CA2540639C - Salts and polymorphs of a pyrrole-substituted indolinone compound - Google Patents
Salts and polymorphs of a pyrrole-substituted indolinone compound Download PDFInfo
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- CA2540639C CA2540639C CA2540639A CA2540639A CA2540639C CA 2540639 C CA2540639 C CA 2540639C CA 2540639 A CA2540639 A CA 2540639A CA 2540639 A CA2540639 A CA 2540639A CA 2540639 C CA2540639 C CA 2540639C
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- Prior art keywords
- salt
- pyrrole
- fluoro
- methyl
- ylpropyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50810403P | 2003-10-02 | 2003-10-02 | |
| US60/508,104 | 2003-10-02 | ||
| PCT/IB2004/003070 WO2005033098A1 (en) | 2003-10-02 | 2004-09-20 | Salts and polymorphs of a pyrrole-substituted indolinone compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2540639A1 CA2540639A1 (en) | 2005-04-14 |
| CA2540639C true CA2540639C (en) | 2010-08-31 |
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| CA2540639A Expired - Fee Related CA2540639C (en) | 2003-10-02 | 2004-09-20 | Salts and polymorphs of a pyrrole-substituted indolinone compound |
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| US20050182122A1 (en) * | 2003-11-20 | 2005-08-18 | Bello Carlo L. | Method of treating abnormal cell growth using indolinone compounds |
| AU2006227880A1 (en) * | 2005-03-23 | 2006-09-28 | Pfizer Products Inc. | Anti-CTLA4 antibody and indolinone combination therapy for treatment of cancer |
| WO2007034327A1 (en) * | 2005-09-20 | 2007-03-29 | Pfizer Products Inc. | Dosage forms and methods of treatment using a tyrosine kinase inhibitor |
| TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
| CN101631747B (zh) * | 2007-04-04 | 2012-09-19 | 大塚化学株式会社 | 钛酸钾及其制造方法、以及摩擦材料和树脂组合物 |
| JO2889B1 (en) * | 2008-09-17 | 2015-03-15 | نوفارتيس ايه جي | Salts 6N - (CIS-2, 6-dimethyl morpholine-4-yl) pyridine-3-yl-methyl-4 ’- (tetrafluoromethoxy) [1,1,-2-phenyl] -3-carboxamide |
| RU2430361C1 (ru) * | 2010-07-05 | 2011-09-27 | Государственное образовательное учреждение высшего профессионального образования "Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого Министерства здравоохранения и социального развития Российской Федерации" | Способ прогнозирования риска развития диабетической ретинопатии при сахарном диабете типа 2 у якутов |
| WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
| US9851313B2 (en) * | 2015-03-03 | 2017-12-26 | Panalytical B.V. | Quantitative X-ray analysis—ratio correction |
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| SU1575936A3 (ru) * | 1986-04-10 | 1990-06-30 | Е.И.Дюпон Де Немур Энд Ко.(Фирма) | Способ получени 3,3-дизамещенных индолин-2-ионов или их солей |
| US5534522A (en) * | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| DE19622489A1 (de) * | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| CA2399358C (en) * | 2000-02-15 | 2006-03-21 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| AU2002324684B2 (en) * | 2001-08-15 | 2006-10-05 | Pharmacia And Upjohn Company Llc | Crystals including a malic acid salt of N-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3H-indole-3-ylidene) methyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof |
| YU67702A (sh) | 2001-09-28 | 2004-12-31 | Pfizer Products Inc. | Postupak za dobijanje alkansulfonil piridina |
| TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| EP1476443A2 (en) * | 2002-02-15 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Process for preparing indolinone derivatives |
| HN2003000272A (es) * | 2002-09-10 | 2008-07-29 | Pharmacia Italia Spa | Formulaciones que comprenden un compuesto de indolinona |
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2004
- 2004-09-20 DE DE602004028028T patent/DE602004028028D1/de not_active Expired - Lifetime
- 2004-09-20 CN CNB2004800287364A patent/CN100432072C/zh not_active Expired - Fee Related
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