ES2335368T3 - Gen de fusion eml4-alk. - Google Patents
Gen de fusion eml4-alk. Download PDFInfo
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- ES2335368T3 ES2335368T3 ES07254044T ES07254044T ES2335368T3 ES 2335368 T3 ES2335368 T3 ES 2335368T3 ES 07254044 T ES07254044 T ES 07254044T ES 07254044 T ES07254044 T ES 07254044T ES 2335368 T3 ES2335368 T3 ES 2335368T3
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- Proteomics, Peptides & Aminoacids (AREA)
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- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| JP2006-277718 | 2006-10-11 | ||
| JP2007120670 | 2007-05-01 | ||
| JP2007-120670 | 2007-05-01 | ||
| CA 2598893 CA2598893C (en) | 2006-10-11 | 2007-08-24 | Eml4-alk fusion gene |
| CA2598893 | 2007-08-24 |
Publications (1)
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| ES2335368T3 true ES2335368T3 (es) | 2010-03-25 |
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| ES09006058.3T Active ES2515170T3 (es) | 2006-10-11 | 2007-10-11 | Gen de fusión EML4-ALK |
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| ES09006058.3T Active ES2515170T3 (es) | 2006-10-11 | 2007-10-11 | Gen de fusión EML4-ALK |
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| DE (1) | DE602007003543D1 (enExample) |
| ES (2) | ES2335368T3 (enExample) |
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| US8168383B2 (en) * | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| JP5562640B2 (ja) * | 2007-04-13 | 2014-07-30 | セル・シグナリング・テクノロジー・インコーポレイテツド | ヒト固形腫瘍における遺伝子欠失及び突然変異ａｌｋキナーゼ |
| TWI389893B (zh) * | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二（芳胺基）芳基化合物 |
| WO2009102446A2 (en) * | 2008-02-12 | 2009-08-20 | The Brigham And Women's Hospital, Inc. | Fish assay for eml4 and alk fusion in lung cancer |
| JP2009219728A (ja) * | 2008-03-18 | 2009-10-01 | Daito Giken:Kk | 遊技台 |
| PL2300013T5 (pl) | 2008-05-21 | 2025-04-28 | Takeda Pharmaceutical Company Limited | Pochodne fosforu jako inhibitor kinazy |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| CA2762108A1 (en) * | 2009-05-15 | 2010-11-18 | Insight Genetics, Inc. | Methods and compositions relating to fusions of alk for diagnosing and treating cancer |
| WO2011043220A1 (ja) | 2009-10-06 | 2011-04-14 | 富士レビオ株式会社 | 融合遺伝子の測定方法 |
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| TW201202703A (en) * | 2010-04-16 | 2012-01-16 | Response Genetics Inc | Primers, probes, methods, and kits for the detection of EML4-ALK variants |
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| CA2808210C (en) | 2010-08-20 | 2019-10-01 | Chugai Seiyaku Kabushiki Kaisha | Tetracyclic compounds having alk inhibitory activity and compositions thereof |
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| KR101521861B1 (ko) * | 2011-02-02 | 2015-05-21 | 노파르티스 아게 | Ａｌｋ 억제제의 사용 방법 |
| US20140296181A1 (en) * | 2011-04-07 | 2014-10-02 | Coferon, Inc. | Methods of modulating oncogenic fusion proteins |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| EP2752486B1 (en) | 2011-08-31 | 2016-12-28 | Kurume University | Method for exclusive selection of circularized dna from monomolecular dna when circularizing dna molecules |
| DK2838998T3 (en) | 2012-04-18 | 2018-01-15 | Cell Signaling Technology Inc | EGFR AND ROS1 IN CANCER |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| US9084456B1 (en) * | 2012-05-28 | 2015-07-21 | Jack Zemer | Linkage for jewelry components |
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| JP6534930B2 (ja) | 2013-07-26 | 2019-06-26 | 公益財団法人がん研究会 | Ｎｔｒｋ３融合体の検出法 |
| WO2015064621A1 (ja) * | 2013-10-29 | 2015-05-07 | 公益財団法人がん研究会 | 新規融合体及びその検出法 |
| JP6806440B2 (ja) * | 2013-10-29 | 2021-01-06 | 公益財団法人がん研究会 | 新規融合体及びその検出法 |
| US10048277B2 (en) | 2014-01-24 | 2018-08-14 | Japanese Foundation For Cancer Research | Method for detecting an FGFR3/TACC3 fusion protein, or encoding gene thereof |
| CA2946518C (en) | 2014-04-25 | 2022-07-26 | Chugai Seiyaku Kabushiki Kaisha | Preparation containing tetracyclic compound at high dose |
| MX378186B (es) | 2014-04-25 | 2025-03-10 | Chugai Pharmaceutical Co Ltd | Cristales novedosos de 9-etil-6,6-dimetil-8-(4-morfolin-4-il-piperidin-1-il)-11-oxo-6,11-dihidro-5h-benzo[b]carbazol-3-carbonitrilo. |
| TWI803187B (zh) | 2014-08-08 | 2023-05-21 | 日商中外製藥股份有限公司 | 包含４環性化合物的非晶質體之固體分散體及製劑 |
| EP2990493B1 (en) | 2014-09-01 | 2017-05-24 | ARKRAY, Inc. | Primer reagent for amplifying alk fusion gene, alk fusion gene amplification reagent kit including the same, and alk fusion gene amplification method and alk fusion gene analysis method using the same |
| WO2017122816A1 (ja) | 2016-01-15 | 2017-07-20 | 公益財団法人がん研究会 | 新規融合体及びその検出法 |
| JP6740172B2 (ja) * | 2017-05-02 | 2020-08-12 | セル・シグナリング・テクノロジー・インコーポレイテツド | ヒト固形腫瘍における遺伝子欠失及び突然変異ａｌｋキナーゼ |
| US12473548B2 (en) * | 2018-06-27 | 2025-11-18 | City Of Hope | Modification of small RNAs for therapeutic uses |
| EP4316598B1 (en) | 2018-06-29 | 2025-06-18 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising a poorly soluble basic agent |
| JP7385191B2 (ja) * | 2019-08-30 | 2023-11-22 | 学校法人同志社 | Ｅｍｌ４－ａｌｋ阻害ペプチドおよびこれを含む肺がん治療薬 |
| JP2020156481A (ja) * | 2020-04-06 | 2020-10-01 | セル・シグナリング・テクノロジー・インコーポレイテツド | ヒト固形腫瘍における遺伝子欠失及び突然変異ａｌｋキナーゼ |
| EP4424313A4 (en) | 2021-10-28 | 2025-07-09 | Chugai Pharmaceutical Co Ltd | PREPARATION OF SYRUP |
| TW202412771A (zh) | 2022-07-04 | 2024-04-01 | 日商中外製藥股份有限公司 | 併用醫藥 |
| KR20250055574A (ko) | 2022-08-30 | 2025-04-24 | 추가이 세이야쿠 가부시키가이샤 | 병용 의약 |
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| WO2001034785A1 (en) | 1999-11-11 | 2001-05-17 | Yamanouchi Pharmaceutical Co., Ltd. | Novel metalloprotease having aggrecanase activity |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| US7872014B2 (en) | 2003-07-23 | 2011-01-18 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| DK2287156T3 (da) | 2003-08-15 | 2013-08-26 | Novartis Ag | 2,4-Di(phenylamino)-pyrimidiner egnede i behandling af neoplastiske sygdomme, inflammatoriske lidelser og lidelser i immunsystemet |
| WO2005097765A1 (en) | 2004-03-31 | 2005-10-20 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| CA2598893C (en) | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| JP5562640B2 (ja) * | 2007-04-13 | 2014-07-30 | セル・シグナリング・テクノロジー・インコーポレイテツド | ヒト固形腫瘍における遺伝子欠失及び突然変異ａｌｋキナーゼ |
| TWI389893B (zh) | 2007-07-06 | 2013-03-21 | Astellas Pharma Inc | 二（芳胺基）芳基化合物 |
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- 2007-10-11 ES ES09006058.3T patent/ES2515170T3/es active Active
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2008
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2009
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2017
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Also Published As
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| US7964710B2 (en) | 2011-06-21 |
| ATE450547T1 (de) | 2009-12-15 |
| US20080090776A1 (en) | 2008-04-17 |
| US7728120B2 (en) | 2010-06-01 |
| US9029521B2 (en) | 2015-05-12 |
| JP5172736B2 (ja) | 2013-03-27 |
| EP2116553B1 (en) | 2014-07-30 |
| CA2598893C (en) | 2012-04-10 |
| US20150184161A1 (en) | 2015-07-02 |
| US8197818B2 (en) | 2012-06-12 |
| DE602007003543D1 (de) | 2010-01-14 |
| US20100240673A1 (en) | 2010-09-23 |
| US20130158095A1 (en) | 2013-06-20 |
| JP2008295444A (ja) | 2008-12-11 |
| US20110230545A1 (en) | 2011-09-22 |
| US20090099193A1 (en) | 2009-04-16 |
| JP4303303B2 (ja) | 2009-07-29 |
| EP2116553A1 (en) | 2009-11-11 |
| US9932589B2 (en) | 2018-04-03 |
| CA2598893A1 (en) | 2008-04-11 |
| ES2515170T3 (es) | 2014-10-29 |
| US7605131B2 (en) | 2009-10-20 |
| US20180066266A1 (en) | 2018-03-08 |
| JP2009100783A (ja) | 2009-05-14 |
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