ES2330145T3 - Derivados benzofuralino como inhibidores del receptor 5-ht6. - Google Patents

Derivados benzofuralino como inhibidores del receptor 5-ht6. Download PDF

Info

Publication number
ES2330145T3
ES2330145T3 ES06763743T ES06763743T ES2330145T3 ES 2330145 T3 ES2330145 T3 ES 2330145T3 ES 06763743 T ES06763743 T ES 06763743T ES 06763743 T ES06763743 T ES 06763743T ES 2330145 T3 ES2330145 T3 ES 2330145T3
Authority
ES
Spain
Prior art keywords
disorders
treatment
receptor
body weight
prophylaxis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06763743T
Other languages
English (en)
Spanish (es)
Inventor
Patrizia Caldirola
Gary Johansson
Lori Sutin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swedish Orphan Biovitrum AB
Original Assignee
Biovitrum AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum AB filed Critical Biovitrum AB
Application granted granted Critical
Publication of ES2330145T3 publication Critical patent/ES2330145T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES06763743T 2005-06-17 2006-06-15 Derivados benzofuralino como inhibidores del receptor 5-ht6. Active ES2330145T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE2005101383 2005-06-17
SE0501383 2005-06-17
US70652305P 2005-08-09 2005-08-09
US706523P 2005-08-09

Publications (1)

Publication Number Publication Date
ES2330145T3 true ES2330145T3 (es) 2009-12-04

Family

ID=36659956

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06763743T Active ES2330145T3 (es) 2005-06-17 2006-06-15 Derivados benzofuralino como inhibidores del receptor 5-ht6.

Country Status (18)

Country Link
US (1) US7582767B2 (cg-RX-API-DMAC7.html)
EP (1) EP1896460B1 (cg-RX-API-DMAC7.html)
JP (1) JP2008543813A (cg-RX-API-DMAC7.html)
KR (1) KR20080017482A (cg-RX-API-DMAC7.html)
CN (1) CN101193885B (cg-RX-API-DMAC7.html)
AU (1) AU2006259082B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0612746A2 (cg-RX-API-DMAC7.html)
CA (1) CA2610383A1 (cg-RX-API-DMAC7.html)
DE (1) DE602006008002D1 (cg-RX-API-DMAC7.html)
DK (1) DK1896460T3 (cg-RX-API-DMAC7.html)
EA (1) EA015671B1 (cg-RX-API-DMAC7.html)
ES (1) ES2330145T3 (cg-RX-API-DMAC7.html)
IL (1) IL187575A (cg-RX-API-DMAC7.html)
MX (1) MX2007015988A (cg-RX-API-DMAC7.html)
NO (1) NO20080354L (cg-RX-API-DMAC7.html)
NZ (1) NZ563510A (cg-RX-API-DMAC7.html)
WO (1) WO2006134150A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200710468B (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
WO2014013014A1 (en) 2012-07-18 2014-01-23 Fundació Privada Centre De Regulació Genòmica (Crg) Jak inhibitors for activation of epidermal stem cell populations
CN103880797B (zh) * 2014-03-26 2015-12-02 沈阳大学 苯并呋喃类化合物及其医药用途
WO2018041989A1 (en) 2016-09-02 2018-03-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating refractory celiac disease type 2
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
EP3947737A2 (en) 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US20220202820A1 (en) 2019-04-16 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
EP4526469A1 (en) 2022-05-16 2025-03-26 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
ATE319683T1 (de) 1998-12-11 2006-03-15 Univ Virginia Commonwealth Selektive 5-ht 6-rezeptor-liganden
WO2002100822A1 (en) 2001-06-11 2002-12-19 Biovitrum Ab Substituted sulfonamide compounds, process for their use as medicament for the treatment of cns disorders, obesity and type ii diabetes
RS44204A (sr) * 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1
NZ552282A (en) 2002-06-20 2008-07-31 Biovitrum Ab Publ New compounds useful for the treatment of obesity, type II diabetes and CNS disorders
US7943639B2 (en) * 2002-06-20 2011-05-17 Proximagen Limited Compounds
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes

Also Published As

Publication number Publication date
ZA200710468B (en) 2009-04-29
CN101193885B (zh) 2011-07-27
BRPI0612746A2 (pt) 2010-11-30
NZ563510A (en) 2011-01-28
NO20080354L (no) 2008-01-17
US7582767B2 (en) 2009-09-01
IL187575A0 (en) 2008-03-20
EA015671B1 (ru) 2011-10-31
JP2008543813A (ja) 2008-12-04
US20060293361A1 (en) 2006-12-28
HK1112918A1 (en) 2008-09-19
AU2006259082A1 (en) 2006-12-21
EP1896460A1 (en) 2008-03-12
KR20080017482A (ko) 2008-02-26
CA2610383A1 (en) 2006-12-21
MX2007015988A (es) 2008-03-07
EP1896460B1 (en) 2009-07-22
IL187575A (en) 2012-12-31
CN101193885A (zh) 2008-06-04
WO2006134150A1 (en) 2006-12-21
AU2006259082B2 (en) 2011-07-14
DK1896460T3 (da) 2009-11-16
EA200800071A1 (ru) 2008-10-30
DE602006008002D1 (de) 2009-09-03

Similar Documents

Publication Publication Date Title
ES2786563T3 (es) Productos intermedios para la preparación de moduladores de transportadores del casete de unión a ATP
US20060148818A1 (en) Novel tetraydrospiro(piperdine-2,7'- pyrrolo{3,2-b}pyridine derivatives and novel in-dole derivatives useful in the treatment of 5-ht6 receptor-related disorders
CA2575764A1 (en) Diaryl ureas as cb1 antagonists
TW201006801A (en) Imidazole carboxamides
ES2330145T3 (es) Derivados benzofuralino como inhibidores del receptor 5-ht6.
CN103214450A (zh) 作为atp-结合盒转运蛋白调节剂的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物
Burris et al. Characterization of [125I](R)-trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl) amino] tetralin binding to dopamine D3 receptors in rat olfactory tubercle.
WO2000037471A1 (en) 2-amino-9-alkylpurines: gaba brain receptor ligands
NO180486B (no) Nye indolforbindelser og anvendelse av disse i farmasöytiske preparater
TW550240B (en) Compounds having [2.2.1] bicyclo skeleton
Hocke et al. 18F‐labeled FAUC 346 and BP 897 derivatives as subtype‐selective potential PET radioligands for the dopamine D3 receptor
JP2003527377A (ja) ５−置換アリルピリミジン
TW568786B (en) A combination, pharmaceutical formulation, and kit for use in the treatment of affective disorders
Modica et al. Design, synthesis and binding properties of novel and selective 5-HT3 and 5-HT4 receptor ligands
Böhme et al. Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands
JP3830378B2 (ja) アシルアミノシクロプロパン誘導体
HK1112918B (en) Benzofuranyl derivatives as 5-ht6-receptor inhibitors
Favaloro et al. Novel imidazoline compounds that inhibit Kir-mediated vasorelaxation in rat middle cerebral artery
Chen et al. Design, synthesis and evaluation of novel tetrahydrothieno [3, 2-c] pyridine derivatives as potent smoothened antagonists
CZ287164B6 (en) Novel forms of 1-[5-methanesulfonamidoindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine crystal
US6150533A (en) N-aryloxyethyl-indoly-alkylamines for the treatment of depression
WO2022221774A1 (en) Aryl-ring-substituted 3-phenylazetidines and their use in methods for treating 5-ht2 responsive conditions
JP2002510681A (ja) うつ病治療用のｎ−アリールオキシエチル−インドリル−アルキルアミン
ZA200602756B (en) Novel tetraydrospiro{piperidine-2,7'-pyrrolo[3,2-b]pyridine derivatives and novel indole derivatives useful in the treatment of 5-HT6 receptor-related disorders
EP1897876A2 (en) Compounds useful for the treatment of obesity, type II diabetes and CNS disorders