MX2007015988A - Derivados de benzofuranilo como inhibidores del receptor 5-ht6. - Google Patents

Derivados de benzofuranilo como inhibidores del receptor 5-ht6.

Info

Publication number
MX2007015988A
MX2007015988A MX2007015988A MX2007015988A MX2007015988A MX 2007015988 A MX2007015988 A MX 2007015988A MX 2007015988 A MX2007015988 A MX 2007015988A MX 2007015988 A MX2007015988 A MX 2007015988A MX 2007015988 A MX2007015988 A MX 2007015988A
Authority
MX
Mexico
Prior art keywords
treatment
receptor
body weight
disorders
compound according
Prior art date
Application number
MX2007015988A
Other languages
English (en)
Spanish (es)
Inventor
Patrizia Caldirola
Gary Johansson
Lori Sutin
Original Assignee
Biovitrum Ab Publ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab Publ filed Critical Biovitrum Ab Publ
Publication of MX2007015988A publication Critical patent/MX2007015988A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MX2007015988A 2005-06-17 2006-06-15 Derivados de benzofuranilo como inhibidores del receptor 5-ht6. MX2007015988A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0501383 2005-06-17
US70652305P 2005-08-09 2005-08-09
PCT/EP2006/063249 WO2006134150A1 (en) 2005-06-17 2006-06-15 Benzofuranyl derivatives as 5-ht6-receptor inhibitors

Publications (1)

Publication Number Publication Date
MX2007015988A true MX2007015988A (es) 2008-03-07

Family

ID=36659956

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007015988A MX2007015988A (es) 2005-06-17 2006-06-15 Derivados de benzofuranilo como inhibidores del receptor 5-ht6.

Country Status (18)

Country Link
US (1) US7582767B2 (cg-RX-API-DMAC7.html)
EP (1) EP1896460B1 (cg-RX-API-DMAC7.html)
JP (1) JP2008543813A (cg-RX-API-DMAC7.html)
KR (1) KR20080017482A (cg-RX-API-DMAC7.html)
CN (1) CN101193885B (cg-RX-API-DMAC7.html)
AU (1) AU2006259082B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0612746A2 (cg-RX-API-DMAC7.html)
CA (1) CA2610383A1 (cg-RX-API-DMAC7.html)
DE (1) DE602006008002D1 (cg-RX-API-DMAC7.html)
DK (1) DK1896460T3 (cg-RX-API-DMAC7.html)
EA (1) EA015671B1 (cg-RX-API-DMAC7.html)
ES (1) ES2330145T3 (cg-RX-API-DMAC7.html)
IL (1) IL187575A (cg-RX-API-DMAC7.html)
MX (1) MX2007015988A (cg-RX-API-DMAC7.html)
NO (1) NO20080354L (cg-RX-API-DMAC7.html)
NZ (1) NZ563510A (cg-RX-API-DMAC7.html)
WO (1) WO2006134150A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200710468B (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
WO2014013014A1 (en) 2012-07-18 2014-01-23 Fundació Privada Centre De Regulació Genòmica (Crg) Jak inhibitors for activation of epidermal stem cell populations
CN103880797B (zh) * 2014-03-26 2015-12-02 沈阳大学 苯并呋喃类化合物及其医药用途
WO2018041989A1 (en) 2016-09-02 2018-03-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating refractory celiac disease type 2
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
EP3947737A2 (en) 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US20220202820A1 (en) 2019-04-16 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
EP4526469A1 (en) 2022-05-16 2025-03-26 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
ATE319683T1 (de) 1998-12-11 2006-03-15 Univ Virginia Commonwealth Selektive 5-ht 6-rezeptor-liganden
WO2002100822A1 (en) 2001-06-11 2002-12-19 Biovitrum Ab Substituted sulfonamide compounds, process for their use as medicament for the treatment of cns disorders, obesity and type ii diabetes
RS44204A (sr) * 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1
NZ552282A (en) 2002-06-20 2008-07-31 Biovitrum Ab Publ New compounds useful for the treatment of obesity, type II diabetes and CNS disorders
US7943639B2 (en) * 2002-06-20 2011-05-17 Proximagen Limited Compounds
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes

Also Published As

Publication number Publication date
ZA200710468B (en) 2009-04-29
CN101193885B (zh) 2011-07-27
BRPI0612746A2 (pt) 2010-11-30
NZ563510A (en) 2011-01-28
NO20080354L (no) 2008-01-17
US7582767B2 (en) 2009-09-01
IL187575A0 (en) 2008-03-20
EA015671B1 (ru) 2011-10-31
JP2008543813A (ja) 2008-12-04
US20060293361A1 (en) 2006-12-28
HK1112918A1 (en) 2008-09-19
AU2006259082A1 (en) 2006-12-21
EP1896460A1 (en) 2008-03-12
KR20080017482A (ko) 2008-02-26
CA2610383A1 (en) 2006-12-21
EP1896460B1 (en) 2009-07-22
IL187575A (en) 2012-12-31
CN101193885A (zh) 2008-06-04
ES2330145T3 (es) 2009-12-04
WO2006134150A1 (en) 2006-12-21
AU2006259082B2 (en) 2011-07-14
DK1896460T3 (da) 2009-11-16
EA200800071A1 (ru) 2008-10-30
DE602006008002D1 (de) 2009-09-03

Similar Documents

Publication Publication Date Title
Audinot et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors
RU2449990C2 (ru) Индолы в качестве модуляторов 5-ht6
CA2540861A1 (en) Novel tetraydrospiro{piperidine-2,7' -pyrrolo[3,2-b]pyridine derivatives and novel indole derivatives useful in the treatment of 5-ht6 receptor -related disorders
US20060142269A1 (en) New compounds
Seggel et al. A structure-affinity study of the binding of 4-substituted analogs of 1-(2, 5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors
JP2002535322A (ja) ピペリジン、テトラヒドロピリジン及びピペラジン誘導体、それらの製造方法及びそれらの使用方法
JP2004516239A (ja) メラニン凝集ホルモン受容体リガンド
TWI237023B (en) Benzoxazinone derivatives, their preparation and use
NO314185B1 (no) Nye alkoksyarylforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
RU2191776C2 (ru) Эрголиновые производные, способ их получения, фармацевтическая композиция
JP2007502272A (ja) ５‐ＨＴ２Ｃ受容体アゴニストとしての６‐（２，２，２‐トリフルオロエチルアミノ）‐７‐クロロ‐２，３，４，５‐テトラヒドロ‐１Ｈ‐ベンゾ［ｄ］アゼピン
EP2567698B1 (en) GPR 17 agonists and screening assay
NO180486B (no) Nye indolforbindelser og anvendelse av disse i farmasöytiske preparater
MX2007015988A (es) Derivados de benzofuranilo como inhibidores del receptor 5-ht6.
US8138333B2 (en) Sulfonyl-indole derivatives
JP2010508344A (ja) ８−スルホニル−１，３，４，８−テトラヒドロ−２ｈ−［１，４］オキサゼピノ［６，７−ｅ］インドール誘導体、および５−ｈｔ６受容体リガンドとしてのその使用
Schlachter et al. Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor
JPH037257A (ja) ピリジン誘導体及びそれを有効成分とする向精神剤
Magli et al. Synthesis, docking studies, and pharmacological evaluation of 5HT2C ligands containing the N′‐cyanoisonicotinamidine or N′‐cyanopicolinamidine nucleus
TW568786B (en) A combination, pharmaceutical formulation, and kit for use in the treatment of affective disorders
HK1112918B (en) Benzofuranyl derivatives as 5-ht6-receptor inhibitors
Stjernlöf et al. 5-, 6-, 7-and 8-amino-2-(N, N-di-n-propylamino)-1, 2, 3, 4-tetrahydronaphthalenes: centrally acting DA and 5-HT1A agonists
Kakefuda et al. N-Methylbenzanilide derivatives as a novel class of selective V1A receptor antagonists
Demopoulos et al. Kurzmitteilungen: Synthesis and Biological Evaluation of 3‐(2‐Aminoethyl) pyrrole Derivatives Synthese und biologische Bewertung von 3‐(2‐Aminoethyl) pyrrol‐Derivaten
KR20070020373A (ko) 5-ＨＴ6 수용체-관련 장애의 치료에 유용한 신규한 테트라히드로스피로｛피페리딘-2,7'-피롤로[3,2-ｂ]피리딘｝ 유도체 및 신규한 인돌 유도체

Legal Events

Date Code Title Description
FG Grant or registration