ES2297125T5 - Ésteres de astaxantina - Google Patents
Ésteres de astaxantina Download PDFInfo
- Publication number
- ES2297125T5 ES2297125T5 ES03702554T ES03702554T ES2297125T5 ES 2297125 T5 ES2297125 T5 ES 2297125T5 ES 03702554 T ES03702554 T ES 03702554T ES 03702554 T ES03702554 T ES 03702554T ES 2297125 T5 ES2297125 T5 ES 2297125T5
- Authority
- ES
- Spain
- Prior art keywords
- astaxanthin
- food
- formulation
- astaxanthin derivative
- carotenoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001514 astaxanthins Chemical class 0.000 title claims abstract description 32
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 60
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 39
- 235000013793 astaxanthin Nutrition 0.000 claims description 39
- 239000001168 astaxanthin Substances 0.000 claims description 39
- 229940022405 astaxanthin Drugs 0.000 claims description 39
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 38
- 235000013305 food Nutrition 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 22
- 241001465754 Metazoa Species 0.000 claims description 18
- 238000009472 formulation Methods 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 12
- 235000021466 carotenoid Nutrition 0.000 claims description 11
- 150000001747 carotenoids Chemical class 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000000049 pigment Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- 235000019198 oils Nutrition 0.000 claims description 5
- 239000003960 organic solvent Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 239000000084 colloidal system Substances 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 238000001027 hydrothermal synthesis Methods 0.000 claims description 4
- 230000001681 protective effect Effects 0.000 claims description 4
- FFYPMLJYZAEMQB-UHFFFAOYSA-N diethyl pyrocarbonate Chemical compound CCOC(=O)OC(=O)OCC FFYPMLJYZAEMQB-UHFFFAOYSA-N 0.000 claims description 3
- PHELOKYCCWVWFE-UHFFFAOYSA-N 2,2-dimethoxyacetic acid Chemical compound COC(OC)C(O)=O PHELOKYCCWVWFE-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 235000019871 vegetable fat Nutrition 0.000 claims 2
- 239000003925 fat Substances 0.000 claims 1
- 230000000485 pigmenting effect Effects 0.000 claims 1
- 239000010773 plant oil Substances 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 51
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 18
- 235000013372 meat Nutrition 0.000 description 12
- 241000251468 Actinopterygii Species 0.000 description 11
- 235000019688 fish Nutrition 0.000 description 11
- 230000019612 pigmentation Effects 0.000 description 11
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 10
- 241000277331 Salmonidae Species 0.000 description 9
- 239000013078 crystal Substances 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 230000032050 esterification Effects 0.000 description 8
- 238000005886 esterification reaction Methods 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 230000015556 catabolic process Effects 0.000 description 7
- 238000006731 degradation reaction Methods 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 241000238424 Crustacea Species 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 235000019621 digestibility Nutrition 0.000 description 6
- 238000001125 extrusion Methods 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- -1 astaxanthin diesters Chemical class 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 241000972773 Aulopiformes Species 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 235000019515 salmon Nutrition 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000238557 Decapoda Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 238000009360 aquaculture Methods 0.000 description 3
- 244000144974 aquaculture Species 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical group C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 150000008065 acid anhydrides Chemical class 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 239000000378 calcium silicate Substances 0.000 description 2
- 229910052918 calcium silicate Inorganic materials 0.000 description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000013505 freshwater Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 241000894007 species Species 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- SCCCIUGOOQLDGW-UHFFFAOYSA-N 1,1-dicyclohexylurea Chemical compound C1CCCCC1N(C(=O)N)C1CCCCC1 SCCCIUGOOQLDGW-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- XWGXLRRTBBCVMC-UHFFFAOYSA-N 2-methylbutanedioyl dichloride Chemical compound ClC(=O)C(C)CC(Cl)=O XWGXLRRTBBCVMC-UHFFFAOYSA-N 0.000 description 1
- SMJRBWINMFUUDS-UHFFFAOYSA-N 2-thienylacetic acid Chemical compound OC(=O)CC1=CC=CS1 SMJRBWINMFUUDS-UHFFFAOYSA-N 0.000 description 1
- 241001519451 Abramis brama Species 0.000 description 1
- 241000473391 Archosargus rhomboidalis Species 0.000 description 1
- 241000238017 Astacoidea Species 0.000 description 1
- 241000252229 Carassius auratus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- OIFBSDVPJOWBCH-UHFFFAOYSA-N Diethyl carbonate Chemical compound CCOC(=O)OCC OIFBSDVPJOWBCH-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 241000269969 Limanda Species 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 229930182559 Natural dye Natural products 0.000 description 1
- 241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
- 241001600434 Plectroglyphidodon lacrymatus Species 0.000 description 1
- 241000277263 Salmo Species 0.000 description 1
- 241000316146 Salmo trutta trutta Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 241000276707 Tilapia Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 150000003927 aminopyridines Chemical class 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 235000012682 canthaxanthin Nutrition 0.000 description 1
- FDSDTBUPSURDBL-DKLMTRRASA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-DKLMTRRASA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 241001233037 catfish Species 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 150000004292 cyclic ethers Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- MSYBLBLAMDYKKZ-UHFFFAOYSA-N hydron;pyridine-3-carbonyl chloride;chloride Chemical compound Cl.ClC(=O)C1=CC=CN=C1 MSYBLBLAMDYKKZ-UHFFFAOYSA-N 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000001087 myotubule Anatomy 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 235000015074 other food component Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000009372 pisciculture Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
- A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
- A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Birds (AREA)
- Marine Sciences & Fisheries (AREA)
- Insects & Arthropods (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02002728 | 2002-02-06 | ||
| EP02002728 | 2002-02-06 | ||
| PCT/EP2003/000873 WO2003066583A1 (en) | 2002-02-06 | 2003-01-29 | Astaxanthin esters |
Publications (2)
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| ES2297125T3 ES2297125T3 (es) | 2008-05-01 |
| ES2297125T5 true ES2297125T5 (es) | 2013-07-03 |
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| JP (1) | JP4420675B2 (enExample) |
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| CA (1) | CA2474208C (enExample) |
| DE (1) | DE60317770T3 (enExample) |
| ES (1) | ES2297125T5 (enExample) |
| IN (1) | IN2004CH01714A (enExample) |
| MX (1) | MX247604B (enExample) |
| NO (1) | NO328928B1 (enExample) |
| WO (1) | WO2003066583A1 (enExample) |
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| US20080008798A1 (en) * | 2002-02-06 | 2008-01-10 | Arnold Gloor | Salts of astaxathin esters |
| CA2495167C (en) * | 2002-07-29 | 2018-08-21 | Hawaii Biotech, Inc. | Structural carotenoid analogs for the inhibition and amelioration of disease |
| US7521584B2 (en) | 2002-07-29 | 2009-04-21 | Cardax Pharmaceuticals, Inc. | Carotenoid analogs or derivatives for the inhibition and amelioration of disease |
| US7320997B2 (en) | 2002-07-29 | 2008-01-22 | Cardax Pharmaceuticals, Inc. | Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease |
| US7345091B2 (en) | 2002-07-29 | 2008-03-18 | Cardax Pharmaceuticals, Inc. | Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease |
| US7375133B2 (en) | 2002-07-29 | 2008-05-20 | Cardax Pharmaceuticals, Inc. | Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease |
| AU2003277393A1 (en) * | 2002-10-25 | 2004-05-25 | Prodemex, S.A. De C.V. | Method for producing esterified astaxanthin from esterified zeaxanthin |
| US7691901B2 (en) | 2004-04-14 | 2010-04-06 | Cardax Pharmaceuticals Inc. | Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation |
| PT1806982T (pt) | 2004-09-28 | 2018-11-15 | Avivagen Inc | Composições e métodos para a promoção do aumento de peso e da conversão de alimentos |
| US20060183185A1 (en) | 2004-10-01 | 2006-08-17 | Lockwood Samuel F | Method for the synthesis of astaxanthin |
| WO2006041903A2 (en) | 2004-10-08 | 2006-04-20 | Coho Hydroclean Sa | A method of cultivating animals to develop a desired color and to increase their rate of growth |
| CA2602183C (en) | 2005-03-18 | 2014-05-06 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| CA2610502A1 (en) | 2005-03-29 | 2006-10-05 | Cardax Pharmaceuticals, Inc. | Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof |
| MX2008012758A (es) * | 2006-04-05 | 2008-12-10 | Chemaphor Inc | Suplemento dietario que contiene carotenoides. |
| US20070293568A1 (en) | 2006-06-16 | 2007-12-20 | Yamaha Hatsudoki Kabushiki Kaisha | Neurocyte Protective Agent |
| WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| EP2111125B2 (de) | 2007-01-16 | 2016-11-16 | Basf Se | Flüssige formulierungen enthaltend carotinoide |
| EP1952845A1 (en) | 2007-01-26 | 2008-08-06 | DSMIP Assets B.V. | Use of an astaxathin derivative for cosmetic purposes |
| CN101796025B (zh) * | 2007-08-31 | 2013-06-12 | 巴斯夫欧洲公司 | 生产虾青素衍生物的含油溶液的方法 |
| CA2704098C (en) | 2007-10-26 | 2018-01-02 | Chemaphor Inc. | Compositions and methods for enhancing immune response |
| WO2009068432A1 (de) | 2007-11-29 | 2009-06-04 | Basf Se | Pulverförmige carotinoidzubereitung für die färbung von getränken |
| WO2009112506A1 (en) * | 2008-03-11 | 2009-09-17 | Dsm Ip Assets B.V. | Novel use of carotenoid (ester)s |
| ES2563640T5 (es) | 2008-10-07 | 2021-11-22 | Basf Se | Emulsión estable, lista para usar |
| PE20120208A1 (es) * | 2008-11-28 | 2012-03-06 | Pronova Biopharma Norge As | Composicion que comprende una mezcla comestible procesada de aceite o grasa |
| EP2403364B1 (de) | 2009-03-05 | 2013-01-09 | Basf Se | Verfahren zur herstellung von lösungen von astaxanthin-derivaten |
| CN102340998B (zh) * | 2009-03-05 | 2014-03-26 | 巴斯夫欧洲公司 | 虾青素衍生物的配制剂及其应用i |
| EP2403363B1 (de) | 2009-03-05 | 2012-12-26 | Basf Se | Formulierung von astaxanthin-derivaten und deren verwendung ii |
| CN102341004B (zh) * | 2009-03-05 | 2014-04-16 | 巴斯夫欧洲公司 | 虾青素衍生物的粉状组合物i |
| DK2403362T3 (da) * | 2009-03-05 | 2013-04-15 | Basf Se | Pulverformede sammensætninger af astaxanthin-derivater II |
| WO2010100232A2 (de) * | 2009-03-05 | 2010-09-10 | Basf Se | Formulierung von astaxanthin-derivaten und deren verwendung iii |
| ES2813909T3 (es) | 2009-04-30 | 2021-03-25 | Avivagen Inc | Métodos y composiciones para mejorar la salud de los animales |
| US8492579B2 (en) | 2010-02-08 | 2013-07-23 | Basf Se | Method for producing astaxanthin dimethyldisuccinate |
| TWI501946B (zh) * | 2010-02-08 | 2015-10-01 | Basf Se | 蝦紅素二琥珀酸二甲酯之製造方法 |
| GB201009271D0 (en) | 2010-06-02 | 2010-07-21 | Promar As | Compositions |
| CA2916759C (en) | 2013-08-08 | 2023-02-28 | Knipbio | Methylotrophs for aquaculture and animal feed |
| KR101963946B1 (ko) | 2014-05-20 | 2019-03-29 | 아스타 파마슈티칼즈 가부시키가이샤 | 카로테노이드 유도체, 그 약학상 허용되는 염 또는 그 약학상 허용되는 에스테르류 혹은 아미드류 |
| WO2016037785A1 (de) | 2014-09-11 | 2016-03-17 | Basf Se | Verfahren zur herstellung von astaxanthinestern |
| US10160831B2 (en) | 2014-10-19 | 2018-12-25 | Shenkar College Of Engineering And Design | Astaxanthin based polymer and uses thereof |
| CN106543323B (zh) * | 2015-09-23 | 2018-10-16 | 合肥炜烨光学科技有限公司 | 一种聚类胡萝卜素丙烯酸酯蓝光吸收剂及其制备方法 |
| CN105504865A (zh) * | 2015-12-15 | 2016-04-20 | 重庆大学 | 一种酯化修饰萝卜红色素的制备及纯化方法 |
| CN105646869B (zh) * | 2016-01-04 | 2018-01-16 | 中国海洋大学 | 一种水溶性虾青素衍生物及其制备方法 |
| CN109689610A (zh) * | 2016-09-16 | 2019-04-26 | 巴斯夫欧洲公司 | 制备作为类胡萝卜素的结构单元的12’-阿朴胡萝卜素醛酯的方法 |
| CN106748946A (zh) * | 2017-02-14 | 2017-05-31 | 烟台固特丽生物科技股份有限公司 | 一种含水溶性虾青素作物营养液的制备方法 |
| CN114761380A (zh) * | 2019-09-27 | 2022-07-15 | 科达士公司 | 虾青素酯及其使用方法 |
| EP4267118A4 (en) * | 2020-12-24 | 2025-01-22 | Axelyf ehf. | XANTHOPHYLL DERIVATIVES |
| EP4067342B1 (en) | 2021-04-02 | 2023-12-27 | Kemijski Institut / National Institute of Chemistry | Sustainable preparation of xanthophyll esters |
| CN118108646B (zh) * | 2024-04-22 | 2024-08-02 | 潍坊富邦药业有限公司 | 一种水溶性虾青素衍生物及其制备方法 |
| CN118063368B (zh) * | 2024-04-22 | 2024-08-02 | 潍坊富邦药业有限公司 | 一种水溶性虾青素衍生物及其合成方法 |
| CN118084755B (zh) * | 2024-04-22 | 2024-08-02 | 潍坊富邦药业有限公司 | 一种高水溶性虾青素衍生物及制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4871551A (en) | 1988-02-08 | 1989-10-03 | Microbio Resources, Inc. | Pigmentation supplements for animal feed compositions |
| JPH01202261A (ja) | 1988-02-09 | 1989-08-15 | Kyowa Hakko Kogyo Co Ltd | 赤色魚用餌料と赤色魚の養殖方法 |
| DE4322277A1 (de) * | 1993-07-05 | 1995-01-12 | Basf Ag | Verbessertes Verfahren zur Herstellung von Astaxanthin, neue Zwischenprodukte hierfür sowie ein Verfahren zu deren Herstellung |
| DE4430289A1 (de) * | 1993-09-04 | 1995-03-09 | Basf Ag | Verbessertes Verfahren zur Herstellung von Astaxanthin |
| JPH07300421A (ja) † | 1994-04-28 | 1995-11-14 | Itano Reitou Kk | 抗炎症剤 |
| DE19649062A1 (de) * | 1996-11-27 | 1998-05-28 | Basf Ag | Flüssige, mit Öl mischbare Carotinoid-Zubereitungen |
| US5959138A (en) † | 1997-11-25 | 1999-09-28 | Industrial Organica S.A. De C.V. | Short chain diesters and process for making the same |
| CA2261456A1 (en) † | 1998-02-23 | 1999-08-23 | F. Hoffmann-La Roche Ag | Preparation of a finely divided pulverous carotenoid preparation |
| NL1010351C2 (nl) † | 1998-10-19 | 2001-01-08 | Werklust & Beheer B V | Esters van caroteno´den voor gebruik in de preventie en behandeling van oogaandoeningen. |
| NO309386B1 (no) | 1999-04-19 | 2001-01-22 | Norsk Hydro As | Pigment |
-
2003
- 2003-01-29 WO PCT/EP2003/000873 patent/WO2003066583A1/en not_active Ceased
- 2003-01-29 CN CNB038034018A patent/CN100375740C/zh not_active Expired - Fee Related
- 2003-01-29 MX MXPA04007557 patent/MX247604B/es active IP Right Grant
- 2003-01-29 CA CA2474208A patent/CA2474208C/en not_active Expired - Lifetime
- 2003-01-29 EP EP03702554A patent/EP1474388B2/en not_active Expired - Lifetime
- 2003-01-29 JP JP2003565958A patent/JP4420675B2/ja not_active Expired - Fee Related
- 2003-01-29 ES ES03702554T patent/ES2297125T5/es not_active Expired - Lifetime
- 2003-01-29 US US10/503,696 patent/US7253297B2/en not_active Expired - Lifetime
- 2003-01-29 DE DE60317770T patent/DE60317770T3/de not_active Expired - Lifetime
- 2003-01-29 AU AU2003205699A patent/AU2003205699B8/en not_active Ceased
-
2004
- 2004-08-03 IN IN1714CH2004 patent/IN2004CH01714A/en unknown
- 2004-08-05 KR KR20047012137A patent/KR100958483B1/ko not_active Expired - Fee Related
- 2004-09-06 NO NO20043728A patent/NO328928B1/no not_active IP Right Cessation
-
2007
- 2007-01-10 US US11/652,263 patent/US20070110881A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070110881A1 (en) | 2007-05-17 |
| IN2004CH01714A (enExample) | 2006-02-24 |
| NO20043728L (no) | 2004-09-06 |
| NO20043728D0 (no) | 2004-09-06 |
| US7253297B2 (en) | 2007-08-07 |
| EP1474388B2 (en) | 2013-03-06 |
| EP1474388A1 (en) | 2004-11-10 |
| CA2474208A1 (en) | 2003-08-14 |
| MX247604B (es) | 2007-07-30 |
| ES2297125T3 (es) | 2008-05-01 |
| KR20040083437A (ko) | 2004-10-01 |
| CN1628097A (zh) | 2005-06-15 |
| AU2003205699A1 (en) | 2003-09-02 |
| AU2003205699B8 (en) | 2008-06-05 |
| CA2474208C (en) | 2011-03-29 |
| JP4420675B2 (ja) | 2010-02-24 |
| EP1474388B1 (en) | 2007-11-28 |
| NO328928B1 (no) | 2010-06-21 |
| DE60317770T2 (de) | 2008-10-30 |
| MXPA04007557A (es) | 2004-11-10 |
| DE60317770T3 (de) | 2013-07-25 |
| US20050096477A1 (en) | 2005-05-05 |
| DE60317770D1 (en) | 2008-01-10 |
| WO2003066583A1 (en) | 2003-08-14 |
| AU2003205699B2 (en) | 2008-05-08 |
| JP2005517010A (ja) | 2005-06-09 |
| CN100375740C (zh) | 2008-03-19 |
| KR100958483B1 (ko) | 2010-05-17 |
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