

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KR1020087000428A Ceased KR20080007520A (ko) 2003-10-02 2004-09-20 피롤-치환된 인돌리논 화합물의 염 및 다형체

Country Status (25)

Country Link
US (1) US7247627B2 (cg-RX-API-DMAC7.html)
EP (1) EP1670785B1 (cg-RX-API-DMAC7.html)
JP (1) JP4933259B2 (cg-RX-API-DMAC7.html)
KR (2) KR20060058728A (cg-RX-API-DMAC7.html)
CN (1) CN100432072C (cg-RX-API-DMAC7.html)
AR (1) AR047762A1 (cg-RX-API-DMAC7.html)
AT (1) ATE473223T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004277464B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415022A (cg-RX-API-DMAC7.html)
CA (1) CA2540639C (cg-RX-API-DMAC7.html)
CY (1) CY1110771T1 (cg-RX-API-DMAC7.html)
DE (1) DE602004028028D1 (cg-RX-API-DMAC7.html)
DK (1) DK1670785T3 (cg-RX-API-DMAC7.html)
ES (1) ES2348623T3 (cg-RX-API-DMAC7.html)
IL (1) IL174414A (cg-RX-API-DMAC7.html)
MX (1) MXPA06003661A (cg-RX-API-DMAC7.html)
NO (1) NO20061246L (cg-RX-API-DMAC7.html)
NZ (1) NZ546001A (cg-RX-API-DMAC7.html)
PL (1) PL1670785T3 (cg-RX-API-DMAC7.html)
PT (1) PT1670785E (cg-RX-API-DMAC7.html)
RU (1) RU2319702C2 (cg-RX-API-DMAC7.html)
SI (1) SI1670785T1 (cg-RX-API-DMAC7.html)
TW (1) TW200524921A (cg-RX-API-DMAC7.html)
WO (1) WO2005033098A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200602691B (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050182122A1 (en) * 2003-11-20 2005-08-18 Bello Carlo L. Method of treating abnormal cell growth using indolinone compounds
AU2006227880A1 (en) * 2005-03-23 2006-09-28 Pfizer Products Inc. Anti-CTLA4 antibody and indolinone combination therapy for treatment of cancer
WO2007034327A1 (en) * 2005-09-20 2007-03-29 Pfizer Products Inc. Dosage forms and methods of treatment using a tyrosine kinase inhibitor
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
CN101631747B (zh) * 2007-04-04 2012-09-19 大塚化学株式会社 钛酸钾及其制造方法、以及摩擦材料和树脂组合物
JO2889B1 (en) * 2008-09-17 2015-03-15 نوفارتيس ايه جي Salts 6N - (CIS-2, 6-dimethyl morpholine-4-yl) pyridine-3-yl-methyl-4 ’- (tetrafluoromethoxy) [1,1,-2-phenyl] -3-carboxamide
RU2430361C1 (ru) * 2010-07-05 2011-09-27 Государственное образовательное учреждение высшего профессионального образования "Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого Министерства здравоохранения и социального развития Российской Федерации" Способ прогнозирования риска развития диабетической ретинопатии при сахарном диабете типа 2 у якутов
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
US9851313B2 (en) * 2015-03-03 2017-12-26 Panalytical B.V. Quantitative X-ray analysis—ratio correction

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1575936A3 (ru) * 1986-04-10 1990-06-30 Е.И.Дюпон Де Немур Энд Ко.(Фирма) Способ получени 3,3-дизамещенных индолин-2-ионов или их солей
US5534522A (en) * 1995-06-07 1996-07-09 Warner-Lambert Company (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
DE19622489A1 (de) * 1996-06-05 1997-12-11 Hoechst Ag Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters
CA2399358C (en) * 2000-02-15 2006-03-21 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
AU2002324684B2 (en) * 2001-08-15 2006-10-05 Pharmacia And Upjohn Company Llc Crystals including a malic acid salt of N-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3H-indole-3-ylidene) methyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
YU67702A (sh) 2001-09-28 2004-12-31 Pfizer Products Inc. Postupak za dobijanje alkansulfonil piridina
TWI259081B (en) * 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
EP1476443A2 (en) * 2002-02-15 2004-11-17 PHARMACIA & UPJOHN COMPANY Process for preparing indolinone derivatives
HN2003000272A (es) * 2002-09-10 2008-07-29 Pharmacia Italia Spa Formulaciones que comprenden un compuesto de indolinona

Also Published As

Publication number Publication date
PT1670785E (pt) 2010-09-16
NO20061246L (no) 2006-03-29
BRPI0415022A (pt) 2006-11-28
KR20080007520A (ko) 2008-01-21
US20050118255A1 (en) 2005-06-02
ATE473223T1 (de) 2010-07-15
JP4933259B2 (ja) 2012-05-16
CA2540639C (en) 2010-08-31
EP1670785A1 (en) 2006-06-21
CN100432072C (zh) 2008-11-12
TW200524921A (en) 2005-08-01
AR047762A1 (es) 2006-02-22
CN1863796A (zh) 2006-11-15
JP2007507482A (ja) 2007-03-29
WO2005033098A8 (en) 2006-04-20
DK1670785T3 (da) 2010-10-18
ZA200602691B (en) 2007-06-27
US7247627B2 (en) 2007-07-24
RU2006110541A (ru) 2006-08-27
AU2004277464B2 (en) 2010-07-08
HK1093068A1 (zh) 2007-02-23
ES2348623T3 (es) 2010-12-09
RU2319702C2 (ru) 2008-03-20
WO2005033098A9 (en) 2006-05-26
SI1670785T1 (sl) 2010-10-29
MXPA06003661A (es) 2006-06-05
PL1670785T3 (pl) 2010-12-31
IL174414A0 (en) 2008-02-09
WO2005033098A1 (en) 2005-04-14
CA2540639A1 (en) 2005-04-14
DE602004028028D1 (de) 2010-08-19
AU2004277464A1 (en) 2005-04-14
EP1670785B1 (en) 2010-07-07
IL174414A (en) 2011-12-29
CY1110771T1 (el) 2015-06-10
NZ546001A (en) 2009-09-25

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