ES2296812T3 - Heterociclos biciclicos, medicamentos que contienen estos compuestos, su uso y procedimiento para su preparacion. - Google Patents
Heterociclos biciclicos, medicamentos que contienen estos compuestos, su uso y procedimiento para su preparacion. Download PDFInfo
- Publication number
- ES2296812T3 ES2296812T3 ES01976107T ES01976107T ES2296812T3 ES 2296812 T3 ES2296812 T3 ES 2296812T3 ES 01976107 T ES01976107 T ES 01976107T ES 01976107 T ES01976107 T ES 01976107T ES 2296812 T3 ES2296812 T3 ES 2296812T3
- Authority
- ES
- Spain
- Prior art keywords
- chloro
- oxo
- quinazoline
- amino
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 8
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 claims abstract description 5
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims abstract description 3
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims abstract description 3
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 3
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims abstract description 3
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims abstract description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 38
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10042059A DE10042059A1 (de) | 2000-08-26 | 2000-08-26 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10042059 | 2000-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2296812T3 true ES2296812T3 (es) | 2008-05-01 |
Family
ID=7653946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01976107T Expired - Lifetime ES2296812T3 (es) | 2000-08-26 | 2001-08-18 | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su uso y procedimiento para su preparacion. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1315718B1 (enExample) |
| JP (1) | JP4901055B2 (enExample) |
| AU (1) | AU2001295481A1 (enExample) |
| CA (1) | CA2417652C (enExample) |
| DE (2) | DE10042059A1 (enExample) |
| ES (1) | ES2296812T3 (enExample) |
| MX (1) | MXPA03001725A (enExample) |
| WO (1) | WO2002018372A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| JP5377332B2 (ja) | 2007-02-06 | 2013-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式へテロ環、それらの化合物を含む薬剤、その使用及びその製法 |
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| MX2010012442A (es) | 2008-05-13 | 2011-10-11 | Astrazeneca Ab | Sal de fumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(n-m etilcarbamoilmetil) piperidin-4-il]oxi}quinazolina. |
| EP2313397B1 (de) | 2008-08-08 | 2016-04-20 | Boehringer Ingelheim International GmbH | Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| SI2451445T1 (sl) | 2009-07-06 | 2019-07-31 | Boehringer Ingelheim International Gmbh | Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino |
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| US9353123B2 (en) | 2013-02-20 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| BR112016005317A2 (pt) * | 2013-09-19 | 2017-09-12 | Centre Nat Rech Scient | derivados de quinazolina e seu uso como inibidores de dna metiltransferase |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| KR20160099084A (ko) | 2013-11-01 | 2016-08-19 | 칼라 파마슈티컬스, 인크. | 치료 화합물의 결정질 형태 및 그의 용도 |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| CN105461729B (zh) * | 2015-11-18 | 2017-12-05 | 乳源瑶族自治县大众药品贸易有限公司 | 一种egfr抑制剂的盐、晶型及其用途 |
| CN105294716B (zh) * | 2015-11-18 | 2017-12-22 | 乳源瑶族自治县大众药品贸易有限公司 | 一种氨基喹唑啉类衍生物的二水杨酸盐及其晶型 |
| WO2018048750A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| EP3509421A4 (en) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
| IL303606A (en) * | 2020-12-22 | 2023-08-01 | Hanmi Pharmaceutical Co Ltd | A new QUINAZOLINE derivative compound as an SOS1 inhibitor, and its use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| JP2994165B2 (ja) * | 1992-06-26 | 1999-12-27 | ゼネカ・リミテッド | キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤 |
| GB9510757D0 (en) * | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| HU230728B1 (hu) * | 1998-09-29 | 2017-12-28 | Wyeth Holdings Llc | Szubsztituált 3-cianokinolinok mint protein tirozin kinázok inhibitorai |
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10042058A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
-
2000
- 2000-08-26 DE DE10042059A patent/DE10042059A1/de not_active Withdrawn
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2001
- 2001-08-18 MX MXPA03001725A patent/MXPA03001725A/es active IP Right Grant
- 2001-08-18 EP EP01976107A patent/EP1315718B1/de not_active Expired - Lifetime
- 2001-08-18 WO PCT/EP2001/009533 patent/WO2002018372A1/de not_active Ceased
- 2001-08-18 CA CA002417652A patent/CA2417652C/en not_active Expired - Fee Related
- 2001-08-18 ES ES01976107T patent/ES2296812T3/es not_active Expired - Lifetime
- 2001-08-18 DE DE50113328T patent/DE50113328D1/de not_active Expired - Lifetime
- 2001-08-18 AU AU2001295481A patent/AU2001295481A1/en not_active Abandoned
- 2001-08-18 JP JP2002523887A patent/JP4901055B2/ja not_active Expired - Fee Related
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|---|---|
| CA2417652A1 (en) | 2003-01-28 |
| AU2001295481A1 (en) | 2002-03-13 |
| DE50113328D1 (de) | 2008-01-10 |
| MXPA03001725A (es) | 2004-12-06 |
| JP4901055B2 (ja) | 2012-03-21 |
| EP1315718B1 (de) | 2007-11-28 |
| WO2002018372A1 (de) | 2002-03-07 |
| DE10042059A1 (de) | 2002-03-07 |
| EP1315718A1 (de) | 2003-06-04 |
| JP2004507535A (ja) | 2004-03-11 |
| CA2417652C (en) | 2008-10-28 |
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